메뉴 건너뛰기




Volumn 94, Issue 4, 2014, Pages 1287-1312

The biology of YAP/TAZ: Hippo signaling and beyond

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; HIPPO PROTEIN; LATS PROTEIN; MERLIN; MST PROTEIN; NF2 PROTEIN; PROTEIN; PROTEIN KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TAZ PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN; YAP PROTEIN; PHOSPHOPROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

EID: 84916633921     PISSN: 00319333     EISSN: 15221210     Source Type: Journal    
DOI: 10.1152/physrev.00005.2014     Document Type: Article
Times cited : (1277)

References (270)
  • 1
    • 84886409934 scopus 로고    scopus 로고
    • Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases
    • Adler JJ, Johnson DE, Heller BL, Bringman LR, Ranahan WP, Conwell MD, Sun Y, Hudmon A, Wells CD. Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases. Proc Natl Acad Sci USA 110: 17368–17373, 2013.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 17368-17373
    • Adler, J.J.1    Johnson, D.E.2    Heller, B.L.3    Bringman, L.R.4    Ranahan, W.P.5    Conwell, M.D.6    Sun, Y.7    Hudmon, A.8    Wells, C.D.9
  • 4
    • 84883466306 scopus 로고    scopus 로고
    • A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors
    • Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N, Dupont S, Piccolo S. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell 154: 1047–1059, 2013.
    • (2013) Cell , vol.154 , pp. 1047-1059
    • Aragona, M.1    Panciera, T.2    Manfrin, A.3    Giulitti, S.4    Michielin, F.5    Elvassore, N.6    Dupont, S.7    Piccolo, S.8
  • 5
    • 33749334018 scopus 로고    scopus 로고
    • A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
    • Aylon Y, Michael D, Shmueli A, Yabuta N, Nojima H, Oren M. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev 20: 2687–2700, 2006.
    • (2006) Genes Dev , vol.20 , pp. 2687-2700
    • Aylon, Y.1    Michael, D.2    Shmueli, A.3    Yabuta, N.4    Nojima, H.5    Oren, M.6
  • 6
    • 78049435859 scopus 로고    scopus 로고
    • The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1
    • Aylon Y, Ofir-Rosenfeld Y, Yabuta N, Lapi E, Nojima H, Lu X, Oren M. The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1. Genes Dev 24: 2420–2429, 2010.
    • (2010) Genes Dev , vol.24 , pp. 2420-2429
    • Aylon, Y.1    Ofir-Rosenfeld, Y.2    Yabuta, N.3    Lapi, E.4    Nojima, H.5    Lu, X.6    Oren, M.7
  • 7
    • 72449125594 scopus 로고    scopus 로고
    • Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation
    • Aylon Y, Yabuta N, Besserglick H, Buganim Y, Rotter V, Nojima H, Oren M. Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation. Oncogene 28: 4469–4479, 2009.
    • (2009) Oncogene , vol.28 , pp. 4469-4479
    • Aylon, Y.1    Yabuta, N.2    Besserglick, H.3    Buganim, Y.4    Rotter, V.5    Nojima, H.6    Oren, M.7
  • 11
    • 84873558051 scopus 로고    scopus 로고
    • WNT signaling in bone homeostasis and disease: From human mutations to treatments
    • Baron R, Kneissel M. WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nature Med 19: 179–192, 2013.
    • (2013) Nature Med , vol.19 , pp. 179-192
    • Baron, R.1    Kneissel, M.2
  • 14
    • 0037249343 scopus 로고    scopus 로고
    • Akt phosphorylates the Yesassociated protein, YAP, to induce interaction with 14–3-3 and attenuation of p73- mediated apoptosis
    • Basu S, Totty NF, Irwin MS, Sudol M, Downward J. Akt phosphorylates the Yesassociated protein, YAP, to induce interaction with 14–3-3 and attenuation of p73- mediated apoptosis. Mol Cell 11: 11–23, 2003.
    • (2003) Mol Cell , vol.11 , pp. 11-23
    • Basu, S.1    Totty, N.F.2    Irwin, M.S.3    Sudol, M.4    Downward, J.5
  • 17
    • 84876679294 scopus 로고    scopus 로고
    • The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells
    • Cai H, Xu Y. The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells. Cell Commun Signal 11: 31, 2013.
    • (2013) Cell Commun Signal , vol.11 , pp. 31
    • Cai, H.1    Xu, Y.2
  • 18
    • 78049451932 scopus 로고    scopus 로고
    • The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
    • Cai J, Zhang N, Zheng Y, de Wilde RF, Maitra A, Pan D. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev 24: 2383–2388, 2010.
    • (2010) Genes Dev , vol.24 , pp. 2383-2388
    • Cai, J.1    Zhang, N.2    Zheng, Y.3    De Wilde, R.F.4    Maitra, A.5    Pan, D.6
  • 21
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487: 330–337, 2012.
    • (2012) Nature , vol.487 , pp. 330-337
  • 22
    • 57749122174 scopus 로고    scopus 로고
    • YAP regulates neural progenitor cell number via the TEA domain transcription factor
    • Cao X, Pfaff SL, Gage FH. YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev 22: 3320–3334, 2008.
    • (2008) Genes Dev , vol.22 , pp. 3320-3334
    • Cao, X.1    Pfaff, S.L.2    Gage, F.H.3
  • 26
    • 84891383662 scopus 로고    scopus 로고
    • Actin-binding and cell proliferation activities of angiomotin family members are regulated by hippo pathway-mediated phosphorylation
    • Chan SW, Lim CJ, Guo F, Tan I, Leung T, Hong W. Actin-binding and cell proliferation activities of angiomotin family members are regulated by hippo pathway-mediated phosphorylation. J Biol Chem 288: 37296–37307, 2013.
    • (2013) J Biol Chem , vol.288 , pp. 37296-37307
    • Chan, S.W.1    Lim, C.J.2    Guo, F.3    Tan, I.4    Leung, T.5    Hong, W.6
  • 27
  • 29
    • 67649770134 scopus 로고    scopus 로고
    • TEADs mediate nuclear retention of TAZ to promote oncogenic transformation
    • Chan SW, Lim CJ, Loo LS, Chong YF, Huang C, Hong W. TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J Biol Chem 284: 14347–14358, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 14347-14358
    • Chan, S.W.1    Lim, C.J.2    Loo, L.S.3    Chong, Y.F.4    Huang, C.5    Hong, W.6
  • 30
    • 84893097200 scopus 로고    scopus 로고
    • The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and miRNA Biogenesis Through Let-7
    • Chaulk SG, Lattanzi VJ, Hiemer SE, Fahlman RP, Varelas X. The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and miRNA Biogenesis Through Let-7. J Biol Chem 289: 1886–1891, 2014.
