Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

Journal of Hepatology

Volumn 59, Issue 1, 2013, Pages 98-104

  Hernández Gea, Virginia ^a   Hilscher, Moira ^a   Rozenfeld, Raphael ^a   Lim, Maribel P ^a   Nieto, Natalia ^a   Werner, Sabine ^b   Devi, Lakshmi A ^a   Friedman, Scott L ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b ETH ZURICH   (Switzerland)

Author keywords

Autophagy; ER stress; Hepatic stellate cells; Liver fibrosis; Nrf2

Indexed keywords

ALCOHOL; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN IRE1; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; AUTOPHAGY; CELL ACTIVATION; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; ELECTROPHILICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVE SITE; FIBROGENESIS; GENE EXPRESSION; IMMUNOBLOTTING; LIVER CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA SPLICING; SELECTIVE AUTOPHAGY; SIGNAL TRANSDUCTION; STELLATE CELL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; AUTOPHAGY; CELL LINE; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; RNA SPLICING; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84879160597     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.02.016     Document Type: Article

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