ORF50-dependent and ORF50-independent activation of the ORF45 gene of Kaposi's sarcoma-associated herpesvirus

Virology

Volumn 442, Issue 1, 2013, Pages 38-50

  Chang, Pey Jium ^a,b   Wang, Shie Shan ^b   Chen, Li Yu ^a   Hung, Chien Hui ^a   Huang, Hsiao Yun ^b   Shih, Ying Ju ^a   Yen, Ju Bei ^a,b   Liou, Jieh Yuan ^b   Chen, Lee Wen ^c  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

KSHV; NF Y; ORF45; ORF50; RBP Jkappa; Sodium butyrate; Sp1

Indexed keywords

IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; NUCLEAR FACTOR Y; ORF50 PROTEIN; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENE INDUCTION; GENE MAPPING; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; NONHUMAN; ORF45 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION; VIRUS GENE;

BINDING SITES; BUTYRATES; CCAAT-BINDING FACTOR; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 8, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; PROTEIN KINASES; TRANS-ACTIVATORS; VIRAL PROTEINS; VIRUS ACTIVATION;

HUMAN HERPESVIRUS 8;

EID: 84878904422     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2013.03.023     Document Type: Article

References (65)

1. AuCoin D.P., Colletti K.S., Cei S.A., Papouskova I., Tarrant M., Pari G.S. Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP). Virology 2004, 318:542-555.
2. Bustin S.A., Benes V., Garson J.A., Hellemans J., Huggett J., Kubista M., Mueller R., Nolan T., Pfaffl M.W., Shipley G.L., Vandesompele J., Wittwer C.T. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 2009, 55:611-622.
3. Cesarman E., Chang Y., Moore P.S., Said J.W., Knowles D.M. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS- related body-cavity-based lymphomas. N. Engl. J. Med. 1995, 332:1186-1191.
4. Chang J., Renne R., Dittmer D., Ganem D. Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication. Virology 2000, 266:17-25.
5. Chang M., Brown H.J., Collado-Hidalgo A., Arevalo J.M., Galic Z., Symensma T.L., Tanaka L., Deng H., Zack J.A., Sun R., Cole S.W. beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA. J. Virol. 2005, 79:13538-13547.
6. Chang P.J., Boonsiri J., Wang S.S., Chen L.Y., Miller G. Binding of RBP-Jkappa (CSL) protein to the promoter of the Kaposi's sarcoma-associated herpesvirus ORF47 (gL) gene is a critical but not sufficient determinant of transactivation by ORF50 protein. Virology 2010, 398:38-48.
7. Chang P.J., Chen L.W., Shih Y.C., Tsai P.H., Liu A.C., Hung C.H., Liou J.Y., Wang S.S. Role of the cellular transcription factor YY1 in the latent-lytic switch of Kaposi's sarcoma-associated herpesvirus. Virology 2011, 413:194-204.
8. Chang P.J., Miller G. Autoregulation of DNA binding and protein stability of Kaposi's sarcoma-associated herpesvirus ORF50 protein. J. Virol. 2004, 78:10657-10673.
9. Chang P.J., Shedd D., Gradoville L., Cho M.S., Chen L.W., Chang J., Miller G. Open reading frame 50 protein of Kaposi's sarcoma-associated herpesvirus directly activates the viral PAN and K12 genes by binding to related response elements. J. Virol. 2002, 76:3168-3178.
10. Chang P.J., Shedd D., Miller G. Two subclasses of Kaposi's sarcoma-associated herpesvirus lytic cycle promoters distinguished by open reading frame 50 mutant proteins that are deficient in binding to DNA. J. Virol. 2005, 79:8750-8763.
11. Chang P.J., Shedd D., Miller G. A mobile functional region of Kaposi's sarcoma-associated herpesvirus ORF50 protein independently regulates DNA binding and protein abundance. J. Virol. 2008, 82:9700-9716.
12. Chang Y., Cesarman E., Pessin M.S., Lee F., Culpepper J., Knowles D.M., Moore P.S. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994, 266:1865-1869.
13. Chen H.S., Wikramasinghe P., Showe L., Lieberman P.M. Cohesins repress Kaposi's sarcoma-associated herpesvirus immediate early gene transcription during latency. J. Virol. 2012, 86:9454-9464.
14. Chen J., Ye F., Xie J., Kuhne K., Gao S.J. Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA. Virology 2009, 386:290-302.
15. Chu S., Ferro T.J. Sp1: regulation of gene expression by phosphorylation. Gene 2005, 348:1-11.
16. Dalton-Griffin L., Wilson S.J., Kellam P. X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditions. J. Virol. 2009, 83:7202-7209.
17. Davie J.R. Inhibition of histone deacetylase activity by butyrate. J. Nutr. 2003, 133:2485S-2493S.