    • (2014) J Biol Chem , vol.289 , pp. 1886-1891
    • Chaulk, S.G.1    Lattanzi, V.J.2    Hiemer, S.E.3    Fahlman, R.P.4    Varelas, X.5
  • 33
    • 84896824055 scopus 로고    scopus 로고
    • A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis
    • Chen Q, Zhang N, Gray RS, Li H, Ewald AJ, Zahnow CA, Pan D. A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis. Genes Dev 28: 432–437, 2014.
    • (2014) Genes Dev , vol.28 , pp. 432-437
    • Chen, Q.1    Zhang, N.2    Gray, R.S.3    Li, H.4    Ewald, A.J.5    Zahnow, C.A.6    Pan, D.7
  • 34
    • 0028034269 scopus 로고
    • Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice
    • Chen Z, Friedrich GA, Soriano P. Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev 8: 2293–2301, 1994.
    • (1994) Genes Dev , vol.8 , pp. 2293-2301
    • Chen, Z.1    Friedrich, G.A.2    Soriano, P.3
  • 36
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 127: 469–480, 2006.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 37
    • 84879935313 scopus 로고    scopus 로고
    • The Hippo pathway member Nf2 is required for inner cell mass specification
    • Cockburn K, Biechele S, Garner J, Rossant J. The Hippo pathway member Nf2 is required for inner cell mass specification. Curr Biol 23: 1195–1201, 2013.
    • (2013) Curr Biol , vol.23 , pp. 1195-1201
    • Cockburn, K.1    Biechele, S.2    Garner, J.3    Rossant, J.4
  • 40
    • 0037306788 scopus 로고    scopus 로고
    • Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ
    • Cui CB, Cooper LF, Yang X, Karsenty G, Aukhil I. Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ. Mol Cell Biol 23: 1004–1013, 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 1004-1013
    • Cui, C.B.1    Cooper, L.F.2    Yang, X.3    Karsenty, G.4    Aukhil, I.5
  • 46
    • 84857769158 scopus 로고    scopus 로고
    • Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells
    • Diep CH, Zucker KM, Hostetter G, Watanabe A, Hu C, Munoz RM, Von Hoff DD, Han H. Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells. PloS One 7: e32783, 2012.
    • (2012) Plos One , vol.7
    • Diep, C.H.1    Zucker, K.M.2    Hostetter, G.3    Watanabe, A.4    Hu, C.5    Munoz, R.M.6    Von Hoff, D.D.7    Han, H.8
  • 48
    • 67649920749 scopus 로고    scopus 로고
    • Growth factors, matrices, and forces combine and control stem cells
    • Discher DE, Mooney DJ, Zandstra PW. Growth factors, matrices, and forces combine and control stem cells. Science 324: 1673–1677, 2009.
    • (2009) Science , vol.324 , pp. 1673-1677
    • Discher, D.E.1    Mooney, D.J.2    Zandstra, P.W.3
  • 51
    • 77955928161 scopus 로고    scopus 로고
    • Tumors as organs: Complex tissues that interface with the entire organism
    • Egeblad M, Nakasone ES, Werb Z. Tumors as organs: complex tissues that interface with the entire organism. Dev Cell 18: 884–901, 2010.
    • (2010) Dev Cell , vol.18 , pp. 884-901
    • Egeblad, M.1    Nakasone, E.S.2    Werb, Z.3
  • 52
    • 77957221459 scopus 로고    scopus 로고
    • Dynamic interplay between the collagen scaffold and tumor evolution
    • Egeblad M, Rasch MG, Weaver VM. Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol 22: 697–706, 2010.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 697-706
    • Egeblad, M.1    Rasch, M.G.2    Weaver, V.M.3
  • 53
    • 84887969452 scopus 로고    scopus 로고
    • Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo
    • [Epub ahead of print]
    • Elsum IA, Yates LL, Pearson HB, Phesse TJ, Long F, O’Donoghue R, Ernst M, Cullinane C, Humbert PO. Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo. Oncogene 2013; doi:10.1038/onc.2013.498 [Epub ahead of print].
    • (2013) Oncogene
    • Elsum, I.A.1    Yates, L.L.2    Pearson, H.B.3    Phesse, T.J.4    Long, F.5    O’Donoghue, R.6    Ernst, M.7    Cullinane, C.8    Humbert, P.O.9
  • 54
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 126: 677–689, 2006.
    • (2006) Cell , vol.126 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 57
    • 79956327002 scopus 로고    scopus 로고
    • Actincapping protein and the hippo pathway regulate F-actin and tissue growth in Drosophila
    • Fernandez BG, Gaspar P, Bras-Pereira C, Jezowska B, Rebelo SR, Janody F. Actincapping protein and the hippo pathway regulate F-actin and tissue growth in Drosophila. Development 138: 2337–2346, 2011.
    • (2011) Development , vol.138 , pp. 2337-2346
    • Fernandez, B.G.1    Gaspar, P.2    Bras-Pereira, C.3    Jezowska, B.4    Rebelo, S.R.5    Janody, F.6
  • 58
    • 0037173716 scopus 로고    scopus 로고
    • Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling
    • Ferrigno O, Lallemand F, Verrecchia F, L’Hoste S, Camonis J, Atfi A, Mauviel A. Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene 21: 4879–4884, 2002.
    • (2002) Oncogene , vol.21 , pp. 4879-4884
    • Ferrigno, O.1    Lallemand, F.2    Verrecchia, F.3    L’Hoste, S.4    Camonis, J.5    Atfi, A.6    Mauviel, A.7
  • 59
    • 0018140371 scopus 로고
    • Role of cell shape in growth control
    • Folkman J, Moscona A. Role of cell shape in growth control. Nature 273: 345–349, 1978.
    • (1978) Nature , vol.273 , pp. 345-349
    • Folkman, J.1    Moscona, A.2
  • 60
    • 2442603612 scopus 로고    scopus 로고
    • A novel TEAD1 mutation is the causative allele in Sveinsson’s chorioretinal atrophy (Helicoid peripapillary chorioretinal degeneration)
    • Fossdal R, Jonasson F, Kristjansdottir GT, Kong A, Stefansson H, Gosh S, Gulcher JR, Stefansson K. A novel TEAD1 mutation is the causative allele in Sveinsson’s chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration). Hum Mol Genet 13: 975–981, 2004.
