-
1
-
-
0036175321
-
The pathogenesis of mesothelioma
-
Carbone,M. et al. (2002) The pathogenesis of mesothelioma. Semin. Oncol., 29, 2-17.
-
(2002)
Semin. Oncol
, vol.29
, pp. 2-17
-
-
Carbone, M.1
-
2
-
-
2942547767
-
Malignant pleural mesothelioma
-
Pass,H.I. et al. (2004) Malignant pleural mesothelioma. Curr. Probl. Cancer, 28, 93-174.
-
(2004)
Curr. Probl. Cancer
, vol.28
, pp. 93-174
-
-
Pass, H.I.1
-
3
-
-
26444458845
-
Advances in malignant mesothelioma
-
Robinson,B.W. et al. (2005) Advances in malignant mesothelioma. N. Engl. J. Med., 353, 1591-1603.
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 1591-1603
-
-
Robinson, B.W.1
-
4
-
-
33745598173
-
Cellular and molecular parameters of mesothelioma
-
Ramos-Nino,M.E. et al. (2006) Cellular and molecular parameters of mesothelioma. J. Cell. Biochem., 98, 723-734.
-
(2006)
J. Cell. Biochem
, vol.98
, pp. 723-734
-
-
Ramos-Nino, M.E.1
-
5
-
-
0041629528
-
Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
-
Vogelzang,N.J. et al. (2003) Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J. Clin. Oncol., 21, 2636-2644.
-
(2003)
J. Clin. Oncol
, vol.21
, pp. 2636-2644
-
-
Vogelzang, N.J.1
-
6
-
-
27244447448
-
Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: An intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada
-
van Meerbeeck,J.P. et al. (2005) Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: An intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada. J. Clin. Oncol., 23, 6881-6889.
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 6881-6889
-
-
van Meerbeeck, J.P.1
-
7
-
-
0035332369
-
DNA copy number changes in familial malignant mesothelioma
-
Ascoli,V. et al. (2001) DNA copy number changes in familial malignant mesothelioma. Cancer Genet. Cytogenet., 127, 80-82.
-
(2001)
Cancer Genet. Cytogenet
, vol.127
, pp. 80-82
-
-
Ascoli, V.1
-
8
-
-
42149162212
-
Transcriptome sequencing of malignant pleural mesothelioma tumors
-
Sugarbaker,D.J. et al. (2008) Transcriptome sequencing of malignant pleural mesothelioma tumors. Proc. Natl Acad. Sci. USA, 105, 3521-3526.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 3521-3526
-
-
Sugarbaker, D.J.1
-
9
-
-
20444411897
-
Implications of P16/CDKN2A deletion in pleural mesotheliomas
-
Ladanyi,M. (2005) Implications of P16/CDKN2A deletion in pleural mesotheliomas. Lung Cancer, 49 (suppl. 1), S95-S98.
-
(2005)
Lung Cancer
, vol.49
, Issue.SUPPL. 1
-
-
Ladanyi, M.1
-
10
-
-
33748444562
-
Cytogenetic and molecular genetic changes in malignant mesothelioma
-
Musti,M. et al. (2006) Cytogenetic and molecular genetic changes in malignant mesothelioma. Cancer Genet. Cytogenet., 170, 9-15.
-
(2006)
Cancer Genet. Cytogenet
, vol.170
, pp. 9-15
-
-
Musti, M.1
-
11
-
-
33748305989
-
High-resolution analysis of 9p loss in human cancer cells using single nucleotide polymorphism-based mapping arrays
-
Pei,J. et al. (2006) High-resolution analysis of 9p loss in human cancer cells using single nucleotide polymorphism-based mapping arrays. Cancer Genet. Cytogenet., 170, 65-68.
-
(2006)
Cancer Genet. Cytogenet
, vol.170
, pp. 65-68
-
-
Pei, J.1
-
12
-
-
0028907620
-
Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer
-
Sekido,Y. et al. (1995) Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer. Cancer Res., 55, 1227-1231.
-
(1995)
Cancer Res
, vol.55
, pp. 1227-1231
-
-
Sekido, Y.1
-
13
-
-
0028818921
-
High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas
-
Bianchi,A.B. et al. (1995) High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas. Proc. Natl Acad. Sci. USA, 92, 10854-10858.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 10854-10858
-
-
Bianchi, A.B.1
-
14
-
-
0001387683
-
Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: Evidence for a two-hit mechanism of NF2 inactivation
-
Cheng,J.Q. et al. (1999) Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: Evidence for a two-hit mechanism of NF2 inactivation. Genes Chromosomes Cancer, 24, 238-242.
-
(1999)
Genes Chromosomes Cancer
, vol.24
, pp. 238-242
-
-
Cheng, J.Q.1
-
15
-
-
33645757835
-
The distribution of constitutional and somatic mutations in the neurofibromatosis 2 gene
-
Baser,M.E. (2006) The distribution of constitutional and somatic mutations in the neurofibromatosis 2 gene. Hum. Mutat., 27, 297-306.
