AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Cell

Volumn 107, Issue 4, 2001, Pages 451-464

  Chen, Ching Yi ^a   Gherzi, Roberto ^a,e   Ong, Shao En ^b   Chan, Edward L ^c   Raijmakers, Reinout ^d   Pruijn, Ger J M ^d   Stoecklin, Georg ^f   Moroni, Christoph ^f   Mann, Matthias ^b   Karin, Michael ^a  

^a San Diego   (United States)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF GENOA   (Italy)

^f UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; HUR PROTEIN; MESSENGER RNA; PROTEIN; RNA BINDING PROTEIN; TRISTETRAPROLIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; EXOSOME; HUMAN; MASS SPECTROMETRY; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN RNA BINDING; REVIEW; RNA DEGRADATION; RNA PROCESSING; RNA STABILITY; YEAST;

MAMMALIA;

EID: 18044371822     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00578-5     Document Type: Article

References (49)

1. Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: A unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex
2. Functions of the exosome in rRNA, snoRNA and snRNA synthesis
3. The yeast exosome and human PM-Scl are related complexes of 3′→5′ exonucleases
4. Degradation of ribosomal RNA precursors by the exosome
5. Mutations synthetically lethal with cep1 target S. cerevisiae kinetochore components
6. ARED: Human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins
7. Identification of a regulated pathway for nuclear pre-mRNA turnover
8. Characterization of c-myc 3′ to 5′ mRNA decay activities in an in vitro system
9. Three novel components of the human exosome
10. The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo
11. Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae
12. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
13. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability
14. Purification of a human polyribosome-associated 3′ to 5′ exoribonuclease
15. AU-rich elements: Characterization and importance in mRNA degradation
16. Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation
17. Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: Emergence of a new gene family
18. Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3′ end formation of 5.8S rRNA in Saccharomyces cerevisiae
19. Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs
20. ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system
21. Interaction between a poly(A)-specific ribonuclease and the 5′ cap influences mRNA deadenylation rates in vitro
22. A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements
23. Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen
24. Yeast cells lacking 5′→3′ exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5′ cap structure
25. The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex
26. Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme
27. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
28. Control of mRNA decay by heat shock-ubiquitin-proteasome pathway
29. Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element
30. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer
31. Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase
32. The exosome: A conserved eukaryotic RNA processing complex containing multiple 3′→5′ exoribonucleases
33. Musing on the structural organization of the exosome complex
34. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein
35. A generic protein purification method for protein complex characterization and proteome exploration
36. mRNA stability in mammalian cells
37. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
38. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay
39. Somatic mRNA turnover mutants implicate tristeraprolin in the interleukin-3 mRNA degradation pathway
40. Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae
41. The exosome: A proteasome for RNA?
42. Yeast exosome mutants accumulate 3′-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs
43. Function of the ski4p (Csl4p) and Ski7p proteins in 3′-to-5′ degradation of mRNA
44. Regulated ARE-mediated mRNA decay in Saccharomyces cerevisiae
45. Analytical properties of the nanoelectrospray ion source
46. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry
47. The cap-to-tail guide to mRNA turnover
48. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: Key sequence features controlling mRNA deadenylation and decay
49. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1