Mechanisms of Kaposi's sarcoma-associated herpesvirus latency and reactivation

Advances in Virology

Volumn 2011, Issue , 2011, Pages

  Ye, Fengchun ^a   Lei, Xiufen ^a   Gao, Shou Jiang ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN HERPESVIRUS 8;

EID: 84865293571     PISSN: 16878639     EISSN: 16878647     Source Type: Journal    
DOI: 10.1155/2011/193860     Document Type: Review

References (241)

1. Chang Y., Cesarman E., Pessin M. S., Lee F., Culpepper J., Knowles D. M., Moore P. S., Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994 266 5192 1865 1869 2-s2.0-0028588064
2. Sarid R., Gao S. J., Viruses and human cancer: from detection to causality. Cancer Letters 2011 305 2 218 227
3. Boshoff C., Kaposi's sarcoma biology. IUBMB Life 2002 53 4-5 259 261 2-s2.0-0035991694 10.1080/15216540212645 (Pubitemid 34728937)
4. Cesarman E., Chang Y., Moore P. S., Said J. W., Knowles D. M., Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS- related body-cavity-based lymphomas. The New England Journal of Medicine 1995 332 18 1186 1191 2-s2.0-0029069445 10.1056/NEJM199505043321802
5. Cesarman E., Nador R. G., Aozasa K., Delsol G., Said J. W., Knowles D. M., Kaposi's sarcoma-associated herpesvirus in non-AIDS-related lymphomas occurring in body cavities. American Journal of Pathology 1996 149 1 53 57 2-s2.0-0029957877 (Pubitemid 26230978)
6. Soulier J., Grollet L., Oksenhendler E., Cacoub P., Cazals-Hatem D., Babinet P., D'Agay M. F., Clauvel J. P., Raphael M., Degos L., Sigaux F., Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 1995 86 4 1276 1280 2-s2.0-0029166033
7. Boshoff C., Chang Y., Kaposi's sarcoma-associated herpesvirus: a new DNA tumor virus. Annual Review of Medicine 2001 52 453 470 2-s2.0-0035127174 10.1146/annurev.med.52.1.453 (Pubitemid 32195335)
8. Ciufo D. M., Cannon J. S., Poole L. J., Wu F. Y., Murray P., Ambinder R. F., Hayward G. S., Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures. Journal of Virology 2001 75 12 5614 5626 2-s2.0-0035024652 10.1128/JVI.75.12. 5614-5626.2001 (Pubitemid 32488155)
9. Gao S. J., Deng J. H., Zhou F. U. C., Productive lytic replication of a recombinant Kaposi's sarcoma-associated herpesvirus in efficient primary infection of primary human endothelial cells. Journal of Virology 2003 77 18 9738 9749 2-s2.0-0141682147 10.1128/JVI.77.18.9738-9749.2003 (Pubitemid 37122054)
10. Pan H., Zhou F., Gao S. J., Kaposi's sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cells. Cancer Research 2004 64 12 4064 4068 2-s2.0-3042582107 10.1158/0008-5472.CAN-04-0657 (Pubitemid 38802405)
11. Wang H. W., Trotter M. W. B., Lagos D., Bourboulia D., Henderson S., Mäkinen T., Elliman S., Flanagan A. M., Alitalo K., Boshoff C., Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nature Genetics 2004 36 7 687 693 2-s2.0-3042738138 10.1038/ng1384 (Pubitemid 38886628)
12. Hong Y. K., Foreman K., Shin J. W., Hirakawa S., Curry C. L., Sage D. R., Libermann T., Dezube B. J., Fingeroth J. D., Detmar M., Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nature Genetics 2004 36 7 683 685 2-s2.0-3042780203 10.1038/ng1383 (Pubitemid 38886627)
13. Carroll P. A., Brazeau E., Lagunoff M., Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation. Virology 2004 328 1 7 18 2-s2.0-4544388334 10.1016/j.virol. 2004.07.008 (Pubitemid 39221907)
14. Qian L. I. W., Xie J., Ye F., Gao S. J., Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinases. Journal of Virology 2007 81 13 7001 7010 2-s2.0-34250811336 10.1128/JVI.00016-07 (Pubitemid 46986636)
15. Ye F. C., Blackbourn D. J., Mengel M., Xie J. P., Qian L. I. W., Greene W., Yeh I. T., Graham D., Gao S. J., Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1. Journal of Virology 2007 81 8 3980 3991 2-s2.0-34247117937 10.1128/JVI.02089-06 (Pubitemid 46586893)
16. Qian L. I. W., Greene W., Ye F., Gao S. J., Kaposi's sarcoma-associated herpesvirus disrupts adherens junctions and increases endothelial permeability by inducing degradation of VE-cadherin. Journal of Virology 2008 82 23 11902 11912 2-s2.0-56449122995 10.1128/JVI.01042-08
17. Naranatt P. P., Krishnan H. H., Svojanovsky S. R., Bloomer C., Mathur S., Chandran B., Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infection. Cancer Research 2004 64 1 72 84 2-s2.0-1642453832 10.1158/0008-5472.CAN-03-2767 (Pubitemid 38114084)
18. Sharma-Walia N., Raghu H., Sadagopan S., Sivakumar R., Veettil M. V., Naranatt P. P., Smith M. M., Chandran B., Cyclooxygenase 2 induced by Kaposi's sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expression. Journal of Virology 2006 80 13 6534 6552 2-s2.0-33745286003 10.1128/JVI.00231-06 (Pubitemid 43927455)
19. Sadagopan S., Sharma-Walia N., Veettil M. V., Raghu H., Sivakumar R., Bottero V., Chandran B., Kaposi's sarcoma-associated herpesvirus induces sustained NF- κ B activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression. Journal of Virology 2007 81 8 3949 3968 2-s2.0-34247119790 10.1128/JVI.02333-06 (Pubitemid 46586891)
20. Cattelan A. M., Calabrò M. L., De Rossi A., Aversa S. M., Barbierato M., Trevenzoli M., Gasperini P., Zanchetta M., Cadrobbi P., Monfardini S., Chieco-Bianchi L., Long-term clinical outcome of AIDS-related Kaposi's sarcoma during highly active antiretroviral therapy. International Journal of Oncology 2005 27 3 779 785 2-s2.0-24344467478
21. Cattelan A. M., Calabrò M. L., Gasperini P., Aversa S. M., Zanchetta M., Meneghetti F., De Rossi A., Chieco-Bianchi L., Acquired immunodeficiency syndrome-related Kaposi's sarcoma regression after highly active antiretroviral therapy: biologic correlates of clinical outcome. Journal of the National Cancer Institute. Monographs 2001 28 44 49 2-s2.0-1842638271
22. Pellet C., Kerob D., Dupuy A., Carmagnat M. V., Mourah S., Podgorniak M. P., Toledano C., Morel P., Vérola O., Dosquet C., Hamel Y., Calvo F., Rabian C., Lebbé C., Kaposi's sarcoma-associated herpesvirus viremia is associated with the progression of classic and endemic Kaposi's sarcoma. Journal of Investigative Dermatology 2006 126 3 621 627 2-s2.0-32844459671 10.1038/sj.jid.5700083 (Pubitemid 43255651)
23. Duprez R., Kassa-Kelembho E., Plancoulaine S., Brière J., Fossi M., Kobangue L., Minsart P., Huerre M., Gessain A., Human herpesvirus 8 serological markers and viral load in patients with AIDS-associated Kaposi's sarcoma in Central African Republic. Journal of Clinical Microbiology 2005 43 9 4840 4843 2-s2.0-24744463576 10.1128/JCM.43.9.4840-4843.2005 (Pubitemid 41298290)
24. Guttman-Yassky E., Abada R., Kra-Oz Z., Sattinger J., Perelman A., Bergman R., Sarid R., Relationship between human herpesvirus 8 loads and disease stage in classic Kaposi sarcoma patients. Diagnostic Microbiology and Infectious Disease 2007 57 4 387 392 2-s2.0-33947708979 10.1016/j.diagmicrobio. 2006.09.012 (Pubitemid 46498653)
25. Marcelin A. G., Motol J., Guihot A., Caumes E., Viard J. P., Dussaix E., Cadranel J., Francès C., Carcelain G., Calvez V., Dupin N., Relationship between the quantity of Kaposi sarcoma-associated herpesvirus (KSHV) in peripheral blood and effusion fluid samples and KSHV-associated disease. Journal of Infectious Diseases 2007 196 8 1163 1166 2-s2.0-35348842680 10.1086/521625 (Pubitemid 47580271)
26. Song J., Yoshida A., Yamamoto Y., Katano H., Hagihara K., Oka S., Kimura S., Yoshizaki K., Viral load of human herpesvirus 8 (HHV-8) in the circulatory blood cells correlates with clinical progression in a patient with HHV-8-associated solid lymphoma with AIDS-associated Kaposi's sarcoma. Leukemia and Lymphoma 2004 45 11 2343 2347 2-s2.0-8644263991 10.1080/10428190412331283242 (Pubitemid 39504333)
