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Volumn 22, Issue 7, 2012, Pages 339-346

The Hippo signaling pathway and stem cell biology

Author keywords

Hippo signaling; Regeneration; Size regulation; Stem cells; Tumorigenesis; Yap

Indexed keywords

HIPPO PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

EID: 84862764408     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2012.04.006     Document Type: Review
Times cited : (239)

References (84)
  • 1
    • 21744443473 scopus 로고    scopus 로고
    • Ephrin signalling controls brain size by regulating apoptosis of neural progenitors
    • Depaepe V., et al. Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature 2005, 435:1244-1250.
    • (2005) Nature , vol.435 , pp. 1244-1250
    • Depaepe, V.1
  • 2
    • 33847210675 scopus 로고    scopus 로고
    • Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
    • Stanger B.Z., et al. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 2007, 445:886-891.
    • (2007) Nature , vol.445 , pp. 886-891
    • Stanger, B.Z.1
  • 3
    • 0028902594 scopus 로고
    • The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
    • Justice R.W., et al. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 1995, 9:534-546.
    • (1995) Genes Dev. , vol.9 , pp. 534-546
    • Justice, R.W.1
  • 4
    • 0028929414 scopus 로고
    • Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase
    • Xu T.A., et al. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 1995, 121:1053-1063.
    • (1995) Development , vol.121 , pp. 1053-1063
    • Xu, T.A.1
  • 5
    • 34548636132 scopus 로고    scopus 로고
    • Elucidation of a universal size-control mechanism in Drosophila and mammals
    • Dong J., et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007, 130:1120-1133.
    • (2007) Cell , vol.130 , pp. 1120-1133
    • Dong, J.1
  • 6
    • 0042733354 scopus 로고    scopus 로고
    • The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    • Harvey K.F., et al. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003, 114:457-467.
    • (2003) Cell , vol.114 , pp. 457-467
    • Harvey, K.F.1
  • 7
    • 0141505119 scopus 로고    scopus 로고
    • The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
    • Pantalacci S., et al. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat. Cell Biol. 2003, 5:921-927.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 921-927
    • Pantalacci, S.1
  • 8
    • 0142123293 scopus 로고    scopus 로고
    • The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis
    • Jia J., et al. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev. 2003, 17:2514-2519.
    • (2003) Genes Dev. , vol.17 , pp. 2514-2519
    • Jia, J.1
  • 9
    • 0141616617 scopus 로고    scopus 로고
    • Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
    • Udan R.S., et al. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat. Cell Biol. 2003, 5:914-920.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 914-920
    • Udan, R.S.1
  • 10
    • 0042232429 scopus 로고    scopus 로고
    • Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    • Wu S., et al. Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 2003, 114:445-456.
    • (2003) Cell , vol.114 , pp. 445-456
    • Wu, S.1
  • 11
    • 0037162714 scopus 로고    scopus 로고
    • Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    • Tapon N., et al. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 2002, 110:467-478.
    • (2002) Cell , vol.110 , pp. 467-478
    • Tapon, N.1
  • 12
    • 79960997489 scopus 로고    scopus 로고
    • The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
    • Zhao B., et al. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat. Cell Biol. 2011, 13:877-883.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 877-883
    • Zhao, B.1
  • 13
    • 78650724753 scopus 로고    scopus 로고
    • Hippo signaling: growth control and beyond
    • Halder G., Johnson R.L. Hippo signaling: growth control and beyond. Development 2011, 138:9-22.
    • (2011) Development , vol.138 , pp. 9-22
    • Halder, G.1    Johnson, R.L.2
  • 14
    • 77957883342 scopus 로고    scopus 로고
    • The Hippo signaling pathway in development and cancer
    • Pan D. The Hippo signaling pathway in development and cancer. Dev. Cell 2010, 19:491-505.
    • (2010) Dev. Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 15
    • 77957676987 scopus 로고    scopus 로고
    • The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila
    • Chen C.L., et al. The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:15810-15815.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 15810-15815
    • Chen, C.L.1
  • 16
    • 77950485564 scopus 로고    scopus 로고
    • Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms
    • Grzeschik N.A., et al. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr. Biol. 2010, 20:573-581.
    • (2010) Curr. Biol. , vol.20 , pp. 573-581
    • Grzeschik, N.A.1
  • 17
    • 77953738883 scopus 로고    scopus 로고
    • The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
    • Ling C., et al. The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:10532-10537.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 10532-10537
    • Ling, C.1
  • 18
    • 77950478873 scopus 로고    scopus 로고
    • Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded
    • Robinson B.S., et al. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. Curr. Biol. 2010, 20:582-590.
