메뉴 건너뛰기




Volumn 192, Issue PB, 2014, Pages 323-338

The development and application of high throughput cultivation technology in bioprocess development

Author keywords

High throughput culture; HTP culture strategy; Micro bioreactor; Process development

Indexed keywords

BIOREACTOR; CULTURE TECHNIQUE; HIGH THROUGHPUT SCREENING; MICROFLUIDIC ANALYSIS;

EID: 84914117921     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2014.03.028     Document Type: Article
Times cited : (77)

References (117)
  • 1
    • 84856574352 scopus 로고    scopus 로고
    • Characterization and feasibility of a miniaturized stirred tank bioreactor to perform E. coli high cell density fed-batch fermentations
    • Ali S., Perez-Pardo M.A., Aucamp J.P., Craig A., Bracewell D.G., Baganz F. Characterization and feasibility of a miniaturized stirred tank bioreactor to perform E. coli high cell density fed-batch fermentations. Biotechnol. Prog. 2012, 28(1):66-75.
    • (2012) Biotechnol. Prog. , vol.28 , Issue.1 , pp. 66-75
    • Ali, S.1    Perez-Pardo, M.A.2    Aucamp, J.P.3    Craig, A.4    Bracewell, D.G.5    Baganz, F.6
  • 2
    • 84861683733 scopus 로고    scopus 로고
    • Strategies for rapid production of therapeutic proteins in mammalian cells
    • Agrawal V., Bal M. Strategies for rapid production of therapeutic proteins in mammalian cells. BioProcess 2012, 10(4):32-48.
    • (2012) BioProcess , vol.10 , Issue.4 , pp. 32-48
    • Agrawal, V.1    Bal, M.2
  • 3
    • 77951570798 scopus 로고    scopus 로고
    • Novel micro-bioreactor high throughput technology for cell culture process development: reproducibility and scalability assessment of fed-batch CHO cultures
    • Amanullah A., Otero J.M., Mikola M., Hsu A., Zhang J., Aunins J., Schreyer H.B., Hope J.A., Russo A.P. Novel micro-bioreactor high throughput technology for cell culture process development: reproducibility and scalability assessment of fed-batch CHO cultures. Biotechnol. Bioeng. 2010, 106:57-67.
    • (2010) Biotechnol. Bioeng. , vol.106 , pp. 57-67
    • Amanullah, A.1    Otero, J.M.2    Mikola, M.3    Hsu, A.4    Zhang, J.5    Aunins, J.6    Schreyer, H.B.7    Hope, J.A.8    Russo, A.P.9
  • 4
    • 79751527622 scopus 로고    scopus 로고
    • Integrated microbioreactor for culture and analysis of bacteria, algae and yeast
    • Au S.H., Shih S.C., Wheeler A.R. Integrated microbioreactor for culture and analysis of bacteria, algae and yeast. Biomed. Microdevices 2011, 13(1):41-50.
    • (2011) Biomed. Microdevices , vol.13 , Issue.1 , pp. 41-50
    • Au, S.H.1    Shih, S.C.2    Wheeler, A.R.3
  • 5
    • 79851490029 scopus 로고    scopus 로고
    • A review of advanced small-scale parallel bioreactor technology for accelerated process development: current state and future need
    • Bareither R., Pollard D. A review of advanced small-scale parallel bioreactor technology for accelerated process development: current state and future need. Biotechnol. Prog. 2011, 27(1):2-14.
    • (2011) Biotechnol. Prog. , vol.27 , Issue.1 , pp. 2-14
    • Bareither, R.1    Pollard, D.2
  • 6
    • 84886241053 scopus 로고    scopus 로고
    • Automated disposable small scale reactor for high throughput bioprocess development: a proof of concept study
    • Bareither R., Bargh N., Oakeshott R., Watts K., Pollard D. Automated disposable small scale reactor for high throughput bioprocess development: a proof of concept study. Biotechnol. Bioeng. 2013, 110(12):3126-3138.
    • (2013) Biotechnol. Bioeng. , vol.110 , Issue.12 , pp. 3126-3138
    • Bareither, R.1    Bargh, N.2    Oakeshott, R.3    Watts, K.4    Pollard, D.5
  • 7
    • 74849109030 scopus 로고    scopus 로고
    • Microwell engineering characterization for mammalian cell culture process development
    • Barrett T., Wu A., Zhang H., Levy S., Lye G. Microwell engineering characterization for mammalian cell culture process development. Biotechnol. Bioeng. 2010, 105(2):260-275.