    • (2004) Hum Mol Genet , vol.13 , pp. 975-981
    • Fossdal, R.1    Jonasson, F.2    Kristjansdottir, G.T.3    Kong, A.4    Stefansson, H.5    Gosh, S.6    Gulcher, J.R.7    Stefansson, K.8
  • 63
    • 79958128093 scopus 로고    scopus 로고
    • Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone
    • Gee ST, Milgram SL, Kramer KL, Conlon FL, Moody SA. Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone. PLoS One 6: e20309, 2011.
    • (2011) Plos One , vol.20309 , pp. 6
    • Gee, S.T.1    Milgram, S.L.2    Kramer, K.L.3    Conlon, F.L.4    Moody, S.A.5
  • 64
    • 79956046567 scopus 로고    scopus 로고
    • The Hippo pathway and apico-basal cell polarity
    • Genevet A, Tapon N. The Hippo pathway and apico-basal cell polarity. Biochem J 436: 213–224, 2011.
    • (2011) Biochem J , vol.436 , pp. 213-224
    • Genevet, A.1    Tapon, N.2
  • 65
    • 76249093838 scopus 로고    scopus 로고
    • Kibra is a regulator of the Salvador/Warts/Hippo signaling network
    • Genevet A, Wehr MC, Brain R, Thompson BJ, Tapon N. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell 18: 300–308, 2010.
    • (2010) Dev Cell , vol.18 , pp. 300-308
    • Genevet, A.1    Wehr, M.C.2    Brain, R.3    Thompson, B.J.4    Tapon, N.5
  • 69
    • 40849086201 scopus 로고    scopus 로고
    • SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila
    • Goulev Y, Fauny JD, Gonzalez-Marti B, Flagiello D, Silber J, Zider A. SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila. Curr Biol 18: 435–441, 2008.
    • (2008) Curr Biol , vol.18 , pp. 435-441
    • Goulev, Y.1    Fauny, J.D.2    Gonzalez-Marti, B.3    Flagiello, D.4    Silber, J.5    Zider, A.6
  • 70
    • 0035805593 scopus 로고    scopus 로고
    • Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis
    • Graves JD, Draves KE, Gotoh Y, Krebs EG, Clark EA. Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis. J Biol Chem 276: 14909–14915, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 14909-14915
    • Graves, J.D.1    Draves, K.E.2    Gotoh, Y.3    Krebs, E.G.4    Clark, E.A.5
  • 72
    • 77950485564 scopus 로고    scopus 로고
    • Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms
    • Grzeschik NA, Parsons LM, Allott ML, Harvey KF, Richardson HE. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol 20: 573–581, 2010.
    • (2010) Curr Biol , vol.20 , pp. 573-581
    • Grzeschik, N.A.1    Parsons, L.M.2    Allott, M.L.3    Harvey, K.F.4    Richardson, H.E.5
  • 74
    • 78650724753 scopus 로고    scopus 로고
    • Hippo signaling: Growth control and beyond
    • Halder G, Johnson RL. Hippo signaling: growth control and beyond. Development 138: 9–22, 2011.
    • (2011) Development , vol.138 , pp. 9-22
    • Halder, G.1    Johnson, R.L.2
  • 75
    • 0032534902 scopus 로고    scopus 로고
    • The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila
    • Halder G, Polaczyk P, Kraus ME, Hudson A, Kim J, Laughon A, Carroll S. The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila. Genes Dev 12: 3900–3909, 1998.
    • (1998) Genes Dev , vol.12 , pp. 3900-3909
    • Halder, G.1    Polaczyk, P.2    Kraus, M.E.3    Hudson, A.4    Kim, J.5    Laughon, A.6    Carroll, S.7
  • 77
    • 30344445706 scopus 로고    scopus 로고
    • The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
    • Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 8: 27–36, 2006.
    • (2006) Nat Cell Biol , vol.8 , pp. 27-36
    • Hamaratoglu, F.1    Willecke, M.2    Kango-Singh, M.3    Nolo, R.4    Hyun, E.5    Tao, C.6    Jafar-Nejad, H.7    Halder, G.8
  • 79
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 144: 646–674, 2011.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 81
    • 0042733354 scopus 로고    scopus 로고
    • The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    • Harvey KF, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114: 457–467, 2003.
    • (2003) Cell , vol.114 , pp. 457-467
    • Harvey, K.F.1    Pfleger, C.M.2    Hariharan, I.K.3
  • 85
    • 84870534509 scopus 로고    scopus 로고
    • YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: Implications for breast cancer
    • Hergovich A. YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: implications for breast cancer. Breast Cancer Res 14: 326, 2012.
    • (2012) Breast Cancer Res , vol.14 , pp. 326
    • Hergovich, A.1
  • 87
    • 84981237552 scopus 로고    scopus 로고
    • The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development
    • Hirate Y, Sasaki H. The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development. Tissue Barriers 2: e28127, 2014.
    • (2014) Tissue Barriers , vol.2
    • Hirate, Y.1    Sasaki, H.2
  • 91
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
    • Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell 122: 421–434, 2005.
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3    Matthews, K.4    Pan, D.5
  • 92
    • 84876943442 scopus 로고    scopus 로고
    • YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14
    • Huang JM, Nagatomo I, Suzuki E, Mizuno T, Kumagai T, Berezov A, Zhang H, Karlan B, Greene MI, Wang Q. YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14. Oncogene 32: 2220–2229, 2013.
    • (2013) Oncogene , vol.32 , pp. 2220-2229
    • Huang, J.M.1    Nagatomo, I.2    Suzuki, E.3    Mizuno, T.4    Kumagai, T.5    Berezov, A.6    Zhang, H.7    Karlan, B.8    Greene, M.I.9    Wang, Q.10
  • 94
    • 84858002052 scopus 로고    scopus 로고
    • A molecular mechanism that links Hippo signalling to the inhibition of Wnt/beta-catenin signalling
    • Imajo M, Miyatake K, Iimura A, Miyamoto A, Nishida E. A molecular mechanism that links Hippo signalling to the inhibition of Wnt/beta-catenin signalling. EMBO J 31: 1109–1122, 2012.
