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Volumn 26, Issue 1, 2012, Pages 54-68

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

Author keywords

Anoikis; Cancer metastasis; Lats; Phosphorylation; YAP

Indexed keywords

ACTIN; CELL PROTEIN; PROTEIN HIPPO; PROTEIN KINASE; PROTEIN LATS1; PROTEIN LATS2; PROTEIN YAP; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84855326431     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.173435.111     Document Type: Article
Times cited : (637)

References (53)
  • 3
    • 55949128465 scopus 로고    scopus 로고
    • Anoikis: A necessary death program for anchorage-dependent cells
    • Chiarugi P, Giannoni E. 2008. Anoikis: A necessary death program for anchorage-dependent cells. Biochem Pharmacol 76: 1352-1364.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1352-1364
    • Chiarugi, P.1    Giannoni, E.2
  • 6
    • 79956327002 scopus 로고    scopus 로고
    • Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila
    • Fernandez BG, Gaspar P, Bras-Pereira C, Jezowska B, Rebelo SR, Janody F. 2011. Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development 138: 2337-2346.
    • (2011) Development , vol.138 , pp. 2337-2346
    • Fernandez, B.G.1    Gaspar, P.2    Bras-Pereira, C.3    Jezowska, B.4    Rebelo, S.R.5    Janody, F.6
  • 7
    • 78649737455 scopus 로고    scopus 로고
    • The extracellular matrix at a glance
    • Frantz C, Stewart KM, Weaver VM. 2010. The extracellular matrix at a glance. J Cell Sci 123: 4195-4200.
    • (2010) J Cell Sci , vol.123 , pp. 4195-4200
    • Frantz, C.1    Stewart, K.M.2    Weaver, V.M.3
  • 9
    • 78650724753 scopus 로고    scopus 로고
    • Hippo signaling: Growth control and beyond
    • Halder G, Johnson RL. 2011. Hippo signaling: Growth control and beyond. Development 138: 9-22.
    • (2011) Development , vol.138 , pp. 9-22
    • Halder, G.1    Johnson, R.L.2
  • 10
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 11
    • 41949138130 scopus 로고    scopus 로고
    • Tumor suppressor LATS1 is a negative regulator of oncogene YAP
    • Hao Y, Chun A, Cheung K, Rashidi B, Yang X. 2008. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem 283: 5496-5509.
    • (2008) J Biol Chem , vol.283 , pp. 5496-5509
    • Hao, Y.1    Chun, A.2    Cheung, K.3    Rashidi, B.4    Yang, X.5
  • 12
    • 0042733354 scopus 로고    scopus 로고
    • The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    • Harvey KF, Pfleger CM, Hariharan IK. 2003. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114: 457-467.
    • (2003) Cell , vol.114 , pp. 457-467
    • Harvey, K.F.1    Pfleger, C.M.2    Hariharan, I.K.3
  • 13
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    • Huang J, Wu S, Barrera J, Matthews K, Pan D. 2005. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122: 421-434.
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3    Matthews, K.4    Pan, D.5
  • 14
    • 0142123293 scopus 로고    scopus 로고
    • The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis
    • Jia J, Zhang W, Wang B, Trinko R, Jiang J. 2003. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev 17: 2514-2519.
    • (2003) Genes Dev , vol.17 , pp. 2514-2519
    • Jia, J.1    Zhang, W.2    Wang, B.3    Trinko, R.4    Jiang, J.5
  • 15
    • 0028902594 scopus 로고
    • The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
    • Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. 1995. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev 9: 534-546.
    • (1995) Genes Dev , vol.9 , pp. 534-546
    • Justice, R.W.1    Zilian, O.2    Woods, D.F.3    Noll, M.4    Bryant, P.J.5
  • 17
    • 79961087833 scopus 로고    scopus 로고
    • E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
    • Kim NG, Koh E, Chen X, Gumbiner BM. 2011. E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci 108: 11930-11935.
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 11930-11935
    • Kim, N.G.1    Koh, E.2    Chen, X.3    Gumbiner, B.M.4
  • 19