    • (2010) Biotechnol. Bioeng. , vol.105 , Issue.2 , pp. 260-275
    • Barrett, T.1    Wu, A.2    Zhang, H.3    Levy, S.4    Lye, G.5
  • 8
    • 34247162596 scopus 로고    scopus 로고
    • Combinatorial expression vector engineering for tuning of recombinant protein production in Escherichia coli
    • Bandmann N., Nygren P.A. Combinatorial expression vector engineering for tuning of recombinant protein production in Escherichia coli. Nucleic Acids Res. 2007, 35(5):32.
    • (2007) Nucleic Acids Res. , vol.35 , Issue.5 , pp. 32
    • Bandmann, N.1    Nygren, P.A.2
  • 11
    • 33746640411 scopus 로고    scopus 로고
    • Miniature bioreactors: current practices and future opportunities
    • Betts J.L., Baganz F. Miniature bioreactors: current practices and future opportunities. Microb. Cell Fact. 2006, 5(21). 10.1186/1475-2859-5-21.
    • (2006) Microb. Cell Fact. , vol.5 , Issue.21
    • Betts, J.L.1    Baganz, F.2
  • 12
    • 33745039195 scopus 로고    scopus 로고
    • Characterization and application of a miniature 10mL stirred-tank bioreactor, showing scale-down equivalence with a conventional 7L reactor
    • Betts J.I., Doig S.D., Baganz F. Characterization and application of a miniature 10mL stirred-tank bioreactor, showing scale-down equivalence with a conventional 7L reactor. Biotechnol. Prog. 2006, 22(3):681-688.
    • (2006) Biotechnol. Prog. , vol.22 , Issue.3 , pp. 681-688
    • Betts, J.I.1    Doig, S.D.2    Baganz, F.3
  • 13
    • 80053636591 scopus 로고    scopus 로고
    • High throughput construction and small scale expression screening of multi-tag vectors in Escherichia coli
    • Bird L. High throughput construction and small scale expression screening of multi-tag vectors in Escherichia coli. Methods 2011, 55(1):29-37.
    • (2011) Methods , vol.55 , Issue.1 , pp. 29-37
    • Bird, L.1
  • 14
    • 0042927956 scopus 로고    scopus 로고
    • High throughput protein production for functional proteomics
    • Braun P., LaBaer J. High throughput protein production for functional proteomics. Trends Biotech. 2003, 21(9):383-388.
    • (2003) Trends Biotech. , vol.21 , Issue.9 , pp. 383-388
    • Braun, P.1    LaBaer, J.2
  • 15
    • 58149147339 scopus 로고    scopus 로고
    • Micro-bioreactors for fed-batch fermentations with integrated online monitoring and microfluidic devices
    • Buchenauer A., Hofmann M.C., Funke M., Buchs J., Mokwaa W., Schnakenberg U. Micro-bioreactors for fed-batch fermentations with integrated online monitoring and microfluidic devices. Biosens. Bioelectron. 2009, 24:1411-1416.
    • (2009) Biosens. Bioelectron. , vol.24 , pp. 1411-1416
    • Buchenauer, A.1    Hofmann, M.C.2    Funke, M.3    Buchs, J.4    Mokwaa, W.5    Schnakenberg, U.6
  • 18
    • 79960022894 scopus 로고    scopus 로고
    • Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study
    • Busso D., Peleg Y., Heidebrecht T., Romier C., Jacobovitch Y., Dantes A., Celie P.H. Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study. J. Struct. Biol. 2011, 175(2):159-170.
    • (2011) J. Struct. Biol. , vol.175 , Issue.2 , pp. 159-170
    • Busso, D.1    Peleg, Y.2    Heidebrecht, T.3    Romier, C.4    Jacobovitch, Y.5    Dantes, A.6    Celie, P.H.7
  • 19
    • 58149269805 scopus 로고    scopus 로고
    • Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development
    • Chen A., Chitta R., Chang D., Amanullah A. Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development. Biotechnol. Bioeng. 2009, 102(1):148-160.