    • (2012) EMBO J , vol.31 , pp. 1109-1122
    • Imajo, M.1    Miyatake, K.2    Iimura, A.3    Miyamoto, A.4    Nishida, E.5
  • 97
    • 0028902594 scopus 로고
    • The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
    • Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev 9: 534–546, 1995.
    • (1995) Genes Dev , vol.9 , pp. 534-546
    • Justice, R.W.1    Zilian, O.2    Woods, D.F.3    Noll, M.4    Bryant, P.J.5
  • 102
    • 79961087833 scopus 로고    scopus 로고
    • E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
    • Kim NG, Koh E, Chen X, Gumbiner BM. E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci USA 108: 11930–11935, 2011.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11930-11935
    • Kim, N.G.1    Koh, E.2    Chen, X.3    Gumbiner, B.M.4
  • 103
    • 34547907131 scopus 로고    scopus 로고
    • A Sveinsson’s chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ
    • Kitagawa M. A Sveinsson’s chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ. Biochem Biophys Res Commun 361: 1022–1026, 2007.
    • (2007) Biochem Biophys Res Commun , vol.361 , pp. 1022-1026
    • Kitagawa, M.1
  • 104
    • 0042858208 scopus 로고    scopus 로고
    • WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
    • Komuro A, Nagai M, Navin NE, Sudol M. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J Biol Chem 278: 33334–33341, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 33334-33341
    • Komuro, A.1    Nagai, M.2    Navin, N.E.3    Sudol, M.4
  • 105
    • 84878371755 scopus 로고    scopus 로고
    • The Hippo effector Yorkie controls normal tissue growth by antagonizing scallopedmediated default repression
    • Koontz LM, Liu-Chittenden Y, Yin F, Zheng Y, Yu J, Huang B, Chen Q, Wu S, Pan D. The Hippo effector Yorkie controls normal tissue growth by antagonizing scallopedmediated default repression. Dev Cell 25: 388–401, 2013.
    • (2013) Dev Cell , vol.25 , pp. 388-401
    • Koontz, L.M.1    Liu-Chittenden, Y.2    Yin, F.3    Zheng, Y.4    Yu, J.5    Huang, B.6    Chen, Q.7    Wu, S.8    Pan, D.9
  • 106
    • 79953310106 scopus 로고    scopus 로고
    • Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF
    • Lai D, Ho KC, Hao Y, Yang X. Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res 71: 2728–2738, 2011.
    • (2011) Cancer Res , vol.71 , pp. 2728-2738
    • Lai, D.1    Ho, K.C.2    Hao, Y.3    Yang, X.4
  • 107
    • 0038077566 scopus 로고    scopus 로고
    • NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions
    • Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey AI. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev 17: 1090–1100, 2003.
    • (2003) Genes Dev , vol.17 , pp. 1090-1100
    • Lallemand, D.1    Curto, M.2    Saotome, I.3    Giovannini, M.4    McClatchey, A.I.5
  • 110
    • 84880942838 scopus 로고    scopus 로고
    • Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators
    • Lavado A, He Y, Pare J, Neale G, Olson EN, Giovannini M, Cao X. Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development 140: 3323–3334, 2013.
    • (2013) Development , vol.140 , pp. 3323-3334
    • Lavado, A.1    He, Y.2    Pare, J.3    Neale, G.4    Olson, E.N.5    Giovannini, M.6    Cao, X.7
  • 114
    • 41149098966 scopus 로고    scopus 로고
    • TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
    • Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan KL. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol 28: 2426–2436, 2008.
    • (2008) Mol Cell Biol , vol.28 , pp. 2426-2436
    • Lei, Q.Y.1    Zhang, H.2    Zhao, B.3    Zha, Z.Y.4    Bai, F.5    Pei, X.H.6    Zhao, S.7    Xiong, Y.8    Guan, K.L.9
  • 115
    • 84881356173 scopus 로고    scopus 로고
    • Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms
    • Leung CY, Zernicka-Goetz M. Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms. Nature Commun 4: 2251, 2013.
    • (2013) Nature Commun , vol.4 , pp. 2251
    • Leung, C.Y.1    Zernicka-Goetz, M.2
  • 117
    • 38949123978 scopus 로고    scopus 로고
    • Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
    • Levy D, Adamovich Y, Reuven N, Shaul Y. Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29: 350–361, 2008.
    • (2008) Mol Cell , vol.29 , pp. 350-361
    • Levy, D.1    Adamovich, Y.2    Reuven, N.3    Shaul, Y.4
  • 118
    • 33947382284 scopus 로고    scopus 로고
    • The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73
    • Levy D, Adamovich Y, Reuven N, Shaul Y. The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73. Cell Death Differentiation 14: 743–751, 2007.
    • (2007) Cell Death Differentiation , vol.14 , pp. 743-751
    • Levy, D.1    Adamovich, Y.2    Reuven, N.3    Shaul, Y.4
  • 125
    • 84862605178 scopus 로고    scopus 로고
    • Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
    • Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee SJ, Anders RA, Liu JO, Pan D. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev 26: 1300–1305, 2012.
    • (2012) Genes Dev , vol.26 , pp. 1300-1305
    • Liu-Chittenden, Y.1    Huang, B.2    Shim, J.S.3    Chen, Q.4    Lee, S.J.5    Ers, R.A.6    Liu, J.O.7    Pan, D.8
  • 129
    • 33645868635 scopus 로고    scopus 로고
    • The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling
    • Maitra S, Kulikauskas RM, Gavilan H, Fehon RG. The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr Biol 16: 702–709, 2006.
    • (2006) Curr Biol , vol.16 , pp. 702-709
    • Maitra, S.1    Kulikauskas, R.M.2    Gavilan, H.3    Fehon, R.G.4
  • 131
    • 70549098542 scopus 로고    scopus 로고
    • Cytoskeletal control of growth and cell fate switching
    • Mammoto A, Ingber DE. Cytoskeletal control of growth and cell fate switching. Curr Opin Cell Biol 21: 864–870, 2009.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 864-870
    • Mammoto, A.1    Ingber, D.E.2
  • 132
    • 84901236414 scopus 로고    scopus 로고
    • Angiomotins link F-actin architecture to Hippo pathway signaling
    • Mana-Capelli S, Paramasivam M, Dutta S, McCollum D. Angiomotins link F-actin architecture to Hippo pathway signaling. Mol Biol Cell 25: 1676–1685, 2014.
