Role of YAP/TAZ in mechanotransduction

Nature

Volumn 474, Issue 7350, 2011, Pages 179-184

  Dupont, Sirio ^a   Morsut, Leonardo ^a   Aragona, Mariaceleste ^a   Enzo, Elena ^a   Giulitti, Stefano ^b   Cordenonsi, Michelangelo ^a   Zanconato, Francesca ^a   Le Digabel, Jimmy ^c   Forcato, Mattia ^d   Bicciato, Silvio ^d   Elvassore, Nicola ^b   Piccolo, Stefano ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITÉ PARIS DIDEROT   (France)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTIONAL COACTIVATOR WITH PDZ BINDING MOTIF; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN;

BIOCHEMISTRY; CANCER; ENZYME ACTIVITY; GENE EXPRESSION; GERM CELL; GROWTH; MECHANICAL PROPERTY; MOLECULAR ANALYSIS; PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL SHAPE; CELL SURVIVAL; CYTOSKELETON; ENDOTHELIUM CELL; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; MECHANOTRANSDUCTION; MESENCHYMAL STEM CELL; MICROENVIRONMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; RIGIDITY;

ACTIVE TRANSPORT, CELL NUCLEUS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL SHAPE; CELL SURVIVAL; CUES; CYTOSKELETON; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MESENCHYMAL STEM CELLS; MICE; NUCLEAR PROTEINS; PHOSPHOPROTEINS; TRANSCRIPTION FACTORS;

EID: 79958284636     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10137     Document Type: Article

References (44)