    • (2009) Biotechnol. Bioeng. , vol.102 , Issue.1 , pp. 148-160
    • Chen, A.1    Chitta, R.2    Chang, D.3    Amanullah, A.4
  • 20
    • 33645344085 scopus 로고    scopus 로고
    • Industrial experiences with multivariate statistical analysis of batch process data
    • Chiang L., Leardi R., Pell R.J., Seasholtz M.B. Industrial experiences with multivariate statistical analysis of batch process data. Chemometr. Intell. Lab. Syst. 2006, 81:109-119.
    • (2006) Chemometr. Intell. Lab. Syst. , vol.81 , pp. 109-119
    • Chiang, L.1    Leardi, R.2    Pell, R.J.3    Seasholtz, M.B.4
  • 21
    • 84872090939 scopus 로고    scopus 로고
    • Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells
    • Cimetta E., Sirabella D., Yeager K., Davidson K., Simon J., Moonb R.T., Vunjak-Novakovica G. Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells. Lab. Chip. 2013, 13(3):355-364.
    • (2013) Lab. Chip. , vol.13 , Issue.3 , pp. 355-364
    • Cimetta, E.1    Sirabella, D.2    Yeager, K.3    Davidson, K.4    Simon, J.5    Moonb, R.T.6    Vunjak-Novakovica, G.7
  • 22
  • 23
    • 34547471980 scopus 로고    scopus 로고
    • Construction and model-based analysis of a promoter library for E. coli: an indispensable tool for metabolic engineering
    • De Mey M., Maertens J., Lequeux G., Soetaert W., Vandamme E. Construction and model-based analysis of a promoter library for E. coli: an indispensable tool for metabolic engineering. BMC Biotechnol. 2007, 7(1):34.
    • (2007) BMC Biotechnol. , vol.7 , Issue.1 , pp. 34
    • De Mey, M.1    Maertens, J.2    Lequeux, G.3    Soetaert, W.4    Vandamme, E.5
  • 24
    • 84855210636 scopus 로고    scopus 로고
    • Evaluation of parallel milliliter-scale stirred-tank bioreactors for the study of biphasic whole-cell biocatalysis with ionic liquids
    • Dennewald D., Hortsch R., Weuster-Botz D. Evaluation of parallel milliliter-scale stirred-tank bioreactors for the study of biphasic whole-cell biocatalysis with ionic liquids. J. Biotechnol. 2012, 157:253-257.
    • (2012) J. Biotechnol. , vol.157 , pp. 253-257
    • Dennewald, D.1    Hortsch, R.2    Weuster-Botz, D.3
  • 25
    • 35648967032 scopus 로고    scopus 로고
    • Microtiter plates as mini-bioreactors: miniaturization of fermentation methods
    • Duetz W. Microtiter plates as mini-bioreactors: miniaturization of fermentation methods. Trends Microbiol. 2007, 15(10):465-475.
    • (2007) Trends Microbiol. , vol.15 , Issue.10 , pp. 465-475
    • Duetz, W.1
  • 27
    • 0343673773 scopus 로고    scopus 로고
    • Methods for intense aeration, growth, storage, and replication of bacterial strains in microtiter plates
    • Duetz W., Ruedi L., Hermann R., O'Connor K., Buchs J., Witholt B. Methods for intense aeration, growth, storage, and replication of bacterial strains in microtiter plates. Appl. Environ. Microbiol. 2000, 66(6):2641-2646.
    • (2000) Appl. Environ. Microbiol. , vol.66 , Issue.6 , pp. 2641-2646
    • Duetz, W.1    Ruedi, L.2    Hermann, R.3    O'Connor, K.4    Buchs, J.5    Witholt, B.6
  • 28
    • 1042275653 scopus 로고    scopus 로고
    • Oxygen transfer by orbital shaking of square vessels and deepwell microtiter plates of various dimensions
    • Duetz W.A., Witholt B. Oxygen transfer by orbital shaking of square vessels and deepwell microtiter plates of various dimensions. Biochem. Eng. J. 2004, 17:181-185.
