Correction to Histone deacetylase classes I and II regulate Kaposi's sarcomaassociated herpesvirus reactivation [J Virol., 88, 2 (2014) 1281-1292, DOI:10.1128/JVI.02665-13];Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivation

Journal of Virology

Volumn 88, Issue 2, 2014, Pages 1281-1292

  Shin, Hye Jin ^a   DeCotiis, Jennifer ^a   Giron, Mario ^a   Palmeri, Diana ^a   Lukac, David M ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 6; TRICHOSTATIN A; TUBACIN; VALPROIC ACID;

ARTICLE; AUTOPHAGY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REGULATION; GENE OVEREXPRESSION; HISTONE ACETYLATION; HUMAN HERPESVIRUS 8; IMMUNOFLUORESCENCE TEST; KAPOSI SARCOMA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STOICHIOMETRY; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS VIRULENCE;

CELL LINE; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; PROMOTER REGIONS, GENETIC; VIRUS ACTIVATION; VIRUS LATENCY;

EID: 84891704402     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00587-16     Document Type: Erratum

References (96)

1. Boshoff C, Gao S-J, Healy L, Matthews T, Thomas A, Coignet L, Warnke R, Strauchen J, Matutes E, Kamel O, Moore P, Weiss R, Chang Y. 1998. Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice. Blood 91:1671-1679.
2. Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D, Ganem D. 1996. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 2:342-346. http://dx.doi.org/10.1038/nm0396-342.
3. Cesarman E, Moore PS, Rao PH, Inghirami G, Knowles DM, Chang Y. 1995. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood 86:2708-2714.
4. Shaw R, Arbiser J, Offermann MK. 2000. Valproic acid induced human herpesvirus 8 lytic gene expression in BCBL-1 cells. AIDS 14:899-902. http://dx.doi.org/10.1097/00002030-200005050-00021.
5. Lu F, Zhou J, Wiedmer A, Madden K, Yuan Y, Lieberman PM. 2003. Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. J. Virol. 77:11425-11435. http://dx.doi.org/10.1128/JVI.77.21.11425-11435.2003.
6. Miller G, Heston L, Grogan E, Gradoville L, Rigsby M, Sun R, Shedd D, Kushnaryov VM, Grossberg S, Chang Y. 1997. Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells. J. Virol. 71:314-324.
7. Khan O, La Thangue NB. 2012. HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications. Immunol. Cell Biol. 90:85-94. http://dx.doi.org/10.1038/icb.2011.100.
8. Yang XJ, Seto E. 2008. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat. Rev. Mol. Cell Biol. 9:206-218. http://dx.doi.org/10.1038/nrm2346.
9. Jenuwein T, Allis CD. 2001. Translating the histone code. Science 293:1074-1080. http://dx.doi.org/10.1126/science.1063127.
10. Kouzarides T. 2007. Chromatin modifications and their function. Cell 128:693-705. http://dx.doi.org/10.1016/j.cell.2007.02.005.
11. Taverna SD, Li H, Ruthenburg AJ, Allis CD, Patel DJ. 2007. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat. Struct. Mol. Biol. 14:1025-1040. http://dx.doi.org/10.1038/nsmb1338.
12. Young NL, Dimaggio PA, Garcia BA. 2010. The significance, development and progress of high-throughput combinatorial histone code analysis. Cell. Mol. Life Sci. 67:3983-4000. http://dx.doi.org/10.1007/s00018-010-0475-7.
13. Imai S, Guarente L. 2010. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol. Sci. 31:212-220. http://dx.doi.org/10.1016/j.tips.2010.02.003.
14. Wong PG, Glozak MA, Cao TV, Vaziri C, Seto E, Alexandrow M. 2010. Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin. Cell Cycle 9:4351-4363. http://dx.doi.org/10.4161/cc.9.21.13596.
15. Villagra A, Cheng F, Wang HW, Suarez I, Glozak M, Maurin M, Nguyen D, Wright KL, Atadja PW, Bhalla K, Pinilla-Ibarz J, Seto E, Sotomayor EM. 2009. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat. Immunol. 10:92-100. http://dx.doi.org/10.1038/ni.1673.
