메뉴 건너뛰기




Volumn 84, Issue 21, 2010, Pages 11134-11144

Kaposi's sarcoma-associated herpesvirus inhibits interleukin-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latency

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4; JANUS KINASE 1; LATENCY ASSOCIATED NUCLEAR ANTIGEN; STAT6 PROTEIN; STAT6 PROTEIN, HUMAN;

EID: 77957953571     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01293-10     Document Type: Article
Times cited : (36)

References (68)
  • 1
    • 0346336776 scopus 로고    scopus 로고
    • Transcriptional coactivation of c-Jun by the KSHV-encoded LANA
    • An, J., Y. Sun, and M. B. Rettig. 2004. Transcriptional coactivation of c-Jun by the KSHV-encoded LANA. Blood 103:222-228.
    • (2004) Blood , vol.103 , pp. 222-228
    • An, J.1    Sun, Y.2    Rettig, M.B.3
  • 2
    • 0034611717 scopus 로고    scopus 로고
    • Kaposi's sarcoma
    • Antman, K., and Y. Chang. 2000. Kaposi's sarcoma. N. Engl. J. Med. 342:1027-1038.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1027-1038
    • Antman, K.1    Chang, Y.2
  • 3
    • 0037441888 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
    • DOI 10.1182/blood-2002-07-2130
    • Aoki, Y., G. M. Feldman, and G. Tosato. 2003. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood 101:1535-1542. (Pubitemid 36182531)
    • (2003) Blood , vol.101 , Issue.4 , pp. 1535-1542
    • Aoki, Y.1    Feldman, G.M.2    Tosato, G.3
  • 5
    • 0033597453 scopus 로고    scopus 로고
    • Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen
    • Ballestas, M. E., P. A. Chatis, and K. M. Kaye. 1999. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science 284:641-644.
    • (1999) Science , vol.284 , pp. 641-644
    • Ballestas, M.E.1    Chatis, P.A.2    Kaye, K.M.3
  • 6
    • 65349138164 scopus 로고    scopus 로고
    • A Kaposi's sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits, Jak and STAT proteins, and blocks interferon-mediated signal transduction
    • Bisson, S. A., A. L. Page, and D. Ganem. 2009. A Kaposi's sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits, Jak and STAT proteins, and blocks interferon-mediated signal transduction. J. Virol. 83:5056-5066.
    • (2009) J. Virol. , vol.83 , pp. 5056-5066
    • Bisson, S.A.1    Page, A.L.2    Ganem, D.3
  • 8
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • Bromberg, J. 2002. Stat proteins and oncogenesis. J. Clin. Invest. 109:1139-1142.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1139-1142
    • Bromberg, J.1
  • 9
    • 51649092609 scopus 로고    scopus 로고
    • Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines
    • Buglio, D., G. V. Georgakis, S. Hanabuchi, K. Arima, N. M. Khaskhely, Y. J. Liu, and A. Younes. 2008. Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines. Blood 112:1424-1433.
    • (2008) Blood , vol.112 , pp. 1424-1433
    • Buglio, D.1    Georgakis, G.V.2    Hanabuchi, S.3    Arima, K.4    Khaskhely, N.M.5    Liu, Y.J.6    Younes, A.7
  • 10
    • 16444380479 scopus 로고    scopus 로고
    • KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway
    • Burger, M., T. Hartmann, J. A. Burger, and I. Schraufstatter. 2005. KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway. Oncogene 24:2067-2075.
    • (2005) Oncogene , vol.24 , pp. 2067-2075
    • Burger, M.1    Hartmann, T.2    Burger, J.A.3    Schraufstatter, I.4
  • 11
    • 33746787632 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1α to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions
    • Cai, Q., K. Lan, S. C. Verma, H. Si, D. Lin, and E. S. Robertson. 2006. Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1α to upregulate RTA expression during hypoxia: latency control under low oxygen conditions. J. Virol. 80:7965-7975.
    • (2006) J. Virol. , vol.80 , pp. 7965-7975
    • Cai, Q.1    Lan, K.2    Verma, S.C.3    Si, H.4    Lin, D.5    Robertson, E.S.6
  • 12
    • 34648833286 scopus 로고    scopus 로고
    • A potential α-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1α in normoxia
    • Cai, Q., M. Murakami, H. Si, and E. S. Robertson. 2007. A potential α-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1α in normoxia. J. Virol. 81:10413-10423.