    • 79953310106 scopus 로고    scopus 로고
    • Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF
    • Lai D, Ho KC, Hao Y, Yang X. 2011. Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res 71: 2728-2738.
    • (2011) Cancer Res , vol.71 , pp. 2728-2738
    • Lai, D.1    Ho, K.C.2    Hao, Y.3    Yang, X.4
  • 21
    • 41149098966 scopus 로고    scopus 로고
    • TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
    • Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan KL. 2008. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol 28: 2426-2436.
    • (2008) Mol Cell Biol , vol.28 , pp. 2426-2436
    • Lei, Q.Y.1    Zhang, H.2    Zhao, B.3    Zha, Z.Y.4    Bai, F.5    Pei, X.H.6    Zhao, S.7    Xiong, Y.8    Guan, K.L.9
  • 22
    • 78549275131 scopus 로고    scopus 로고
    • The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFb-TrCP E3 ligase
    • Liu CY, Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, Li T, Chan SW, Lim CJ, Hong W, et al. 2010. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFb-TrCP E3 ligase. J Biol Chem 285: 37159-37169.
    • (2010) J Biol Chem , vol.285 , pp. 37159-37169
    • Liu, C.Y.1    Zha, Z.Y.2    Zhou, X.3    Zhang, H.4    Huang, W.5    Zhao, D.6    Li, T.7    Chan, S.W.8    Lim, C.J.9    Hong, W.10
  • 24
    • 70549098542 scopus 로고    scopus 로고
    • Cytoskeletal control of growth and cell fate switching
    • Mammoto A, Ingber DE. 2009. Cytoskeletal control of growth and cell fate switching. Curr Opin Cell Biol 21: 864-870.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 864-870
    • Mammoto, A.1    Ingber, D.E.2
  • 26
    • 44449111555 scopus 로고    scopus 로고
    • Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    • Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. 2008. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 68: 3645- 3654.
    • (2008) Cancer Res , vol.68 , pp. 3645-3654
    • Onder, T.T.1    Gupta, P.B.2    Mani, S.A.3    Yang, J.4    Lander, E.S.5    Weinberg, R.A.6
  • 28
    • 77957883342 scopus 로고    scopus 로고
    • The hippo signaling pathway in development and cancer
    • Pan D. 2010. The hippo signaling pathway in development and cancer. Dev Cell 19: 491-505.
    • (2010) Dev Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 29
    • 0141505119 scopus 로고    scopus 로고
    • The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
    • Pantalacci S, Tapon N, Leopold P. 2003. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol 5: 921-927.
    • (2003) Nat Cell Biol , vol.5 , pp. 921-927
    • Pantalacci, S.1    Tapon, N.2    Leopold, P.3
  • 30
    • 77956064817 scopus 로고    scopus 로고
    • Cell adhesion: Integrating cytoskeletal dynamics and cellular tension
    • Parsons JT, Horwitz AR, Schwartz MA. 2010. Cell adhesion: Integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol 11: 633-643.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 633-643
    • Parsons, J.T.1    Horwitz, A.R.2    Schwartz, M.A.3
  • 31
    • 40149111984 scopus 로고    scopus 로고
    • MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
    • Praskova M, Xia F, Avruch J. 2008. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol 18: 311-321.
    • (2008) Curr Biol , vol.18 , pp. 311-321
    • Praskova, M.1    Xia, F.2    Avruch, J.3
  • 34
    • 79957462240 scopus 로고    scopus 로고
    • a-Catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1
    • doi: 10.1126/scisignal.2001823
    • Silvis MR, Kreger BT, Lien WH, Klezovitch O, Rudakova GM, Camargo FD, Lantz DM, Seykora JT, Vasioukhin V. 2011. a-Catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal 4: ra33. doi: 10.1126/scisignal.2001823.
    • (2011) Sci Signal , vol.4
    • Silvis, M.R.1    Kreger, B.T.2    Lien, W.H.3    Klezovitch, O.4    Rudakova, G.M.5    Camargo, F.D.6    Lantz, D.M.7    Seykora, J.T.8    Vasioukhin, V.9
  • 37
    • 0037162714 scopus 로고    scopus 로고
    • Hariharan IK. 2002. salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    • Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK. 2002. salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110: 467-478.