27. Guadalupe M., Pollock B. H., Westbrook S., Redding S., Bullock D., Anstead G., Agan B. K., Marconi V. C., Barbieri S., Sankar V., Rebeles J., Flahive Y., Schoolfield J., Wang L., Lei X., Dow D., Yeh C.-K., Dang H., Infante A. J., Gao S.-J., gaos@uthscsa.edu Risk factors influencing antibody responses to kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes 2011 56 1 83 90 10.1097/QAI.0b013e3181fdc928
28. Jones J. L., Hanson D. L., Chu S. Y., Ward J. W., Jaffe H. W., AIDS-associated Kaposi's sarcoma. Science 1995 267 5201 1077 1078 2-s2.0-37049178451
29. Mocroft A., Youle M., Gazzard B., Anti-herpesvirus treatment and risk of Kaposi's sarcoma in HIV infection. Royal Free/Chelsea and Westminster Hospitals Collaborative Group. AIDS 1996 10 10 1101 1105 (Pubitemid 26283347)
30. Martin D. F., dmart04@emory.edu Kuppermann B. D., Wolitz R. A., Palestine A. G., Li H., Robinson C. A., Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. The New England Journal of Medicine 1999 340 14 1063 1070 10.1056/NEJM199904083401402 (Pubitemid 29162510)
31. Hwang S., Wu T. T., Tong L. M., Kyeong S. K., Martinez-Guzman D., Colantonio A. D., Uittenbogaart C. H., Sun R., Persistent gammaherpesvirus replication and dynamic interaction with the host in vivo. Journal of Virology 2008 82 24 12498 12509 2-s2.0-57349185974 10.1128/JVI.01152-08
32. Perry S. T., Compton T., Kaposi's sarcoma-associated herpesvirus virions inhibit interferon responses induced by envelope glycoprotein gpK8.1. Journal of Virology 2006 80 22 11105 11114 2-s2.0-33750683382 10.1128/JVI.00846-06 (Pubitemid 44706551)
33. Monini P., Carlini F., Stürzl M., Rimessi P., Superti F., Franco M., Melucci-Vigo G., Cafaro A., Goletti D., Sgadari C., Butto' S., Leone P., Leone P., Chiozzini C., Barresi C., Tinari A., Bonaccorsi A., Capobianchi M. R., Giuliani M., Di Carlo A., Andreoni M., Rezza G., Ensoli B., Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells. Journal of Virology 1999 73 5 4029 4041 2-s2.0-0032923485 (Pubitemid 29189848)
34. Chang J., Renne R., Dittmer D., Ganem D., Inflammatory cytokines and the reactivation of Kaposi's sarcoma- associated herpesvirus lytic replication. Virology 2000 266 1 17 25 2-s2.0-0034606671 10.1006/viro.1999.0077 (Pubitemid 30048632)
35. Chatterjee M., Osborne J., Bestetti G., Chang Y., Moore P. S., Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science 2002 298 5597 1432 1435 2-s2.0-0037112208 10.1126/science.1074883 (Pubitemid 35346145)
36. Pozharskaya V. P., Weakland L. L., Zimring J. C., Krug L. T., Unger E. R., Neisch A., Joshi H., Inoue N., Offermann M. K., Short duration of elevated vIRF-1 expression during lytic replication of human herpesvirus 8 limits its ability to block antiviral responses induced by alpha interferon in BCBL-1 cells. Journal of Virology 2004 78 12 6621 6635 2-s2.0-2642557788 10.1128/JVI.78.12.6621-6635.2004 (Pubitemid 38715958)
37. Pozharskaya V. P., Weakland L. L., Offermann M. K., Inhibition of infectious human herpesvirus 8 production by gamma interferon and alpha interferon in BCBL-1 cells. Journal of General Virology 2004 85 10 2779 2787 2-s2.0-5444229781 10.1099/vir.0.80214-0 (Pubitemid 39360020)
38. Krug L. T., Pozharskaya V. P., Yu Y., Inoue N., Offermann M. K., Inhibition of infection and replication of human herpesvirus 8 in microvascular endothelial cells by alpha interferon and phosphonoformic acid. Journal of Virology 2004 78 15 8359 8371 2-s2.0-3242713054 10.1128/JVI.78.15.8359-8371.2004 (Pubitemid 38944320)
39. Wang J., Zhang J., Zhang L., Harrington W., West J. T., Wood C., Modulation of human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus replication and transcription activator transactivation by interferon regulatory factor 7. Journal of Virology 2005 79 4 2420 2431 2-s2.0-13444310875 10.1128/JVI.79.4.2420-2431.2005 (Pubitemid 40204597)
40. Zhang T., Wang Y., Zhang L., Liu B., Xie J., Wood C., cwood1@unl.edu Wang J., wangjinzhong@nankai.edu.cn Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. Journal of General Virology 2011 92 1 181 187 10.1099/vir.0.021816-0
41. Tempera I., Lieberman P. M., Chromatin organization of gammaherpesvirus latent genomes. Biochimica et Biophysica Acta 2010 1799 3-4 236 245 2-s2.0-77949274530 10.1016/j.bbagrm.2009.10.004
42. Pantry S. N., Medveczky P. G., Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus replication. Seminars in Cancer Biology 2009 19 3 153 157 2-s2.0-63449083968 10.1016/j.semcancer.2009.02.010
43. Lu F., Day L., Gao S. J., Lieberman P. M., Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription. Journal of Virology 2006 80 11 5273 5282 2-s2.0-33646723291 10.1128/JVI.02541-05
44. Günther T., Grundhoff A., adam.grundhoff@hpi.uni-hamburg.de The epigenetic landscape of latent kaposi sarcoma-associated herpesvirus genomes. PLoS Pathogens 2010 6 6 e1000935 10.1371/journal.ppat.1000935
45. Toth Z., Maglinte D. T., Lee S. H., Lee H. R., Wong L. Y., Brulois K. F., Lee S., Buckley J. D., Laird P. W., Marquez V. E., Jung J. U., Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathogens 2010 6 7 e1001013 10.1371/journal.ppat.1001013
46. Dittmer D., Lagunoff M., Renne R., Staskus K., Haase A., Ganem D., A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. Journal of Virology 1998 72 10 8309 8315 2-s2.0-0031714795 (Pubitemid 28421829)
47. Umbach J. L., Cullen B. R., In-depth analysis of Kaposi's sarcoma-associated herpesvirus microrna expression provides insights into the mammalian microRNA-processing machinery. Journal of Virology 2010 84 2 695 703 2-s2.0-73849149037 10.1128/JVI.02013-09
48. Kang H., Lieberman P. M., Cell cycle control of Kaposi's sarcoma-associated herpesvirus latency transcription by CTCF-cohesin interactions. Journal of Virology 2009 83 12 6199 6210 2-s2.0-66149123638 10.1128/JVI.00052-09
49. Stedman W., Kang H., Lin S., Kissil J. L., Bartolomei M. S., Lieberman P. M., Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators. The EMBO Journal 2008 27 4 654 666 2-s2.0-39449111307 10.1038/emboj.2008.1 (Pubitemid 351273124)
50. Gao S. J., Kingsley L., Hoover D. R., Spira T. J., Rinaldo C. R., Saah A., Phair J., Detels R., Parry P., Chang Y., Moore P. S., Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. The New England Journal of Medicine 1996 335 4 233 241 2-s2.0-8944226103 10.1056/ NEJM199607253350403 (Pubitemid 26249571)
51. Gao S. J., Kingsley L., Li M., Zheng W., Parravicini C., Ziegler J., Newton R., Rinaldo C. R., Saah A., Phair J., Detels R., Chang Y., Moore P. S., KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nature Medicine 1996 2 8 925 927 2-s2.0-16044368963 10.1038/nm0896-925 (Pubitemid 26296765)
52. Kedes D. H., Operskalski E., Busch M., Kohn R., Flood J., Ganem D., The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nature Medicine 1996 2 8 918 924 2-s2.0-0029817693 10.1038/nm0896-918 (Pubitemid 26296764)
53. Gao S. J., Zhang Y. J., Deng J. H., Rabkin C. S., Flore O., Jenson H. B., Molecular polymorphism of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes. Journal of Infectious Diseases 1999 180 5 1466 1476 2-s2.0-0032702945 10.1086/315098 (Pubitemid 29506447)
54. Rainbow L., Platt G. M., Simpson G. R., Sarid R., Gao S. J., Stoiber H., Herrington C. S., Moore P. S., Schulz T. F., The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. Journal of Virology 1997 71 8 5915 5921 2-s2.0-0030834122 (Pubitemid 27304928)
55. Ballestas M. E., Chatis P. A., Kaye K. M., Efficient persistence of extrachromosomal KSHV DNA mediated by latency- associated nuclear antigen. Science 1999 284 5414 641 644 2-s2.0-0033597453 10.1126/science.284.5414.641 (Pubitemid 29289588)
56. Cotter M. A., Robertson E. S., The latency-associated nuclear antigen tethers the Kaposi's sarcoma- associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. Virology 1999 264 2 254 264 2-s2.0-0033604613 10.1006/viro.1999.9999
57. Hu J., Garber A. C., Renne R., The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells. Journal of Virology 2002 76 22 11677 11687 2-s2.0-0036827642 10.1128/JVI.76.22.11677-11687.2002 (Pubitemid 35231322)