    • (2007) J. Virol. , vol.81 , pp. 10413-10423
    • Cai, Q.1    Murakami, M.2    Si, H.3    Robertson, E.S.4
  • 13
    • 33750464049 scopus 로고    scopus 로고
    • EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors
    • Cai, Q. L., J. S. Knight, S. C. Verma, P. Zald, and E. S. Robertson. 2006. EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors. PLoS Pathog. 2:e116.
    • (2006) PLoS Pathog. , vol.2
    • Cai, Q.L.1    Knight, J.S.2    Verma, S.C.3    Zald, P.4    Robertson, E.S.5
  • 14
    • 0029069445 scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
    • Cesarman, E., Y. Chang, P. S. Moore, J. W. Said, and D. M. Knowles. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332:1186-1191.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1186-1191
    • Cesarman, E.1    Chang, Y.2    Moore, P.S.3    Said, J.W.4    Knowles, D.M.5
  • 15
    • 0028588064 scopus 로고
    • Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    • Chang, Y., E. Cesarman, M. S. Pessin, F. Lee, J. Culpepper, D. M. Knowles, and P. S. Moore. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865-1869.
    • (1994) Science , vol.266 , pp. 1865-1869
    • Chang, Y.1    Cesarman, E.2    Pessin, M.S.3    Lee, F.4    Culpepper, J.5    Knowles, D.M.6    Moore, P.S.7
  • 16
    • 72949118092 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice
    • Chen, X., L. Cheng, X. Jia, Y. Zeng, S. Yao, Z. Lv, D. Qin, X. Fang, Y. Lei, and C. Lu. 2009. Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice. Neoplasia 11:1272-1284.
    • (2009) Neoplasia , vol.11 , pp. 1272-1284
    • Chen, X.1    Cheng, L.2    Jia, X.3    Zeng, Y.4    Yao, S.5    Lv, Z.6    Qin, D.7    Fang, X.8    Lei, Y.9    Lu, C.10
  • 17
    • 0025763290 scopus 로고
    • T and B cell collaboration: Induction of motility in small, resting B cells by interleukin 4
    • Clinchy, B., C. Elenstrom, E. Severinson, and G. Moller. 1991. T and B cell collaboration: induction of motility in small, resting B cells by interleukin 4. Eur. J. Immunol. 21:1445-1451.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1445-1451
    • Clinchy, B.1    Elenstrom, C.2    Severinson, E.3    Moller, G.4
  • 18
    • 0033604613 scopus 로고    scopus 로고
    • The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells
    • Cotter, M. A., II, and E. S. Robertson. 1999. The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. Virology 264:254-264.
    • (1999) Virology , vol.264 , pp. 254-264
    • Cotter II, M.A.1    Robertson, E.S.2
  • 19
    • 0033905684 scopus 로고    scopus 로고
    • STAT6 is required for the regulation of IL-4-induced cytoskeletal events in B cells
    • Davey, E. J., G. Greicius, J. Thyberg, and E. Severinson. 2000. STAT6 is required for the regulation of IL-4-induced cytoskeletal events in B cells. Int. Immunol. 12:995-1003.
    • (2000) Int. Immunol. , vol.12 , pp. 995-1003
    • Davey, E.J.1    Greicius, G.2    Thyberg, J.3    Severinson, E.4
  • 20
    • 0032103026 scopus 로고    scopus 로고
    • Regulation of cell morphology in B lymphocytes by IL-4: Evidence for induced cytoskeletal changes
    • Davey, E. J., J. Thyberg, D. H. Conrad, and E. Severinson. 1998. Regulation of cell morphology in B lymphocytes by IL-4: evidence for induced cytoskeletal changes. J. Immunol. 160:5366-5373.
    • (1998) J. Immunol. , vol.160 , pp. 5366-5373
    • Davey, E.J.1    Thyberg, J.2    Conrad, D.H.3    Severinson, E.4
  • 21
    • 0028917885 scopus 로고
    • Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: Regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50
    • Delphin, S., and J. Stavnezer. 1995. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50. J. Exp. Med. 181:181-192.
    • (1995) J. Exp. Med. , vol.181 , pp. 181-192
    • Delphin, S.1    Stavnezer, J.2
  • 22
    • 44649172694 scopus 로고    scopus 로고
    • KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor
    • Di Bartolo, D. L., M. Cannon, Y. F. Liu, R. Renne, A. Chadburn, C. Boshoff, and E. Cesarman. 2008. KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor. Blood 111:4731-4740.
