Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP

Oncogene

Volumn 31, Issue 1, 2012, Pages 128-134

  Oka, T ^a,d   Schmitt, A P ^b   Sudol, M ^a,c  

^a WEIS CENTER FOR RESEARCH   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

angiomotin family; apoptosis; cell detachment; PDZ domains; WW domains; YAP as scaffold

Indexed keywords

ANGIOMOTIN; PROTEIN; PROTEIN ZO2; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN;

APOPTOSIS; ARTICLE; CELL STRAIN HEK293; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; ONCOGENE; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; YAP GENE;

APOPTOSIS; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS;

EID: 84855344741     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.216     Document Type: Article

References (23)

1. Basu S, Totty NF, Irwin MS, Sudol M, Downward J. (2003). Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell 11: 11-23. (Pubitemid 36126587)
2. Bratt A, Birot O, Sinha I, Veitonmaki N, Aase K, Ernkvist M et al. (2005). Angiomotin regulates endothelial cell-cell junctions and cell motility. J Biol Chem 280: 34859-34869. (Pubitemid 41504620)
3. Bratt A, Wilson WJ, Troyanovsky B, Aase K, Kessler R, Van Meir EG et al. (2002). Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. Gene 298: 69-77. (Pubitemid 35284264)
4. Chan SW, Lim CJ, Chong YF, Pobbati AV, Huang C, Hong W. (2011). Hippo pathway-independent restriction of TAZ and YAP by angiomotin. J Biol Chem 286: 7018-7026.
5. Ehsanian R, Brown M, Lu H, Yang XP, Pattatheyil A, Yan B et al. (2010). YAP dysregulation by phosphorylation or DeltaNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets. Oncogene 29: 6160-6171.
6. Matallanas D, Romano D, Yee K, Meissl K, Kucerova L, Piazzolla D et al. (2007). RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell 27: 962-975. (Pubitemid 47495894)
7. Matsuda T, Cepko CL. (2007). Controlled expression of transgenes introduced by in vivo electroporation. Proc Natl Acad Sci USA 104: 1027-1032. (Pubitemid 46154730)
8. Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y et al. (2002). JEAP, a novel component of tight junctions in exocrine cells. J Biol Chem 277: 5583-5587. (Pubitemid 34968611)
9. Oka T, Mazack V, Sudol M. (2008). Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J Biol Chem 283: 27534-27546.
10. Oka T, Remue E, Meerschaert K, Vanloo B, Boucherie C, Gfeller D et al. (2010). Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling. Biochem J 432: 461-472.
11. Oka T, Sudol M. (2009). Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif. Genes Cells 14: 607-615.
12. Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC et al. (2006). Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci USA 103:12405-12410. (Pubitemid 44267272)
13. Pan D. (2010). The hippo signaling pathway in development and cancer. Dev Cell 19: 491-505.
14. Pei Z, Bai Y, Schmitt AP. (2010). PIV5M protein interaction with host protein angiomotin-like 1. Virology 397: 155-166.
15. Sowa ME, Bennett EJ, Gygi SP, Harper JW. (2009). Defining the human deubiquitinating enzyme interaction landscape. Cell 138: 389-403.
16. Strano S, Munarriz E, Rossi M, Castagnoli L, Shaul Y, Sacchi A et al. (2001). Physical interaction with Yes-associated protein enhancesp73 transcriptional activity. J Biol Chem 276: 15164-15173.
17. Sudol M, Harvey KF. (2010). Modularity in the Hippo signaling pathway. Trends Biochem Sci 35: 627-633.
18. Sudol M. (2010). Newcomers to the WW domain-mediated network of the Hippo tumor suppressor pathway. Genes Cancer 1: 1115-1118.
19. Sugihara-Mizuno Y, Adachi M, Kobayashi Y, Hamazaki Y,Nishimura M, Imai T et al. (2007). Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patjand their endogenous properties. Genes Cells 12: 473-486. (Pubitemid 46488583)
20. Troyanovsky B, Levchenko T, Mansson G, Matvijenko O,Holmgren L. (2001). Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation. J Cell Biol 152: 1247-1254. (Pubitemid 34280181)
21. Wang W, Huang J, Chen J. (2011). Angiomotin-like Proteins Associate with and Negatively Regulate YAP1. J Biol Chem 286: 4364-4370.
22. Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Hanada T et al. (2008). Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death Differ 15: 1752-1759.
23. Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q et al. (2011). Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev 25: 51-63.