Obesity-dependent metabolic signatures associated with nonalcoholic fatty liver disease progression

Journal of Proteome Research

Volumn 11, Issue 4, 2012, Pages 2521-2532

  Barr, J ^a   Caballeria J ^b   Martinez Arranz I ^a   Dominguez Diez A ^c   Alonso, C ^a   Muntane J ^d   Perez Cormenzana M ^a   Garcia Monzon C ^e   Mayo, R ^a   Martin Duce A ^f   Romero Gomez M ^g   Iacono, O Lo ^h   Tordjman, J ⁱ   Andrade, R J ^m   Perez Carreras M ⁿ   Marchand Brustel, Y Le ^k   Tran, A ^k   Fernandez Escalante C ^c   Arevalo E ^d   Garcia Unzueta M ^c   Clement, K ^i,j,k,l   Crespo, J ^c   Gual, P ^k   Gomez Fleitas M ^c   Martinez Chantar M L ^e   Castro, A ^a   Lu, S C ^o   Vazquez Chantada M ^a   Mato, J M ^e   more..

^a OWL   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c UNIVERSITY OF CANTABRIA   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

^f HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

^g HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^h Aranjuez   (Spain)

ⁱ Institut Cardiométabolisme et Nutrition Pitié Salpêtrière   (France)

^j PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^k INSERM   (France)

^l SORBONNE UNIVERSITÉ   (France)

^m HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

ⁿ HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^o UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

more..

Author keywords

biomarkers; metabolomics; NAFLD; NASH; steatosis

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; BILE ACID; BIOLOGICAL MARKER; CARNITINE; CHOLESTEROL; CHOLESTEROL ESTER; FATTY ACID; GLUCOSE; GLYCEROPHOSPHOLIPID; SPHINGOLIPID;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE COURSE; FATTY ACID BLOOD LEVEL; FATTY LIVER; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIPID BLOOD LEVEL; LIVER BIOPSY; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; METABOLISM; METABOLOMICS; MULTIVARIATE ANALYSIS; NONALCOHOLIC FATTY LIVER; OBESITY; PATHOGENESIS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; QUALITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADULT; AGED; AREA UNDER CURVE; BIOLOGICAL MARKERS; BODY MASS INDEX; DISEASE PROGRESSION; FATTY LIVER; FEMALE; HUMANS; MALE; METABOLOME; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84859568138     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr201223p     Document Type: Article

References (45)