    • (2010) Curr. Biol. , vol.20 , pp. 582-590
    • Robinson, B.S.1
  • 19
    • 79952298459 scopus 로고    scopus 로고
    • Yap1 acts downstream of α-catenin to control epidermal proliferation
    • Schlegelmilch K., et al. Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell 2011, 144:782-795.
    • (2011) Cell , vol.144 , pp. 782-795
    • Schlegelmilch, K.1
  • 20
    • 14844297327 scopus 로고    scopus 로고
    • Control of cell proliferation and apoptosis by mob as tumor suppressor, mats
    • Lai Z.C., et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 2005, 120:675-685.
    • (2005) Cell , vol.120 , pp. 675-685
    • Lai, Z.C.1
  • 21
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
    • Huang J., et al. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell 2005, 122:421-434.
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1
  • 22
    • 0032954260 scopus 로고    scopus 로고
    • Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
    • Tao W., et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat. Genet. 1999, 21:177-181.
    • (1999) Nat. Genet. , vol.21 , pp. 177-181
    • Tao, W.1
  • 23
    • 0037133034 scopus 로고    scopus 로고
    • Identification of a novel Ras-regulated proapoptotic pathway
    • Khokhlatchev A., et al. Identification of a novel Ras-regulated proapoptotic pathway. Curr. Biol. 2002, 12:253-265.
    • (2002) Curr. Biol. , vol.12 , pp. 253-265
    • Khokhlatchev, A.1
  • 24
    • 33645050117 scopus 로고    scopus 로고
    • Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis
    • Oh H.J., et al. Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res. 2006, 66:2562-2569.
    • (2006) Cancer Res. , vol.66 , pp. 2562-2569
    • Oh, H.J.1
  • 25
    • 16444373346 scopus 로고    scopus 로고
    • The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
    • Chan E.H., et al. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 2005, 24:2076-2086.
    • (2005) Oncogene , vol.24 , pp. 2076-2086
    • Chan, E.H.1
  • 26
    • 47549115586 scopus 로고    scopus 로고
    • Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1
    • Hirabayashi S., et al. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene 2008, 27:4281-4292.
    • (2008) Oncogene , vol.27 , pp. 4281-4292
    • Hirabayashi, S.1
  • 27
    • 40149111984 scopus 로고    scopus 로고
    • MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
    • Praskova M., et al. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr. Biol. 2008, 18:311-321.
    • (2008) Curr. Biol. , vol.18 , pp. 311-321
    • Praskova, M.1
  • 28
    • 42549092233 scopus 로고    scopus 로고
    • In vivo regulation of Yorkie phosphorylation and localization
    • Oh H., Irvine K.D. In vivo regulation of Yorkie phosphorylation and localization. Development 2008, 135:1081-1088.
    • (2008) Development , vol.135 , pp. 1081-1088
    • Oh, H.1    Irvine, K.D.2
  • 29
    • 41949138130 scopus 로고    scopus 로고
    • Tumor suppressor LATS1 is a negative regulator of oncogene YAP
    • Hao Y., et al. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J. Biol. Chem. 2008, 283:5496-5509.
    • (2008) J. Biol. Chem. , vol.283 , pp. 5496-5509
    • Hao, Y.1
  • 30
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao B., et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007, 21:2747-2761.
    • (2007) Genes Dev. , vol.21 , pp. 2747-2761
    • Zhao, B.1
  • 31
    • 42349084868 scopus 로고    scopus 로고
    • Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway
    • Zhang J., et al. Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. Cancer Res. 2008, 68:2789-2794.
    • (2008) Cancer Res. , vol.68 , pp. 2789-2794
    • Zhang, J.1
  • 32
    • 41149098966 scopus 로고    scopus 로고
    • TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
    • Lei Q.Y., et al. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol. Cell. Biol. 2008, 28:2426-2436.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 2426-2436
    • Lei, Q.Y.1
  • 33
    • 55549098921 scopus 로고    scopus 로고
    • Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)
    • Oka T., et al. Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J. Biol. Chem. 2008, 283:27534-27546.
    • (2008) J. Biol. Chem. , vol.283 , pp. 27534-27546
    • Oka, T.1
  • 34
    • 47549095853 scopus 로고    scopus 로고
    • TEAD mediates YAP-dependent gene induction and growth control
    • Zhao B., et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008, 22:1962-1971.