-
(2006)
Hum. Mutat
, vol.27
, pp. 297-306
-
-
Baser, M.E.1
-
16
-
-
0036860545
-
Protein 4.1 tumor suppressors: Getting a FERM grip on growth regulation
-
Sun,C.X. et al. (2002) Protein 4.1 tumor suppressors: Getting a FERM grip on growth regulation. J. Cell Sci., 115, 3991-4000.
-
(2002)
J. Cell Sci
, vol.115
, pp. 3991-4000
-
-
Sun, C.X.1
-
17
-
-
25844447107
-
Membrane organization and tumorigenesis - the NF2 tumor suppressor, Merlin
-
McClatchey,A.I. et al. (2005) Membrane organization and tumorigenesis - the NF2 tumor suppressor, Merlin. Genes Dev., 19, 2265-2277.
-
(2005)
Genes Dev
, vol.19
, pp. 2265-2277
-
-
McClatchey, A.I.1
-
18
-
-
33846674993
-
Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32
-
Taniguchi,T. et al. (2007) Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32. Cancer Sci., 98, 438-446.
-
(2007)
Cancer Sci
, vol.98
, pp. 438-446
-
-
Taniguchi, T.1
-
19
-
-
0042858208
-
WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
-
Komuro,A. et al. (2003) WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J. Biol. Chem., 278, 33334-33341.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 33334-33341
-
-
Komuro, A.1
-
20
-
-
28244448285
-
ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features
-
Osada,H. et al. (2005) ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features. Cancer Res., 65 10680-10685.
-
(2005)
Cancer Res
, vol.65
, pp. 10680-10685
-
-
Osada, H.1
-
21
-
-
0037249343
-
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
-
Basu,S. et al. (2003) Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol. Cell, 11, 11-23.
-
(2003)
Mol. Cell
, vol.11
, pp. 11-23
-
-
Basu, S.1
-
22
-
-
27544495514
-
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation
-
Hayashita,Y. et al. (2005) A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res., 65, 9628-9632.
-
(2005)
Cancer Res
, vol.65
, pp. 9628-9632
-
-
Hayashita, Y.1
-
23
-
-
0027522363
-
Persistent induction of c-fos and c-jun expression by asbestos
-
Heintz,N.H. et al. (1993) Persistent induction of c-fos and c-jun expression by asbestos. Proc. Natl Acad. Sci. USA, 90, 3299-3303.
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 3299-3303
-
-
Heintz, N.H.1
-
24
-
-
34047161940
-
JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas
-
Mariani,O. et al. (2007) JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas. Cancer Cell, 11, 361-374.
-
(2007)
Cancer Cell
, vol.11
, pp. 361-374
-
-
Mariani, O.1
-
25
-
-
33745253109
-
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
-
Zender,L. et al. (2006) Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell, 125, 1253-1267.
-
(2006)
Cell
, vol.125
, pp. 1253-1267
-
-
Zender, L.1
-
26
-
-
33747591465
-
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
-
Overholtzer,M. et al. (2006) Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc. Natl Acad. Sci. USA, 103, 12405-12410.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 12405-12410
-
-
Overholtzer, M.1
-
27
-
-
23744458034
-
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
-
Huang,J. et al. (2005) The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell, 122, 421-434.
-
(2005)
Cell
, vol.122
, pp. 421-434
-
-
Huang, J.1
-
28
-
-
0033571594
-
Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50
-
Mohler,P.J. et al. (1999) Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. J. Cell Biol., 147, 879-890.
-
(1999)
J. Cell Biol
, vol.147
, pp. 879-890
-
-
Mohler, P.J.1
-
29
-
-
0031890998
-
NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins
-
Murthy,A. et al. (1998) NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. J. Biol. Chem., 273, 1273-1276.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 1273-1276
-
-
Murthy, A.1
-
30
-
-
0033031878
-
Evaluation of the clonal relationship between primary and metastatic renal cell carcinoma by comparative genomic hybridization
-
Bissig,H. et al. (1999) Evaluation of the clonal relationship between primary and metastatic renal cell carcinoma by comparative genomic hybridization. Am. J. Pathol., 155, 267-274.
-
(1999)
Am. J. Pathol
, vol.155
, pp. 267-274
-
-
Bissig, H.1
-
31
-
-
0035884398
-
Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas
-
Imoto,I. et al. (2001) Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas. Cancer Res., 61, 6629-6634.
-
(2001)
Cancer Res
, vol.61
, pp. 6629-6634
-
-
Imoto, I.1
-
32
-
-
0037388691
-
A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes
-
Dai,Z. et al. (2003) A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes. Hum. Mol. Genet., 12, 791-801.
-
(2003)
Hum. Mol. Genet
, vol.12
, pp. 791-801
-
-
Dai, Z.1
-
33
-
-
24744439504
-
Multiple microalterations detected at high frequency in oral cancer
-
Baldwin,C. et al. (2005) Multiple microalterations detected at high frequency in oral cancer. Cancer Res., 65, 7561-7567.
