Copper ions inhibit S-adenosylhomocysteine hydrolase by causing dissociation of NAD+ cofactor

Biochemistry

Volumn 46, Issue 41, 2007, Pages 11451-11458

  Li, Mengyao ^a   Li, Yanjie ^a   Chen, Jiejin ^a   Wei, Wei ^a   Pan, Xiaowei ^a   Liu, Jing ^a   Liu, Qingyu ^a   Leu, Wei ^a   Zhang, Liangren ^a   Yang, Xiaoda ^a   Lu, Jingfen ^a   Wang, Kui ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; COPPER COMPOUNDS; DISSOCIATION; DRUG PRODUCTS; METHYLATION; MUTAGENESIS;

BIOMETHYLATION; CATALYTIC MECHANISM; DRUG DESIGN; S-ADENOSYLHOMOCYSTEINE HYDROLASE (SAHH);

ENZYME INHIBITION;

ADENOSYLHOMOCYSTEINASE; COPPER ION; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; COMPUTER SIMULATION; CRYSTAL STRUCTURE; DISSOCIATION; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME RELEASE; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ADENOSYLHOMOCYSTEINASE; APOENZYMES; COPPER; DRUG DESIGN; FEMALE; HUMANS; KINETICS; MICROWAVES; NAD; PLACENTA; PREGNANCY; PROTEIN BINDING; RECOMBINANT PROTEINS;

RATTUS;

EID: 35348872710     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700395d     Document Type: Article

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