58. Si H., Verma S. C., Lampson M. A., Cai Q., Robertson E. S., Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregation. Journal of Virology 2008 82 13 6734 6746 2-s2.0-45749151740 10.1128/JVI.00342-08 (Pubitemid 351875148)
59. Cotter M. A., Subramanian C., Robertson E. S., The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen binds to specific sequences at the left end of the viral genome through its carboxy-terminus. Virology 2001 291 2 241 259 2-s2.0-0035697261 10.1006/viro.2001.1202 (Pubitemid 34095181)
60. Ballestas M. E., Kaye K. M., Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA. Journal of Virology 2001 75 7 3250 3258 2-s2.0-0035100879 10.1128/JVI.75.7.3250-3258. 2001 (Pubitemid 32225888)
61. Garber A. C., Shu M. A., Hu J., Renne R., DNA binding and modulation of gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2001 75 17 7882 7892 2-s2.0-0034870212 10.1128/JVI.75.17.7882-7892.2001 (Pubitemid 32743660)
62. Fejér G., Medveczky M. M., Horvath E., Lane B., Chang Y., Medveczky P. G., The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication. Journal of General Virology 2003 84 6 1451 1462 2-s2.0-0038315219 10.1099/vir.0.18940-0 (Pubitemid 36675515)
63. Grundhoff A., Ganem D., The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids. Journal of Virology 2003 77 4 2779 2783 2-s2.0-0037321704 10.1128/JVI.77.4.2779-2783.2003 (Pubitemid 36222806)
64. Hu J., Renne R., Characterization of the minimal replicator of Kaposi's sarcoma-associated herpesvirus latent origin. Journal of Virology 2005 79 4 2637 2642 2-s2.0-13444283729 10.1128/JVI.79.4.2637-2642.2005 (Pubitemid 40204619)
65. Barbera A. J., Ballestas M. E., Kaye K. M., The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence. Journal of Virology 2004 78 1 294 301 2-s2.0-0346995212 10.1128/JVI.78.1.294-301.2004 (Pubitemid 37549742)
66. Canham M., Talbot S. J., A naturally occurring C-terminal truncated isoform of the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus does not associate with viral episomal DNA. Journal of General Virology 2004 85 6 1363 1369 2-s2.0-2942666035 10.1099/vir.0.79802-0 (Pubitemid 38811423)
67. Komatsu T., Ballestas M. E., Barbera A. J., Kelley-Clarke B., Kaye K. M., KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence. Virology 2004 319 2 225 236 2-s2.0-1342321886 10.1016/j.virol.2003. 11.002 (Pubitemid 38251264)
68. Ohsaki E., Ueda K., Sakakibara S., Do E., Yada K., Yamanishi K., Poly(ADP-ribose) polymerase 1 binds to Kaposi's sarcoma-associated herpesvirus (KSHV) terminal repeat sequence and modulates KSHV replication in latency. Journal of Virology 2004 78 18 9936 9946 2-s2.0-4444294852 10.1128/JVI.78.18. 9936-9946.2004 (Pubitemid 39187112)
69. Verma S. C., Bajaj B. G., Cai Q., Si H., Seelhammer T., Robertson E. S., Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virus. Journal of Virology 2006 80 22 11178 11190 2-s2.0-33750714473 10.1128/JVI.01334-06 (Pubitemid 44706557)
70. Verma S. C., Choudhuri T., Kaul R., Robertson E. S., Latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus interacts with origin recognition complexes at the LANA binding sequence within the terminal repeats. Journal of Virology 2006 80 5 2243 2256 2-s2.0-33144488605 10.1128/JVI.80.5.2243-2256.2006 (Pubitemid 43271531)
71. Verma S. C., Choudhuri T., Robertson E. S., The minimal replicator element of the Kaposi's sarcoma-associated herpesvirus terminal repeat supports replication in a semiconservative and cell-cycle-dependent manner. Journal of Virology 2007 81 7 3402 3413 2-s2.0-33947375574 10.1128/JVI.01607-06 (Pubitemid 46456649)
72. Stedman W., Deng Z., Lu F., Lieberman P. M., ORC, MCM, and histone hyperacetylation at the Kaposi's sarcoma-associated herpesvirus latent replication origin. Journal of Virology 2004 78 22 12566 12575 2-s2.0-7644241815 10.1128/JVI.78.22.12566-12575.2004 (Pubitemid 39458775)
73. Lim C., Choi C., Choe J., Mitotic chromosome-binding activity of latency-associated nuclear antigen 1 is required for DNA replication from terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2004 78 13 7248 7256 2-s2.0-2942635073 10.1128/JVI.78.13.7248-7256.2004 (Pubitemid 38781562)
74. Kelley-Clarke B., De Leon-Vazquez E., Slain K., Barbera A. J., Kaye K. M., Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence. Journal of Virology 2009 83 9 4326 4337 2-s2.0-66149113937 10.1128/JVI.02395-08
75. Kelley-Clarke B., Ballestas M. E., Srinivasan V., Barbera A. J., Komatsu T., Harris TE. A., Kazanjian M., Kaye K. M., Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA binding. Journal of Virology 2007 81 8 4348 4356 2-s2.0-34247112857 10.1128/JVI.01289-06 (Pubitemid 46586930)
76. Kelley-Clarke B., Ballestas M. E., Komatsu T., Kaye K. M., Kaposi's sarcoma herpesvirus C-terminal LANA concentrates at pericentromeric and peri-telomeric regions of a subset of mitotic chromosomes. Virology 2007 357 2 149 157 2-s2.0-33751428916 10.1016/j.virol.2006.07.052 (Pubitemid 44821297)
77. Shinohara H., Fukushi M., Higuchi M., Oie M., Hoshi O., Ushiki T., Hayashi J. I., Fujii M., Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1. Journal of Virology 2002 76 24 12917 12924 2-s2.0-0036893366 10.1128/JVI.76.24.12917-12924. 2002 (Pubitemid 35386975)
78. Krithivas A., Fujimuro M., Weidner M., Young D. B., Hayward S. D., Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes. Journal of Virology 2002 76 22 11596 11604 2-s2.0-0036828167 10.1128/JVI.76.22.11596-11604.2002 (Pubitemid 35231315)
79. Matsumura S., Persson L. M., Wong L., Wilson A. C., The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domains. Journal of Virology 2010 84 5 2318 2330 2-s2.0-77649216736 10.1128/JVI.01097-09
80. You J., Srinivasan V., Denis G. V., Harrington W. J., Ballestas M. E., Kaye K. M., Howley P. M., Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. Journal of Virology 2006 80 18 8909 8919 2-s2.0-33748484257 10.1128/JVI.00502-06 (Pubitemid 44359965)
81. Xiao B., Verma S. C., Cai Q., Kaul R., Lu J., Saha A., Robertson E. S., erle@mail.med.upenn.edu Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores. Journal of Virology 2010 84 19 9718 9732 10.1128/JVI.00713-10
82. Ye F. C., Zhou F. U. C., Seung M. Y., Xie J. P., Browning P. J., Gao S. J., Disruption of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen leads to abortive episome persistence. Journal of Virology 2004 78 20 11121 11129 2-s2.0-4644232252 10.1128/JVI.78.20.11121-11129.2004 (Pubitemid 39299652)
83. Krithivas A., Young D. B., Liao G., Greene D., Hayward S. D., Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. Journal of Virology 2000 74 20 9637 9645 2-s2.0-0033809462 10.1128/JVI.74.20.9637-9645.2000
84. Pan H. Y., Zhang Y. J., Wang X. P., Deng J. H., Zhou F. U. C., Gao S. J., Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2003 77 18 9758 9768 2-s2.0-0141570687 10.1128/JVI.77.18.9758-9768. 2003 (Pubitemid 37122056)
85. Mattsson K., Kiss C., Platt G. M., Simpson G. R., Kashuba E., Klein G., Schulz T. F., Szekely L., Latent nuclear antigen of Kaposi's sarcoma herpesvirus/human herpesvirus-8 induces and relocates RING3 to nuclear heterochromatin regions. Journal of General Virology 2002 83 1 179 188 2-s2.0-0036136470 (Pubitemid 34030822)
86. Platt G. M., Simpson G. R., Mittnacht S., Schulz T. F., Latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with RING3, a homolog of the Drosophila female sterile homeotic (fsh) gene. Journal of Virology 1999 73 12 9789 9795 2-s2.0-0032752995
87. Shamay M., Krithivas A., Zhang J., Hayward S. D., Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA. Proceedings of the National Academy of Sciences of the United States of America 2006 103 39 14554 14559 2-s2.0-33749243937 10.1073/pnas.0604469103 (Pubitemid 44484788)