16. Lukac DM, Kirshner JR, Ganem D. 1999. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J. Virol. 73:9348-9361.
17. Sun R, Lin SF, Gradoville L, Yuan Y, Zhu F, Miller G. 1998. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. U. S. A. 95:10866-10871. http://dx.doi.org/10.1073/pnas.95.18.10866.
18. Gradoville L, Gerlach J, Grogan E, Shedd D, Nikiforow S, Metroka C, Miller G. 2000. Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire lytic cycle in the HH-B2 primary effusion lymphoma cell line. J. Virol. 74:6207-6212. http://dx.doi.org/10.1128/JVI.74.13.6207-6212.2000.
19. Chen HS, Wikramasinghe P, Showe L, Lieberman PM. 2012. Cohesins repress Kaposi's sarcoma-associated herpesvirus immediate early gene transcription during latency. J. Virol. 86:9454-9464. http://dx.doi.org/10.1128/JVI.00787-12.
20. Gunther T, Grundhoff A. 2010. The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes. PLoS Pathog. 6:e1000935. http://dx.doi.org/10.1371/journal.ppat.1000935.
21. Stedman W, Deng Z, Lu F, Lieberman PM. 2004. ORC, MCM, and histone hyperacetylation at the Kaposi's sarcoma-associated herpesvirus latent replication origin. J. Virol. 78:12566-12575. http://dx.doi.org/10.1128/JVI.78.22.12566-12575.2004.
22. Toth Z, Maglinte DT, Lee SH, Lee HR, Wong LY, Brulois KF, Lee S, Buckley JD, Laird PW, Marquez VE, Jung JU. 2010. Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog. 6:e1001013. http://dx.doi.org/10.1371/journal.ppat.1001013.
23. Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES. 2006. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125:315-326. http://dx.doi.org/10.1016/j.cell.2006.02.041.
24. Kang H, Wiedmer A, Yuan Y, Robertson E, Lieberman PM. 2011. Coordination of KSHV latent and lytic gene control by CTCF-cohesin mediated chromosome conformation. PLoS Pathog. 7:e1002140. http://dx.doi.org/10.1371/journal.ppat.1002140.
25. Ye J, Shedd D, Miller G. 2005. An Sp1 response element in the Kaposi's sarcoma-associated herpesvirus open reading frame 50 promoter mediates lytic cycle induction by butyrate. J. Virol. 79:1397-1408. http://dx.doi.org/10.1128/JVI.79.3.1397-1408.2005.
26. Bolden JE, Peart MJ, Johnstone RW. 2006. Anticancer activities of histone deacetylase inhibitors. Nat. Rev. Drug Discov. 5:769-784. http://dx.doi.org/10.1038/nrd2133.
27. Bu W, Carroll KD, Palmeri D, Lukac DM. 2007. The Kaposi's sarcomaassociated herpesvirus/human herpesvirus-8 ORF50/Rta lytic switch protein functions as a tetramer. J. Virol. 81:5788-5806. http://dx.doi.org/10.1128/JVI.00140-07.
28. Gantt S, Carlsson J, Ikoma M, Gachelet E, Gray M, Geballe AP, Corey L, Casper C, Lagunoff M, Vieira J. 2011. The HIV protease inhibitor nelfinavir inhibits Kaposi's sarcoma-associated herpesvirus replication in vitro. Antimicrob. Agents Chemother. 55:2696-2703. http://dx.doi.org/10.1128/AAC.01295-10.
29. Vieira J, O'Hearn PM. 2004. Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression. Virology 325:225-240. http://dx.doi.org/10.1016/j.virol.2004.03.049.
30. Scognamiglio A, Nebbioso A, Manzo F, Valente S, Mai A, Altucci L. 2008. HDAC-class II specific inhibition involves HDAC proteasomedependent degradation mediated by RANBP2. Biochim. Biophys. Acta 1783:2030-2038. http://dx.doi.org/10.1016/j.bbamcr.2008.07.007.