    • (2008) Genes Dev. , vol.22 , pp. 1962-1971
    • Zhao, B.1
  • 35
    • 67649412006 scopus 로고    scopus 로고
    • TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
    • Zhang H., et al. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J. Biol. Chem. 2009, 284:13355-13362.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13355-13362
    • Zhang, H.1
  • 36
    • 30344445706 scopus 로고    scopus 로고
    • The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
    • Hamaratoglu F., et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat. Cell Biol. 2006, 8:27-36.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 27-36
    • Hamaratoglu, F.1
  • 37
    • 77954945373 scopus 로고    scopus 로고
    • The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
    • Zhang N., et al. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev. Cell 2010, 19:27-38.
    • (2010) Dev. Cell , vol.19 , pp. 27-38
    • Zhang, N.1
  • 38
    • 84862767779 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato T., et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009, 470:353-358.
    • (2009) Nature , vol.470 , pp. 353-358
    • Sato, T.1
  • 39
    • 36549074631 scopus 로고    scopus 로고
    • YAP1 increases organ size and expands undifferentiated progenitor cells
    • Camargo F.D., et al. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr. Biol. 2007, 17:2054-2060.
    • (2007) Curr. Biol. , vol.17 , pp. 2054-2060
    • Camargo, F.D.1
  • 40
    • 84859514394 scopus 로고    scopus 로고
    • Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and Hippo Pathway effectors by Notch1
    • Li Y., et al. Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and Hippo Pathway effectors by Notch1. Stem Cells 2012, 30:741-752.
    • (2012) Stem Cells , vol.30 , pp. 741-752
    • Li, Y.1
  • 41
    • 79952297528 scopus 로고    scopus 로고
    • Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
    • Zhang H., et al. Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:2270-2275.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 2270-2275
    • Zhang, H.1
  • 42
    • 77949487623 scopus 로고    scopus 로고
    • Yap is a novel regulator of C2C12 myogenesis
    • Watt K.I., et al. Yap is a novel regulator of C2C12 myogenesis. Biochem. Biophys. Res. Commun. 2010, 393:619-624.
    • (2010) Biochem. Biophys. Res. Commun. , vol.393 , pp. 619-624
    • Watt, K.I.1
  • 43
    • 0037131389 scopus 로고    scopus 로고
    • "Stemness": transcriptional profiling of embryonic and adult stem cells
    • Ramalho-Santos M. "Stemness": transcriptional profiling of embryonic and adult stem cells. Science 2002, 298:597-600.
    • (2002) Science , vol.298 , pp. 597-600
    • Ramalho-Santos, M.1
  • 44
    • 0001003110 scopus 로고    scopus 로고
    • XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
    • Molenaar M., et al. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell 1996, 86:391-399.
    • (1996) Cell , vol.86 , pp. 391-399
    • Molenaar, M.1
  • 45
    • 78650885839 scopus 로고    scopus 로고
    • Mst1/2 signaling to Yap: gatekeeper for liver size and tumour development
    • Avruch J., et al. Mst1/2 signaling to Yap: gatekeeper for liver size and tumour development. Br. J. Cancer 2011, 104:24-32.
    • (2011) Br. J. Cancer , vol.104 , pp. 24-32
    • Avruch, J.1
  • 46
    • 76549127712 scopus 로고    scopus 로고
    • Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
    • Song H., et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:1431-1436.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 1431-1436
    • Song, H.1
  • 47
    • 76549124517 scopus 로고    scopus 로고
    • Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
    • Lu L., et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:1437-1442.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 1437-1442
    • Lu, L.1
  • 48
    • 77952336576 scopus 로고    scopus 로고
    • The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size and liver tumorigenesis
    • Lee K.P., et al. The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size and liver tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:8248-8253.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 8248-8253
    • Lee, K.P.1
  • 49
    • 77955868800 scopus 로고    scopus 로고
    • Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver
    • Benhamouche S., et al. Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev. 2010, 24:1718-1730.
    • (2010) Genes Dev. , vol.24 , pp. 1718-1730
    • Benhamouche, S.1
  • 50
    • 33847235717 scopus 로고    scopus 로고
    • Scratching the surface of skin development
    • Fuchs E. Scratching the surface of skin development. Nature 2007, 445:834-842.
    • (2007) Nature , vol.445 , pp. 834-842
    • Fuchs, E.1
  • 51
    • 33645085841 scopus 로고    scopus 로고
    • AlphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway
    • Lien W.H., et al. alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science 2006, 311:1609-1612.