    • (2004) Biochem. Eng. J. , vol.17 , pp. 181-185
    • Duetz, W.A.1    Witholt, B.2
  • 29
    • 84876589414 scopus 로고    scopus 로고
    • High throughput solution-based measurement of antibody-antigen affinity and epitope binning
    • Estep P., Reid F., Nauman C., Liu Y., Sun T., Sun J., Xu Y. High throughput solution-based measurement of antibody-antigen affinity and epitope binning. Landes Biosci. 2013, 5(2):0-1.
    • (2013) Landes Biosci. , vol.5 , Issue.2 , pp. 0-1
    • Estep, P.1    Reid, F.2    Nauman, C.3    Liu, Y.4    Sun, T.5    Sun, J.6    Xu, Y.7
  • 30
    • 84914104078 scopus 로고    scopus 로고
    • PAT applied in biopharmaceutical process development and manufacturing: an enabling tool for Quality-by-Design
    • CRC Press
    • Fazenda M.L., Harvey L.M., McNeil B. PAT applied in biopharmaceutical process development and manufacturing: an enabling tool for Quality-by-Design. CHAPTER 9: Cell Culture PAT Multiplexing NIR 2011, CRC Press.
    • (2011) CHAPTER 9: Cell Culture PAT Multiplexing NIR
    • Fazenda, M.L.1    Harvey, L.M.2    McNeil, B.3
  • 31
    • 80054124219 scopus 로고    scopus 로고
    • Miniaturization in biotechnology: speeding up the development of bioprocesses
    • Fernandes P., Carvalho F., PC Marques M. Miniaturization in biotechnology: speeding up the development of bioprocesses. Recent Patents Biotechnol. 2011, 5(3):160-173.
    • (2011) Recent Patents Biotechnol. , vol.5 , Issue.3 , pp. 160-173
    • Fernandes, P.1    Carvalho, F.2    Marques, M.3
  • 32
    • 34250815100 scopus 로고    scopus 로고
    • Study of the application of multiway multivariate techniques to model data from an industrial fermentation process
    • Ferreira A.P., Lopes J.A., Menezes J.C. Study of the application of multiway multivariate techniques to model data from an industrial fermentation process. Anal. Chim. Acta 2007, 595:120-127.
    • (2007) Anal. Chim. Acta , vol.595 , pp. 120-127
    • Ferreira, A.P.1    Lopes, J.A.2    Menezes, J.C.3
  • 33
    • 84864830402 scopus 로고    scopus 로고
    • Optimization of a Saccharomyces Cerevisiae fermentation process for production of a therapeutic recombinant protein using a multivariate bayesian approach
    • Fu Z., Leighton J., Cheng A., Appelbaum E., Aon J.C. Optimization of a Saccharomyces Cerevisiae fermentation process for production of a therapeutic recombinant protein using a multivariate bayesian approach. Biotechnol. Prog. 2012, 28:1095-1105.
    • (2012) Biotechnol. Prog. , vol.28 , pp. 1095-1105
    • Fu, Z.1    Leighton, J.2    Cheng, A.3    Appelbaum, E.4    Aon, J.C.5
  • 34
    • 78149303999 scopus 로고    scopus 로고
    • Bioprocess control in microscale: Scalable fermentations in disposable and user-friendly microfluidic systems
    • Funke M., Buchenauer A., Mokwa W., Kluge S., Hein L., Muller C., Kensy F., Büchs J. Bioprocess control in microscale: Scalable fermentations in disposable and user-friendly microfluidic systems. Microb. Cell Fact. 2010, 9(1):86.
    • (2010) Microb. Cell Fact. , vol.9 , Issue.1 , pp. 86
    • Funke, M.1    Buchenauer, A.2    Mokwa, W.3    Kluge, S.4    Hein, L.5    Muller, C.6    Kensy, F.7    Büchs, J.8
  • 36
    • 68149131918 scopus 로고    scopus 로고
    • The baffled microtitre plate: Increased oxygen transfer and improved online monitoring in small scale fermentations
    • Funke M., Diederichs S., Kensy F., Müller F., Buechs J. The baffled microtitre plate: Increased oxygen transfer and improved online monitoring in small scale fermentations. Biotechnol. Bioeng. 2009, 103(6):1118-1128.
