ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis

Journal of Hepatology

Volumn 61, Issue 5, 2014, Pages 1126-1134

  Fucho, Raquel ^a,b   Martínez, Laura ^a,b   Baulies, Anna ^a,b   Torres, Sandra ^a,b   Tarrats, Nuria ^a,b   Fernandez, Anna ^a,b   Ribas, Vicente ^a,b   Astudillo, Alma M ^c   Balsinde, Jesús ^c   Garcia Rovés, Pablo ^d   Elena, Montserrat ^d   Bergheim, Ina ^e   Lotersztajn, Sophie ^f   Trautwein, Christian ^g   Appelqvist, Hanna ^h   Paton, Adrienne W ⁱ   Paton, James C ⁱ   Czaja, Mark J ^j   Kaplowitz, Neil ^k   Fernandez Checa, Jose C ^a,b,k   García Ruiz, Carmen ^a,b,k   more..

^a INST D INVESTIGACIONS B   (Spain)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c Universidad de Valladolid y Consejo Superior de Investigaciones Científicas   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

^e FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^f UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^g UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^h LINKÖPING UNIVERSITY   (Sweden)

ⁱ UNIVERSITY OF ADELAIDE   (Australia)

^j ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^k UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

more..

Author keywords

Autophagy; Ceramide; Endoplasmic reticulum stress; Fatty liver; Lysosomal membrane permeabilization

Indexed keywords

AMITRIPTYLINE; BREFELDIN A; CHLOROQUINE; OXYSTEROL; PALMITIC ACID; RAPAMYCIN; SPHINGOMYELIN PHOSPHODIESTERASE; TUNICAMYCIN; ASMASE, MOUSE; CERAMIDE; CHOLESTEROL; METHIONINE; SPHINGOMYELIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; LIPID DIET; LIVER CELL; LYSOSOME MEMBRANE; MEMBRANE PERMEABILITY; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; COMPLICATION; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; HUMAN; KNOCKOUT MOUSE; LIVER; LYSOSOME; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; PATHOLOGY; PERMEABILITY; PHYSIOLOGY; VITAMIN DEFICIENCY;

AMITRIPTYLINE; ANIMALS; AUTOPHAGY; CERAMIDES; CHOLESTEROL; CHOLINE DEFICIENCY; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; HUMANS; LIVER; LYSOSOMES; METHIONINE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NON-ALCOHOLIC FATTY LIVER DISEASE; PERMEABILITY; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS;

EID: 84938513264     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.06.009     Document Type: Article

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