    • (2006) Science , vol.311 , pp. 1609-1612
    • Lien, W.H.1
  • 52
    • 33748449057 scopus 로고    scopus 로고
    • Cadherin-catenin proteins in vertebrate development
    • Lien W.H., et al. Cadherin-catenin proteins in vertebrate development. Curr. Opin. Cell Biol. 2006, 18:499-506.
    • (2006) Curr. Opin. Cell Biol. , vol.18 , pp. 499-506
    • Lien, W.H.1
  • 53
    • 79957462240 scopus 로고    scopus 로고
    • α-Catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1
    • Silvis M.R., et al. α-Catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci. Signal. 2011, 4:ra33.
    • (2011) Sci. Signal. , vol.4
    • Silvis, M.R.1
  • 54
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker N., et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007, 449:1003-1007.
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1
  • 55
    • 65549086537 scopus 로고    scopus 로고
    • Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
    • Fre S., et al. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:6309-6314.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 6309-6314
    • Fre, S.1
  • 56
    • 47549099591 scopus 로고    scopus 로고
    • The intestinal stem cell
    • Barker N., et al. The intestinal stem cell. Genes Dev. 2008, 22:1856-1864.
    • (2008) Genes Dev. , vol.22 , pp. 1856-1864
    • Barker, N.1
  • 57
    • 83755195660 scopus 로고    scopus 로고
    • Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance
    • Zhou D., et al. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:E1312-E1320.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108
    • Zhou, D.1
  • 58
    • 78049451932 scopus 로고    scopus 로고
    • The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
    • Cai J., et al. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 2010, 24:2383-2388.
    • (2010) Genes Dev. , vol.24 , pp. 2383-2388
    • Cai, J.1
  • 59
    • 79955405757 scopus 로고    scopus 로고
    • Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size
    • Heallen T., et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 2011, 332:458-461.
    • (2011) Science , vol.332 , pp. 458-461
    • Heallen, T.1
  • 60
    • 80054965145 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size
    • Xin M., et al. Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci. Signal. 2011, 4:ra70.
    • (2011) Sci. Signal. , vol.4
    • Xin, M.1
  • 61
    • 67649908864 scopus 로고    scopus 로고
    • Adult neural stem cells in the mammalian central nervous system
    • Ma D.K., et al. Adult neural stem cells in the mammalian central nervous system. Cell Res. 2009, 19:672-682.
    • (2009) Cell Res. , vol.19 , pp. 672-682
    • Ma, D.K.1
  • 62
    • 57749122174 scopus 로고    scopus 로고
    • YAP regulates neural progenitor cell number via the TEA domain transcription factor
    • Cao X., et al. YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev. 2008, 22:3320-3334.
    • (2008) Genes Dev. , vol.22 , pp. 3320-3334
    • Cao, X.1
  • 63
    • 79958128093 scopus 로고    scopus 로고
    • Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone
    • Gee S.T., et al. Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone. PLoS ONE 2011, 6:e20309.
    • (2011) PLoS ONE , vol.6
    • Gee, S.T.1
  • 64
    • 72549090299 scopus 로고    scopus 로고
    • YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
    • Fernandez-L A., et al. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 2009, 23:2729-2741.
    • (2009) Genes Dev. , vol.23 , pp. 2729-2741
    • Fernandez-L, A.1
  • 65
    • 79959524651 scopus 로고    scopus 로고
    • Yes-Associated Protein 1 is widely expressed in human brain tumors and promotes glioblastoma growth
    • Orr B.A., et al. Yes-Associated Protein 1 is widely expressed in human brain tumors and promotes glioblastoma growth. J. Neuropathol. Exp. Neurol. 2011, 70:568-577.
    • (2011) J. Neuropathol. Exp. Neurol. , vol.70 , pp. 568-577
    • Orr, B.A.1
  • 66
    • 80053145319 scopus 로고    scopus 로고
    • Discovering pluripotency: 30 years of mouse embryonic stem cells
    • Evans M. Discovering pluripotency: 30 years of mouse embryonic stem cells. Nat. Rev. Mol. Cell Biol. 2011, 12:680-686.
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 680-686
    • Evans, M.1
  • 67
    • 6044269157 scopus 로고    scopus 로고
    • Self-renewal of teratocarcinoma and embryonic stem cells
    • Chambers I., Smith A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene 2004, 23:7150-7160.
    • (2004) Oncogene , vol.23 , pp. 7150-7160
    • Chambers, I.1    Smith, A.2
  • 69
    • 34249698153 scopus 로고    scopus 로고
    • Human embryonic stem cells: the battle between self-renewal and differentiation
    • Darr H., Benvenisty N. Human embryonic stem cells: the battle between self-renewal and differentiation. Regen. Med. 2006, 3:317-325.