    • (2009) Biotechnol. Bioeng. , vol.103 , Issue.6 , pp. 1118-1128
    • Funke, M.1    Diederichs, S.2    Kensy, F.3    Müller, F.4    Buechs, J.5
  • 37
    • 58149145737 scopus 로고    scopus 로고
    • A prototype microfluidic chip using fluorescent yeast for detection of toxic compounds
    • Garcia-Alonso J., Greenway G.M., Hardege J.D., Haswell S.J. A prototype microfluidic chip using fluorescent yeast for detection of toxic compounds. Biosens. Bioelectron. 2009, 24:1508-1511.
    • (2009) Biosens. Bioelectron. , vol.24 , pp. 1508-1511
    • Garcia-Alonso, J.1    Greenway, G.M.2    Hardege, J.D.3    Haswell, S.J.4
  • 38
    • 33644688779 scopus 로고    scopus 로고
    • Validation of an optical sensor-based high-throughput bioreactor system for mammalian cell culture
    • Ge X., Hanson M., Shen H., Kostov Y., Brorson K.A., Frey D.D., Moreira A.R., Rao G. Validation of an optical sensor-based high-throughput bioreactor system for mammalian cell culture. J. Biotechnol. 2006, 122(3):293-306.
    • (2006) J. Biotechnol. , vol.122 , Issue.3 , pp. 293-306
    • Ge, X.1    Hanson, M.2    Shen, H.3    Kostov, Y.4    Brorson, K.A.5    Frey, D.D.6    Moreira, A.R.7    Rao, G.8
  • 39
    • 79958248811 scopus 로고    scopus 로고
    • A new microfluidic concept for parallel operated milliliter-scale stirred tank bioreactors
    • Gebhardt G., Hortsch R., Kaufmann K., Arnold M., Weuster-Botz D. A new microfluidic concept for parallel operated milliliter-scale stirred tank bioreactors. Biotechnol. Prog. 2011, 27:684-690.
    • (2011) Biotechnol. Prog. , vol.27 , pp. 684-690
    • Gebhardt, G.1    Hortsch, R.2    Kaufmann, K.3    Arnold, M.4    Weuster-Botz, D.5
  • 41
    • 48649111182 scopus 로고    scopus 로고
    • Quantification of power consumption and oxygen transfer characteristics of a stirred miniature bioreactor for predictive fermentation scale-up
    • Gill N.K., Appleton M., Baganz F., Lye G.J. Quantification of power consumption and oxygen transfer characteristics of a stirred miniature bioreactor for predictive fermentation scale-up. Biotechnol. Bioeng. 2008, 100(6):1144-1155.
    • (2008) Biotechnol. Bioeng. , vol.100 , Issue.6 , pp. 1144-1155
    • Gill, N.K.1    Appleton, M.2    Baganz, F.3    Lye, G.J.4
  • 42
    • 84886015424 scopus 로고    scopus 로고
    • Optimal periodic perfusion strategy for robust long term microfluidic cell culture
    • Giulitti S., Magrofuoco E., Prevedello L., Elvassore N. Optimal periodic perfusion strategy for robust long term microfluidic cell culture. Lab. Chip. 2013, 13(22):4430-4441.
    • (2013) Lab. Chip. , vol.13 , Issue.22 , pp. 4430-4441
    • Giulitti, S.1    Magrofuoco, E.2    Prevedello, L.3    Elvassore, N.4
  • 43
    • 80054053868 scopus 로고    scopus 로고
    • Finding a bioreactor that's right for you: choosing between stainless steel and single-use getting easier as niches become better defined
    • Glaser V. Finding a bioreactor that's right for you: choosing between stainless steel and single-use getting easier as niches become better defined. Genet. Eng. Biotechnol. News 2011, 31(14):44-47.
    • (2011) Genet. Eng. Biotechnol. News , vol.31 , Issue.14 , pp. 44-47
    • Glaser, V.1
  • 47
    • 84875494549 scopus 로고    scopus 로고
    • Microfabricated devices in microbial bioenergy sciences
    • Han A., Hou H., Li L., Kim H.S., de Figueiredo P. Microfabricated devices in microbial bioenergy sciences. Trends Biotechnol. 2013, 31(4):225-232.
    • (2013) Trends Biotechnol. , vol.31 , Issue.4 , pp. 225-232
    • Han, A.1    Hou, H.2    Li, L.3    Kim, H.S.4    de Figueiredo, P.5
  • 48
    • 45149110911 scopus 로고    scopus 로고
    • Defining process design space for biotech products: case study of Pichia pastoris fermentation
    • Harms J., Wang X., Kim T., Yang X., Rathore A.S. Defining process design space for biotech products: case study of Pichia pastoris fermentation. Biotechnol. Prog. 2008, 24:655-662.
