Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 49, 2011, Pages

  Zhou, Dawang ^a,b,c   Zhang, Yongyou ^d   Wu, Hongtan ^a,b,c   Barryg, Evan ^e,f,g   Yin, Yi ^a,b   Lawrence, Earl ^h   Dawson, Dawn ^d,h   Willis, Joseph E ^d,h   Markowitz, Sanford D ^d,h   Camargo, Fernando D ^e,f,g   Avruch, Joseph ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c XIAMEN UNIVERSITY   (China)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f Harvard University   (United States)

^g HARVARD STEM CELL INSTITUTE   (United States)

^h UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MST1 PROTEIN; MST2 PROTEIN; NOTCH RECEPTOR; PROTEIN KINASE; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL PROLIFERATION; COLON ADENOMA; COLON CANCER; CONTROLLED STUDY; DROSOPHILA; GENE OVEREXPRESSION; INTESTINE EPITHELIUM; LARGE INTESTINE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMALL INTESTINE; STEM CELL; SURVIVAL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; COLON; COLONIC NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINES; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; STEM CELLS; TISSUE ARRAY ANALYSIS;

EID: 83755195660     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110428108     Document Type: Article

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