1. Frayn, K. N. Adipose tissue as a buffer for daily lipid flux Diabetologia 2002, 45 (9) 1201-1210
2. Angulo, P. Nonalcoholic fatty liver disease N. Engl. J. Med. 2002, 346 (16) 1221-1231
3. Cohen, J. C.; Horton, J. D.; Hobbs, H. H. Human fatty liver disease: old questions and new insights Science 2011, 332 (6037) 1519-1523
4. Bass, N. M. Lipidomic dissection of nonalcoholic steatohepatitis: moving beyond foie gras to fat traffic Hepatology 2010, 51 (1) 4-7
5. Neuschwander-Tetri, B. A. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites Hepatology 2010, 52 (2) 774-788
6. Matteoni, C. A.; Younossi, Z. M.; Gramlich, T.; Boparai, N.; Liu, Y. C.; McCullough, A. J. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity Gastroenterology 1999, 116 (6) 1413-1419
7. Starley, B. Q.; Calcagno, C. J.; Harrison, S. A. Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection Hepatology 2010, 51 (5) 1820-1832
8. Angulo, P. Obesity and nonalcoholic fatty liver disease Nutr. Rev. 2007, 65, S57-S63
9. Machado, M. V.; Cortez-Pinto, H. No need for a large belly to have NASH J. Hepatol. 2011, 54 (6) 1090-1093
10. Baker, M. Metabolomics: from small molecules to big ideas Nat. Methods 2011, 8 (2) 117-121
11. Nicholson, J. K.; Lindon, J. C. Systems biology: Metabonomics Nature 2008, 455 (7216) 1054-1056
12. Kalhan, S. C.; Guo, L.; Edmison, J.; Dasarathy, S.; McCullough, A. J.; Hanson, R. W.; Milburn, M. Plasma metabolomic profile in nonalcoholic fatty liver disease Metab.: Clin. Exp. 2010, 60 (3) 404-413
13. Puri, P.; Wiest, M. M.; Cheung, O.; Mirshahi, F.; Sargeant, C.; Min, H.-K.; Contos, M. J.; Sterling, R. K.; Fuchs, M.; Zhou, H.; Watkins, S. M.; Sanyal, A. J. The plasma lipidomic signature of nonalcoholic steatohepatitis Hepatology 2009, 50 (6) 1827-1838
14. Barr, J.; Vazquez-Chantada, M.; Alonso, C.; Perez-Cormenzana, M.; Mayo, R.; Galan, A.; Caballeria, J.; Martin-Duce, A.; Tran, A.; Wagner, C.; Luka, Z.; Lu, S. C.; Castro, A.; Le Marchand-Brustel, Y.; Martinez-Chantar, M. L.; Veyrie, N.; Clement, K.; Tordjman, J.; Gual, P.; Mato, J. M. Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease J. Proteome Res. 2010, 9 (9) 4501-4512
15. van der Kloet, F. M.; Bobeldijk, I.; Verheij, E. R.; Jellema, R. H. Analytical error reduction using single point calibration for accurate and precise metabolomic phenotyping J. Proteome Res. 2009, 8 (11) 5132-5141
16. Kleiner, D. E.; Brunt, E. M.; Van Natta, M.; Behling, C.; Contos, M. J.; Cummings, O. W.; Ferrell, L. D.; Liu, Y. C.; Torbenson, M. S.; Unalp-Arida, A.; Yeh, M.; McCullough, A. J.; Sanyal, A. J. Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 2005, 41 (6) 1313-21
17. Grumbach, E.; Wheat, T.; Mazzeo, J. A novel method for the analysis of amino acids. Waters Application Notes 2007, Lib. Number WA43226.
18. Murphy, R. C.; Fiedler, J.; Hevko, J. Analysis of Nonvolatile Lipids by Mass Spectrometry Chem. Rev. 2001, 101 (2) 479-526
19. Pietiläinen, K. H.; Róg, T.; Seppänen-Laakso, T.; Virtue, S.; Gopalacharyulu, P.; Tang, J.; Rodriguez-Cuenca, S.; Maciejewski, A.; Naukkarinen, J.; Ruskeepää, A.-L.; Niemelä, P. S.; Yetukuri, L.; Tan, C. Y.; Velagapudi, V.; Castillo, S.; Nygren, H.; Hyötyläinen, T.; Rissanen, A.; Kaprio, J.; Yki-Järvinen, H.; Vattulainen, I.; Vidal-Puig, A.; Orešič, M. Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans PLoS Biol. 2011, 9 (6) e1000623
20. Fu, S.; Yang, L.; Li, P.; Hofmann, O.; Dicker, L.; Hide, W.; Lin, X.; Watkins, S. M.; Ivanov, A. R.; Hotamisligil, G. S. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity Nature 2011, 473 (7348) 528-531
21. Kim, J. Y.; Park, J. Y.; Kim, O. Y.; Ham, B. M.; Kim, H.-J.; Kwon, D. Y.; Jang, Y.; Lee, J. H. Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS) J. Proteome Res. 2010, 9 (9) 4368-4375