    • (2008) Biotechnol. Prog. , vol.24 , pp. 655-662
    • Harms, J.1    Wang, X.2    Kim, T.3    Yang, X.4    Rathore, A.S.5
  • 49
    • 77953576190 scopus 로고    scopus 로고
    • New milliliter-scale stirred tank bioreactors for the cultivation of mycelium forming microorganisms
    • Hortsch R., Stratmann A., Weuster-Botz D. New milliliter-scale stirred tank bioreactors for the cultivation of mycelium forming microorganisms. Biotechnol. Bioeng. 2010, 106:443-451.
    • (2010) Biotechnol. Bioeng. , vol.106 , pp. 443-451
    • Hortsch, R.1    Stratmann, A.2    Weuster-Botz, D.3
  • 50
    • 79954779972 scopus 로고    scopus 로고
    • Growth and recombinant protein expression with Escherichia coli in different batch cultivation media
    • Hortsch R., Weuster-Botz D. Growth and recombinant protein expression with Escherichia coli in different batch cultivation media. Appl. Microbiol. Biotechnol. 2011, 90(1):69-76.
    • (2011) Appl. Microbiol. Biotechnol. , vol.90 , Issue.1 , pp. 69-76
    • Hortsch, R.1    Weuster-Botz, D.2
  • 51
    • 84863629890 scopus 로고    scopus 로고
    • Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae
    • Hou J., Tyo K.E., Liu Z., Petranovic D., Nielsen J. Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae. FEMS Yeast Res. 2012, 12(5):491-510.
    • (2012) FEMS Yeast Res. , vol.12 , Issue.5 , pp. 491-510
    • Hou, J.1    Tyo, K.E.2    Liu, Z.3    Petranovic, D.4    Nielsen, J.5
  • 52
    • 84868461356 scopus 로고    scopus 로고
    • Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors
    • Hsu W.T., Aulakh R.P., Traul D.L., Yuk I.H. Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors. Cytotechnology 2012, 64(6):667-678.
    • (2012) Cytotechnology , vol.64 , Issue.6 , pp. 667-678
    • Hsu, W.T.1    Aulakh, R.P.2    Traul, D.L.3    Yuk, I.H.4
  • 53
    • 69549116398 scopus 로고    scopus 로고
    • Robo-Lector - a novel platform for automated high-throughput cultivations in microtiter plates with high information content
    • Huber R., Ritter D., Hering T., Hillmer A.K., Kensy F., Muller C., Buchs J. Robo-Lector - a novel platform for automated high-throughput cultivations in microtiter plates with high information content. Microb. Cell Fact. 2009, 8(1):42.
    • (2009) Microb. Cell Fact. , vol.8 , Issue.1 , pp. 42
    • Huber, R.1    Ritter, D.2    Hering, T.3    Hillmer, A.K.4    Kensy, F.5    Muller, C.6    Buchs, J.7
  • 54
    • 79952705671 scopus 로고    scopus 로고
    • Utilizing high-throughput experimentation to enhance specific productivity of an E. coli T7 expression system by phosphate limitation
    • Huber R., Roth S., Rahmen N., Buchs J. Utilizing high-throughput experimentation to enhance specific productivity of an E. coli T7 expression system by phosphate limitation. BMC Biotechnol. 2011, 11:22.
    • (2011) BMC Biotechnol. , vol.11 , pp. 22
    • Huber, R.1    Roth, S.2    Rahmen, N.3    Buchs, J.4
  • 55
    • 77958041081 scopus 로고    scopus 로고
    • Parallel bioreactor systems: integrated bioprocess information management
    • Februar-Marz
    • Huther C., Schneider F. Parallel bioreactor systems: integrated bioprocess information management. Biotech. Int. 2009, (Februar-Marz):6-10. http://www.dasgip.com/media/content/pages/downloads/Application_DASGIP_DataMining_Article_BTI_2009.pdf.
