Hippo signaling regulates pancreas development through inactivation of yap

Molecular and Cellular Biology

Volumn 32, Issue 24, 2012, Pages 5116-5128

  George, Nicholas M ^a,b   Day, Caroline E ^a,b   Boerner, Brian P ^a,b   Johnson, Randy L ^c   Sarvetnick, Nora E ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; UNCLASSIFIED DRUG; YAP PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EXOCRINE SECRETION; FEMALE; GENE DELETION; HIPPO SIGNALING; MALE; MOUSE; NONHUMAN; ORGANOGENESIS; PANCREAS DEVELOPMENT; PANCREATITIS; PRIORITY JOURNAL; PROGENY; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEPATOCYTE GROWTH FACTOR; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, KNOCKOUT; PANCREAS; PHOSPHOPROTEINS; PREGNANCY; PROTEIN STABILITY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 84871862870     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01034-12     Document Type: Article

References (36)

1. Adler G, Hupp T, Kern HF. 1979. Course and spontaneous regression of acute pancreatitis in the rat. Virchows Arch. A Pathol. Anat. Histol. 382: 31-47.
2. Bonner-Weir S, et al. 2004. The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr. Diabetes 5:16-22.
3. Cai J, et al. 2010. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 24:2383-2388.
4. Camargo FD, et al. 2007. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr. Biol. 17:2054-2060.
5. Criscimanna A, et al. 2011. Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice. Gastroenterology 141:1451-1462.
6. Desgraz R, Herrera PL. 2009. Pancreatic neurogenin 3-expressing cells are unipotent islet precursors. Development 136:3567-3574.
7. Dong J, et al. 2007. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130:1120-1133.
8. Gradwohl G, Dierich A, LeMeur M, Guillemot F. 2000. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. U. S. A. 97:1607-1611.
9. + cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457.
10. Heallen T, et al. 2011. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 332:458-461.
11. Heiser PW, Lau J, Taketo MM, Herrera PL, Hebrok M. 2006. Stabilization of beta-catenin impacts pancreas growth. Development 133:2023-2032.
12. Hingorani SR, et al. 2003. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4:437-450.
13. Inada A, et al. 2008. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc. Natl. Acad. Sci. U. S. A. 105:19915-19919.
14. + cells to the developing and adult pancreas. Development 138: 431-441.
15. Kopp JL, et al. 2011. Progenitor cell domains in the developing and adult pancreas. Cell Cycle 10:1921-1927.
16. Krapp A, et al. 1998. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 12:3752-3763.
17. Laplante M, Sabatini DM. 2012. mTOR signaling in growth control and disease. Cell 149:274-293.
18. Lu L, et al. 2010. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc. Natl. Acad. Sci. U. S. A. 107:1437-1442.
19. Pan D. 2010. The Hippo signaling pathway in development and cancer. Dev. Cell 19:491-505.
20. Pan FC, Wright C. 2011. Pancreas organogenesis: from bud to plexus to gland. Dev. Dyn. 240:530-565.
21. Pictet RL, Clark WR, Williams RH, Rutter WJ. 1972. An ultrastructural analysis of the developing embryonic pancreas. Dev. Biol. 29:436-467.
22. Pin CL, Rukstalis JM, Johnson C, Konieczny SF. 2001. The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J. Cell Biol. 155:519-530.
23. Rovira M, et al. 2010. Isolation and characterization of centroacinar/ terminal ductal progenitor cells in adult mouse pancreas. Proc. Natl. Acad. Sci. U. S. A. 107:75-80.
24. Schlegelmilch K, et al. 2011. Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell 144:782-795.
25. Song H, et al. 2010. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc. Natl. Acad. Sci. U. S. A. 107:1431-1436.
26. Stanger BZ, et al. 2005. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 8:185-195.
27. Stanger BZ, Tanaka AJ, Melton DA. 2007. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 445:886-891.
28. Strom A, et al. 2007. Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134: 2719-2725.
29. Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML. 2001. TEAD/ TEF transcription factors utilize the activation domain of YAP65, a Src/ Yes-associated protein localized in the cytoplasm. Genes Dev. 15:1229-1241.
30. Zhang H, Pasolli HA, Fuchs E. 2011. Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc. Natl. Acad. Sci. U. S. A. 108:2270-2275.
31. Zhao B, et al. 2007. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 21:2747-2761.
32. Zhao B, et al. 2008. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 22:1962-1971.
33. Zhao B, Li L, Lei Q, Guan KL. 2010. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev. 24:862-874.
34. Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. 2010. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF (beta-TRCP). Genes Dev. 24:72-85.
35. Zhou D, et al. 2011. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yesassociated protein (Yap) overabundance. Proc. Natl. Acad. Sci. U. S. A. 108:E1312-E1320.
36. Zhou Q, et al. 2007. A multipotent progenitor domain guides pancreatic organogenesis. Dev. Cell 13:103-114.