22. WHO Obesity and overweight, 2011.
23. Liaw, A.; Wiener, M. Classification and regression by randomForest R. News 2002, 2 (3) 18-22
24. Williams, C. H.; Stengel, J.; Asike, M. I.; Torres, D. M.; Shaw, J.; Contreras, M.; Landt, C. L.; Harrison, S. A. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study Gastroenterology 2011, 140 (1) 124-131
25. Diehl, A. M. Genetic susceptibility to hepatic steatosis N. Engl. J. Med. 2010, 362 (12) 1142-1143
26. Yeh, M. M.; Brunt, E. M. Pathology of nonalcoholic fatty liver disease Am. J. Clin. Pathol. 2007, 128 (5) 837-47
27. Donnelly, K. L.; Smith, C. I.; Schwarzenberg, S. J.; Jessurun, J.; Boldt, M. D.; Parks, E. J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease J. Clin. Invest. 2005, 115 (5) 1343-1351
28. Timlin, M. T.; Parks, E. J. Temporal pattern of de novo lipogenesis in the postprandial state in healthy men Am. J. Clin. Nutr. 2005, 81 (1) 35-42
29. Aarsland, A.; Wolfe, R. R. Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men J. Lipid Res. 1998, 39 (6) 1280-1286
30. Pessayre, D. Role of mitochondria in non-alcoholic fatty liver disease J. Gastroenterol. Hepatol. 2007, 22, S20-S27
31. Sanyal, A. J.; Campbell-Sargent, C.; Mirshahi, F.; Rizzo, W. B.; Contos, M. J.; Sterling, R. K.; Luketic, V. A.; Shiffman, M. L.; Clore, J. N. Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities Gastroenterology 2001, 120 (5) 1183-1192
32. Bhuiyan, A. K. M. J.; Jackson, S.; Turnbull, D. M.; Aynsley-Green, A.; Leonard, J. V.; Bartlett, K. The measurement of carnitine and acyl-carnitines: Application to the investigation of patients with suspected inherited disorders of mitochondrial fatty acid oxidation Clin. Chim. Acta 1992, 207 (3) 185-204
33. Thyfault, J. P.; Rector, R. S.; Uptergrove, G. M.; Borengasser, S. J.; Morris, E. M.; Wei, Y.; Laye, M. J.; Burant, C. F.; Qi, N. R.; Ridenhour, S. E.; Koch, L. G.; Britton, S. L.; Ibdah, J. A. Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury J. Physiol. 2009, 587 (8) 1805-1816
34. Bass, N. M. Three for the price of one knockout-a mouse model of a congenital peroxisomal disorder, steatohepatitis, and hepatocarcinogenesis Hepatology 1999, 29 (2) 606-608
35. Fan, C.-Y.; Pan, J.; Usuda, N.; Yeldandi, A. V.; Rao, M. S.; Reddy, J. K. Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase J. Biol. Chem. 1998, 273 (25) 15639-15645
36. Green, R. M. NASH-hepatic metabolism and not simply the metabolic syndrome Hepatology 2003, 38 (1) 14-17
37. Morand, O. H.; Zoeller, R. A.; Raetz, C. R. Disappearance of plasmalogens from membranes of animal cells subjected to photosensitized oxidation J. Biol. Chem. 1988, 263 (23) 11597-11606
38. Kalhan, S. C. Fatty acids, insulin resistance, and protein metabolism J. Clin. Endocrinol. Metab. 2009, 94 (8) 2725-2727
39. Unger, R. H. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome Endocrinology 2003, 144 (12) 5159-5165
40. Mari, M.; Fernandez-Checa, J. C. Sphingolipid signalling and liver diseases Liver Int. 2007, 27 (4) 440-50
41. Mato, J. M.; Martinez-Chantar, M. L.; Lu, S. C. Methionine metabolism and liver disease Annu. Rev. Nutr. 2008, 28, 273-93
42. Bohte, A.; van Werven, J.; Bipat, S.; Stoker, J. The diagnostic accuracy of US, CT, MRI and US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis Eur. Radiol. 2011, 21 (1) 87-97
43. Rockey, D. C.; Caldwell, S. H.; Goodman, Z. D.; Nelson, R. C.; Smith, A. D. Liver biopsy Hepatology 2009, 49 (3) 1017-1044
44. Ratziu, V.; Charlotte, F.; Heurtier, A.; Gombert, S.; Giral, P.; Bruckert, E.; Grimaldi, A.; Capron, F.; Poynard, T. Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease Gastroenterology 2005, 128 (7) 1898-1906
45. Mato, J. M.; Lu, S. C. Where are we in the search for noninvasive nonalcoholic steatohepatitis biomarkers? Hepatology 2011, 54 (4) 1115-1117