18. Davis D.A., Rinderknecht A.S., Zoeteweij J.P., Aoki Y., Read-Connole E.L., Tosato G., Blauvelt A., Yarchoan R. Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus. Blood 2001, 97:3244-3250.
19. Dolfini D., Zambelli F., Pavesi G., Mantovani R. A perspective of promoter architecture from the CCAAT box. Cell Cycle 2009, 8:4127-4137.
20. Dourmishev L.A., Dourmishev A.L., Palmeri D., Schwartz R.A., Lukac D.M. Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) epidemiology and pathogenesis. Microbiol. Mol. Biol. Rev. 2003, 67:175-212.
21. Gradoville L., Gerlach J., Grogan E., Shedd D., Nikiforow S., Metroka C., Miller G. Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. J. Virol. 2000, 74:6207-6212.
22. Guito J., Lukac D.M. KSHV Rta promoter specification and viral reactivation. Front. Microbiol. 2012, 3:30.
23. Hu Z., Jin S., Scotto K.W. Transcriptional activation of the MDR1 gene by UV irradiation. Role of NF-Y and Sp1. J. Biol. Chem. 2000, 275:2979-2985.
24. Huang W., Zhao S., Ammanamanchi S., Brattain M., Venkatasubbarao K., Freeman J.W. Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. J. Biol. Chem. 2005, 280:10047-10054.
25. Jin S., Scotto K.W. Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. Mol. Cell Biol. 1998, 18:4377-4384.
26. Kato H., Taniguchi Y., Kurooka H., Minoguchi S., Sakai T., Nomura-Okazaki S., Tamura K., Honjo T. Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Development 1997, 124:4133-4141.
27. Kuang E., Fu B., Liang Q., Myoung J., Zhu F. Phosphorylation of eukaryotic translation initiation factor 4B (EIF4B) by open reading frame 45/p90 ribosomal S6 kinase (ORF45/RSK) signaling axis facilitates protein translation during Kaposi sarcoma-associated herpesvirus (KSHV) lytic replication. J. Biol. Chem. 2011, 286:41171-41182.
28. Kuang E., Tang Q., Maul G.G., Zhu F. Activation of p90 ribosomal S6 kinase by ORF45 of Kaposi's sarcoma-associated herpesvirus and its role in viral lytic replication. J. Virol. 2008, 82:1838-1850.
29. Kuang E., Wu F., Zhu F. Mechanism of sustained activation of ribosomal S6 kinase (RSK) and ERK by kaposi sarcoma-associated herpesvirus ORF45: multiprotein complexes retain active phosphorylated ERK AND RSK and protect them from dephosphorylation. J. Biol. Chem. 2009, 284:13958-13968.
30. Lan K., Kuppers D.A., Robertson E.S. Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jk, the major downstream effector of the Notch signaling pathway. J. Virol. 2005, 79:3468-3478.
31. Liang Y., Chang J., Lynch S.J., Lukac D.M., Ganem D. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. Genes Dev. 2002, 16:1977-1989.
32. Liang Y., Ganem D. Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling. Proc. Natl. Acad. Sci. USA 2003, 100:8490-8495.
33. Liang Y., Ganem D. RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA. J. Virol. 2004, 78:6818-6826.
34. Liu Y., Cao Y., Liang D., Gao Y., Xia T., Robertson E.S., Lan K. Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element. Virology 2008, 380:264-275.
35. Lu C., Zeng Y., Huang Z., Huang L., Qian C., Tang G., Qin D. Human herpesvirus 6 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Am. J. Pathol. 2005, 166:173-183.
36. Lu F., Zhou J., Wiedmer A., Madden K., Yuan Y., Lieberman P.M. Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. J. Virol. 2003, 77:11425-11435.
37. Lu J., Verma S.C., Cai Q., Saha A., Dzeng R.K., Robertson E.S. The RBP-Jkappa binding sites within the RTA promoter regulate KSHV latent infection and cell proliferation. PLoS Pathog. 2012, 8:e1002479.
38. Lu Y., Lotan R. Transcriptional regulation by butyrate of mouse galectin-1 gene in embryonal carcinoma cells. Biochim. Biophys. Acta 1999, 1444:85-91.
39. Lukac D.M., Kirshner J.R., Ganem D. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J. Virol. 1999, 73:9348-9361.
40. Lukac D.M., Renne R., Kirshner J.R., Ganem D. Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 1998, 252:304-312.
41. Marinova Z., Leng Y., Leeds P., Chuang D.M. Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons. Neuropharmacology 2011, 60:1109-1115.
42. Miller G., Heston L., Grogan E., Gradoville L., Rigsby M., Sun R., Shedd D., Kushnaryov V.M., Grossberg S., Chang Y. Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells. J. Virol. 1997, 71:314-324.
