Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

Nature Communications

Volumn 3, Issue , 2012, Pages

  Shen, Dongbiao ^a   Wang, Xiang ^a   Li, Xinran ^a   Zhang, Xiaoli ^a   Yao, Zepeng ^a   Dibble, Shannon ^a   Dong, Xian Ping ^a   Yu, Ting ^b   Lieberman, Andrew P ^b   Showalter, Hollis D ^a   Xu, Haoxing ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHOLESTEROL; GCAMP3 PROTEIN; ION TRANSPORT AFFECTING AGENT; MUCOLIPIN SYNTHETIC AGONIST 1; MUCOLIPIN TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; PROTEIN; SF 51; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; UNCLASSIFIED DRUG; MCOLN1 PROTEIN, HUMAN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL C;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL MIGRATION; CONTROLLED STUDY; FEMALE; HYDROLYSIS; INHIBITION KINETICS; LIPID STORAGE; LYSOSOME; NIEMANN PICK DISEASE; NONHUMAN; PATCH CLAMP; PROTEIN EXPRESSION; ANIMAL; BAGG ALBINO MOUSE; CELL STRAIN COS1; CERCOPITHECUS; DRUG ANTAGONISM; HAMSTER; HUMAN; MACROPHAGE; METABOLISM; MOUSE; MOUSE MUTANT; PROTEIN TRANSPORT;

ANIMALS; CALCIUM; CERCOPITHECUS AETHIOPS; CHOLESTEROL; COS CELLS; CRICETINAE; HUMANS; LYSOSOMES; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NIEMANN-PICK DISEASES; PATCH-CLAMP TECHNIQUES; PROTEIN TRANSPORT; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPC CATION CHANNELS;

EID: 84859175854     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1735     Document Type: Article

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