Acid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways

Journal of Hepatology

Volumn 62, Issue 1, 2016, Pages 219-233

  Garcia Ruiz, Carmen ^a,b,c,d   Mato, Jose M ^c,e   Vance, Dennis ^f   Kaplowitz, Neil ^d   Fernández Checa, José C ^a,b,c,d  

^a INST D INVESTIGACIONS B   (Spain)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e CIC BIOGUNE   (Spain)

^f UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Acid sphingomyelinase; Alcoholic steatohepatitis; Autophagy; Ceramide; ER stress; Lysosomal membrane permeabilization; Non Alcoholic steatohepatitis; Phosphatidylcholine; S Adenosyl L methionine

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CATHEPSIN B; CERAMIDE; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; LIPID; METHIONINE; METHIONINE SYNTHASE; PHOSPHATIDYLCHOLINE; SPHINGOMYELIN PHOSPHODIESTERASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

AUTOPHAGY; DNA METHYLATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HYPERHOMOCYSTEINEMIA; LIPID METABOLISM; LIPOTOXICITY; LIVER FIBROSIS; LYSOSOME MEMBRANE; MEMBRANE PERMEABILITY; NONALCOHOLIC FATTY LIVER; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; METABOLISM;

ANIMALS; AUTOPHAGY; CERAMIDES; HUMANS; NON-ALCOHOLIC FATTY LIVER DISEASE; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84918817256     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.09.023     Document Type: Review

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