    • (2009) Biotech. Int. , pp. 6-10
    • Huther, C.1    Schneider, F.2
  • 56
    • 41249099087 scopus 로고    scopus 로고
    • Scale-up of Escherichia coli growth and recombinant protein expression conditions from microwell to laboratory and pilot scale based on matched kLa
    • Islam R., Tisi D., Levy M., Lye G. Scale-up of Escherichia coli growth and recombinant protein expression conditions from microwell to laboratory and pilot scale based on matched kLa. Biotechnol. Bioeng. 2008, 99(5):1128-1139.
    • (2008) Biotechnol. Bioeng. , vol.99 , Issue.5 , pp. 1128-1139
    • Islam, R.1    Tisi, D.2    Levy, M.3    Lye, G.4
  • 57
    • 84865844890 scopus 로고    scopus 로고
    • A new stoichiometric miniaturization strategy for screening of industrial microbial strains: application to cellulase hyper-producing Trichoderma reesei strains
    • Jourdier E., Poughon L., Larroche C., Monot F., Chaabane F.B. A new stoichiometric miniaturization strategy for screening of industrial microbial strains: application to cellulase hyper-producing Trichoderma reesei strains. Microb. Cell Fact. 2012, 11:70.
    • (2012) Microb. Cell Fact. , vol.11 , pp. 70
    • Jourdier, E.1    Poughon, L.2    Larroche, C.3    Monot, F.4    Chaabane, F.B.5
  • 58
    • 28644437025 scopus 로고    scopus 로고
    • Characterization of operation conditions and online monitoring of physiological culture parameters in shaken 24-well microtiter plates
    • Kensy F., John G.T., Hofmann B., Buchs J. Characterization of operation conditions and online monitoring of physiological culture parameters in shaken 24-well microtiter plates. Bioprocess Biosyst. Eng. 2005, 28(2):75-81.
    • (2005) Bioprocess Biosyst. Eng. , vol.28 , Issue.2 , pp. 75-81
    • Kensy, F.1    John, G.T.2    Hofmann, B.3    Buchs, J.4
  • 59
    • 74549211232 scopus 로고    scopus 로고
    • Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations
    • Kensy F., Engelbrecht C., Buchs J. Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations. Microb. Cell Fact. 2009, 8:68.
    • (2009) Microb. Cell Fact. , vol.8 , pp. 68
    • Kensy, F.1    Engelbrecht, C.2    Buchs, J.3
  • 60
    • 84862184762 scopus 로고    scopus 로고
    • Mini-scale bioprocessing systems for highly parallel animal cell cultures
    • Kim B.J., Diao J., Shuler M.I. Mini-scale bioprocessing systems for highly parallel animal cell cultures. Biotechnol. Prog. 2012, 28:595-607.
    • (2012) Biotechnol. Prog. , vol.28 , pp. 595-607
    • Kim, B.J.1    Diao, J.2    Shuler, M.I.3
  • 61
    • 84871716860 scopus 로고    scopus 로고
    • A system of miniaturized stirred bioreactors for parallel continuous cultivation of yeast with online measurement of dissolved oxygen and off-gas
    • Klein T., Schneider K., Heinzle E. A system of miniaturized stirred bioreactors for parallel continuous cultivation of yeast with online measurement of dissolved oxygen and off-gas. Biotechnol. Bioeng. 2013, 110(2):535-542.
    • (2013) Biotechnol. Bioeng. , vol.110 , Issue.2 , pp. 535-542
    • Klein, T.1    Schneider, K.2    Heinzle, E.3
  • 62
    • 36448960919 scopus 로고    scopus 로고
    • Fiber-optic microsensors for simultaneous sensing of oxygen and pH, and of oxygen and temperature
    • Kocincova A.S., Borisov S.M., Krause C., Wolfbeis O.S. Fiber-optic microsensors for simultaneous sensing of oxygen and pH, and of oxygen and temperature. Anal. Chem. 2007, 79(22):8486-8493.
    • (2007) Anal. Chem. , vol.79 , Issue.22 , pp. 8486-8493
    • Kocincova, A.S.1    Borisov, S.M.2    Krause, C.3    Wolfbeis, O.S.4
  • 64
    • 80054757882 scopus 로고    scopus 로고
    • A high-throughput screen for directed evolution of the natural product sulfotransferase LipB
    • Koryakina I., Neville J., Nonaka K., Van Lanen S.G., Williams G.J. A high-throughput screen for directed evolution of the natural product sulfotransferase LipB. J. Biomol. Screen. 2011, 16(8):845-851.
