Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation

Journal of Biological Chemistry

Volumn 288, Issue 52, 2013, Pages 37296-37307

  Chan, Siew Wee ^a   Lim, Chun Jye ^a   Guo, Fusheng ^a   Tan, Ivan ^a   Leung, Thomas ^a   Hong, Wanjin ^a,b  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

COACTIVATORS; PROLIFERATION ACTIVITY;

CELL PROLIFERATION; ENZYMES; PHOSPHORYLATION;

PROTEINS;

ACTIN; ANGIOMOTIN; LONG ACTING THYROID STIMULATOR 1; LONG ACTING THYROID STIMULATOR 2; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENE OVEREXPRESSION; HIPPO PATHWAY; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84891383662     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.527598     Document Type: Article

References (24)

1. Zhao, B., Tumaneng, K., and Guan, K. L. (2011) The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat. Cell Biol. 13, 877-883
2. Harvey, K., and Tapon, N. (2007) The Salvador-Warts-Hippo pathway. An emerging tumour-suppressor network. Nat. Rev. Cancer 7, 182-191
3. Harvey, K. F., Zhang, X., and Thomas, D. M. (2013) The Hippo pathway and human cancer. Nat. Rev. Cancer 13, 246-257
4. Chan, S. W., Lim, C. J., Chen, L., Chong, Y. F., Huang, C., Song, H., and Hong, W. (2011) The Hippo pathway in biological control and cancer development. J. Cell. Physiol. 226, 928-939
5. Bossuyt, W., Chen, C. L., Chen, Q., Sudol, M., McNeill, H., Pan, D., Kopp, A., and Halder, G. (2013) An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene 10.1038/onc.2013.82
6. Troyanovsky, B., Levchenko, T., Månsson, G., Matvijenko, O., and Holmgren, L. (2001) Angiomotin. An angiostatin binding protein that regulates endothelial cell migration and tube formation. J. Cell Biol. 152, 1247-1254
7. Bratt, A., Wilson, W. J., Troyanovsky, B., Aase, K., Kessler, R., Van Meir, E. G., Holmgren, L., and Meir, E. G. (2002) Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. Gene 298, 69-77
8. Ernkvist, M., Aase, K., Ukomadu, C., Wohlschlegel, J., Blackman, R., Veitonmäki, N., Bratt, A., Dutta, A., and Holmgren, L. (2006) p130-angiomotin associates to actin and controls endothelial cell shape. FEBS J. 273, 2000-2011
9. Levchenko, T., Bratt, A., Arbiser, J. L., and Holmgren, L. (2004) Angiomotin expression promotes hemangioendothelioma invasion. Oncogene 23, 1469-1473
10. Jiang, W. G., Watkins, G., Douglas-Jones, A., Holmgren, L., and Mansel, R. E. (2006) Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer. BMC Cancer 6, 16
11. Ernkvist, M., Birot, O., Sinha, I., Veitonmaki, N., Nyström, S., Aase, K., and Holmgren, L. (2008) Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells. Biochim. Biophys. Acta 1783, 429-437
12. Bratt, A., Birot, O., Sinha, I., Veitonmäki, N., Aase, K., Ernkvist, M., and Holmgren, L. (2005) Angiomotin regulates endothelial cell-cell junctions and cell motility. J. Biol. Chem. 280, 34859-34869
13. Chan, S. W., Lim, C. J., Chong, Y. F., Pobbati, A. V., Huang, C., and Hong, W. (2011) Hippo pathway-independent restriction of TAZ and YAP by angiomotin. J. Biol. Chem. 286, 7018-7026
14. Zhao, B., Li, L., Lu, Q., Wang, L. H., Liu, C. Y., Lei, Q., and Guan, K. L. (2011) Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev. 25, 51-63
15. Wang, W., Huang, J., and Chen, J. (2011) Angiomotin-like proteins associate with and negatively regulate YAP1. J. Biol. Chem. 286, 4364-4370
16. Yi, C., Troutman, S., Fera, D., Stemmer-Rachamimov, A., Avila, J. L., Christian, N., Persson, N. L., Shimono, A., Speicher, D. W., Marmorstein, R., Holmgren, L., and Kissil, J. L. (2011) A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. Cancer Cell 19, 527-540
17. Chan, S. W., Lim, C. J., Guo, K., Ng, C. P., Lee, I., Hunziker, W., Zeng, Q., and Hong, W. (2008) A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res. 68, 2592-2598
18. Chan, S. W., Lim, C. J., Loo, L. S., Chong, Y. F., Huang, C., and Hong, W. (2009) TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J. Biol. Chem. 284, 14347-14358
19. Chan, S. W., Lim, C. J., Huang, C., Chong, Y. F., Gunaratne, H. J., Hogue, K. A., Blackstock, W. P., Harvey, K. F., and Hong, W. (2011)WWdomainmediated interaction with Wbp2 is important for the oncogenic property of TAZ. Oncogene 30, 600-610
20. Paramasivam, M., Sarkeshik, A., Yates, J. R., 3rd, Fernandes, M. J., and McCollum, D. (2011) Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor. Mol. Biol. Cell 22, 3725-3733
21. Wells, C. D., Fawcett, J. P., Traweger, A., Yamanaka, Y., Goudreault, M., Elder, K., Kulkarni, S., Gish, G., Virag, C., Lim, C., Colwill, K., Starostine, A., Metalnikov, P., and Pawson, T. (2006) A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell 125, 535-548
22. Dai, X., She, P., Chi, F., Feng, Y., Liu, H., Jin, D., Zhao, Y., Guo, X., Jiang, D., Guan, K. L., Zhong, T. P., and Zhao, B. (2013) Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration and angiogenesis. J. Biol. Chem. 288, 34041-34051
23. Hirate, Y., Hirahara, S., Inoue, K., Suzuki, A., Alarcon, V. B., Akimoto, K., Hirai, T., Hara, T., Adachi, M., Chida, K., Ohno, S., Marikawa, Y., Nakao, K., Shimono, A., and Sasaki, H. (2013) Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr. Biol. 23, 1181-1194
24. Adler, J. J., Johnson, D. E., Heller, B. L., Bringman, L. R., Ranahan, W. P., Conwell, M. D., Sun, Y., Hudmon, A., and Wells, C. D. (2013) Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases. Proc. Natl. Acad. Sci. U.S.A. 110, 17368-17373