    • (2008) Blood , vol.111 , pp. 4731-4740
    • Di Bartolo, D.L.1    Cannon, M.2    Liu, Y.F.3    Renne, R.4    Chadburn, A.5    Boshoff, C.6    Cesarman, E.7
  • 24
    • 33644651607 scopus 로고    scopus 로고
    • The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma
    • Fakhari, F. D., J. H. Jeong, Y. Kanan, and D. P. Dittmer. 2006. The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma. J. Clin. Invest. 116:735-742.
    • (2006) J. Clin. Invest. , vol.116 , pp. 735-742
    • Fakhari, F.D.1    Jeong, J.H.2    Kanan, Y.3    Dittmer, D.P.4
  • 25
    • 0033599006 scopus 로고    scopus 로고
    • p53 inhibition by the LANA protein of KSHV protects against cell death
    • Friborg, J., Jr., W. Kong, M. O. Hottiger, and G. J. Nabel. 1999. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 402:889-894.
    • (1999) Nature , vol.402 , pp. 889-894
    • Friborg Jr., J.1    Kong, W.2    Hottiger, M.O.3    Nabel, G.J.4
  • 26
    • 0037348372 scopus 로고    scopus 로고
    • A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency
    • Fujimuro, M., F. Y. Wu, C. ApRhys, H. Kajumbula, D. B. Young, G. S. Hayward, and S. D. Hayward. 2003. A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat. Med. 9:300-306.
    • (2003) Nat. Med. , vol.9 , pp. 300-306
    • Fujimuro, M.1    Wu, F.Y.2    ApRhys, C.3    Kajumbula, H.4    Young, D.B.5    Hayward, G.S.6    Hayward, S.D.7
  • 27
  • 28
    • 0034870212 scopus 로고    scopus 로고
    • DNA binding and modulation of gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
    • DOI 10.1128/JVI.75.17.7882-7892.2001
    • Garber, A. C., M. A. Shu, J. Hu, and R. Renne. 2001. DNA binding and modulation of gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J. Virol. 75:7882-7892. (Pubitemid 32743660)
    • (2001) Journal of Virology , vol.75 , Issue.17 , pp. 7882-7892
    • Garber, A.C.1    Shu, M.A.2    Hu, J.3    Renne, R.4
  • 29
    • 0030862919 scopus 로고    scopus 로고
    • Responsiveness of human neutrophils to interleukin-4: Induction of cytoskeletal rearrangements, de novo protein synthesis and delay of apoptosis
    • Girard, D., R. Paquin, and A. D. Beaulieu. 1997. Responsiveness of human neutrophils to interleukin-4: induction of cytoskeletal rearrangements, de novo protein synthesis and delay of apoptosis. Biochem. J. 325:147-153.
    • (1997) Biochem. J. , vol.325 , pp. 147-153
    • Girard, D.1    Paquin, R.2    Beaulieu, A.D.3
  • 31
    • 33744546660 scopus 로고    scopus 로고
    • Signaling mechanisms, interaction partners, and target genes of STAT6
    • DOI 10.1016/j.cytogfr.2006.01.004, PII S1359610106000025
    • Hebenstreit, D., G. Wirnsberger, J. Horejs-Hoeck, and A. Duschl. 2006. Signaling mechanisms, interaction partners, and target genes of STAT6. Cytokine Growth Factor Rev. 17:173-188. (Pubitemid 43816893)
    • (2006) Cytokine and Growth Factor Reviews , vol.17 , Issue.3 , pp. 173-188
    • Hebenstreit, D.1    Wirnsberger, G.2    Horejs-Hoeck, J.3    Duschl, A.4
  • 32
    • 0035892769 scopus 로고    scopus 로고
    • Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignancies
    • Katano, H., Y. Sato, and T. Sata. 2001. Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignancies. Cancer 92:3076-3084.
    • (2001) Cancer , vol.92 , pp. 3076-3084
    • Katano, H.1    Sato, Y.2    Sata, T.3
  • 33
    • 0030734037 scopus 로고    scopus 로고
    • Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus
    • Kedes, D. H., M. Lagunoff, R. Renne, and D. Ganem. 1997. Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J. Clin. Invest. 100:2606-2610.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2606-2610
    • Kedes, D.H.1    Lagunoff, M.2    Renne, R.3    Ganem, D.4
  • 34
    • 0032018175 scopus 로고    scopus 로고
    • Regulation of gene expression, growth, and cell survival by IL-4: Contribution of multiple signaling pathways
    • Keegan, A. D., and J. Zamorano. 1998. Regulation of gene expression, growth, and cell survival by IL-4: contribution of multiple signaling pathways. Cell Res. 8:1-13.
