Hippo pathway inhibits wnt signaling to restrain cardiomyocyte proliferation and heart size

Science

Volumn 332, Issue 6028, 2011, Pages 458-461

  Heallen, Todd ^a   Zhang, Min ^a   Wang, Jun ^a   Bonilla Claudio, Margarita ^a   Klysik, Ela ^a   Johnson, Randy L ^b   Martin, James F ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; HIPPO PROTEIN; PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; WNT PROTEIN;

APOPTOSIS; FLY; GENE EXPRESSION; GENETIC ANALYSIS; HETEROZYGOSITY; INHIBITION; PHENOTYPE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARDIOMEGALY; CELL NUCLEUS; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE INTERACTION; GROWTH REGULATION; HEART MUSCLE CELL; HEART SIZE; HETEROZYGOSITY; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BETA CATENIN; CARDIOMEGALY; CELL CYCLE PROTEINS; CELL NUCLEUS; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; MICE; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; ORGAN SIZE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; WNT PROTEINS;

MAMMALIA;

EID: 79955405757     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1199010     Document Type: Article

References (17)

1. I. Conlon, M. Raff, Cell 96, 235 (1999).
2. B. Z. Stanger, A. J. Tanaka, D. A. Melton, Nature 445, 886 (2007).
3. M. Affolter, K. Basler, Nat. Rev. Genet. 8, 663 (2007).
4. D. Pan, Dev. Cell 19, 491 (2010).
5. L. Lu et al., Proc. Natl. Acad. Sci. U.S.A. 107, 1437 (2010).
6. K. A. Moses, F. DeMayo, R. M. Braun, J. L. Reecy, R. J. Schwartz, Genesis 31, 176 (2001).
7. Materials and methods are available as supporting material on Science Online.
8. M. Koyanagi et al., Circ. Res. 106, 1290 (2010).
9. K. Takahashi, S. Yamanaka, Cell 126, 663 (2006).
10. A. Cano et al., Nat. Cell Biol. 2, 76 (2000).
11. A. Islam et al., Oncogene 19, 617 (2000).
12. S. Wu, Y. Liu, Y. Zheng, J. Dong, D. Pan, Dev. Cell 14, 388 (2008).
13. E. Tzahor, Dev. Cell 13, 10 (2007).
14. M. Ota, H. Sasaki, Development 135, 4059 (2008).
15. Y. Matsui et al., Circ. Res. 103, 1309 (2008).
16. X. Varelas et al., Dev. Cell 18, 579 (2010).
17. E. D. Cohen, Y. Tian, E. E. Morrisey, Development 135, 789 (2008).