1. Mammoto, T. Ingber, D. E. Mechanical control of tissue and organ development. Development 137, 1407-1420 (2010).
2. Jaalouk, D. E. Lammerding, J. Mechanotransduction gone awry. Nature Rev. Mol. Cell Biol. 10, 63-73 (2009).
3. Schwartz, M. A. Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb. Perspect. Biol. 2, a005066 (2010).
4. Vogel, V. Sheetz, M. Local force and geometry sensing regulate cell functions. Nature Rev. Mol. Cell Biol. 7, 265-275 (2006).
5. McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K. Chen, C. S. Cell shape, cytoskeletal tension, and RhoA regulate stemcell lineage commitment. Dev. Cell 6, 483-495 (2004). (Pubitemid 38456178)
6. Engler, A. J., Sen, S.,Sweeney, H. L. Discher, D. E.Matrix elasticity directs stemcell lineage specification. Cell 126, 677-689 (2006). (Pubitemid 44233625)
7. Gilbert, P. M. et al. Substrate elasticity regulates skeletal muscle stem cell selfrenewal in culture. Science 329, 1078-1081 (2010).
8. Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M. Ingber, D. E. Geometric control of cell life and death. Science 276, 1425-1428 (1997). (Pubitemid 27235413)
9. Provenzano, P. P., Inman, D. R., Eliceiri, K. W. Keely, P. J. Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage. Oncogene 28, 4326-4343 (2009).
10. Olson, E. N. Nordheim, A. Linking actin dynamics and gene transcription to drive cellular motile functions. Nature Rev. Mol. Cell Biol. 11, 353-365 (2010).
11. Zhao, B. et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibitionandtissuegrowthcontrol.GenesDev. 21,2747-2761(2007). (Pubitemid 350070721)
12. Fu, J. et al. Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nature Methods 7, 733-736 (2010).
13. Miralles, F., Posern, G., Zaromytidou, A. I. Treisman, R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113, 329-342 (2003). (Pubitemid 36556115)
14. Pan, D. The hippo signaling pathway in development and cancer. Dev. Cell 19, 491-505 (2010).
15. Oka, T.,Mazack, V. Sudol, M.Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J. Biol. Chem. 283, 27534-27546 (2008).
16. Lei, Q. Y. et al. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol. Cell. Biol. 28, 2426-2436 (2008).
17. Chen, Z., Friedrich, G. A. Soriano, P. Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 8, 2293-2301 (1994). (Pubitemid 24314291)
18. Makita, R. et al. Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am. J. Physiol. Renal Physiol. 294, F542-F553 (2008). (Pubitemid 351442224)
19. Morin-Kensicki, E. M. et al. Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol. Cell. Biol. 26, 77-87 (2006).
20. Skouloudaki, K. et al. Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc. Natl Acad. Sci. USA 106, 8579-8584 (2009).
21. Nienhaus, U., Aegerter-Wilmsen, T. Aegerter, C. M. Determination of mechanical stress distribution in Drosophila wing discs using photoelasticity. Mech. Dev. 126, 942-949 (2009).
22. Schwank, G. Basler, K. Regulation of organ growth bymorphogen gradients. Cold Spring Harb. Perspect. Biol. 2, a001669 (2010).
23. Hong, J. H. et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309, 1074-1078 (2005).
24. Tse, J. R. Engler, A. J. Preparation of hydrogel substrates with tunablemechanical properties. Curr. Protoc. Cell Biol. 47, 10.16.1-10.16.16 (2010).
25. du Roure, O. et al. Force mapping in epithelial cell migration. Proc. Natl Acad. Sci. USA 102, 2390-2395 (2005).
26. Mahoney, W. M. Jr, Hong, J. H., Yaffe, M. B. Farrance, I. K. The transcriptional coactivator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. Biochem. J. 388, 217-225 (2005). (Pubitemid 40732949)
27. Martello, G. et al. A MicroRNA targeting Dicer for metastasis control. Cell 141, 1195-1207 (2010).
28. Dupont, S. et al. FAM/USP9x, a deubiquitinating enzyme essential for TGFb signaling, controls Smad4 monoubiquitination. Cell 136, 123-135 (2009).
29. Morsut, L. et al. Negative control of Smadactivity by ectodermin/Tif1c patterns the mammalian embryo. Development 137, 2571-2578 (2010).
30. Galbraith, C. G., Yamada, K. M. Sheetz, M. P. The relationship between force and focal complex development. J. Cell Biol. 159, 695-705 (2002).
31. Giannone, G., Jiang, G., Sutton, D. H., Critchley, D. R. Sheetz, M. P. Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J. Cell Biol. 163, 409-419 (2003). (Pubitemid 37363140)
32. Padua, D. et al. TGFb primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133, 66-77 (2008). (Pubitemid 351442989)
33. Adorno, M. et al. A mutant-p53/Smad complex opposes p63 to empower TGFbinduced metastasis. Cell 137, 87-98 (2009).
34. Bild, A. H. et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (2006). (Pubitemid 43128862)
35. Mackay, A. et al. cDNAmicroarray analysis of genes associated with ERBB2 (HER2/ neu) overexpression in human mammary luminal epithelial cells. Oncogene 22, 2680-2688 (2003).
36. Zhao, B. et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 22, 1962-1971 (2008). (Pubitemid 352008643)
37. Dong, J. et al. Elucidation of a universal size-control mechanismin Drosophila and mammals. Cell 130, 1120-1133 (2007). (Pubitemid 47410268)
38. Ota, M. Sasaki, H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development 135, 4059-4069 (2008).
39. Zhang, H. et al. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J. Biol. Chem. 284, 13355-13362 (2009).
40. DiMeo, T. A. et al. A novel lungmetastasis signature linksWnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res. 69, 5364-5373 (2009).
41. Mazzone, M. et al. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc. Natl Acad. Sci. USA 107, 5012-5017 (2010).
42. Descot, A. et al. Negative regulation of the EGFR-MAPK cascade by actin-MALmediated Mig6/Errfi-1 induction. Mol. Cell 35, 291-304 (2009).
43. Selvaraj, A. Prywes, R. Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent. BMC Mol. Biol. 5, 13 (2004).
44. Park, B. K. et al. NF-kB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nature Med. 13, 62-69 (2006). (Pubitemid 46067387)