    • (1998) Cell Res. , vol.8 , pp. 1-13
    • Keegan, A.D.1    Zamorano, J.2
  • 35
    • 0031261173 scopus 로고    scopus 로고
    • Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genome
    • Kellam, P., C. Boshoff, D. Whitby, S. Matthews, R. A. Weiss, and S. J. Talbot. 1997. Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genome. J. Hum. Virol. 1:19-29.
    • (1997) J. Hum. Virol. , vol.1 , pp. 19-29
    • Kellam, P.1    Boshoff, C.2    Whitby, D.3    Matthews, S.4    Weiss, R.A.5    Talbot, S.J.6
  • 36
    • 0027418575 scopus 로고
    • IL-4 regulates the morphology, cytoskeleton, and proliferation of human umbilical vein endothelial cells: Relationship between vimentin and CD23
    • Klein, N. J., K. P. Rigley, and R. E. Callard. 1993. IL-4 regulates the morphology, cytoskeleton, and proliferation of human umbilical vein endothelial cells: relationship between vimentin and CD23. Int. Immunol. 5:293-301.
    • (1993) Int. Immunol. , vol.5 , pp. 293-301
    • Klein, N.J.1    Rigley, K.P.2    Callard, R.E.3
  • 37
    • 0029128491 scopus 로고
    • A novel IL-4 responsive element of the e alpha MHC class II promoter that binds to an inducible factor
    • Kretsovali, A., and J. Papamatheakis. 1995. A novel IL-4 responsive element of the E alpha MHC class II promoter that binds to an inducible factor. Nucleic Acids Res. 23:2919-2928.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 2919-2928
    • Kretsovali, A.1    Papamatheakis, J.2
  • 38
    • 0011992409 scopus 로고
    • Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities
    • Lee, F., T. Yokota, T. Otsuka, P. Meyerson, D. Villaret, R. Coffman, T. Mosmann, D. Rennick, N. Roehm, C. Smith, et al. 1986. Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities. Proc. Natl. Acad. Sci. U. S. A. 83:2061-2065.
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 2061-2065
    • Lee, F.1    Yokota, T.2    Otsuka, T.3    Meyerson, P.4    Villaret, D.5    Coffman, R.6    Mosmann, T.7    Rennick, D.8    Roehm, N.9    Smith, C.10
  • 39
    • 0034711332 scopus 로고    scopus 로고
    • IL-4 induces apoptosis of endothelial cells through the caspase-3-dependent pathway
    • Lee, Y. W., H. Kuhn, B. Hennig, and M. Toborek. 2000. IL-4 induces apoptosis of endothelial cells through the caspase-3-dependent pathway. FEBS Lett. 485:122-126.
    • (2000) FEBS Lett. , vol.485 , pp. 122-126
    • Lee, Y.W.1    Kuhn, H.2    Hennig, B.3    Toborek, M.4
  • 40
    • 0033767391 scopus 로고    scopus 로고
    • Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity
    • Lim, C., H. Sohn, Y. Gwack, and J. Choe. 2000. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. J. Gen. Virol. 81:2645-2652.
    • (2000) J. Gen. Virol. , vol.81 , pp. 2645-2652
    • Lim, C.1    Sohn, H.2    Gwack, Y.3    Choe, J.4
  • 41
    • 0026509451 scopus 로고
    • IL-4 enhances programmed cell death (apoptosis) in stimulated human monocytes
    • Mangan, D. F., B. Robertson, and S. M. Wahl. 1992. IL-4 enhances programmed cell death (apoptosis) in stimulated human monocytes. J. Immunol. 148:1812-1816.
    • (1992) J. Immunol. , vol.148 , pp. 1812-1816
    • Mangan, D.F.1    Robertson, B.2    Wahl, S.M.3
  • 42
    • 50149115756 scopus 로고    scopus 로고
    • Activation of Akt through gp130 receptor signaling is required for Kaposi's sarcoma-associated herpesvirus-induced lymphatic reprogramming of endothelial cells
    • Morris, V. A., A. S. Punjabi, and M. Lagunoff. 2008. Activation of Akt through gp130 receptor signaling is required for Kaposi's sarcoma-associated herpesvirus-induced lymphatic reprogramming of endothelial cells. J. Virol. 82:8771-8779.
