The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFβ-TrCP E3 ligase

Journal of Biological Chemistry

Volumn 285, Issue 48, 2010, Pages 37159-37169

  Liu, Chen Ying ^a,b   Zha, Zheng Yu ^a   Zhou, Xin ^a,b   Zhang, Heng ^a,b   Huang, Wei ^a,b   Zhao, Di ^a,b   Li, Tingting ^a,b   Chan, Siew Wee ^c   Lim, Chun Jye ^c   Hong, Wanjin ^c   Zhao, Shimin ^a   Xiong, Yue ^a,b,d   Lei, Qun Ying ^a,b   Guan, Kun Liang ^a,b,e  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; CYTOPLASMIC LOCALIZATION; E3 LIGASE; EPITHELIAL-MESENCHYMAL TRANSITION; NUCLEAR ACCUMULATION; PROTEIN STABILITY; TUMOR SUPPRESSORS;

CELL PROLIFERATION; PHOSPHORYLATION; TUMORS;

DEGRADATION;

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; CASEIN KINASE I; CASEIN KINASE IEPSILON; CELL PROTEIN; LATS PROTEIN; PROTEASOME; TAZ PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; IN VITRO STUDY; PHOSPHODEGRON; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; CASEIN KINASE I; DROSOPHILA PROTEINS; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; TRANSCRIPTION FACTORS;

EID: 78549275131     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.152942     Document Type: Article

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