Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

Journal of Clinical Investigation

Volumn 122, Issue 12, 2012, Pages 4505-4518

  Nishio, Miki ^a   Hamada, Koichi ^a   Kawahara, Kohichi ^a   Sasaki, Masato ^b,c   Noguchi, Fumihito ^d   Chiba, Shuhei ^e   Mizuno, Kensaku ^e   Suzuki, Satoshi O ^f   Dong, Youyi ^g   Tokuda, Masaaki ^g   Morikawa, Takumi ^a   Hikasa, Hiroki ^a   Eggenschwiler, Jonathan ^h   Yabuta, Norikazu ⁱ   Nojima, Hiroshi ⁱ   Nakagawa, Kentaro ^j   Hata, Yutaka ^j   Nishina, Hiroshi ^j   Mimori, Koshi ^k   Mori, Masaki ^d,k   Sasaki, Takehiko ^b   Mak, Tak W ^c   Nakano, Toru ^l   Itami, Satoshi ^d   Suzuki, Akira ^a,b   more..

^a KYUSHU UNIVERSITY   (Japan)

^b AKITA UNIVERSITY   (Japan)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

^f KYUSHU UNIVERSITY   (Japan)

^g KAGAWA UNIVERSITY   (Japan)

^h PRINCETON UNIVERSITY   (United States)

ⁱ OSAKA UNIVERSITY   (Japan)

^j TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^k KYUSHU UNIVERSITY BEPPU HOSPITAL   (Japan)

^l OSAKA UNIVERSITY   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; MPS ONE BINDER 1A PROTEIN; MPS ONE BINDER 1B PROTEIN; TAMOXIFEN; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOMA; CELL PROLIFERATION; CELL RENEWAL; CENTROSOME; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE FREQUENCY; HIPPO SIGNALING PATHWAY; HOMEOSTASIS; HOMOZYGOSITY; KERATINOCYTE; LETHALITY; MALE; MALNUTRITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRICHILEMMAL CARCINOMA;

ABNORMALITIES, MULTIPLE; ANIMALS; CARCINOMA; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EMBRYO CULTURE TECHNIQUES; EMBRYO, MAMMALIAN; FEMALE; GENES, LETHAL; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HOMEOSTASIS; HOMOZYGOTE; HUMANS; KERATINOCYTES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASMS; PHOSPHOPROTEINS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SKIN; SKIN ABNORMALITIES; SKIN NEOPLASMS; TUMOR SUPPRESSOR PROTEINS;

EID: 84870572443     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI63735     Document Type: Article

References (59)