31. Lukac DM, Renne R, Kirshner JR, Ganem D. 1998. Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 252:304-312. http://dx.doi.org/10.1006/viro.1998.9486.
32. Palmeri D, Carroll KD, Gonzalez-Lopez O, Lukac DM. 2011. Kaposi's sarcoma-associated herpesvirus Rta tetramers make high-affinity interactions with repetitive DNA elements in the Mta promoter to stimulate DNA binding of RBP-Jk/CSL. J. Virol. 85:11901-11915. http://dx.doi.org/10.1128/JVI.05479-11.
33. Palmeri D, Spadavecchia S, Carroll K, Lukac DM. 2007. Promoter and cell-specific transcriptional activation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein. J. Virol. 81:13299-13314. http://dx.doi.org/10.1128/JVI.00732-07.
34. Emiliani S, Fischle W, Van Lint C, Al-Abed Y, Verdin E. 1998. Characterization of a human RPD3 ortholog, HDAC3. Proc. Natl. Acad. Sci. U. S. A. 95:2795-2800. http://dx.doi.org/10.1073/pnas.95.6.2795.
35. Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E. 1999. A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. J. Biol. Chem. 274:11713-11720. http://dx.doi.org/10.1074/jbc.274.17.11713.
36. North BJ, Marshall BL, Borra MT, Denu JM, Verdin E. 2003. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell 11:437-444. http://dx.doi.org/10.1016/S1097-2765(03)00038-8.
37. Kanda T, Sullivan KF, Wahl GM. 1998. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr. Biol. 8:377-385. http://dx.doi.org/10.1016/S0960-9822(98)70156-3.
38. Zhou FC, Zhang YJ, Deng JH, Wang XP, Pan HY, Hettler E, Gao SJ. 2002. Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysis. J. Virol. 76:6185-6196. http://dx.doi.org/10.1128/JVI.76.12.6185-6196.2002.
39. Schneider CA, Rasband WS, Eliceiri KW. 2012. NIH Image to ImageJ: 25 years of image analysis. Nat. Methods 9:671-675. http://dx.doi.org/10.1038/nmeth.2089.
40. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402-408. http://dx.doi.org/10.1006/meth.2001.1262.
41. Khan N, Jeffers M, Kumar S, Hackett C, Boldog F, Khramtsov N, Qian X, Mills E, Berghs SC, Carey N, Finn PW, Collins LS, Tumber A, Ritchie JW, Jensen PB, Lichenstein HS, Sehested M. 2008. Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors. Biochem. J. 409:581-589. http://dx.doi.org/10.1042/BJ20070779.
42. Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL. 2003. Domain-selective small-molecule inhibitor of histone deacetylase 6(HDAC6)-mediated tubulin deacetylation. Proc. Natl. Acad. Sci. U. S. A. 100:4389-4394. http://dx.doi.org/10.1073/pnas.0430973100.
43. Rodriguez-Gonzalez A, Lin T, Ikeda AK, Simms-Waldrip T, Fu C, Sakamoto KM. 2008. Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation. Cancer Res. 68:2557-2560. http://dx.doi.org/10.1158/0008-5472.CAN-07-5989.
44. Ma H, Nguyen C, Lee KS, Kahn M. 2005. Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression. Oncogene 24:3619-3631. http://dx.doi.org/10.1038/sj.onc.1208433.
45. Riolo MT, Cooper ZA, Holloway MP, Cheng Y, Bianchi C, Yakirevich E, Ma L, Chin YE, Altura RA. 2012. Histone deacetylase 6 (HDAC6) deacetylates survivin for its nuclear export in breast cancer. J. Biol. Chem. 287:10885-10893. http://dx.doi.org/10.1074/jbc.M111.308791.
46. Wickstrom SA, Masoumi KC, Khochbin S, Fassler R, Massoumi R. 2010. CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J. 29:131-144. http://dx.doi.org/10.1038/emboj.2009.317.
47. van der Vlag J, Otte AP. 1999. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat. Genet. 23:474-478. http://dx.doi.org/10.1038/70602.
48. Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM. 2002. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419:624-629. http://dx.doi.org/10.1038/nature01075.