    • (2014) Mol Biol Cell , vol.25 , pp. 1676-1685
    • Mana-Capelli, S.1    Paramasivam, M.2    Dutta, S.3    McCollum, D.4
  • 134
    • 84655169623 scopus 로고    scopus 로고
    • Epithelial cell polarity, stem cells and cancer
    • Martin-Belmonte F, Perez-Moreno M. Epithelial cell polarity, stem cells and cancer. Nat Rev Cancer 12: 23–38, 2011.
    • (2011) Nat Rev Cancer , vol.12 , pp. 23-38
    • Martin-Belmonte, F.1    Perez-Moreno, M.2
  • 137
    • 1842426730 scopus 로고    scopus 로고
    • Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
    • McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6: 483–495, 2004.
    • (2004) Dev Cell , vol.6 , pp. 483-495
    • McBeath, R.1    Pirone, D.M.2    Nelson, C.M.3    Bhadriraju, K.4    Chen, C.S.5
  • 138
    • 0032522603 scopus 로고    scopus 로고
    • Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
    • McClatchey AI, Saotome I, Mercer K, Crowley D, Gusella JF, Bronson RT, Jacks T. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev 12: 1121–1133, 1998.
    • (1998) Genes Dev , vol.12 , pp. 1121-1133
    • McClatchey, A.I.1    Saotome, I.2    Mercer, K.3    Crowley, D.4    Gusella, J.F.5    Bronson, R.T.6    Jacks, T.7
  • 139
    • 0030924657 scopus 로고    scopus 로고
    • The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation
    • McClatchey AI, Saotome I, Ramesh V, Gusella JF, Jacks T. The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev 11: 1253–1265, 1997.
    • (1997) Genes Dev , vol.11 , pp. 1253-1265
    • McClatchey, A.I.1    Saotome, I.2    Ramesh, V.3    Gusella, J.F.4    Jacks, T.5
  • 143
  • 145
    • 84867182034 scopus 로고    scopus 로고
    • Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)
    • Mo JS, Yu FX, Gong R, Brown JH, Guan KL. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev 26: 2138–2143, 2012.
    • (2012) Genes Dev , vol.26 , pp. 2138-2143
    • Mo, J.S.1    Yu, F.X.2    Gong, R.3    Brown, J.H.4    Guan, K.L.5
  • 149
    • 84896847445 scopus 로고    scopus 로고
    • Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer
    • Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo FD, Gregory RI. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell 156: 893–906, 2014.
    • (2014) Cell , vol.156 , pp. 893-906
    • Mori, M.1    Triboulet, R.2    Mohseni, M.3    Schlegelmilch, K.4    Shrestha, K.5    Camargo, F.D.6    Gregory, R.I.7
  • 151
    • 67649878206 scopus 로고    scopus 로고
    • Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma
    • Morris ZS, McClatchey AI. Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Proc Natl Acad Sci USA 106: 9767–9772, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9767-9772
    • Morris, Z.S.1    McClatchey, A.I.2
  • 154
    • 84862207091 scopus 로고    scopus 로고
    • Mitotic and mitogenic Wnt signalling
    • Niehrs C, Acebron SP. Mitotic and mitogenic Wnt signalling. EMBO J 31: 2705–2713, 2012.
    • (2012) EMBO J , vol.31 , pp. 2705-2713
    • Niehrs, C.1    Acebron, S.P.2
  • 159
    • 11144267126 scopus 로고    scopus 로고
    • Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
    • O’Neill E, Rushworth L, Baccarini M, Kolch W. Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 306: 2267–2270, 2004.
    • (2004) Science , vol.306 , pp. 2267-2270
    • O’Neill, E.1    Rushworth, L.2    Baccarini, M.3    Kolch, W.4
  • 160
  • 163
    • 84855344741 scopus 로고    scopus 로고
    • Opposing roles of angiomotin-like-1 and zona occludens- 2 on pro-apoptotic function of YAP
    • Oka T, Schmitt AP, Sudol M. Opposing roles of angiomotin-like-1 and zona occludens- 2 on pro-apoptotic function of YAP. Oncogene 31: 128–134, 2012.
    • (2012) Oncogene , vol.31 , pp. 128-134
    • Oka, T.1    Schmitt, A.P.2    Sudol, M.3
  • 164
    • 1542358888 scopus 로고    scopus 로고
    • Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level
    • Omerovic J, Puggioni EM, Napoletano S, Visco V, Fraioli R, Frati L, Gulino A, Alimandi M. Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level. Exp Cell Res 294: 469–479, 2004.
    • (2004) Exp Cell Res , vol.294 , pp. 469-479
    • Omerovic, J.1    Puggioni, E.M.2    Napoletano, S.3    Visco, V.4    Fraioli, R.5    Frati, L.6    Gulino, A.7    Alimandi, M.8
  • 165
    • 60849138138 scopus 로고    scopus 로고
    • Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
    • Ota M, Sasaki H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development 135: 4059–4069, 2008.
    • (2008) Development , vol.135 , pp. 4059-4069
    • Ota, M.1    Sasaki, H.2
  • 168
    • 77957883342 scopus 로고    scopus 로고
    • The hippo signaling pathway in development and cancer
    • Pan D. The hippo signaling pathway in development and cancer. Dev Cell 19: 491–505, 2010.
    • (2010) Dev Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 173
    • 3242794878 scopus 로고    scopus 로고
    • Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
    • Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J 381: 453–462, 2004.
    • (2004) Biochem J , vol.381 , pp. 453-462
    • Praskova, M.1    Khoklatchev, A.2    Ortiz-Vega, S.3    Avruch, J.4
  • 174
    • 40149111984 scopus 로고    scopus 로고
    • MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
    • Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol 18: 311–321, 2008.
    • (2008) Curr Biol , vol.18 , pp. 311-321
    • Praskova, M.1    Xia, F.2    Avruch, J.3
  • 175
    • 84862764408 scopus 로고    scopus 로고
    • The Hippo signaling pathway and stem cell biology
    • Ramos A, Camargo FD. The Hippo signaling pathway and stem cell biology. Trends Cell Biol 22: 339–346, 2012.