43. Persson L.M., Wilson A.C. Wide-scale use of Notch signaling factor CSL/RBP-Jkappa in RTA-mediated activation of Kaposi's sarcoma-associated herpesvirus lytic genes. J. Virol. 2010, 84:1334-1347.
44. Renne R., Zhong W., Herndier B., McGrath M., Abbey N., Kedes D., Ganem D. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 1996, 2:342-346.
45. Sathish N., Zhu F.X., Golub E.E., Liang Q., Yuan Y. Mechanisms of autoinhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi's sarcoma-associated herpesvirus protein ORF45. J. Biol. Chem. 2011, 286:746-756.
46. Sathish N., Zhu F.X., Yuan Y. Kaposi's sarcoma-associated herpesvirus ORF45 interacts with kinesin-2 transporting viral capsid-tegument complexes along microtubules. PLoS Pathog. 2009, 5:e1000332.
47. Song M.J., Li X., Brown H.J., Sun R. Characterization of interactions between RTA and the promoter of polyadenylated nuclear RNA in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J. Virol. 2002, 76:5000-5013.
48. Soulier J., Grollet L., Oksenhendler E., Cacoub P., Cazals-Hatem D., Babinet P., d'Agay M.F., Clauvel J.P., Raphael M., Degos L., et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 1995, 86:1276-1280.
49. Sun R., Lin S.F., Gradoville L., Yuan Y., Zhu F., Miller G. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. USA 1998, 95:10866-10871.
50. Sun R., Lin S.F., Staskus K., Gradoville L., Grogan E., Haase A., Miller G. Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression. J. Virol. 1999, 73:2232-2242.
51. Walker G.E., Wilson E.M., Powell D., Oh Y. Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: molecular mechanism involves an Sp1/Sp3 multiprotein complex. Endocrinology 2001, 142:3817-3827.
52. Wang S., Liu S., Wu M., Geng Y., Wood C. Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 ORF50 gene product contains a potent C-terminal activation domain which activates gene expression via a specific target sequence. Arch. Virol. 2001, 146:1415-1426.
53. Wang S.S., Chang P.J., Chen L.W., Chen L.Y., Hung C.H., Liou J.Y., Yen J.B. Positive and negative regulation in the promoter of the ORF46 gene of Kaposi's sarcoma-associated herpesvirus. Virus Res. 2012, 165:157-169.
54. Wang S.S., Chen L.W., Chen L.Y., Tsai H.H., Shih Y.C., Yang C.T., Chang P.J. Transcriptional regulation of the ORF61 and ORF60 genes of Kaposi's sarcoma-associated herpesvirus. Virology 2010, 397:311-321.
55. Wang Y., Li H., Chan M.Y., Zhu F.X., Lukac D.M., Yuan Y. Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: cis-acting requirements for replication and ori-Lyt-associated RNA transcription. J. Virol. 2004, 78:8615-8629.
56. Wang Y., Yuan Y. Essential role of RBP-Jkappa in activation of the K8 delayed-early promoter of Kaposi's sarcoma-associated herpesvirus by ORF50/RTA. Virology 2007, 359:19-27.
57. Xu H., Fu J., Ha S.W., Ju D., Zheng J., Li L., Xie Y. The CCAAT box-binding transcription factor NF-Y regulates basal expression of human proteasome genes. Biochim. Biophys. Acta 2012, 1823:818-825.
58. Xu Y., AuCoin D.P., Huete A.R., Cei S.A., Hanson L.J., Pari G.S. A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replication. J. Virol. 2005, 79:3479-3487.
59. Yang J., Kawai Y., Hanson R.W., Arinze I.J. Sodium butyrate induces transcription from the G alpha(i2) gene promoter through multiple Sp1 sites in the promoter and by activating the MEK-ERK signal transduction pathway. J. Biol. Chem. 2001, 276:25742-25752.
60. Ye F., Zhou F., Bedolla R.G., Jones T., Lei X., Kang T., Guadalupe M., Gao S.J. Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathog. 2011, 7:e1002054.
61. Ye J., Shedd D., Miller G. An Sp1 response element in the Kaposi's sarcoma-associated herpesvirus open reading frame 50 promoter mediates lytic cycle induction by butyrate. J. Virol. 2005, 79:1397-1408.
62. Zhu F.X., Cusano T., Yuan Y. Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirus. J. Virol. 1999, 73:5556-5567.
63. Zhu F.X., King S.M., Smith E.J., Levy D.E., Yuan Y. A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation. Proc. Natl. Acad. Sci. USA 2002, 99:5573-5578.
64. Zhu F.X., Li X., Zhou F., Gao S.J., Yuan Y. Functional characterization of Kaposi's sarcoma-associated herpesvirus ORF45 by bacterial artificial chromosome-based mutagenesis. J. Virol. 2006, 80:12187-12196.
65. Zhu F.X., Yuan Y. The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions. J. Virol. 2003, 77:4221-4230.