49. Bommi PV, Dimri M, Sahasrabuddhe AA, Khandekar J, Dimri GP. 2010. The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors. Cell Cycle 9:2663-2673. http://dx.doi.org/10.4161/cc.9.13.12147.
50. Duenas-Gonzalez A, Candelaria M, Perez-Plascencia C, Perez-Cardenas E, de la Cruz-Hernandez E, Herrera LA. 2008. Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors. Cancer Treatment Rev. 34:206-222. http://dx.doi.org/10.1016/j.ctrv.2007.11.003.
51. Gurvich N, Tsygankova OM, Meinkoth JL, Klein PS. 2004. Histone deacetylase is a target of valproic acid-mediated cellular differentiation. Cancer Res. 64:1079-1086. http://dx.doi.org/10.1158/0008-5472.CAN-03-0799.
52. Jung JW, Lee S, Seo MS, Park SB, Kurtz A, Kang SK, Kang KS. 2010. Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3. Cell. Mol. Life Sci. 67:1165-1176. http://dx.doi.org/10.1007/s00018-009-0242-9.
53. Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, Ghosh D, Sewalt RG, Otte AP, Hayes DF, Sabel MS, Livant D, Weiss SJ, Rubin MA, Chinnaiyan AM. 2003. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 100:11606-11611. http://dx.doi.org/10.1073/pnas.1933744100.
54. Dannenberg LO, Edenberg HJ. 2006. Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. BMC Genomics 7:181. http://dx.doi.org/10.1186/1471-2164-7-181.
55. Kramer OH, Zhu P, Ostendorff HP, Golebiewski M, Tiefenbach J, Peters MA, Brill B, Groner B, Bach I, Heinzel T, Gottlicher M. 2003. The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J. 22:3411-3420. http://dx.doi.org/10.1093/emboj/cdg315.
56. Detich N, Bovenzi V, Szyf M. 2003. Valproate induces replication-independent active DNA demethylation. J. Biol. Chem. 278:27586-27592. http://dx.doi.org/10.1074/jbc.M303740200.
57. Chen J, Ueda K, Sakakibara S, Okuno T, Parravicini C, Corbellino M, Yamanishi K. 2001. Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator. Proc. Natl. Acad. Sci. U. S. A. 98:4119-4124. http://dx.doi.org/10.1073/pnas.051004198.
58. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. 2009. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325:834-840. http://dx.doi.org/10.1126/science.1175371.
59. Monti B, Polazzi E, Contestabile A. 2009. Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection. Curr. Mol. Pharmacol. 2:95-109. http://dx.doi.org/10.2174/1874467210902010095.
60. Buchwald M, Kramer OH, Heinzel T. 2009. HDACi-targets beyond chromatin. Cancer Lett. 280:160-167. http://dx.doi.org/10.1016/j.canlet.2009.02.028.
61. Toth Z, Brulois KF, Wong LY, Lee HR, Chung B, Jung JU. 2012. Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expression. J. Virol. 86:9696-9707. http://dx.doi.org/10.1128/JVI.01012-12.
62. Haberland M, Montgomery RL, Olson EN. 2009. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat. Rev. Genet. 10:32-42. http://dx.doi.org/10.1038/nrg2485.
63. Lusic M, Marcello A, Cereseto A, Giacca M. 2003. Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. EMBO J. 22:6550-6561. http://dx.doi.org/10.1093/emboj/cdg631.
64. Ellison TJ, Izumiya Y, Izumiya C, Luciw PA, Kung HJ. 2009. A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus. Virology 387:76-88. http://dx.doi.org/10.1016/j.virol.2009.02.016.
65. Gwack Y, Baek HJ, Nakamura H, Lee SH, Meisterernst M, Roeder RG, Jung JU. 2003. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol. Cell. Biol. 23:2055-2067. http://dx.doi.org/10.1128/MCB.23.6.2055-2067.2003.
66. Chang PC, Fitzgerald LD, Hsia DA, Izumiya Y, Wu CY, Hsieh WP, Lin SF, Campbell M, Lam KS, Luciw PA, Tepper CG, Kung HJ. 2011. Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor. J. Virol. 85:3283-3293. http://dx.doi.org/10.1128/JVI.02485-10.
