XSpatial organization of hippo signaling at the plasma membrane mediated by the tumor suppressor merlin/NF2

Cell

Volumn 154, Issue 6, 2013, Pages 1342-

  Yin, Feng ^a   Yu, Jianzhong ^a   Zheng, Yonggang ^a   Chen, Qian ^a   Zhang, Nailing ^a   Pan, Duojia ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIPPO PROTEIN; LONG ACTING THYROID STIMULATOR; MERLIN; PROTEIN; UNCLASSIFIED DRUG; WTS PROTEIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVITY; GENE INTERACTION; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MALE; MISSENSE MUTATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA INTERFERENCE; SCHWANN CELL; SIGNAL TRANSDUCTION; WILD TYPE;

MAMMALIA;

EID: 84884291548     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2013.08.025     Document Type: Article

References (48)

1. I. Ahronowitz, W. Xin, R. Kiely, K. Sims, M. MacCollin, and F.P. Nunes Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings Hum. Mutat. 28 2007 1 12
2. J. Bischof, R.K. Maeda, M. Hediger, F. Karch, and K. Basler An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases Proc. Natl. Acad. Sci. USA 104 2007 3312 3317
3. W. Bossuyt, C.L. Chen, Q. Chen, M. Sudol, H. McNeill, D. Pan, A. Kopp, and G. Halder An evolutionary shift in the regulation of the Hippo pathway between mice and flies Oncogene 2013 10.1038/onc.2013.82 Published online April 8, 2013
4. A. Bretscher, K. Edwards, and R.G. Fehon ERM proteins and merlin: integrators at the cell cortex Nat. Rev. Mol. Cell Biol. 3 2002 586 599
5. J. Cai, N. Zhang, Y. Zheng, R.F. de Wilde, A. Maitra, and D. Pan The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program Genes Dev. 24 2010 2383 2388
6. S. Dupont, L. Morsut, M. Aragona, E. Enzo, S. Giulitti, M. Cordenonsi, F. Zanconato, J. Le Digabel, M. Forcato, and S. Bicciato Role of YAP/TAZ in mechanotransduction Nature 474 2011 179 183
7. B.G. Fernández, P. Gaspar, C. Brás-Pereira, B. Jezowska, S.R. Rebelo, and F. Janody Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila Development 138 2011 2337 2346
8. A. Genevet, M.C. Wehr, R. Brain, B.J. Thompson, and N. Tapon Kibra is a regulator of the Salvador/Warts/Hippo signaling network Dev. Cell 18 2010 300 308
9. M. Giovannini, E. Robanus-Maandag, M. van der Valk, M. Niwa-Kawakita, V. Abramowski, L. Goutebroze, J.M. Woodruff, A. Berns, and G. Thomas Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2 Genes Dev. 14 2000 1617 1630
10. M.C. Good, J.G. Zalatan, and W.A. Lim Scaffold proteins: hubs for controlling the flow of cellular information Science 332 2011 680 686
11. J.T. Groves, and J. Kuriyan Molecular mechanisms in signal transduction at the membrane Nat. Struct. Mol. Biol. 17 2010 659 665
12. G. Halder, and R.L. Johnson Hippo signaling: growth control and beyond Development 138 2011 9 22
13. F. Hamaratoglu, M. Willecke, M. Kango-Singh, R. Nolo, E. Hyun, C. Tao, H. Jafar-Nejad, and G. Halder The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis Nat. Cell Biol. 8 2006 27 36
14. K. Harvey, and N. Tapon The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network Nat. Rev. Cancer 7 2007 182 191
15. A. Hergovich, S.J. Bichsel, and B.A. Hemmings Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation Mol. Cell. Biol. 25 2005 8259 8272
16. L.L. Ho, X. Wei, T. Shimizu, and Z.C. Lai Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila Dev. Biol. 337 2010 274 283
17. H. Jin, T. Sperka, P. Herrlich, and H. Morrison Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase Nature 442 2006 576 579
18. B.S. Kang, D.R. Cooper, Y. Devedjiev, U. Derewenda, and Z.S. Derewenda The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product Acta Crystallogr. D Biol. Crystallogr. 58 2002 381 391
19. M. Kango-Singh, R. Nolo, C. Tao, P. Verstreken, P.R. Hiesinger, H.J. Bellen, and G. Halder Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila Development 129 2002 5719 5730
20. D.R. LaJeunesse, B.M. McCartney, and R.G. Fehon Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization J. Cell Biol. 141 1998 1589 1599
21. W. Li, L. You, J. Cooper, G. Schiavon, A. Pepe-Caprio, L. Zhou, R. Ishii, M. Giovannini, C.O. Hanemann, and S.B. Long Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus Cell 140 2010 477 490
22. W. Li, J. Cooper, M.A. Karajannis, and F.G. Giancotti Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus EMBO Rep. 13 2012 204 215