88. Lan K. E., Kuppers D. A., Verma S. C., Sharma N., Murakami M., Robertson E. S., Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latency. Journal of Virology 2005 79 12 7453 7465 2-s2.0-19944370134 10.1128/JVI.79.12.7453-7465.2005 (Pubitemid 40756782)
89. Lan K. E., Kuppers D. A., Verma S. C., Robertson E. S., Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency. Journal of Virology 2004 78 12 6585 6594 2-s2.0-2642586357 10.1128/JVI.78.12.6585-6594.2004 (Pubitemid 38715955)
90. Lan K. E., Kuppers D. A., Robertson E. S., Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein J κ the major downstream effector of the notch signaling pathway. Journal of Virology 2005 79 6 3468 3478 2-s2.0-14744269431 10.1128/JVI.79.6.3468-3478.2005 (Pubitemid 40327935)
91. Li Q., Zhou F., Ye F., Gao S. J., Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program. Virology 2008 379 2 234 244 2-s2.0-50349083406 10.1016/j.virol.2008.06.043
92. Cai Q. I. L., Knight J. S., Verma S. C., Zald P., Robertson E. S., EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors. PLoS Pathogens 2006 2 10 e116 2-s2.0-36348973669 10.1371/journal.ppat.0020116 (Pubitemid 44656551)
93. Friborg J. Jr., Kong W. P., Hottlger M. O., Nabel G. J., p53 Inhibition by the LANA protein of KSHV protects against cell death. Nature 1999 402 6764 889 894 2-s2.0-0033599006 10.1038/47266 (Pubitemid 30017172)
94. Katano H., Sato Y., Sata T., Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignancies. Cancer 2001 92 12 3076 3084 2-s2.0-0035892769 10.1002/1097-0142(20011215)92:123076::AID-CNCR10117>3.0.CO;2-D (Pubitemid 33136204)
95. Radkov S. A., Kellam P., Boshoff C., The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nature Medicine 2000 6 10 1121 1127 2-s2.0-0033782793 10.1038/80459
96. Fujimuro M., Wu F. Y., Aprhys C., Kajumbula H., Young D. B., Hayward G. S., Hayward S. D., A novel viral mechanism for dysregulation of β -catenin in Kaposi's sarcoma-associated herpesvirus latency. Nature Medicine 2003 9 3 300 306 2-s2.0-0037348372 10.1038/nm829 (Pubitemid 36362785)
97. Hagen T., Characterization of the interaction between latency-associated nuclear antigen and glycogen synthase kinase 3 β Journal of Virology 2009 83 12 6312 6317 2-s2.0-66149136812 10.1128/JVI.01671-08
98. Liu J., Martin H. J., Liao G., Hayward S. D., The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc. Journal of Virology 2007 81 19 10451 10459 2-s2.0-34648827798 10.1128/JVI.00804-07 (Pubitemid 47463318)
99. Li X., Chen S., Feng J., Deng H., Sun R., rsun@mednet.ucla.edu Myc is required for the maintenance of Kaposi's sarcoma-associated herpesvirus latency. Journal of Virology 2010 84 17 8945 8948 10.1128/JVI.00244-10
100. Godden-Kent D., Talbot S. J., Boshoff C., Chang Y., Moore P., Weiss R. A., Mittnacht S., The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1. Journal of Virology 1997 71 6 4193 4198 2-s2.0-0030992885 (Pubitemid 27204104)
101. Ellis M., Chew Y. P., Fallis L., Freddersdorf S., Boshoff C., Weiss R. A., Lu X., Mittnacht S., Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex. The EMBO Journal 1999 18 3 644 653 2-s2.0-0033081619 10.1093/emboj/18.3.644 (Pubitemid 29057249)
102. Mann D. J., Child E. S., Swanton C., Laman H., Jones N., Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus. The EMBO Journal 1999 18 3 654 663 2-s2.0-0033081065 10.1093/emboj/18.3.654 (Pubitemid 29057250)
103. Ojala P. M., Yamamoto K., Castanos-Velez E., The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2. Nature Cell Biology 2000 2 11 819 825
104. Sarek G., Järviluoma A., Ojala P. M., paivi.ojala@helsinki.fi KSHV viral cyclin inactivates p27KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas. Blood 2006 107 2 725 732 10.1182/blood-2005-06-2534 (Pubitemid 43076399)
105. Sarek G., Järviluoma A., Moore H. M., Tojkander S., Vartia S., Biberfeld P., Laiho M., Ojala P. M., Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. PLoS Pathogens 2010 6 3 2-s2.0-77950444039 10.1371/journal.ppat.1000818 e1000818
106. Hoge A. T., Hendrickson S. B., Burns W. H., Murine gammaherpesvirus 68 cyclin D homologue is required for efficient reactivation from latency. Journal of Virology 2000 74 15 7016 7023 2-s2.0-0033927915 10.1128/JVI.74.15.7016-7023. 2000 (Pubitemid 30470684)
107. Thome M., Schneider P., Hofmann K., Fickenscher H., Meinl E., Neipel F., Mattmann C., Burns K., Bodmer J. L., Schröter M., Scaffidi C., Krammer P. H., Peter M. E., Tschopp J., Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 1997 386 6624 517 521 2-s2.0-0030970013 10.1038/386517a0 (Pubitemid 27164081)
108. Chaudhary P. M., Jasmin A., Eby M. T., Hood L., Modulation of the NF- κ B pathway by virally encoded death effector domains-containing proteins. Oncogene 1999 18 42 5738 5746 2-s2.0-0033554648 10.1038/sj.onc.1202976 (Pubitemid 29507427)
109. Field N., Low W., Daniels M., Howell S., Daviet L., Boshoff C., Collins M., KSHV vFLIP binds to IKK- γ to activate IKK. Journal of Cell Science 2003 116 18 3721 3728 2-s2.0-0141502126 10.1242/jcs.00691 (Pubitemid 37185301)
110. Matta H., Chaudhary P. M., preet.chaudhary@utsouthwestern.edu Activation of alternative NF- κ B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 β -converting enzyme inhibitory protein (vFLIP). Proceedings of the National Academy of Sciences of the United States of America 2004 101 25 9399 9404 10.1073/pnas.0308016101 (Pubitemid 38812886)
111. Matta H., Mazzacurati L., Schamus S., Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation. The Journal of Biological Chemistry 2007 282 34 24858 24865 (Pubitemid 47347558)
112. Brown H. J., Song M. J., Deng H., Wu T. T., Cheng G., Sun R., NF- κ B inhibits gammaherpesvirus lytic replication. Journal of Virology 2003 77 15 8532 8540 2-s2.0-0037770173 10.1128/JVI.77.15.8532-8540.2003 (Pubitemid 36871481)
113. Sgarbanti M., Arguello M., TenOever B. R., Battistini A., Lin R., Hiscott J., A requirement for NF- κ B induction in the production of replication-competent HHV-8 virions. Oncogene 2004 23 34 5770 5780 2-s2.0-4143081387 10.1038/sj.onc.1207707 (Pubitemid 39093022)
114. Zhao J., Punj V., Matta H., Mazzacurati L., Schamus S., Yang Y., Yang T., Hong Y., Chaudhary P. M., chaudharypm@upmc.edu K13 blocks KSHV lytic replication and deregulates vIL6 nad hIL6 expression: a model of lytic replication induced clonal selection in viral oncogenesis. PLoS ONE 2007 2 10 e1067 10.1371/journal.pone.0001067 (Pubitemid 351566507)
115. Grossmann C., Ganem D., Effects of NF κ B activation on KSHV latency and lytic reactivation are complex and context-dependent. Virology 2008 375 1 94 102 2-s2.0-42749088772 10.1016/j.virol.2007.12.044
116. Ye F. C., Zhou F. U. C., Xie J. P., Kang T., Greene W., Kuhne K., Lei X. F., Li Q. H., Gao S. J., Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF- κ B-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latency. Journal of Virology 2008 82 9 4235 4249 2-s2.0-42449106924 10.1128/JVI.02370-07 (Pubitemid 351563661)
117. Pfeffer S., Sewer A., Lagos-Quintana M., Sheridan R., Sander C., Grässer F. A., van Dyk L. F., Kiong Ho C., Shuman S., Chien M., Russo J. J., Ju J., Randall G., Lindenbach B. D., Rice C. M., Simon V., Ho D. D., Zavolan M., Tuschl T., Identification of microRNAs of the herpesvirus family. Nature Methods 2005 2 4 269 276 2-s2.0-20844463414 10.1038/nmeth746 (Pubitemid 41131008)
118. Cai X., Lu S., Zhang Z., Gonzalez C. M., Damania B., Cullen B. R., Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proceedings of the National Academy of Sciences of the United States of America 2005 102 15 5570 5575 2-s2.0-17244375710 10.1073/pnas.0408192102 (Pubitemid 40530298)
119. Samols M. A., Hu J., Skalsky R. L., Renne R., Cloning and identification of a MicroRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2005 79 14 9301 9305 2-s2.0-21644438873 10.1128/JVI.79.14.9301-9305.2005 (Pubitemid 40934841)
