Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression

FASEB Journal

Volumn 25, Issue 4, 2011, Pages 1133-1144

  Osawa, Yosuke ^a   Seki, Ekihiro ^b   Kodama, Yuzo ^b   Suetsugu, Atsushi ^a   Miura, Kouichi ^b   Adachi, Masayuki ^b   Ito, Hiroyasu ^a   Shiratori, Yoshimune ^a   Banno, Yoshiko ^a   Olefsky, Jerrold M ^b   Nagaki, Masahito ^a   Moriwaki, Hisataka ^a   Brenner, David A ^b   Seishima, Mitsuru ^a  

^a GIFU UNIVERSITY   (Japan)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Glucose intolerance; Glucose transporter 2; Glycogen synthase kinase 3 ; Sphingosine 1 phosphate

Indexed keywords

ADENOVIRUS VECTOR; GLUCOSE; GLUCOSE TRANSPORTER 2; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LIPID; PROTEIN KINASE B; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENE OVEREXPRESSION; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; LIPID METABOLISM; LIPID STORAGE; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOOD GLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; GLYCOGEN; HEPATOCYTES; LIPID METABOLISM; MALE; MICE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SPHINGOMYELIN PHOSPHODIESTERASE;

ADENOVIRIDAE; MUS;

EID: 79954572895     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-168351     Document Type: Article

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