23. L. Lu, Y. Li, S.M. Kim, W. Bossuyt, P. Liu, Q. Qiu, Y. Wang, G. Halder, M.J. Finegold, J.S. Lee, and R.L. Johnson Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver Proc. Natl. Acad. Sci. USA 107 2010 1437 1442
24. R.P. Metpally, and R. Sowdhamini Cross genome phylogenetic analysis of human and Drosophila G protein-coupled receptors: application to functional annotation of orphan receptors BMC Genomics 6 2005 106
25. R. Nguyen, D. Reczek, and A. Bretscher Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP J. Biol. Chem. 276 2001 7621 7629
26. D. Pan The hippo signaling pathway in development and cancer Dev. Cell 19 2010 491 505
27. T. Roeder Tyramine and octopamine: ruling behavior and metabolism Annu. Rev. Entomol. 50 2005 447 477
28. G.A. Rouleau, P. Merel, M. Lutchman, M. Sanson, J. Zucman, C. Marineau, K. Hoang-Xuan, S. Demczuk, C. Desmaze, and B. Plougastel Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2 Nature 363 1993 515 521
29. L. Sansores-Garcia, W. Bossuyt, K. Wada, S. Yonemura, C. Tao, H. Sasaki, and G. Halder Modulating F-actin organization induces organ growth by affecting the Hippo pathway EMBO J. 30 2011 2325 2335
30. H. Scheel, and K. Hofmann A novel interaction motif, SARAH, connects three classes of tumor suppressor Curr. Biol. 13 2003 R899 R900
31. R.J. Shaw, J.G. Paez, M. Curto, A. Yaktine, W.M. Pruitt, I. Saotome, J.P. O'Bryan, V. Gupta, N. Ratner, and C.J. Der The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling Dev. Cell 1 2001 63 72
32. I. Sher, C.O. Hanemann, P.A. Karplus, and A. Bretscher The tumor suppressor merlin controls growth in its open state, and phosphorylation converts it to a less-active more-closed state Dev. Cell 22 2012 703 705
33. G. Struhl, and A. Adachi Nuclear access and action of notch in vivo Cell 93 1998 649 660
34. E.I. Surace, C.A. Haipek, and D.H. Gutmann Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function Oncogene 23 2004 580 587
35. J.A. Trofatter, M.M. MacCollin, J.L. Rutter, J.R. Murrell, M.P. Duyao, D.M. Parry, R. Eldridge, N. Kley, A.G. Menon, and K. Pulaski A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor Cell 72 1993 791 800
36. K. Wada, K. Itoga, T. Okano, S. Yonemura, and H. Sasaki Hippo pathway regulation by cell morphology and stress fibers Development 138 2011 3907 3914
37. S. Wu, J. Huang, J. Dong, and D. Pan hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts Cell 114 2003 445 456
38. L. Xiao, Y. Chen, M. Ji, and J. Dong KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases J. Biol. Chem. 286 2011 7788 7796
39. F.X. Yu, B. Zhao, N. Panupinthu, J.L. Jewell, I. Lian, L.H. Wang, J. Zhao, H. Yuan, K. Tumaneng, and H. Li Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling Cell 150 2012 780 791
40. F.X. Yu, Y. Zhang, H.W. Park, J.L. Jewell, Q. Chen, Y. Deng, D. Pan, S.S. Taylor, Z.C. Lai, and K.L. Guan Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation Genes Dev. 27 2013 1223 1232
41. J. Yu, Y. Zheng, J. Dong, S. Klusza, W.M. Deng, and D. Pan Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded Dev. Cell 18 2010 288 299
42. N. Zhang, H. Bai, K.K. David, J. Dong, Y. Zheng, J. Cai, M. Giovannini, P. Liu, R.A. Anders, and D. Pan The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals Dev. Cell 19 2010 27 38
43. B. Zhao, L. Li, L. Wang, C.Y. Wang, J. Yu, and K.L. Guan Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis Genes Dev. 26 2012 54 68
44. D. Zhou, C. Conrad, F. Xia, J.S. Park, B. Payer, Y. Yin, G.Y. Lauwers, W. Thasler, J.T. Lee, J. Avruch, and N. Bardeesy Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene Cancer Cell 16 2009 425 438
45. J. Dong, G. Feldmann, J. Huang, S. Wu, N. Zhang, S.A. Comerford, M.F. Gayyed, R.A. Anders, A. Maitra, and D. Pan Elucidation of a universal size-control mechanism in Drosophila and mammals Cell 130 2007 1120 1133
46. C. Gonzalez-Agosti, L. Xu, D. Pinney, R. Beauchamp, W. Hobbs, J. Gusella, and V. Ramesh The merlin tumor suppressor localizes preferentially in membrane ruffles Oncogene 13 1996 1239 1247
47. J. Huang, S. Wu, J. Barrera, K. Matthews, and D. Pan The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP Cell 122 2005 421 434
48. S. Maitra, R.M. Kulikauskas, H. Gavilan, and R.G. Fehon The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling Curr. Biol. 16 2006 702 709