    • (2012) Trends Cell Biol , vol.22 , pp. 339-346
    • Ramos, A.1    Camargo, F.D.2
  • 178
    • 72649088969 scopus 로고    scopus 로고
    • Hippo signaling regulates Yorkie nuclear localization and activity through 14–3-3 dependent and independent mechanisms
    • Ren F, Zhang L, Jiang J. Hippo signaling regulates Yorkie nuclear localization and activity through 14–3-3 dependent and independent mechanisms. Dev Biol 337: 303–312, 2010.
    • (2010) Dev Biol , vol.337 , pp. 303-312
    • Ren, F.1    Zhang, L.2    Jiang, J.3
  • 179
    • 70349174971 scopus 로고    scopus 로고
    • The RASSF proteins in cancer; from epigenetic silencing to functional characterization
    • Richter AM, Pfeifer GP, Dammann RH. The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim Biophys Acta 1796: 114–128, 2009.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 114-128
    • Richter, A.M.1    Pfeifer, G.P.2    Dammann, R.H.3
  • 182
    • 43249089639 scopus 로고    scopus 로고
    • Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival
    • Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H. Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol 28: 3177–3189, 2008.
    • (2008) Mol Cell Biol , vol.28 , pp. 3177-3189
    • Sawada, A.1    Kiyonari, H.2    Ukita, K.3    Nishioka, N.4    Imuta, Y.5    Sasaki, H.6
  • 189
    • 84866993770 scopus 로고    scopus 로고
    • Nuclear expression of Yes-associated protein 1 correlates with poor prognosis in intestinal type gastric cancer
    • Song M, Cheong JH, Kim H, Noh SH, Kim H. Nuclear expression of Yes-associated protein 1 correlates with poor prognosis in intestinal type gastric cancer. Anticancer Res 32: 3827–3834, 2012.
    • (2012) Anticancer Res , vol.32 , pp. 3827-3834
    • Song, M.1    Cheong, J.H.2    Kim, H.3    Noh, S.H.4    Kim, H.5
  • 191
    • 67649634849 scopus 로고    scopus 로고
    • Defining the human deubiquitinating enzyme interaction landscape
    • Sowa ME, Bennett EJ, Gygi SP, Harper JW. Defining the human deubiquitinating enzyme interaction landscape. Cell 138: 389–403, 2009.
    • (2009) Cell , vol.138 , pp. 389-403
    • Sowa, M.E.1    Bennett, E.J.2    Gygi, S.P.3    Harper, J.W.4
  • 192
    • 0021069981 scopus 로고
    • Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes
    • Spiegelman BM, Ginty CA. Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes. Cell 35: 657–666, 1983.
    • (1983) Cell , vol.35 , pp. 657-666
    • Spiegelman, B.M.1    Ginty, C.A.2
  • 195
    • 0033940009 scopus 로고    scopus 로고
    • Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations
    • Stokowski RP, Cox DR. Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations. Am J Hum Genet 66: 873–891, 2000.
    • (2000) Am J Hum Genet , vol.66 , pp. 873-891
    • Stokowski, R.P.1    Cox, D.R.2
  • 198
    • 84872354595 scopus 로고    scopus 로고
    • Expression of Yes-associated protein in non-small cell lung cancer and its relationship with clinical pathological factors
    • Su LL, Ma WX, Yuan JF, Shao Y, Xiao W, Jiang SJ. Expression of Yes-associated protein in non-small cell lung cancer and its relationship with clinical pathological factors. Chin Med J 125: 4003–4008, 2012.
    • (2012) Chin Med J , vol.125 , pp. 4003-4008
    • Su, L.L.1    Ma, W.X.2    Yuan, J.F.3    Shao, Y.4    Xiao, W.5    Jiang, S.J.6
  • 199
    • 0028283579 scopus 로고
    • Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product
    • Sudol M. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. Oncogene 9: 2145–2152, 1994.
    • (1994) Oncogene , vol.9 , pp. 2145-2152
    • Sudol, M.1
  • 201
    • 0037162714 scopus 로고    scopus 로고
    • Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    • Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber D, Hariharan IK. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110: 467–478, 2002.
    • (2002) Cell , vol.110 , pp. 467-478
    • Tapon, N.1    Harvey, K.F.2    Bell, D.W.3    Wahrer, D.C.4    Schiripo, T.A.5    Haber, D.6    Hariharan, I.K.7
  • 202
    • 33745700212 scopus 로고    scopus 로고
    • Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells
    • Teraishi F, Guo W, Zhang L, Dong F, Davis JJ, Sasazuki T, Shirasawa S, Liu J, Fang B. Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells. Cancer Res 66: 6072–6079, 2006.
    • (2006) Cancer Res , vol.66 , pp. 6072-6079
    • Teraishi, F.1    Guo, W.2    Zhang, L.3    Dong, F.4    Davis, J.J.5    Sasazuki, T.6    Shirasawa, S.7    Liu, J.8    Fang, B.9
  • 203
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 139: 871–890, 2009.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 204
    • 77952116604 scopus 로고    scopus 로고
    • Structural and functional analysis of the YAP-binding domain of human TEAD2
    • Tian W, Yu J, Tomchick DR, Pan D, Luo X. Structural and functional analysis of the YAP-binding domain of human TEAD2. Proc Natl Acad Sci USA 107: 7293–7298, 2010.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7293-7298
    • Tian, W.1    Yu, J.2    Tomchick, D.R.3    Pan, D.4    Luo, X.5
  • 209
    • 0035873391 scopus 로고    scopus 로고
    • TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm
    • Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev 15: 1229–1241, 2001.
    • (2001) Genes Dev , vol.15 , pp. 1229-1241
    • Vassilev, A.1    Kaneko, K.J.2    Shu, H.3    Zhao, Y.4    Depamphilis, M.L.5
  • 210
    • 0032735880 scopus 로고    scopus 로고
    • TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation
    • Vaudin P, Delanoue R, Davidson I, Silber J, Zider A. TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation. Development 126: 4807–4816, 1999.
    • (1999) Development , vol.126 , pp. 4807-4816
    • Vaudin, P.1    Delanoue, R.2    Davidson, I.3    Silber, J.4    Zider, A.5
  • 211
    • 57649102412 scopus 로고    scopus 로고
    • NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis
    • Vichalkovski A, Gresko E, Cornils H, Hergovich A, Schmitz D, Hemmings BA. NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr Biol 18: 1889–1895, 2008.
