Yes-associated protein isoform 1 (Yapl) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury

Journal of Biological Chemistry

Volumn 288, Issue 6, 2013, Pages 3977-3988

  Del Re, Dominic P ^a   Yang, Yanfei ^a   Nakano, Noritsugu ^a   Cho, Jaeyeaon ^a   Zhai, Peiyong ^a   Yamamoto, Takanobu ^a   Zhang, Nailing ^b   Yabuta, Norikazu ^c   Nojima, Hiroshi ^c   Pan, Duojia ^b   Sadoshima, Junichi ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; CELL DEATH; GENE EXPRESSION; MAMMALS; PATHOLOGY;

CARDIAC FUNCTIONS; CARDIOMYOCYTE SURVIVAL; CARDIOMYOCYTES; DILATED CARDIOMYOPATHY; HEART DEVELOPMENT; ISCHEMIC INJURIES; MYOCARDIAL INFARCTION; PREMATURE DEATH;

HEART;

HYDROGEN PEROXIDE; PHENYLEPHRINE; TRANSCRIPTION FACTOR YAP1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL GROWTH; CELL ISOLATION; CELL PROLIFERATION; CELL PROTECTION; CELL SIZE; CELL SURVIVAL; CHRONIC DISEASE; CONTROLLED STUDY; FIBROSIS; GENE EXPRESSION; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HETEROZYGOSITY; HOMEOSTASIS AND REGULATION; HOMOZYGOSITY; HYPERTROPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRESS;

EID: 84873665320     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.436311     Document Type: Article

References (30)