-
(2005)
Cancer Res
, vol.65
, pp. 7561-7567
-
-
Baldwin, C.1
-
34
-
-
34548719212
-
Gene expression profiling and gene copy-number changes in malignant mesothelioma cell lines
-
Zanazzi,C. et al. (2007) Gene expression profiling and gene copy-number changes in malignant mesothelioma cell lines. Genes Chromosomes Cancer, 46, 895-908.
-
(2007)
Genes Chromosomes Cancer
, vol.46
, pp. 895-908
-
-
Zanazzi, C.1
-
35
-
-
30344445706
-
The tumour-suppressor genes NF2/ Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
-
Hamaratoglu,F. et al. (2006) The tumour-suppressor genes NF2/ Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat. Cell Biol., 8, 27-36.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 27-36
-
-
Hamaratoglu, F.1
-
36
-
-
34247191134
-
Hippo signaling in organ size control
-
Pan,D. (2007) Hippo signaling in organ size control. Genes Dev., 21, 886-897.
-
(2007)
Genes Dev
, vol.21
, pp. 886-897
-
-
Pan, D.1
-
37
-
-
35948961118
-
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
-
Zhao,B. et al. (2007) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev., 21, 2747-2761.
-
(2007)
Genes Dev
, vol.21
, pp. 2747-2761
-
-
Zhao, B.1
-
38
-
-
0033522472
-
A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator
-
Yagi,R. et al. (1999) A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J., 18, 2551-2562.
-
(1999)
EMBO J
, vol.18
, pp. 2551-2562
-
-
Yagi, R.1
-
39
-
-
42449103970
-
The RUNX2 transcription factor cooperates with the YES-associated protein, YAP65, to promote cell transformation
-
Vitolo,M.I. et al. (2007) The RUNX2 transcription factor cooperates with the YES-associated protein, YAP65, to promote cell transformation. Cancer Biol. Ther., 6, 856-863.
-
(2007)
Cancer Biol. Ther
, vol.6
, pp. 856-863
-
-
Vitolo, M.I.1
-
40
-
-
23044492008
-
WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function
-
Aqeilan,R.I. et al. (2005) WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res., 65, 6764-6772.
-
(2005)
Cancer Res
, vol.65
, pp. 6764-6772
-
-
Aqeilan, R.I.1
-
41
-
-
0035873391
-
TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm
-
Vassilev,A. et al. (2001) TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev., 15, 1229-1241.
-
(2001)
Genes Dev
, vol.15
, pp. 1229-1241
-
-
Vassilev, A.1
-
42
-
-
0035805487
-
Physical interaction with Yes-associated protein enhances p73 transcriptional activity
-
Strano,S. et al. (2001) Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J. Biol. Chem., 276, 15164-15173.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 15164-15173
-
-
Strano, S.1
-
43
-
-
21044442524
-
The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage
-
Strano,S. et al. (2005) The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage. Mol. Cell, 18, 447-459.
-
(2005)
Mol. Cell
, vol.18
, pp. 447-459
-
-
Strano, S.1
-
44
-
-
34748812613
-
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
-
Matallanas,D. et al. (2007) RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol. Cell, 27, 962-975.
-
(2007)
Mol. Cell
, vol.27
, pp. 962-975
-
-
Matallanas, D.1
-
45
-
-
14844355090
-
The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
-
Xiao,G.H. et al. (2005) The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol. Cell. Biol., 25, 2384-2394.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 2384-2394
-
-
Xiao, G.H.1
-
46
-
-
33749188461
-
Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK
-
Poulikakos,P.I. et al. (2006) Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK. Oncogene, 25, 5960-5968.
-
(2006)
Oncogene
, vol.25
, pp. 5960-5968
-
-
Poulikakos, P.I.1
-
47
-
-
33947249662
-
Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
-
Lee,H. et al. (2007) Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. Mol. Cell. Biol., 27, 2103-2119.
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 2103-2119
-
-
Lee, H.1
-
48
-
-
0038548168
-
Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours
-
Fleury-Feith,J. et al. (2003) Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours. Oncogene, 22, 3799-3805.
-
(2003)
Oncogene
, vol.22
, pp. 3799-3805
-
-
Fleury-Feith, J.1
-
49
-
-
24944522720
-
A mouse model recapitulating molecular features of human mesothelioma
-
Altomare,D.A. et al. (2005) A mouse model recapitulating molecular features of human mesothelioma. Cancer Res., 65, 8090-8095.
-
(2005)
Cancer Res
, vol.65
, pp. 8090-8095
-
-
Altomare, D.A.1
-
50
-
-
39849089040
-
A conditional mouse model for malignant mesothelioma
-
Jongsma,J. et al. (2008) A conditional mouse model for malignant mesothelioma. Cancer Cell, 13, 261-271.
-
(2008)
Cancer Cell
, vol.13
, pp. 261-271
-
-
Jongsma, J.1
|