SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

Journal of Clinical Investigation

Volumn 121, Issue 11, 2011, Pages 4257-4267

  Pearson, Helen B ^a   Perez Mancera, Pedro A ^b   Dow, Lukas E ^a,c   Ryan, Andrew ^d   Tennstedt, Pierre ^e   Bogani, Debora ^f   Elsum, Imogen ^a,g   Greenfield, Andy ^f   Tuveson, David A ^b   Simon, Ronald ^e   Humbert, Patrick O ^a,g  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b Li Ka Shing Centre   (United Kingdom)

^c Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^d Tissupath Pty Ltd   (Australia)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f MEDICAL RESEARCH COUNCIL   (United Kingdom)

^g UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; SCRIB PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL POLARITY; DISEASE PREDISPOSITION; FEMALE; GENE LOSS; GENE MUTATION; GENOTYPE; HETEROZYGOSITY; HOMEOSTASIS; HUMAN; MALE; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN DEFECT; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE KNOCKOUT TECHNIQUES; GENES, RAS; HETEROZYGOTE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KAPLAN-MEIER ESTIMATE; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUTATION; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; RNA, MESSENGER; RNA, NEOPLASM; TISSUE ARRAY ANALYSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 80555157484     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI58509     Document Type: Article

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