1. Blanpain C, Horsley V, Fuchs E. Epithelial stem cells: turning over new leaves. Cell. 2007;128(3):445-458. (Pubitemid 46198895)
2. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001;414(6859):105-111. (Pubitemid 33041634)
3. Headington JT. Tumors of the hair follicle. A review. Am J Pathol. 1976;85(2):479-514.
4. Fan H, Oro AE, Scott MP, Khavari PA. Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat Med. 1997;3(7):788-792.
5. Oro AE, Higgins KM, Hu Z, Bonifas JM, Epstein EH Jr, Scott MP. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science. 1997;276(5313):817- 821. (Pubitemid 27199865)
6. Edgar BA. From cell structure to transcription: Hippo forges a new path. Cell. 2006;124(2):267-273. (Pubitemid 43121976)
7. Harvey K, Tapon N. The Salvador-Warts-Hippo pathway - an emerging tumour - suppressor network. Nat Rev Cancer. 2007;7(3):182-191.
8. Hamaratoglu F, et al. The tumour-suppressor genes NF2/Merlin and expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006;8(1):27-36. (Pubitemid 43064794)
9. Creasy CL, Chernoff J. Cloning and characterization of a human protein kinase with homology to Ste20. J Biol Chem. 1995;270(37):21695-21700.
10. Tao W, et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet. 1999;21(2):177-181. (Pubitemid 29070362)
11. Valverde P. Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene. Biochem Biophys Res Commun. 2000;276(3):990-998.
12. Moreno CS, Lane WS, Pallas DC. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. J Biol Chem. 2001;276(26):24253-24260.
13. Sudol M, et al. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995;270(24):14733-14741.
14. St John MA, et al. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet. 1999;21(2):182-186. (Pubitemid 29070363)
15. Zhou D, et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 2009;16(5):425-438.
16. Tapon N, et al. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell. 2002;110(4):467-478. (Pubitemid 35232290)
17. Lai ZC, et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell. 2005;120(5):675-685.
18. Pan D. The hippo signaling pathway in development and cancer. Dev Cell. 2010;19(4):491-505.
19. McClatchey AI, Saotome I, Ramesh V, Gusella JF, Jacks T. The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev. 1997;11(10):1253-1265. (Pubitemid 27235358)
20. Lee JH, et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008;27(8):1231-1242.
21. McPherson JP, et al. Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 2004;23(18):3677-3688. (Pubitemid 39336289)
22. Morin-Kensicki EM, et al. Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol Cell Biol. 2006;26(1):77-87.
23. Schlegelmilch K, et al. Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Cell. 2011;144(5):782-795.
24. Luca FC, Winey M. MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Mol Biol Cell. 1998;9(1):29-46. (Pubitemid 28065279)
25. Luca FC, Mody M, Kurischko C, Roof DM, Giddings TH, Winey M. Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit. Mol Cell Biol. 2001;21(20):6972-6983. (Pubitemid 32911257)
26. Bardin AJ, Amon A. Men and sin: what's the difference? Nat Rev Mol Cell Biol. 2001;2(11):815-826. (Pubitemid 33674082)
27. Yoshida S, Toh-e A. Regulation of the localization of Dbf2 and mob1 during cell division of saccharomyces cerevisiae. Genes Genet Syst. 2001;76(2):141-147. (Pubitemid 32499741)
28. Mah AS, Jang J, Deshaies RJ. Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proc Natl Acad Sci U S A 2001;98(13):7325-7330. (Pubitemid 32567947)
29. Hergovich A, Hemmings BA. Hippo signalling in the G2/M cell cycle phase: Lessons learned from the yeast MEN and SIN pathways. Semin Cell Dev Biol. 2012;23(7):794-802.
30. Chow A, Hao Y, Yang X. Molecular characterization of human homologs of yeast MOB1. Int J Cancer. 2010;126(9):2079-2089.
31. Stavridi ES, et al. Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways. Structure. 2003;11(9):1163- 1170. (Pubitemid 37103077)
32. Bothos J, Tuttle RL, Ottey M, Luca FC, Halazonetis TD. Human LATS1 is a mitotic exit network kinase. Cancer Res. 2005;65(15):6568-6575. (Pubitemid 41060692)
33. Kosaka Y, Mimori K, Tanaka F, Inoue H, Watanabe M, Mori M. Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer. Int J Oncol. 2007;31(2):333-338.
34. Sasaki H, et al. Human MOB1 expression in non-small-cell lung cancer. Clin Lung Cancer. 2007;8(4):273-276. (Pubitemid 46333574)
35. Vasioukhin V, Degenstein L, Wise B, Fuchs E. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A. 1999;96(15):8551-8556. (Pubitemid 29354829)
36. Hardy MH. The secret life of the hair follicle. Trends Genet. 1992;8(2):55-61.
37. Yabuta N, et al. Lats2 is an essential mitotic regulator required for the coordination of cell division. J Biol Chem. 2007;282(26):19259-19271. (Pubitemid 47100176)
38. Hao Y, Chun A, Cheung K, Rashidi B, Yang X. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem. 2008;283(9):5496-5509.
39. Hirabayashi S, et al. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene. 2008;27(31):4281-4292. (Pubitemid 352009997)
40. Mill P, et al. Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev. 2003;17(2):282-294. (Pubitemid 36105899)
41. Ewing RM, et al. Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
42. Rual JF, et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005;437(7062):1173-1178.
43. Tamm C, Bower N, Anneren C. Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF. J Cell Sci. 2011;124(pt7):1136-1144.
44. Lian I, et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010;24(11):1106-1118.
45. Nishioka N, et al. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cel. 2009;16(3):398-410.
46. Yagi R, et al. Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development. 2007;134(21):3827-3836. (Pubitemid 350187342)
47. Farooq A, Walker LJ, Bowling J, Audisio RA. Cowden syndrome. Cancer Treat Rev. 2010;36(8):577-583.
48. Zhang H, Pasolli HA, Fuchs E. Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci U S A. 2011;108(6):2270-2275.
49. Kang W, et al. Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis. Clin Cancer Res. 2011;17(8):2130-2139.
50. Lim JY, et al. Merlin suppresses the SRE-dependent transcription by inhibiting the activation of Ras-ERK pathway. Biochem Biophys Res Commun. 2003;302(2):238-245. (Pubitemid 36397912)
51. Kilili GK, Kyriakis JM. Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation. J Biol Chem. 2010;285(20):15076-15087.
52. Takahashi Y, Miyoshi Y, Morimoto K, Taguchi T, Tamaki Y, Noguchi S. Low LATS2 mRNA level can predict favorable response to epirubicin plus cyclophosphamide, but not to docetaxel, in breast cancers. J Cancer Res Clin Oncol. 2007;133(8):501-509. (Pubitemid 46955677)
53. Matsuura K, et al. Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma. BMC Cancer. 2011;11:523.
54. Gu H, Zou YR, Rajewsky K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell. 1993;73(6):1155-1164. (Pubitemid 23180489)
55. Suzuki A, et al. Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 1997;11(10):1242-1252. (Pubitemid 27235357)
56. Verrou C, Zhang Y, Zurn C, Schamel WW, Reth M. Comparison of the tamoxifen regulated chimeric Cre recombinases MerCreMer and CreMer. Biol Chem. 1999;380(12):1435-1438. (Pubitemid 30021366)
57. Takata M, et al. Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. EMBO J. 1994;13(6):1341-1349.
58. Sakai Y, Yoshiura Y, Nakazawa K. Embryoid body culture of mouse embryonic stem cells using microwell and micropatterned chips. J Biosci Bioeng. 2011;111(1):85-91.
59. Lichti U, Anders J, Yuspa SH. Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice. Nat Protoc. 2008;3(5):799-810. (Pubitemid 351639024)