Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

Nature Genetics

Volumn 46, Issue 6, 2014, Pages 583-587

  Kakiuchi, Miwako ^a,b   Nishizawa, Takashi ^c   Ueda, Hiroki ^a   Gotoh, Kengo ^a   Tanaka, Atsushi ^b   Hayashi, Akimasa ^b   Yamamoto, Shogo ^a,d   Tatsuno, Kenji ^a,d   Katoh, Hiroto ^e   Watanabe, Yoshiaki ^f   Ichimura, Takashi ^b   Ushiku, Tetsuo ^b   Funahashi, Shinichi ^c   Tateishi, Keisuke ^b   Wada, Ikuo ^b   Shimizu, Nobuyuki ^b   Nomura, Sachiyo ^b   Koike, Kazuhiko ^b   Seto, Yasuyuki ^b   Fukayama, Masashi ^b   Aburatani, Hiroyuki ^a,d   Ishikawa, Shumpei ^a,b,e   more..

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Research Division   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^f CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLYCINE; GUANINE NUCLEOTIDE; MUTANT PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TYROSINE;

ARTICLE; CANCER INFILTRATION; CANCER PROGNOSIS; CONTROLLED STUDY; DIFFUSE TYPE GASTRIC CARCINOMA; EXOME; GAIN OF FUNCTION MUTATION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; RHOA GENE; STOMACH ADENOCARCINOMA; STOMACH CARCINOMA;

ADENOCARCINOMA; AMINO ACID SEQUENCE; CARCINOMA; CELL DIFFERENTIATION; DNA MUTATIONAL ANALYSIS; GASTRIC MUCOSA; GENE LIBRARY; GERM-LINE MUTATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PROGNOSIS; RHOA GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SEQUENCE HOMOLOGY, AMINO ACID; STOMACH NEOPLASMS; STROMAL CELLS;

EID: 84901677114     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2984     Document Type: Article

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