120. Lei X., Bai Z., Ye F., Xie J., Kim C. G., Huang Y., Gao S. J., Regulation of NF-B inhibitor IB α and viral replication by a KSHV microRNA. Nature Cell Biology 2010 12 2 193 199 2-s2.0-75949087264 10.1038/ncb2019
121. Lu C.-C., Li Z., Chu C.-Y., Feng J., Feng J., Sun R., Rana T. M., trana@sanfordburnham.org MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle. EMBO Reports 2010 11 10 784 790 10.1038/embor.2010.132
122. Bellare P., Ganem D., Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic Reactivation. Cell Host and Microbe 2010 6 6 570 575 2-s2.0-75149168431 10.1016/j.chom.2009.11.008
123. Ziegelbauer J. M., Sullivan C. S., Ganem D., Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs. Nature Genetics 2009 41 1 130 134 2-s2.0-58149151064 10.1038/ng.266
124. Lu F., Stedman W., Yousef M., Renne R., Lieberman P. M., Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway. Journal of Virology 2010 84 6 2697 2706 2-s2.0-77649123174 10.1128/JVI.01997-09
125. Gottwein E., Mukherjee N., Sachse C., Frenzel C., Majoros W. H., Chi J. T. A., Braich R., Manoharan M., Soutschek J., Ohler U., Cullen B. R., A viral microRNA functions as an orthologue of cellular miR-155. Nature 2007 450 7172 1096 1099 2-s2.0-37249092180 10.1038/nature05992 (Pubitemid 350273603)
126. Skalsky R. L., Samols M. A., Plaisance K. B., Boss I. W., Riva A., Lopez M. C., Baker H. V., Renne R., Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155. Journal of Virology 2007 81 23 12836 12845 2-s2.0-36349035211 10.1128/JVI.01804-07 (Pubitemid 350156921)
127. Qin Z., Freitas E., Sullivan R., Mohan S., Bacelieri R., Branch D., Romano M., Kearney P., Oates J., Plaisance K., Renne R., Kaleeba J., Parsons C., Upregulation of xCT by KSHV-encoded microRNAs facilitates KSHV dissemination and persistence in an environment of oxidative stress. PLoS Pathogens 2010 6 1 2-s2.0-77649207029 10.1371/journal.ppat.1000742 e1000742
128. Abend J. R., Uldrick T., Ziegelbauer J. M., ziegelbauerjm@mail.nih.gov Regulation of tumor necrosis factor-like weak inducer of apoptosis receptor protein (TWEAKR) expression by Kaposi's sarcoma-associated herpesvirus microrna prevents tweak-induced apoptosis and inflammatory cytokine expression. Journal of Virology 2010 84 23 12139 12151 10.1128/JVI.00884-10
129. He Y., Vogelstein B., Velculescu V. E., Papadopoulos N., Kinzler K. W., The antisense transcriptomes of human cells. Science 2008 322 5909 1855 1857 2-s2.0-57849105533 10.1126/science.1163853
130. Chandriani S., Xu Y., Ganem D., don.ganem@ucsf.edu The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes. Journal of Virology 2010 84 16 7934 7942 10.1128/JVI.00645-10
131. Lin Y.-T., Kincaid R. P., Arasappan D., Dowd S. E., Hunicke-Smith S. P., Sullivan C. S., Chrissullivan@mail.utexas.edu Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs. RNA 2010 16 8 1540 1558 10.1261/rna.1967910
132. Xu Y., Ganem D., Making sense of antisense: seemingly noncoding RNAs antisense to the master regulator of Kaposi's sarcoma-associated herpesvirus lytic replication do not regulate that transcript but serve as mRNAs encoding small peptides. Journal of Virology 2010 84 11 5465 5475 2-s2.0-77952003905 10.1128/JVI.02705-09
133. Ensoli B., Sgadari C., Barillari G., Sirianni M. C., Stürzl M., Monini P., Biology of Kaposi's sarcoma. European Journal of Cancer 2001 37 10 1251 1269 2-s2.0-0034969034 10.1016/S0959-8049(01)00121-6 (Pubitemid 32553770)
134. Davis D. A., Rinderknecht A. S., Paul Zoeteweij J., Aoki Y., Read-Connole E. L., Tosato G., Blauvelt A., Yarchoan R., Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus. Blood 2001 97 10 3244 3250 2-s2.0-0035874496 10.1182/blood.V97.10.3244
135. Haque M., Davis D. A., Wang V., Widmer I., Yarchoan R., Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains hypoxia response elements: relevance to lytic induction by hypoxia. Journal of Virology 2003 77 12 6761 6768 2-s2.0-0038279972 10.1128/JVI.77.12.6761-6768.2003 (Pubitemid 36666870)
136. Haque M., Wang V., Davis D. A., Zheng Z. M., Yarchoan R., Genetic organization and hypoxic activation of the Kaposi's sarcoma-associated herpesvirus ORF34-37 gene cluster. Journal of Virology 2006 80 14 7037 7051 2-s2.0-33745800234 10.1128/JVI.00553-06 (Pubitemid 44025202)
137. Dalton-Griffin L., Wilson S. J., Kellam P., X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditions. Journal of Virology 2009 83 14 7202 7209 2-s2.0-67650407491 10.1128/JVI.00076-09
138. Cai Q., Lan K., Verma S. C., Si H., Lin D., Robertson E. S., erle@mail.med.upenn.edu Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 α to upregulate RTA expression during hypoxia: latency control under low oxygen conditions. Journal of Virology 2006 80 16 7965 7975 10.1128/JVI.00689-06 (Pubitemid 44182297)
139. Merat R., Amara A., Lebbe C., De The H., Morel P., Saib A., HIV-1 infection of primary effusion lymphoma cell line triggers Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation. International Journal of Cancer 2002 97 6 791 795 2-s2.0-0037138427 10.1002/ijc.10086 (Pubitemid 34106334)
140. Varthakavi V., Smith R. M., Deng H., Sun R., Spearman P., Human immunodeficiency virus type-1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus through induction of KSHV Rta. Virology 2002 297 2 270 280 10.1006/viro.2002.1434 (Pubitemid 34734899)
141. Zeng Y. I., Zhang X., Huang Z., Cheng L., Yao S., Qin DI., Chen X., Tang Q., Lv Z., Zhang L., Lu C., Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling. Journal of Virology 2007 81 5 2401 2417 2-s2.0-33847193148 10.1128/JVI.02024-06
142. Vieira J., O'Hearn P., Kimball L., Chandran B., Corey L., Activation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus. Journal of Virology 2001 75 3 1378 1386 2-s2.0-0035148492 10.1128/JVI.75.3.1378-1386.2001 (Pubitemid 32094696)
143. Lu C., Zeng Y. I., Huang Z., Huang L. I., Qian C., Tang G., Qin DI., Human herpesvirus 6 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. American Journal of Pathology 2005 166 1 173 183 2-s2.0-11144242118 (Pubitemid 40051670)
144. Qin DI., Zeng Y. I., Qian C., Huang Z., Lv Z., Cheng L., Yao S., Tang Q., Chen X., Lu C., Induction of lytic cycle replication of Kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1: involvement of IL-10 and IL-4. Cellular Microbiology 2008 10 3 713 728 2-s2.0-38849116900 10.1111/j.1462-5822.2007.01079.x (Pubitemid 351194097)
145. Gregory S. M., West J. A., Dillon P. J., Hilscher C., Dittmer D. P., Damania B., Toll-like receptor signaling controls reactivation of KSHV from latency. Proceedings of the National Academy of Sciences of the United States of America 2009 106 28 11725 11730 2-s2.0-67650899077 10.1073/pnas.0905316106
146. Mercader M., Taddeo B., Panella J. R., Chandran B., Nickoloff B. J., Foreman K. E., Induction of HHV-8 lytic cycle replication by inflammatory cytokines produced by HIV-1-infected T cells. American Journal of Pathology 2000 156 6 1961 1971 2-s2.0-0033902645 (Pubitemid 30641765)
147. Blackbourn D. J., Fujimura S., Kutzkey T., Levy J. A., Induction of human herpesvirus-8 gene expression by recombinant interferon gamma. AIDS 2000 14 1 98 99 2-s2.0-0033969044 10.1097/00002030-200001070-00017 (Pubitemid 30072088)
148. Milligan S., Robinson M., O'Donnell E., Blackbourn D. J., Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells. Journal of Virology 2004 78 5 2591 2596 2-s2.0-1242342056 10.1128/JVI.78.5.2591-2596.2004 (Pubitemid 38228955)
149. Ye F. C., Zhou F. C., Bedolla R. G., Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathogens 2011 7 5 e1002054
150. Li X., Feng J., Sun R., Oxidative stress induces reactivation of Kaposi's sarcoma-associated herpesvirus and death of primary effusion lymphoma cells. Journal of Virology 2011 85 2 715 724