67. Rossetto CC, Pari G. 2012. KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome. PLoS Pathog. 8:e1002680. http://dx.doi.org/10.1371/journal.ppat.1002680.
68. Hauser C, Schuettengruber B, Bartl S, Lagger G, Seiser C. 2002. Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. Mol. Cell. Biol. 22:7820-7830. http://dx.doi.org/10.1128/MCB.22.22.7820-7830.2002.
69. Hayakawa T, Nakayama J. 2011. Physiological roles of class I HDAC complex and histone demethylase. J. Biomed. Biotechnol. 2011:129383. http://dx.doi.org/10.1155/2011/129383.
70. Bantscheff M, Hopf C, Savitski MM, Dittmann A, Grandi P, Michon AM, Schlegl J, Abraham Y, Becher I, Bergamini G, Boesche M, Delling M, Dumpelfeld B, Eberhard D, Huthmacher C, Mathieson T, Poeckel D, Reader V, Strunk K, Sweetman G, Kruse U, Neubauer G, Ramsden NG, Drewes G. 2011. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat. Biotechnol. 29:255-265. http://dx.doi.org/10.1038/nbt.1759.
71. You A, Tong JK, Grozinger CM, Schreiber SL. 2001. CoREST is an integral component of the CoREST-human histone deacetylase complex. Proc. Natl. Acad. Sci. U. S. A. 98:1454-1458. http://dx.doi.org/10.1073/pnas.98.4.1454.
72. Sengupta N, Seto E. 2004. Regulation of histone deacetylase activities. J. Cell. Biochem. 93:57-67. http://dx.doi.org/10.1002/jcb.20179.
73. Krithivas A, Young DB, Liao G, Greene D, Hayward SD. 2000. Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. J. Virol. 74:9637-9645. http://dx.doi.org/10.1128/JVI.74.20.9637-9645.2000.
74. Sarek G, Jarviluoma A, Moore HM, Tojkander S, Vartia S, Biberfeld P, Laiho M, Ojala PM. 2010. Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. PLoS Pathog. 6:e1000818. http://dx.doi.org/10.1371/journal.ppat.1000818.
75. Icardi L, Mori R, Gesellchen V, Eyckerman S, De Cauwer L, Verhelst J, Vercauteren K, Saelens X, Meuleman P, Leroux-Roels G, De Bosscher K, Boutros M, Tavernier J. 2012. The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proc. Natl. Acad. Sci. U. S. A. 109:12058-12063. http://dx.doi.org/10.1073/pnas.1206458109.
76. Silverstein RA, Ekwall K. 2005. Sin3: a flexible regulator of global gene expression and genome stability. Curr. Genet. 47:1-17. http://dx.doi.org/10.1007/s00294-004-0541-5.
77. Zupkovitz G, Tischler J, Posch M, Sadzak I, Ramsauer K, Egger G, Grausenburger R, Schweifer N, Chiocca S, Decker T, Seiser C. 2006. Negative and positive regulation of gene expression by mouse histone deacetylase 1. Mol. Cell. Biol. 26:7913-7928. http://dx.doi.org/10.1128/MCB.01220-06.
78. Kidder BL, Palmer S. 2012. HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells. Nucleic Acids Res. 40:2925-2939. http://dx.doi.org/10.1093/nar/gkr1151.
79. Di Marcotullio L, Canettieri G, Infante P, Greco A, Gulino A. 2011. Protected from the inside: endogenous histone deacetylase inhibitors and the road to cancer. Biochim. Biophys. Acta 1815:241-252. http://dx.doi.org/10.1016/j.bbcan.2011.01.002.
80. Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB, Yoshida M, Stein GS, Li X. 2002. Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol. Cell. Biol. 22:7982-7992. http://dx.doi.org/10.1128/MCB.22.22.7982-7992.2002.
81. Chou CW, Chen CC. 2008. HDAC inhibition upregulates the expression of angiostatic ADAMTS1. FEBS Lett. 582:4059-4065. http://dx.doi.org/10.1016/j.febslet.2008.10.048.