    • Cell , vol.110 , pp. 467-478
    • Tapon, N.1    Harvey, K.F.2    Bell, D.W.3    Wahrer, D.C.4    Schiripo, T.A.5    Haber, D.A.6
  • 39
    • 0141616617 scopus 로고    scopus 로고
    • Hippo promotes proliferation arrest and apoptosis in the Salvador/ Warts pathway
    • Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G. 2003. Hippo promotes proliferation arrest and apoptosis in the Salvador/ Warts pathway. Nat Cell Biol 5: 914-920.
    • (2003) Nat Cell Biol , vol.5 , pp. 914-920
    • Udan, R.S.1    Kango-Singh, M.2    Nolo, R.3    Tao, C.4    Halder, G.5
  • 41
    • 80051923057 scopus 로고    scopus 로고
    • Hippo pathway regulation by cell morphology and stress fibers
    • Wada K, Itoga K, Okano T, Yonemura S, Sasaki H. 2011. Hippo pathway regulation by cell morphology and stress fibers. Development 138: 3907-3914.
    • (2011) Development , vol.138 , pp. 3907-3914
    • Wada, K.1    Itoga, K.2    Okano, T.3    Yonemura, S.4    Sasaki, H.5
  • 42
    • 79953010044 scopus 로고    scopus 로고
    • Angiomotin-like proteins associate with and negatively regulate YAP1
    • Wang W, Huang J, Chen J. 2011. Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem 286: 4364-4370.
    • (2011) J Biol Chem , vol.286 , pp. 4364-4370
    • Wang, W.1    Huang, J.2    Chen, J.3
  • 43
    • 0042232429 scopus 로고    scopus 로고
    • Pan D. 2003. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    • Wu S, Huang J, Dong J, Pan D. 2003. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114: 445-456.
    • Cell , vol.114 , pp. 445-456
    • Wu, S.1    Huang, J.2    Dong, J.3
  • 44
    • 0028929414 scopus 로고
    • Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene encodes a putative protein kinase
    • Xu T, Wang W, Zhang S, Stewart RA, Yu W. 1995. Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene encodes a putative protein kinase. Development 121: 1053-1063.
    • (1995) Development , vol.121 , pp. 1053-1063
    • Xu, T.1    Wang, W.2    Zhang, S.3    Stewart, R.A.4    Yu, W.5
  • 48
    • 79952297528 scopus 로고    scopus 로고
    • Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
    • Zhang H, Pasolli HA, Fuchs E. 2011. Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci 108: 2270-2275.
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 2270-2275
    • Zhang, H.1    Pasolli, H.A.2    Fuchs, E.3
  • 49
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, et al. 2007. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 21: 2747-2761.
    • (2007) Genes Dev , vol.21 , pp. 2747-2761
    • Zhao, B.1    Wei, X.2    Li, W.3    Udan, R.S.4    Yang, Q.5    Kim, J.6    Xie, J.7    Ikenoue, T.8    Yu, J.9    Li, L.10
  • 51
    • 73549095761 scopus 로고    scopus 로고
    • A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(b-TRCP)
    • Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. 2010. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(b-TRCP). Genes Dev 24: 72-85.
    • (2010) Genes Dev , vol.24 , pp. 72-85
    • Zhao, B.1    Li, L.2    Tumaneng, K.3    Wang, C.Y.4    Guan, K.L.5
  • 52
    • 78650895035 scopus 로고    scopus 로고
    • Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
    • Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q, Guan KL. 2011. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev 25: 51-63.
    • (2011) Genes Dev , vol.25 , pp. 51-63
    • Zhao, B.1    Li, L.2    Lu, Q.3    Wang, L.H.4    Liu, C.Y.5    Lei, Q.6    Guan, K.L.7
  • 53
    • 70350502865 scopus 로고    scopus 로고
    • Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    • Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, et al. 2009. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16: 425-438.
    • (2009) Cancer Cell , vol.16 , pp. 425-438
    • Zhou, D.1    Conrad, C.2    Xia, F.3    Park, J.S.4    Payer, B.5    Yin, Y.6    Lauwers, G.Y.7    Thasler, W.8    Lee, J.T.9    Avruch, J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.