151. Gil L., Martínez G., González I., Tarinas A., Álvarez A., Giuliani A., Molina R., Tápanes R., Pérez J., León O. S., Contribution to characterization of oxidative stress in HIV/AIDS patients. Pharmacological Research 2003 47 3 217 224 2-s2.0-12244286787 10.1016/S1043-6618(02)00320-1 (Pubitemid 36259924)
152. Khatami M., mkgoodness@aol.com Inflammation, aging, and cancer: tumoricidal versus tumorigenesis of immunity. Cell Biochemistry and Biophysics 2009 55 2 55 79 10.1007/s12013-009-9059-2
153. Laubach V. E., Kron I. L., Pulmonary inflammation after lung transplantation. Surgery 2009 146 1 1 4 2-s2.0-67349216596 10.1016/j.surg.2009. 02.011
154. Salahudeen A. A., Bruick R. K., Maintaining mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk. Annals of the New York Academy of Sciences 2009 1177 30 38 2-s2.0-70350357467 10.1111/j.1749-6632.2009.05038.x
155. Simonart T., Noel J. C., Andrei G., Parent D., Van Yooren J. P., Hermans P., Lunardi-Yskandar Y., Lambert C., Dieye T., Farber C. M., Liesnard C., Snoeck R., Heenen M., Boelaert J. R., Iron as a potential co-factor in the pathogenesis of Kaposi's sarcoma? International Journal of Cancer 1998 78 6 720 726 2-s2.0-0031795720 10.1002/(SICI)1097-0215(19981209)78:6720::AID-IJC9>3.0. CO;2-F (Pubitemid 28530395)
156. Johnson A. S., Maronian N., Vieira J., Activation of Kaposi's sarcoma-associated herpesvirus lytic gene expression during epithelial differentiation. Journal of Virology 2005 79 21 13769 13777 2-s2.0-27144533897 10.1128/JVI.79.21.13769-13777.2005 (Pubitemid 41508188)
157. Yu F., Feng J., Harada J. N., Chanda S. K., Kenney S. C., Sun R., B cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirus. The FEBS Letters 2007 581 18 3485 3488 2-s2.0-34447285052 10.1016/j.febslet.2007.06.056 (Pubitemid 47048199)
158. Wilson S. J., Tsao E. H., Webb B. L. J., Ye H., Dalton-Griffin L., Tsantoulas C., Gale C. V., Du M. Q., Whitehouse A., Kellam P., X box binding protein XBP-1s transactivates the Kaposi's Sarcoma-Associated Herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency. Journal of Virology 2007 81 24 13578 13586 2-s2.0-37049016021 10.1128/JVI.01663-07 (Pubitemid 350247851)
159. Simonart T., Iron: a target for the management of Kaposi's sarcoma? BMC Cancer 2004 4, article 1 2-s2.0-3042836376 10.1186/1471-2407-4-1 (Pubitemid 38851348)
160. Simonart T., Role of environmental factors in the pathogenesis of classic and African-endemic Kaposi sarcoma. Cancer Letters 2006 244 1 1 7 2-s2.0-33749236613 10.1016/j.canlet.2006.02.005 (Pubitemid 44485873)
161. Cho H. J., Yu F., Sun R., Lee D., Song M. J., Lytic induction of Kaposi's sarcoma-associated herpesvirus in primary effusion lymphoma cells with natural products identified by a cell-based fluorescence moderate-throughput screening. Archives of Virology 2008 153 8 1517 1525 2-s2.0-47549119646 10.1007/s00705-008-0144-4
162. Whitby D., Marshall V. A., Bagni R. K., Miley W. J., McCloud T. G., Hines-Boykin R., Goedert J. J., Conde B. A., Nagashima K., Mikovits J., Dittmer D. P., Newman D. J., Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regions. International Journal of Cancer 2007 120 2 321 328 2-s2.0-33845603155 10.1002/ijc.22205 (Pubitemid 44956841)
163. Zoeteweij J. P., Moses A. V., Rinderknecht A. S., Davis D. A., Overwijk W. W., Yarchoan R., Orenstein J. M., Blauvelt A., Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus. Blood 2001 97 8 2374 2380 2-s2.0-0035871808 10.1182/blood.V97.8.2374 (Pubitemid 32291484)
164. Deutsch E., Cohen A., Kazimirsky G., Dovrat S., Rubinfeld H., Brodie C., Sarid R., Role of protein kinase C δ in reactivation of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2004 78 18 10187 10192 2-s2.0-4444319172 10.1128/JVI.78.18.10187-10192.2004 (Pubitemid 39187136)
165. Yu F., Harada J. N., Brown H. J., Deng H., Moon J. S., Wu T. T., Kato-Stankiewicz J., Nelson C. G., Vieira J., Tamanoi F., Chanda S. K., Sun R., Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus. PLoS Pathogens 2007 3 3 e44 2-s2.0-34047204739 10.1371/journal.ppat.0030044 (Pubitemid 46535816)
166. Wang S. E., Wu F. Y., Chen H., Shamay M., Zheng Q., Hayward G. S., Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway. Journal of Virology 2004 78 8 4248 4267 2-s2.0-1842431602 10.1128/JVI.78.8.4248-4267.2004 (Pubitemid 38437229)
167. AuCoin D. P., Colletti K. S., Cei S. A., Papousková I., Tarrant M., Pari G. S., Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP). Virology 2004 318 2 542 555 2-s2.0-1242328736 10.1016/j.virol.2003.10.016 (Pubitemid 38224298)
168. Xie J., Ajibade A. O., Ye F., Kuhne K., Gao S. J., Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathways. Virology 2008 371 1 139 154 2-s2.0-38049070690 10.1016/j.virol.2007.09.040
169. Pan H., Xie J., Ye F., Gao S. J., Modulation of Kaposi's sarcoma-associated herpesvirus infection and replication by MEK/ERK, JNK, and p38 multiple mitogen-activated protein kinase pathways during primary infection. Journal of Virology 2006 80 11 5371 5382 2-s2.0-33646747652 10.1128/JV1.02299-05
170. Xie J., Pan H., Yoo S., Gao S. J., Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways. Journal of Virology 2005 79 24 15027 15037 2-s2.0-29744457034 10.1128/JVI.79.24.15027- 15037.2005 (Pubitemid 43032284)
171. Cohen A., Brodie C., Sarid R., An essential role of ERK signalling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus. Journal of General Virology 2006 87 4 795 802 2-s2.0-33645554691 10.1099/vir.0.81619-0
172. Ford P. W., Bryan B. A., Dyson O. F., Weidner D. A., Chintalgattu V., Akula S. M., Raf/MEK/ERK signalling triggers reactivation of Kaposi's sarcoma-associated herpesvirus latency. Journal of General Virology 2006 87 5 1139 1144 2-s2.0-33646148957 10.1099/vir.0.81628-0
173. Cheng F., Weidner-Glunde M., Varjosalo M., Rainio E. M., Lehtonen A., Schulz T. F., Koskinen P. J., Taipale J., Ojala P. M., KSHV reactivation from latency requires pim-1 and pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PLoS Pathogens 2009 5 3 e1000324 2-s2.0-63449097051 10.1371/journal.ppat.1000324
174. Izumiya Y., Izumiya C., Hsia D., Ellison T. J., Luciw P. A., Kung H. J., NF- κ B serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-J κ coactivator. Journal of Virology 2009 83 9 4435 4446 2-s2.0-66149112412 10.1128/JVI.01999-08
175. Lagunoff M., Bechtel J., Venetsanakos E., Roy A. M., Abbey N., Herndier B., McMahon M., Ganem D., De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. Journal of Virology 2002 76 5 2440 2448 2-s2.0-0036171260 10.1128/jvi.76.5.2440-2448.2002 (Pubitemid 34150712)
176. Krishnan H. H., Naranatt P. P., Smith M. S., Zeng L., Bloomer C., Chandran B., Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. Journal of Virology 2004 78 7 3601 3620 2-s2.0-1842509993 10.1128/JVI.78.7.3601-3620.2004 (Pubitemid 38568301)
177. Foglieni C., Scabini S., Belloni D., Broccolo F., Lusso P., Malnati M. S., Ferrero E., Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformations. European Journal of Histochemistry 2005 49 3 273 284 2-s2.0-33644674815
178. Seung M. Y., Zhou F. U. C., Ye F. C., Pan H. Y., Gao S. J., Early and sustained expression of latent and host modulating genes in coordinated transcriptional program of KSHV productive primary infection of human primary endothelial cells. Virology 2005 343 1 47 64 2-s2.0-27644467562 10.1016/j.virol.2005.08.018 (Pubitemid 41572233)
179. Sharma-Walia N., Krishnan H. H., Naranatt P. P., Zeng L., Smith M. S., Chandran B., ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection. Journal of Virology 2005 79 16 10308 10329 2-s2.0-23244461927 10.1128/JVI.79.16.10308-10329.2005 (Pubitemid 41098572)
180. Peng L. I., Wu T. T., Tchieu J. H., Feng J., Brown H. J., Feng J., Li X., Qi J., Deng H., Vivanco I., Melinghoff I. K., Jamieson C., Sun R., Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency. Journal of General Virology 2010 91 2 463 469 2-s2.0-76249099841 10.1099/vir.0.015073-0