    • (2008) Curr Biol , vol.18 , pp. 1889-1895
    • Vichalkovski, A.1    Gresko, E.2    Cornils, H.3    Hergovich, A.4    Schmitz, D.5    Hemmings, B.A.6
  • 212
    • 77958494807 scopus 로고    scopus 로고
    • LATS tumor suppressor: A new governor of cellular homeostasis
    • Visser S, Yang X. LATS tumor suppressor: a new governor of cellular homeostasis. Cell Cycle 9: 3892–3903, 2010.
    • (2010) Cell Cycle , vol.9 , pp. 3892-3903
    • Visser, S.1    Yang, X.2
  • 213
    • 84862517728 scopus 로고    scopus 로고
    • Cancer stem cells: Current status and evolving complexities
    • Visvader JE, Lindeman GJ. Cancer stem cells: current status and evolving complexities. Cell Stem Cell 10: 717–728, 2012.
    • (2012) Cell Stem Cell , vol.10 , pp. 717-728
    • Visvader, J.E.1    Lindeman, G.J.2
  • 215
    • 84892702028 scopus 로고    scopus 로고
    • Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer
    • Vlug EJ, van de Ven RA, Vermeulen JF, Bult P, van Diest PJ, Derksen PW. Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer. Cell Oncol 36: 375–384, 2013.
    • (2013) Cell Oncol , vol.36 , pp. 375-384
    • Vlug, E.J.1    Van De Ven, R.A.2    Vermeulen, J.F.3    Bult, P.4    Van Diest, P.J.5    Derksen, P.W.6
  • 217
    • 80051923057 scopus 로고    scopus 로고
    • Hippo pathway regulation by cell morphology and stress fibers
    • Wada K, Itoga K, Okano T, Yonemura S, Sasaki H. Hippo pathway regulation by cell morphology and stress fibers. Development 138: 3907–3914, 2011.
    • (2011) Development , vol.138 , pp. 3907-3914
    • Wada, K.1    Itoga, K.2    Okano, T.3    Yonemura, S.4    Sasaki, H.5
  • 218
    • 84878834780 scopus 로고    scopus 로고
    • Overexpression of YAP and TAZ is an independent predictor of prognosis in colorectal cancer and related to the proliferation and metastasis of colon cancer cells
    • Wang L, Shi S, Guo Z, Zhang X, Han S, Yang A, Wen W, Zhu Q. Overexpression of YAP and TAZ is an independent predictor of prognosis in colorectal cancer and related to the proliferation and metastasis of colon cancer cells. PloS One 8: e65539, 2013.
    • (2013) Plos One , vol.8
    • Wang, L.1    Shi, S.2    Guo, Z.3    Zhang, X.4    Han, S.5    Yang, A.6    Wen, W.7    Zhu, Q.8
  • 220
    • 79953010044 scopus 로고    scopus 로고
    • Angiomotin-like proteins associate with and negatively regulate YAP1
    • Wang W, Huang J, Chen J. Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem 286: 4364–4370, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 4364-4370
    • Wang, W.1    Huang, J.2    Chen, J.3
  • 223
    • 48349094384 scopus 로고    scopus 로고
    • Unraveling the microenvironmental influences on the normal mammary gland and breast cancer
    • Weigelt B, Bissell MJ. Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol 18: 311–321, 2008.
    • (2008) Semin Cancer Biol , vol.18 , pp. 311-321
    • Weigelt, B.1    Bissell, M.J.2
  • 224
    • 84879413598 scopus 로고    scopus 로고
    • A self-organization framework for symmetry breaking in the mammalian embryo
    • Wennekamp S, Mesecke S, Nedelec F, Hiiragi T. A self-organization framework for symmetry breaking in the mammalian embryo. Nat Rev Mol Cell Biol 14: 452–459, 2013.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 452-459
    • Wennekamp, S.1    Mesecke, S.2    Nedelec, F.3    Hiiragi, T.4
  • 225
    • 58049220350 scopus 로고    scopus 로고
    • Mechanotransduction in development: A growing role for contractility
    • Wozniak MA, Chen CS. Mechanotransduction in development: a growing role for contractility. Nat Rev Mol Cell Biol 10: 34–43, 2009.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 34-43
    • Wozniak, M.A.1    Chen, C.S.2
  • 227
    • 42049116586 scopus 로고    scopus 로고
    • The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway
    • Wu S, Liu Y, Zheng Y, Dong J, Pan D. The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell 14: 388–398, 2008.
    • (2008) Dev Cell , vol.14 , pp. 388-398
    • Wu, S.1    Liu, Y.2    Zheng, Y.3    Dong, J.4    Pan, D.5
  • 228
    • 84898723715 scopus 로고    scopus 로고
    • YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients
    • Xia Y, Chang T, Wang Y, Liu Y, Li W, Li M, Fan HY. YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients. PloS One 9: e91770, 2014.
    • (2014) Plos One , vol.91770 , pp. 9
    • Xia, Y.1    Chang, T.2    Wang, Y.3    Liu, Y.4    Li, W.5    Li, M.6    Fan, H.Y.7
  • 230
    • 79953150067 scopus 로고    scopus 로고
    • KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases
    • Xiao L, Chen Y, Ji M, Dong J. KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases. J Biol Chem 286: 7788–7796, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 7788-7796
    • Xiao, L.1    Chen, Y.2    Ji, M.3    Dong, J.4
  • 236
    • 0028929414 scopus 로고
    • Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene encodes a putative protein kinase
    • Xu T, Wang W, Zhang S, Stewart RA, Yu W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121: 1053–1063, 1995.
    • (1995) Development , vol.121 , pp. 1053-1063
    • Xu, T.1    Wang, W.2    Zhang, S.3    Stewart, R.A.4    Yu, W.5
  • 239
    • 84923068190 scopus 로고    scopus 로고
    • Knockdown of YAP1 inhibits the proliferation of osteosarcoma cells in vitro and in vivo
    • Yang Z, Zhang M, Xu K, Liu L, Hou WK, Cai YZ, Xu P, Yao JF. Knockdown of YAP1 inhibits the proliferation of osteosarcoma cells in vitro and in vivo. Oncol Reports 2014; doi: 10.3892/or.2014.3305 [Epub ahead of print].
    • (2014) Oncol Reports
    • Yang, Z.1    Zhang, M.2    Xu, K.3    Liu, L.4    Hou, W.K.5    Cai, Y.Z.6    Xu, P.7    Yao, J.F.8
  • 243
    • 84884291548 scopus 로고    scopus 로고
    • Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2
    • Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D. Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell 154: 1342–1355, 2013.
