Apoptosis and dysregulated ceramide metabolism in a murine model of alcohol-enhanced lipopolysaccharide hepatotoxicity

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 10, 2000, Pages 1557-1565

  Deaciuc, Ion V ^a   Nikolova Karakashian, Mariana ^a   Fortunato, Franco ^a   Lee, E Y ^a   Hill, Daniell B ^a   McClain, Craig J ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b LEXINGTON VA MEDICAL CENTER   (United States)

Author keywords

Caspase; Liver Ceramide; Liver TUNEL Response; Plasma Hyaluronan; Sphingomyelinase

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CASPASE 8; CERAMIDE; DNA; HYALURONIC ACID; LIPOPOLYSACCHARIDE; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL LIVER CIRRHOSIS; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; DRUG ALCOHOL INTERACTION; LIPID STORAGE; LIVER TOXICITY; MALE; MOUSE; NICK END LABELING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALIA; MURINAE;

EID: 0033772936     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000374-200010000-00014     Document Type: Article

References (38)

1. Identifying and quantifying apoptosis: A growth industry in the face of death
2. Endotoxin-induced hepatic necrosis in rats on an alcohol diet
3. A rapid method of total lipid extraction and purification
4. Endotoxemia in patients with alcoholic and non-alcoholic liver cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess
5. Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis and ceramides in rat hepatocytes
6. Alcohol-induced hepatic sinusoidal endothelial cell dysfunction in the mouse is mediated by Kupffer cells
7. Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide
8. Alcohol-induced sinusoidal endothelial cell dysfunction in the mouse is associated with exacerbated apoptosis and can be reversed by caspase inhibition
9. Death receptors in liver biology and pathobiology
10. Effect of alcohol on the functions of Kupffer cells and splenic macrophages in rats
11. Apoptosis in liver disease
12. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
13. Assay of enzymes of lipid metabolism with colored and fluorescent derivatives of natural lipids
14. Ceramide signaling in apoptosis
15. The role of tumor necrosis factor-α in acute endotoxin-induced hepatotoxicity in ethanol-fed rats
16. Ethanol-induced apoptosis and oxidative stress in hepatocytes
17. Ceramide-mediated apoptosis of hepatocytes in vivo: A matter of nucleus?
18. Effect of chronic co-administration of endotoxin and ethanol on rat liver pathology and pro-inflammatory and anti-inflammatory cytokines
19. Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis
20. Cytokine gene expression in experimental alcoholic liver disease
21. Endotoxin levels by a chromogenic assay in portal hepatic and peripheral venous blood in patients with cirrhosis
22. 2
23. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease
24. Apoptosis and alcoholic liver disease
25. Bimodal regulation of ceramidase by interleukin-1β. Implications for the regulation of cytochrome P450 2C11 (CYP2C11)
26. Emerging roles of caspase-3 in apoptosis
27. Caspases: Intracellular signaling proteins
28. Ethanol and lipid metabolism. Differential effects on liver and brain microsomes
29. Liver sinusoid during chronic alcohol consumption in the rat: An electron microscopic study
30. Dose- and time-dependent effects of alcohol on functional and structural aspects of the liver sinusoid in the mouse
31. Ethanol-induce macrophage apoptosis: The role of TGF-β
32. Apoptosis signaling by death receptors
33. TNF-α and IL-6 in alcoholic liver disease
34. Mechanisms of hepatotoxicity. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin
35. A possible role of nuclear ceramide and sphingosine in hepatocyte apoptosis in rat liver
36. On the complexities of ceramide changes in cells undergoing apoptosis: Lack of evidence for a second messenger function in apoptotic induction
37. Chronic ethanol consumption alters transbilayer distribution of phosphatidylcholine in erythrocytes of Sinclair (S-1) miniature swine
38. Apoptosis and Bcl-2 protein expression in experimental alcoholic liver disease in the rat