181. Chen J., Ueda K., Sakakibara S., Okuno T., Parravicini C., Corbellino M., Yamanishi K., Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator. Proceedings of the National Academy of Sciences of the United States of America 2001 98 7 4119 4124 2-s2.0-0035957366 10.1073/pnas.051004198 (Pubitemid 32249908)
182. Lu F., Zhou J., Wiedmer A., Madden K., Yuan Y., Lieberman P. M., Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. Journal of Virology 2003 77 21 11425 11435 2-s2.0-0142060892 10.1128/JVI.77.21.11425-11435.2003 (Pubitemid 37271641)
183. Li Q. H., Gao S. J., Reactivation of KSHV from latency by class III histone deacetylase inhibitors. Proceedings of the 13th International Workshop on Kaposi's Sarcoma-Associated Herpesvirus and Related Agents August 2010 Los Angeles, Calif, USA
184. Lukac D. M., Renne R., Kirshner J. R., Ganem D., Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 1998 252 2 304 312 2-s2.0-0032567394 10.1006/viro.1998.9486 (Pubitemid 29013411)
185. Sun R., Lin S. U. F., Gradoville L., Yuan Y., Zhu F., Miller G., A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proceedings of the National Academy of Sciences of the United States of America 1998 95 18 10866 10871 2-s2.0-0032167919
186. Gradoville L., Gerlach J., Grogan E., Shedd D., Nikiforow S., Metroka C., Miller G., Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. Journal of Virology 2000 74 13 6207 6212 2-s2.0-0034083471 10.1128/JVI.74.13.6207-6212.2000 (Pubitemid 30412996)
187. Xu Y., AuCoin D. P., Rodriguez Huete A., Cei S. A., Hanson L. J., Pari G. S., A kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replication. Journal of Virology 2005 79 6 3479 3487 2-s2.0-14744270253 10.1128/JVI.79.6.3479-3487.2005 (Pubitemid 40327936)
188. Deng H., Young A., Sun R., Auto-activation of the rta gene of human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus. Journal of General Virology 2000 81 12 3043 3048 2-s2.0-0034532496 (Pubitemid 32000651)
189. Bu W., Palmeri D., Krishnan R., Marin R., Aris V. M., Soteropoulos P., Lukac D. M., Identification of direct transcriptional targets of the Kaposi's sarcoma-associated herpesvirus Rta lytic switch protein by conditional nuclear localization. Journal of Virology 2008 82 21 10709 10723 2-s2.0-55249092122 10.1128/JVI.01012-08 (Pubitemid 352691197)
190. Deng H., Song M. J., Chu J. T., Sun R., Transcriptional regulation of the interleukin-6 gene of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). Journal of Virology 2002 76 16 8252 8264 2-s2.0-0036316347 10.1128/JVI.76.16.8252-8264.2002 (Pubitemid 34809080)
191. Moon Jung Song., Brown H. J., Wu T. T., Sun R., Transcription activation of polyadenylated nuclear RNA by Rta in human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2001 75 7 3129 3140 2-s2.0-0035108050 10.1128/JVI.75.7.3129-3140.2001 (Pubitemid 32225877)
192. Byun H., Gwack Y., Hwang S., Choe J., Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements. Molecules and Cells 2002 14 2 185 191 2-s2.0-0037206560 (Pubitemid 41594971)
193. Lukac D. M., Garibyan L., Kirshner J. R., Palmeri D., Ganem D., DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters. Journal of Virology 2001 75 15 6786 6799 2-s2.0-0034953721 10.1128/JVI.75.15. 6786-6799.2001 (Pubitemid 32641564)
194. Ueda K., Ishikawa K., Nishimura K., Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) replication and transcription factor activates the K9 (vIRF) gene through two distinct cis elements by a non-DNA-binding mechanism. Journal of Virology 2002 76 23 12044 12054 (Pubitemid 35304304)
195. Bowser B. S., Morris S., Song M. J., Sun R., Damania B., Characterization of Kaposi's sarcoma-associated herpesvirus (KSHV) K1 promoter activation by Rta. Virology 2006 348 2 309 327 2-s2.0-33646486990 10.1016/j.virol.2006.02.007
196. Song M. J., Deng H., Sun R., Comparative study of regulation of RTA-responsive genes in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. Journal of Virology 2003 77 17 9451 9462 2-s2.0-0041387440 10.1128/JVI.77.17.9451-9462.2003 (Pubitemid 37011041)
197. Seaman W. T., Quinlivan E. B., Lytic switch protein (ORF50) response element in the Kaposi's sarcoma-associated herpesvirus K8 promoter is located within but does not require a palindromic structure. Virology 2003 310 1 72 84 2-s2.0-0038544285 10.1016/S0042-6822(03)00095-3 (Pubitemid 38352583)
198. Ziegelbauer J., Grundhoff A., Ganem D., Exploring the DNA binding interactions of the Kaposi's sarcoma-associated herpesvirus lytic switch protein by selective amplification of bound sequences in vitro. Journal of Virology 2006 80 6 2958 2967 2-s2.0-33644778764 10.1128/JVI.80.6.2958-2967.2006 (Pubitemid 43346391)
199. Chen J., Ye F., Xie J., Kuhne K., Gao S. J., Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA. Virology 2009 386 2 290 302 2-s2.0-62749126635 10.1016/j.virol.2009.01.031
200. Zhang L., Chiu J., Lin J.-C., Activation of human herpesvirus 8 (HHV-8) thymidine kinase (TK) TATAA- less promoter by HHV-80RF50 gene product is SP1 dependent. DNA and Cell Biology 1998 17 9 735 742 (Pubitemid 28462872)
201. Ye J., Shedd D., Miller G., An Sp1 response element in the Kaposi's sarcoma-associated herpesvirus open reading frame 50 promoter mediates lytic cycle induction by butyrate. Journal of Virology 2005 79 3 1397 1408 2-s2.0-13744256651 10.1128/JVI.79.3.1397-1408.2005 (Pubitemid 40459087)
202. Carroll K. D., Khadim F., Spadavecchia S., Palmeri D., Lukac D. M., Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivation. Journal of Virology 2007 81 16 8451 8467 2-s2.0-34547765339 10.1128/JVI.00265-07 (Pubitemid 47242818)
203. Chang P. J., Miller G., Autoregulation of DNA binding and protein stability of Kaposi's sarcoma-associated herpesvirus ORF50 protein. Journal of Virology 2004 78 19 10657 10673 2-s2.0-4544383992 10.1128/JVI.78.19.10657-10673. 2004 (Pubitemid 39258392)
204. Sakakibara S., Ueda K., Chen J., Okuno T., Yamanishi K., Octamer-binding sequence is a key element for the autoregulation of Kaposi's sarcoma-associated herpesvirus ORF50/Lyta gene expression. Journal of Virology 2001 75 15 6894 6900 2-s2.0-0034960341 10.1128/JVI.75.15.6894-6900.2001 (Pubitemid 32641576)
205. Carroll K. D., Bu W., Palmeri D., Spadavecchia S., Lynch S. J., Marras S. A. E., Tyagi S., Lukac D. M., Kaposi's sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway. Journal of Virology 2006 80 19 9697 9709 2-s2.0-33748935192 10.1128/JVI.00746-06 (Pubitemid 44435644)
206. Chang P. J., Boonsiri J., Wang S. S., Chen L. I. Y., Miller G., Binding of RBP-J κ (CSL) protein to the promoter of the Kaposi's sarcoma-associated herpesvirus ORF47 (gL) gene is a critical but not sufficient determinant of transactivation by ORF50 protein. Virology 2010 398 1 38 48 2-s2.0-75849147654 10.1016/j.virol.2009.11.022
207. Persson L. M., Wilson A. C., Wide-scale use of notch signaling factor CSL/RBP-J κ in RTA-mediated activation of kaposi's sarcoma-associated herpesvirus lytic genes. Journal of Virology 2010 84 3 1334 1347 2-s2.0-73949088047 10.1128/JVI.01301-09
208. Lan K. E., Murakami M., Choudhuri T., Kuppers D. A., Robertson E. S., Intracellular-activated Notch1 can reactivate Kaposi's sarcoma-associated herpesvirus from latency. Virology 2006 351 2 393 403 2-s2.0-33746549149 10.1016/j.virol.2006.03.047 (Pubitemid 44137321)
209. Chang H., Dittmer D. P., Chul S. Y., Hong Y., Jung J. U., Role of notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression. Journal of Virology 2005 79 22 14371 14382 2-s2.0-27644526908 10.1128/JVI.79.22.14371-14382.2005 (Pubitemid 41552734)