    • (2013) Cell , vol.154 , pp. 1342-1355
    • Yin, F.1    Yu, J.2    Zheng, Y.3    Chen, Q.4    Zhang, N.5    Pan, D.6
  • 247
    • 76249109900 scopus 로고    scopus 로고
    • Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded
    • Yu J, Zheng Y, Dong J, Klusza S, Deng WM, Pan D. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell 18: 288–299, 2010.
    • (2010) Dev Cell , vol.18 , pp. 288-299
    • Yu, J.1    Zheng, Y.2    Dong, J.3    Klusza, S.4    Deng, W.M.5    Pan, D.6
  • 250
    • 67649822214 scopus 로고    scopus 로고
    • Making a firm decision: Multifaceted regulation of cell fate in the early mouse embryo
    • Zernicka-Goetz M, Morris SA, Bruce AW. Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo. Nature Rev Genet 10: 467–477, 2009.
    • (2009) Nature Rev Genet , vol.10 , pp. 467-477
    • Zernicka-Goetz, M.1    Morris, S.A.2    Bruce, A.W.3
  • 251
    • 56349098933 scopus 로고    scopus 로고
    • Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma
    • Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB, Allred C, Muthuswamy SK. Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 135: 865–878, 2008.
    • (2008) Cell , vol.135 , pp. 865-878
    • Zhan, L.1    Rosenberg, A.2    Bergami, K.C.3    Yu, M.4    Xuan, Z.5    Jaffe, A.B.6    Allred, C.7    Muthuswamy, S.K.8
  • 252
    • 67649412006 scopus 로고    scopus 로고
    • TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
    • Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem 284: 13355–13362, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 13355-13362
    • Zhang, H.1    Liu, C.Y.2    Zha, Z.Y.3    Zhao, B.4    Yao, J.5    Zhao, S.6    Xiong, Y.7    Lei, Q.Y.8    Guan, K.L.9
  • 253
    • 79952297528 scopus 로고    scopus 로고
    • Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
    • Zhang H, Pasolli HA, Fuchs E. Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci USA 108: 2270–2275, 2011.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2270-2275
    • Zhang, H.1    Pasolli, H.A.2    Fuchs, E.3
  • 255
    • 84868012538 scopus 로고    scopus 로고
    • Expression of Yes-associated protein in gastric adenocarcinoma and inhibitory effects of its knockdown on gastric cancer cell proliferation and metastasis
    • Zhang J, Xu ZP, Yang YC, Zhu JS, Zhou Z, Chen WX. Expression of Yes-associated protein in gastric adenocarcinoma and inhibitory effects of its knockdown on gastric cancer cell proliferation and metastasis. Int J Immunopathol Pharmacol 25: 583–590, 2012.
    • (2012) Int J Immunopathol Pharmacol , vol.25 , pp. 583-590
    • Zhang, J.1    Xu, Z.P.2    Yang, Y.C.3    Zhu, J.S.4    Zhou, Z.5    Chen, W.X.6
  • 256
    • 42049120338 scopus 로고    scopus 로고
    • The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
    • Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell 14: 377–387, 2008.
    • (2008) Dev Cell , vol.14 , pp. 377-387
    • Zhang, L.1    Ren, F.2    Zhang, Q.3    Chen, Y.4    Wang, B.5    Jiang, J.6
  • 257
    • 77954945373 scopus 로고    scopus 로고
    • The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
    • Zhang N, Bai H, David KK, Dong J, Zheng Y, Cai J, Giovannini M, Liu P, Anders RA, Pan D. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell 19: 27–38, 2010.
    • (2010) Dev Cell , vol.19 , pp. 27-38
    • Zhang, N.1    Bai, H.2    David, K.K.3    Dong, J.4    Zheng, Y.5    Cai, J.6    Giovannini, M.7    Liu, P.8    Ers, R.A.9    Pan, D.10
  • 261
    • 59149088576 scopus 로고    scopus 로고
    • Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yesassociated protein
    • Zhao B, Kim J, Ye X, Lai ZC, Guan KL. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yesassociated protein. Cancer Res 69: 1089–1098, 2009.
    • (2009) Cancer Res , vol.69 , pp. 1089-1098
    • Zhao, B.1    Kim, J.2    Ye, X.3    Lai, Z.C.4    Guan, K.L.5
  • 262
    • 77951837150 scopus 로고    scopus 로고
    • The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version
    • Zhao B, Li L, Lei Q, Guan KL. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev 24: 862–874, 2010.
    • (2010) Genes Dev , vol.24 , pp. 862-874
    • Zhao, B.1    Li, L.2    Lei, Q.3    Guan, K.L.4
  • 263
    • 78650895035 scopus 로고    scopus 로고
    • Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
    • Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q, Guan KL. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev 25: 51–63, 2011.
    • (2011) Genes Dev , vol.25 , pp. 51-63
    • Zhao, B.1    Li, L.2    Lu, Q.3    Wang, L.H.4    Liu, C.Y.5    Lei, Q.6    Guan, K.L.7
  • 264
    • 73549095761 scopus 로고    scopus 로고
    • A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(Beta-TRCP)
    • Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev 24: 72–85, 2010.
    • (2010) Genes Dev , vol.24 , pp. 72-85
    • Zhao, B.1    Li, L.2    Tumaneng, K.3    Wang, C.Y.4    Guan, K.L.5
  • 265
    • 84855326431 scopus 로고    scopus 로고
    • Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
    • Zhao B, Li L, Wang L, Wang CY, Yu J, Guan KL. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev 26: 54–68, 2012.
    • (2012) Genes Dev , vol.26 , pp. 54-68
    • Zhao, B.1    Li, L.2    Wang, L.3    Wang, C.Y.4    Yu, J.5    Guan, K.L.6
  • 268
    • 84880227965 scopus 로고    scopus 로고
    • Mesenchymal stem cell and chondrocyte fates in a multishear microdevice are regulated by Yes-associated protein
    • Zhong W, Tian K, Zheng X, Li L, Zhang W, Wang S, Qin J. Mesenchymal stem cell and chondrocyte fates in a multishear microdevice are regulated by Yes-associated protein. Stem Cells Dev 22: 2083–2093, 2013.
    • (2013) Stem Cells Dev , vol.22 , pp. 2083-2093
    • Zhong, W.1    Tian, K.2    Zheng, X.3    Li, L.4    Zhang, W.5    Wang, S.6    Qin, J.7
  • 270


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.