    • (2008) J. Virol. , vol.82 , pp. 8771-8779
    • Morris, V.A.1    Punjabi, A.S.2    Lagunoff, M.3
  • 43
    • 29344435531 scopus 로고    scopus 로고
    • Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA
    • Muromoto, R., K. Okabe, M. Fujimuro, K. Sugiyama, H. Yokosawa, T. Seya, and T. Matsuda. 2006. Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA. FEBS Lett. 580:93-98.
    • (2006) FEBS Lett. , vol.580 , pp. 93-98
    • Muromoto, R.1    Okabe, K.2    Fujimuro, M.3    Sugiyama, K.4    Yokosawa, H.5    Seya, T.6    Matsuda, T.7
  • 45
    • 0027751556 scopus 로고
    • Interleukin-2 receptor gamma chain: A functional component of the interleukin-7 receptor
    • Noguchi, M., Y. Nakamura, S. M. Russell, S. F. Ziegler, M. Tsang, X. Cao, and W. J. Leonard. 1993. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 262:1877-1880.
    • (1993) Science , vol.262 , pp. 1877-1880
    • Noguchi, M.1    Nakamura, Y.2    Russell, S.M.3    Ziegler, S.F.4    Tsang, M.5    Cao, X.6    Leonard, W.J.7
  • 46
    • 0025764757 scopus 로고
    • Interleukin-4: A prototypic immunoregulatory lymphokine
    • Paul, W. E. 1991. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 77:1859-1870.
    • (1991) Blood , vol.77 , pp. 1859-1870
    • Paul, W.E.1
  • 47
    • 0023069479 scopus 로고
    • B-cell stimulatory factor-1/interleukin 4
    • Paul, W. E., and J. Ohara. 1987. B-cell stimulatory factor-1/interleukin 4. Annu. Rev. Immunol. 5:429-459.
    • (1987) Annu. Rev. Immunol. , vol.5 , pp. 429-459
    • Paul, W.E.1    Ohara, J.2
  • 48
    • 33847235341 scopus 로고    scopus 로고
    • Persistent activation of STAT3 by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells
    • DOI 10.1128/JVI.01769-06
    • Punjabi, A. S., P. A. Carroll, L. Chen, and M. Lagunoff. 2007. Persistent activation of STAT3 by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells. J. Virol. 81:2449-2458. (Pubitemid 46303361)
    • (2007) Journal of Virology , vol.81 , Issue.5 , pp. 2449-2458
    • Punjabi, A.S.1    Carroll, P.A.2    Chen, L.3    Lagunoff, M.4
  • 49
    • 0033782793 scopus 로고    scopus 로고
    • The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells
    • Radkov, S. A., P. Kellam, and C. Boshoff. 2000. The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat. Med. 6:1121-1127.
    • (2000) Nat. Med. , vol.6 , pp. 1121-1127
    • Radkov, S.A.1    Kellam, P.2    Boshoff, C.3
  • 50
    • 0030834122 scopus 로고    scopus 로고
    • The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen
    • Rainbow, L., G. M. Platt, G. R. Simpson, R. Sarid, S. J. Gao, H. Stoiber, C. S. Herrington, P. S. Moore, and T. F. Schulz. 1997. The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J. Virol. 71:5915-5921.
    • (1997) J. Virol. , vol.71 , pp. 5915-5921
    • Rainbow, L.1    Platt, G.M.2    Simpson, G.R.3    Sarid, R.4    Gao, S.J.5    Stoiber, H.6    Herrington, C.S.7    Moore, P.S.8    Schulz, T.F.9
  • 54
    • 0029001660 scopus 로고
    • Components of a Stat recognition code: Evidence for two layers of molecular selectivity
    • Schindler, U., P. Wu, M. Rothe, M. Brasseur, and S. L. McKnight. 1995. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 2:689-697.
    • (1995) Immunity , vol.2 , pp. 689-697
    • Schindler, U.1    Wu, P.2    Rothe, M.3    Brasseur, M.4    McKnight, S.L.5
  • 55
    • 0037079728 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
    • Skinnider, B. F., A. J. Elia, R. D. Gascoyne, B. Patterson, L. Trumper, U. Kapp, and T. W. Mak. 2002. Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 99:618-626.