    • (2006) Regen. Med. , vol.3 , pp. 317-325
    • Darr, H.1    Benvenisty, N.2
  • 70
    • 33747614295 scopus 로고    scopus 로고
    • Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells
    • Xiao L., et al. Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells 2006, 6:1476-1486.
    • (2006) Stem Cells , vol.6 , pp. 1476-1486
    • Xiao, L.1
  • 71
    • 46049087598 scopus 로고    scopus 로고
    • TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
    • Varelas X., et al. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat. Cell Biol. 2008, 10:837-848.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 837-848
    • Varelas, X.1
  • 72
    • 84859235472 scopus 로고    scopus 로고
    • Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming
    • Qin H., et al. Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming. Hum. Mol. Genet. 2012, 21:2054-2067.
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 2054-2067
    • Qin, H.1
  • 73
    • 70350780570 scopus 로고    scopus 로고
    • Nuclear CDKs drive Smad transcriptional activity and turnover in BMP and TGF-β pathways
    • Alarcón C., et al. Nuclear CDKs drive Smad transcriptional activity and turnover in BMP and TGF-β pathways. Cell 2009, 139:757-769.
    • (2009) Cell , vol.139 , pp. 757-769
    • Alarcón, C.1
  • 74
    • 77953040994 scopus 로고    scopus 로고
    • The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
    • Lian I., et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010, 24:1106-1118.
    • (2010) Genes Dev. , vol.24 , pp. 1106-1118
    • Lian, I.1
  • 75
    • 79953149145 scopus 로고    scopus 로고
    • Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD22 signaling pathway downstream of LIF
    • Tamm C., et al. Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD22 signaling pathway downstream of LIF. J. Cell Sci. 2010, 124:1136-1144.
    • (2010) J. Cell Sci. , vol.124 , pp. 1136-1144
    • Tamm, C.1
  • 76
    • 78650471357 scopus 로고    scopus 로고
    • Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways
    • Ren F., et al. Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:21064-21069.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 21064-21069
    • Ren, F.1
  • 77
    • 78650187792 scopus 로고    scopus 로고
    • The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration
    • Shaw R.L., et al. The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development 2010, 24:4147-4158.
    • (2010) Development , vol.24 , pp. 4147-4158
    • Shaw, R.L.1
  • 78
    • 78650202455 scopus 로고    scopus 로고
    • The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
    • Karpowicz P., et al. The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development 2010, 24:4135-4145.
    • (2010) Development , vol.24 , pp. 4135-4145
    • Karpowicz, P.1
  • 79
    • 39149144034 scopus 로고    scopus 로고
    • Stem cells and niches: mechanisms that promote stem cell maintenance throughout life
    • Morrison S.J., Spradling A.C. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 2008, 132:598-611.
    • (2008) Cell , vol.132 , pp. 598-611
    • Morrison, S.J.1    Spradling, A.C.2
  • 80
    • 80755153752 scopus 로고    scopus 로고
    • Coordinating cell polarity with cell division in space and time
    • Panbianco C., Gotta M. Coordinating cell polarity with cell division in space and time. Trends Cell Biol. 2011, 21:672-680.
    • (2011) Trends Cell Biol. , vol.21 , pp. 672-680
    • Panbianco, C.1    Gotta, M.2
  • 81
    • 78649969033 scopus 로고    scopus 로고
    • The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway
    • Varelas X., et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev. Cell 2010, 19:831-844.
    • (2010) Dev. Cell , vol.19 , pp. 831-844
    • Varelas, X.1
  • 82
    • 33744505111 scopus 로고    scopus 로고
    • Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases
    • Avruch J., et al. Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases. Methods Enzymol. 2006, 407:290-310.
    • (2006) Methods Enzymol. , vol.407 , pp. 290-310
    • Avruch, J.1
  • 83
    • 33646422520 scopus 로고    scopus 로고
    • The human tumour suppressor LATS1 is activated by human MOB1 at the membrane
    • Hergovich A., et al. The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Biochem. Biophys. Res. Commun. 2006, 345:50-58.
    • (2006) Biochem. Biophys. Res. Commun. , vol.345 , pp. 50-58
    • Hergovich, A.1
  • 84
    • 72649099866 scopus 로고    scopus 로고
    • Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila
    • Ho L.L., et al. Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila. Dev. Biol. 2009, 337:274-283.
    • (2009) Dev. Biol. , vol.337 , pp. 274-283
    • Ho, L.L.1


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