1. Velagaleti, R. S., Pencina, M. J., Murabito, J. M., Wang, T. J., Parikh, N. I., D'Agostino, R. B., Levy, D., Kannel, W. B., and Vasan, R. S. (2008) Long term trends in the incidence of heart failure after myocardial infarction. Circulation 118, 2057-2062
2. Narula, J., Haider, N., Virmani, R., DiSalvo, T. G., Kolodgie, F. D., Hajjar, R. J., Schmidt, U., Semigran, M. J., Dec, G. W., and Khaw, B. A. (1996) Apoptosis in myocytes in end-stage heart failure. N. Engl. J. Med. 335, 1182-1189
3. Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., Reed, J. C., and Anversa, P. (1997) Apoptosis in the failing human heart. N. Engl. J. Med. 336, 1131-1141
4. Mani, K., and Kitsis, R. N. (2003) Myocyte apoptosis. Programming ventricular remodeling. J. Am. Coll. Cardiol. 41, 761-764
5. Pan, D. (2010) The Hippo signaling pathway in development and cancer. Dev. Cell 19, 491-505
6. Badouel, C., Garg, A., and McNeill, H. (2009) Herding Hippos. Regulating growth in flies and man. Curr. Opin. Cell Biol. 21, 837-843
7. Halder, G., and Johnson, R. L. (2011) Hippo signaling. Growth control and beyond. Development 138, 9-22
8. Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., and Pan, D. (2007) Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130, 1120-1133
9. Camargo, F.D., Gokhale, S., Johnnidis, J.B., Fu, D., Bell, G. W., Jaenisch, R., and Brummelkamp, T. R. (2007) YAP1 increases organ size and expands undifferentiated progenitor cells. Curr. Biol. 17, 2054-2060
10. Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., and Pan, D. (2010) The Merlin/NF2 tumor suppressor functions through the YAP oncoproteintoregulate tissue homeostasis in mammals. Dev. Cell 19, 27-38
11. Xin, M., Kim, Y., Sutherland, L. B., Qi, X., McAnally, J., Schwartz, R. J., Richardson, J. A., Bassel-Duby, R., and Olson, E. N. (2011) Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci. Signal. 4, ra70
12. von Gise, A., Lin, Z., Schlegelmilch, K., Honor, L.B., Pan, G.M., Buck, J. N., Ma, Q., Ishiwata, T., Zhou, B., Camargo, F. D., and Pu, W. T. (2012) YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc. Natl. Acad. Sci. U.S.A. 109, 2394-2399
13. Agah, R., Frenkel, P. A., French, B. A., Michael, L. H., Overbeek, P. A., and Schneider, M. D. (1997) Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J. Clin. Invest. 100, 169-179
14. Odashima, M., Usui, S., Takagi, H., Hong, C., Liu, J., Yokota, M., and Sadoshima, J. (2007) Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myo-cardial infarction. Circ. Res. 100, 1344-1352
15. Sciarretta, S., Zhai, P., Shao, D., Maejima, Y., Robbins, J., Volpe, M., Con-dorelli, G., and Sadoshima, J. (2012) Rheb is a critical regulator of au-tophagy during myocardial ischemia. Pathophysiological implications in obesity and metabolic syndrome. Circulation 125, 1134-1146
16. Matsui, Y., Nakano, N., Shao, D., Gao, S., Luo, W., Hong, C., Zhai, P., Holle, E., Yu, X., Yabuta, N., Tao, W., Wagner, T., Nojima, H., and Sa-doshima, J. (2008) Lats2 is a negative regulator ofmyocyte size inthe heart. Circ. Res. 103, 1309-1318
17. Yamamoto, S., Yang, G., Zablocki, D., Liu, J., Hong, C., Kim, S. J., Soler, S., Odashima, M., Thaisz, J., Yehia, G., Molina, C. A., Yatani, A., Vatner, D.E., Vatner, S. F., and Sadoshima, J. (2003) Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J. Clin. Invest. 111, 1463-1474
18. Yabuta, N., Okada, N., Ito, A., Hosomi, T., Nishihara, S., Sasayama, Y., Fujimori, A., Okuzaki, D., Zhao, H., Ikawa, M., Okabe, M., and Nojima, H. (2007) Lats2 is an essential mitotic regulator required for the coordination of cell division. J. Biol. Chem. 282, 19259-19271
19. Beltrami, A. P., Urbanek, K., Kajstura, J., Yan, S. M., Finato, N., Bussani, R., Nadal-Ginard, B., Silvestri, F., Leri, A., Beltrami, C. A., and Anversa, P. (2001) Evidence that human cardiac myocytes divide after myocardial infarction. N. Engl. J. Med. 344, 1750-1757
20. Heallen, T., Zhang, M., Wang, J., Bonilla-Claudio, M., Klysik, E., Johnson, R. L., and Martin, J. F. (2011) Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 332, 458-461
21. Del Re, D. P., Matsuda, T., Zhai, P., Gao, S., Clark, G. J., Van Der Weyden, L., and Sadoshima, J. (2010) Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J. Clin. Invest. 120, 3555-3567
22. Morisco, C., Zebrowski, D., Condorelli, G., Tsichlis, P., Vatner, S. F., and Sadoshima, J. (2000) The Akt-glycogen synthase kinase 3/3 pathway regulates transcription of atrial natriuretic factor induced by β-adrenergic receptor stimulation in cardiac myocytes. J. Biol. Chem. 275, 14466-14475
23. Zhou, D., Conrad, C, Xia, F., Park, J. S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W., Lee, J. T., Avruch, J., and Bardeesy, N. (2009) Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16, 425-438
24. Lu, L., Li, Y., Kim, S. M., Bossuyt, W., Liu, P., Qiu, Q., Wang, Y., Halder, G., Finegold, M. J., Lee, J. S., and Johnson, R. L. (2010) Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc. Natl. Acad. Sci. U.S.A. 107, 1437-1442
25. Song, H, Mak, K. K., Topol, L., Yun, K., Hu, J., Garrett, L., Chen, Y., Park, O., Chang, J., Simpson, R. M., Wang, C. Y., Gao, B., Jiang, J., and Yang, Y. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc. Natl. Acad. Sci. U.S.A. 107, 1431-1436
26. Conrad, C. H., Brooks, W. W., Hayes, J. A., Sen, S., Robinson, K. G., and Bing, O. H. (1995) Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat. Circulation 91, 161-170
27. Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C, and Kitsis, R. N. (2003) A mechanistic role for cardiac myocyte apoptosis in heart failure. J. Clin. Invest. 111, 1497-1504
28. Zhao, B., Tumaneng, K., and Guan, K. L. (2011) The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol. 13, 877-883
29. Zhao, B., Li, L., Lei, Q., and Guan, K. L. (2010) The Hippo-YAP pathway in organ size control and tumorigenesis. An updated version. Genes Dev. 24, 862-874
30. Thompson, B. J., and Cohen, S. M. (2006) The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Dro-sophila. Cell 126, 767-774