    • (2002) Blood , vol.99 , pp. 618-626
    • Skinnider, B.F.1    Elia, A.J.2    Gascoyne, R.D.3    Patterson, B.4    Trumper, L.5    Kapp, U.6    Mak, T.W.7
  • 56
    • 0028909292 scopus 로고
    • Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor
    • Smerz-Bertling, C., and A. Duschl. 1995. Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor. J. Biol. Chem. 270:966-970.
    • (1995) J. Biol. Chem. , vol.270 , pp. 966-970
    • Smerz-Bertling, C.1    Duschl, A.2
  • 58
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain, S. L., A. D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796-3806.
    • (1990) J. Immunol. , vol.145 , pp. 3796-3806
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 61
    • 0026073847 scopus 로고
    • Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms
    • Thornhill, M. H., S. M. Wellicome, D. L. Mahiouz, J. S. Lanchbury, U. Kyan-Aung, and D. O. Haskard. 1991. Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms. J. Immunol. 146:592-598.
    • (1991) J. Immunol. , vol.146 , pp. 592-598
    • Thornhill, M.H.1    Wellicome, S.M.2    Mahiouz, D.L.3    Lanchbury, J.S.4    Kyan-Aung, U.5    Haskard, D.O.6
  • 62
    • 4544290097 scopus 로고    scopus 로고
    • Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1
    • Verma, S. C., S. Borah, and E. S. Robertson. 2004. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1. J. Virol. 78:10348-10359.
    • (2004) J. Virol. , vol.78 , pp. 10348-10359
    • Verma, S.C.1    Borah, S.2    Robertson, E.S.3
  • 64
    • 0024412051 scopus 로고
    • Recombinant IL-4 and IFN-gamma activate locomotor capacity in human B lymphocytes
    • Wilkinson, P. C., and L. N. Islam. 1989. Recombinant IL-4 and IFN-gamma activate locomotor capacity in human B lymphocytes. Immunology 67:237-243.
    • (1989) Immunology , vol.67 , pp. 237-243
    • Wilkinson, P.C.1    Islam, L.N.2
  • 65
    • 0037178853 scopus 로고    scopus 로고
    • Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL
    • Wurster, A. L., V. L. Rodgers, M. F. White, T. L. Rothstein, and M. J. Grusby. 2002. Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J. Biol. Chem. 277:27169-27175.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27169-27175
    • Wurster, A.L.1    Rodgers, V.L.2    White, M.F.3    Rothstein, T.L.4    Grusby, M.J.5
  • 66
    • 0028177589 scopus 로고
    • CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
    • Yoshimoto, T., and W. E. Paul. 1994. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285-1295.
    • (1994) J. Exp. Med. , vol.179 , pp. 1285-1295
    • Yoshimoto, T.1    Paul, W.E.2
  • 67
    • 33847193148 scopus 로고    scopus 로고
    • Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: Role of JAK/STAT signaling
    • DOI 10.1128/JVI.02024-06
    • Zeng, Y., X. Zhang, Z. Huang, L. Cheng, S. Yao, D. Qin, X. Chen, Q. Tang, Z. Lv, L. Zhang, and C. Lu. 2007. Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcomaassociated herpesvirus: role of JAK/STAT signaling. J. Virol. 81:2401-2417. (Pubitemid 46303357)
    • (2007) Journal of Virology , vol.81 , Issue.5 , pp. 2401-2417
    • Zeng, Y.1    Zhang, X.2    Huang, Z.3    Cheng, L.4    Yao, S.5    Qin, D.6    Chen, X.7    Tang, Q.8    Lv, Z.9    Zhang, L.10    Lu, C.11
  • 68
    • 33749234543 scopus 로고    scopus 로고
    • STAT6 specific shRNA inhibits proliferation and induces apoptosis in colon cancer HT-29 cells
    • Zhang, M., Y. Zhou, C. Xie, F. Zhou, Y. Chen, G. Han, and W. J. Zhang. 2006. STAT6 specific shRNA inhibits proliferation and induces apoptosis in colon cancer HT-29 cells. Cancer Lett. 243:38-46.
    • (2006) Cancer Lett. , vol.243 , pp. 38-46
    • Zhang, M.1    Zhou, Y.2    Xie, C.3    Zhou, F.4    Chen, Y.5    Han, G.6    Zhang, W.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.