82. Wang Z, Zang C, Cui K, Schones DE, Barski A, Peng W, Zhao K. 2009. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 138:1019-1031. http://dx.doi.org/10.1016/j.cell.2009.06.049.
83. Bali P, Pranpat M, Bradner J, Balasis M, Fiskus W, Guo F, Rocha K, Kumaraswamy S, Boyapalle S, Atadja P, Seto E, Bhalla K. 2005. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J. Biol. Chem. 280:26729-26734. http://dx.doi.org/10.1074/jbc.C500186200.
84. Chen CS, Weng SC, Tseng PH, Lin HP, Chen CS. 2005. Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. J. Biol. Chem. 280:38879-38887. http://dx.doi.org/10.1074/jbc.M505733200.
85. Aldana-Masangkay GI, Sakamoto KM. 2011. The role of HDAC6 in cancer. J. Biomed. Biotechnol. 2011:875824. http://dx.doi.org/10.1155/2011/875824.
86. Namdar M, Perez G, Ngo L, Marks PA. 2010. Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proc. Natl. Acad. Sci. U. S. A. 107:20003-20008. http://dx.doi.org/10.1073/pnas.1013754107.
87. Shubassi G, Robert T, Vanoli F, Minucci S, Foiani M. 2012. Acetylation: a novel link between double-strand break repair and autophagy. Cancer Res. 72:1332-1335. http://dx.doi.org/10.1158/0008-5472.CAN-11-3172.
88. Nikitin PA, Luftig MA. 2011. At a crossroads: human DNA tumor viruses and the host DNA damage response. Future Virol. 6:813-830. http://dx.doi.org/10.2217/fvl.11.55.
89. Kawada J, Zou P, Mazitschek R, Bradner JE, Cohen JI. 2009. Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis. J. Biol. Chem. 284:17102-17109. http://dx.doi.org/10.1074/jbc.M809090200.
90. Marchion DC, Bicaku E, Daud AI, Sullivan DM, Munster PN. 2005. Valproic acid alters chromatin structure by regulation of chromatin modulation proteins. Cancer Res. 65:3815-3822. http://dx.doi.org/10.1158/0008-5472.CAN-04-2478.
91. Lee JS, Li Q, Lee JY, Lee SH, Jeong JH, Lee HR, Chang H, Zhou FC, Gao SJ, Liang C, Jung JU. 2009. FLIP-mediated autophagy regulation in cell death control. Nat. Cell Biol. 11:1355-1362. http://dx.doi.org/10.1038/ncb1980.
92. Leidal AM, Cyr DP, Hill RJ, Lee PW, McCormick C. 2012. Subversion of autophagy by Kaposi's sarcoma-associated herpesvirus impairs oncogene-induced senescence. Cell Host Microbe 11:167-180. http://dx.doi.org/10.1016/j.chom.2012.01.005.
93. Ye FC, Zhou FC, Xie JP, Kang T, Greene W, Kuhne K, Lei XF, Li QH, Gao SJ. 2008. Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-kappaB-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latency. J. Virol. 82:4235-4249. http://dx.doi.org/10.1128/JVI.02370-07.
94. Guasparri I, Keller SA, Cesarman E. 2004. KSHV vFLIP is essential for the survival of infected lymphoma cells. J. Exp. Med. 199:993-1003. http://dx.doi.org/10.1084/jem.20031467.
95. Wen HJ, Yang Z, Zhou Y, Wood C. 2010. Enhancement of autophagy during lytic replication by the Kaposi's sarcoma-associated herpesvirus replication and transcription activator. J. Virol. 84:7448-7458. http://dx.doi.org/10.1128/JVI.00024-10.
96. Park R, Wang'ondu R, Heston L, Shedd D, Miller G. 2011. Efficient induction of nuclear aggresomes by specific single missense mutations in the DNA-binding domain of a viral AP-1 homolog. J. Biol. Chem. 286:9748-9762. http://dx.doi.org/10.1074/jbc.M110.198325.