210. Gwack Y., Baek H. J., Nakamura H., Lee S. H., Meisterernst M., Roeder R. G., Jung J. U., Principal role of TRAP/Mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Molecular and Cellular Biology 2003 23 6 2055 2067 2-s2.0-0037370376 10.1128/MCB.23.6.2055-2067.2003 (Pubitemid 36278816)
211. Wang S., Liu S., Wu M. H., Geng Y., Wood C., Identification of a cellular protein that interacts and synergizes with the RTA (ORF50) protein of Kaposi's sarcoma-associated herpesvirus in transcriptional activation. Journal of Virology 2001 75 24 11961 11973 2-s2.0-0035201957 10.1128/JVI.75.24.11961-11973. 2001 (Pubitemid 33115868)
212. Yang Z., Wood C., The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2007 81 12 6294 6306 2-s2.0-34249931319 10.1128/JVI.02648-06 (Pubitemid 46878036)
213. Yang Z., Wen H. J., Minhas V., Wood C., The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediated gene expression. Virology 2009 391 2 221 231 2-s2.0-68549088708 10.1016/j.virol.2009.06.014
214. Chang P. C., Fitzgerald L. D., Van Geelen A., Izumiya Y., Ellison T. J., Wang D. H., Ann D. K., Luciw P. A., Kung H. J., Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase. Cancer Research 2009 69 14 5681 5689 2-s2.0-67651007508 10.1158/0008-5472.CAN- 08-4570
215. Wang S. E., Wu F. Y., Fujimuro M., Zong J., Diane Hayward S., Hayward G. S., Role of CCAAT/enhancer-binding protein alpha (C/EBP α) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP. Journal of Virology 2003 77 1 600 623 2-s2.0-0037213589 10.1128/JVI.77.1.600-623.2003 (Pubitemid 36004998)
216. Wang S. E., Wu F. Y., Yu Y., Hayward G. S., CCAAT/enhancer-binding protein- α is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivation and together with the KSHV replication and transcription activator (RTA) cooperatively stimulates the viral RTA, MTA, and PAN promoters. Journal of Virology 2003 77 17 9590 9612 2-s2.0-0042890345 10.1128/JVI.77.17.9590-9612.2003 (Pubitemid 37011053)
217. Wang Y., Yuan Y., Essential role of RBP-J κ in activation of the K8 delayed-early promoter of Kaposi's sarcoma-associated herpesvirus by ORF50/RTA. Virology 2007 359 1 19 27 2-s2.0-33846826978 10.1016/j.virol.2006.09.032 (Pubitemid 46215705)
218. Yang Z., Yan Z., Wood C., Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication. Journal of Virology 2008 82 7 3590 3603 2-s2.0-41149167561 10.1128/JVI.02229-07 (Pubitemid 351429935)
219. Yu Y., Wang S. E., Hayward G. S., The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity 2005 22 1 59 70 2-s2.0-12444275739 10.1016/j.immuni.2004.11.011 (Pubitemid 40143451)
220. Gould F., Harrison S. M., Hewitt E. W., Whitehouse A., Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway. Journal of Virology 2009 83 13 6727 6738 2-s2.0-67449101832 10.1128/JVI.00351-09
221. Wang Y., Tang Q., Maul G. G., Yuan Y., Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: dual role of replication and transcription activator. Journal of Virology 2006 80 24 12171 12186 2-s2.0-33845427459 10.1128/JVI.00990-06 (Pubitemid 44904368)
222. Wang Y., Li H., Chan M. Y., Zhu F. X., Lukac D. M., Yuan Y., Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: cis-acting requirements for replication and ori-Lyt-associated RNA transcription. Journal of Virology 2004 78 16 8615 8629 2-s2.0-3543068693 10.1128/JVI.78.16.8615-8629. 2004 (Pubitemid 39025128)
223. AuCoin D. P., Colletti K. S., Xu Y., Cei S. A., Pari G. S., Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains two functional lytic origins of DNA replication. Journal of Virology 2002 76 15 7890 7896 2-s2.0-0036310446 10.1128/JVI.76.15.7890-7896.2002 (Pubitemid 34761013)
224. Han Z., Swaminathan S., Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. Journal of Virology 2006 80 11 5251 5260 2-s2.0-33646735179 10.1128/JVI.02570-05
225. Majerciak V., Pripuzova N., McCoy J. P., Gao S. J., Zheng Z. M., Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8 α and K8.1 and the production of infectious virus. Journal of Virology 2007 81 3 1062 1071 2-s2.0-33846547953 10.1128/JVI.01558-06 (Pubitemid 46167830)
226. Palmeri D., Spadavecchia S., Carroll K. D., Lukac D. M., Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein. Journal of Virology 2007 81 24 13299 13314 2-s2.0-37049020932 10.1128/JVI.00732-07 (Pubitemid 350247827)
227. Malik P., Blackbourn D. J., Cheng M. F., Hayward G. S., Clements J. B., Functional co-operation between the Kaposi's sarcoma-associated herpesvirus ORF57 and ORF50 regulatory proteins. Journal of General Virology 2004 85 8 2155 2166 2-s2.0-4043147875 10.1099/vir.0.79784-0 (Pubitemid 39162586)
228. Nekorchuk M., Han Z., Hsieh T. T., Swaminathan S., Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export. Journal of Virology 2007 81 18 9990 9998 2-s2.0-35348914370 10.1128/JVI.00896-07 (Pubitemid 350067702)
229. Boyne J. R., Jackson B. R., Taylor A., MacNab S. A., Whitehouse A., Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAs. The EMBO Journal 2010 29 11 1851 1864 2-s2.0-77953123485 10.1038/emboj.2010.77
230. Majerciak V., Yamanegi K., Allemand E., Kruhlak M., Krainer A. R., Zheng Z. M., Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing. Journal of Virology 2008 82 6 2792 2801 2-s2.0-40149095094 10.1128/JVI.01856-07 (Pubitemid 351329170)
231. Boyne J. R., Whitehouse A., Nucleolar disruption impairs Kaposi's sarcoma-associated herpesvirus ORF57-mediated nuclear export of intronless viral mRNAs. The FEBS Letters 2009 583 22 3549 3556 2-s2.0-71749109176 10.1016/j.febslet.2009.10.040
232. Malik P., Blackbourn D. J., Clements J. B., The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor. The Journal of Biological Chemistry 2004 279 31 33001 33011 2-s2.0-3542999242 10.1074/jbc.M313008200 (Pubitemid 39014760)
233. Sahin B. B., Patel D., Conrad N. K., Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding rna from cellular RNA decay pathways. PLoS Pathogens 2010 6 3 2-s2.0-77950439778 10.1371/journal.ppat.1000799 e1000799
234. Izumiya Y., Lin S. U. F., Ellison T., Chen L. Y., Izumiya C., Luciw P., Kung H. J., Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression. Journal of Virology 2003 77 2 1441 1451 2-s2.0-0037228039 10.1128/JVI.77.2.1441- 1451.2003 (Pubitemid 36055565)
235. Izumiya Y., Ellison T. J., Yeh E. T. H., Jung J. U., Luciw P. A., Kung H. J., Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. Journal of Virology 2005 79 15 9912 9925 2-s2.0-22544486295 10.1128/JVI.79.15.9912-9925.2005 (Pubitemid 41022333)
236. Ellison T. J., Izumiya Y., Izumiya C., Luciw P. A., Kung H. J., A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus. Virology 2009 387 1 76 88 2-s2.0-63549108515 10.1016/j.virol.2009.02.016
237. Izumiya Y., Izumiya C., Van Geelen A., Wang D. H., Lam K. S., Luciw P. A., Kung H. J., Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP. Journal of Virology 2007 81 3 1072 1082 2-s2.0-33846629003 10.1128/JVI.01473-06 (Pubitemid 46170756)
238. Polson A. G., Huang L., Lukac D. M., Blethrow J. D., Morgan D. O., Burlingame A. L., Ganem D., Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases. Journal of Virology 2001 75 7 3175 3184 2-s2.0-0035108091 10.1128/JVI.75.7.3175-3184.2001 (Pubitemid 32225881)
239. Rossetto C., Yamboliev I., Pari G. S., Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 K-bZIP modulates latency-associated nuclear protein-mediated suppression of lytic origin-dependent DNA synthesis. Journal of Virology 2009 83 17 8492 8501 2-s2.0-69249208678 10.1128/JVI.00922-09
240. Rossetto C., Gao Y., Yamboliev I., Papousková I., Pari G., Transcriptional repression of K-Rta by Kaposi's sarcoma-associated herpesvirus K-bZIP is not required for oriLyt-dependent DNA replication. Virology 2007 369 2 340 350 2-s2.0-36048978977 10.1016/j.virol.2007.08.019 (Pubitemid 350087195)
241. Lefort S., Flamand L., Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines. Journal of Virology 2009 83 11 5869 5880 2-s2.0-66149155481 10.1128/JVI.01821-08