    • (2011) J. Biomol. Screen. , vol.16 , Issue.8 , pp. 845-851
    • Koryakina, I.1    Neville, J.2    Nonaka, K.3    Van Lanen, S.G.4    Williams, G.J.5
  • 65
    • 79954743989 scopus 로고    scopus 로고
    • High-throughput, high-level production of PS-tag-fused single-chain Fvs by microplate-based culture
    • Kumada Y., Takase Y., Sasaki E., Kishimoto M. High-throughput, high-level production of PS-tag-fused single-chain Fvs by microplate-based culture. J. Biosci. Bioeng. 2011, 111(5):569-573.
    • (2011) J. Biosci. Bioeng. , vol.111 , Issue.5 , pp. 569-573
    • Kumada, Y.1    Takase, Y.2    Sasaki, E.3    Kishimoto, M.4
  • 66
    • 77957717433 scopus 로고    scopus 로고
    • Rapid identification of production strains - accelerating protein concentration and functional analyses to improve efficiency
    • Kumaraswamy S., Allen J.R. Rapid identification of production strains - accelerating protein concentration and functional analyses to improve efficiency. Genet. Eng. News 2010, 30(12(June)). http://www.genengnews.com/gen-articles/rapid-identification-of-production-strains/3338/.
    • (2010) Genet. Eng. News , vol.30 , Issue.12 JUNE
    • Kumaraswamy, S.1    Allen, J.R.2
  • 68
    • 33750352421 scopus 로고    scopus 로고
    • Sequential and simultaneous statistical optimization by dynamic design of experiment for peptide overexpression in recombinant Escherichia coli
    • Lee K.M., Rhee C.H., Kang C.K., Kim J.H. Sequential and simultaneous statistical optimization by dynamic design of experiment for peptide overexpression in recombinant Escherichia coli. Appl. Biochem. Biotechnol. 2006, 135(1):59-80.
    • (2006) Appl. Biochem. Biotechnol. , vol.135 , Issue.1 , pp. 59-80
    • Lee, K.M.1    Rhee, C.H.2    Kang, C.K.3    Kim, J.H.4
  • 71
    • 34250350463 scopus 로고    scopus 로고
    • Enhancing the production of Fc fusion protein in fed-batch fermentation of Pichia pastoris by design of experiments
    • Lin H., Kim T., Xiong F., Yang X. Enhancing the production of Fc fusion protein in fed-batch fermentation of Pichia pastoris by design of experiments. Biotechnol. Prog. 2007, 23(3):621-625.
    • (2007) Biotechnol. Prog. , vol.23 , Issue.3 , pp. 621-625
    • Lin, H.1    Kim, T.2    Xiong, F.3    Yang, X.4
  • 72
    • 79955813920 scopus 로고    scopus 로고
    • Strain engineering for improved expression of recombinant protein in bacteria
    • Makino T., Skretas G., Georgiou G. Strain engineering for improved expression of recombinant protein in bacteria. Microb. Cell Fact. 2011, 10(32):1102-1107.
    • (2011) Microb. Cell Fact. , vol.10 , Issue.32 , pp. 1102-1107
    • Makino, T.1    Skretas, G.2    Georgiou, G.3
  • 74
    • 0029828233 scopus 로고    scopus 로고
    • Strategies for achieving high-level expression of genes in Escherichia coli
    • Markrides S.C. Strategies for achieving high-level expression of genes in Escherichia coli. Microbiol. Rev. 1996, 60(3):512-538.
    • (1996) Microbiol. Rev. , vol.60 , Issue.3 , pp. 512-538
    • Markrides, S.C.1
  • 75
    • 77956510121 scopus 로고    scopus 로고
    • Bioprocess scale-up: quest for the parameters to be used as criterion to move from microreactors to lab-scale
    • Marques M.P.C., Cabral J.M.S., Fernandes P. Bioprocess scale-up: quest for the parameters to be used as criterion to move from microreactors to lab-scale. J. Chem. Technol. Biotechnol. 2010, 85:1184-1198.
    • (2010) J. Chem. Technol. Biotechnol. , vol.85 , pp. 1184-1198
    • Marques, M.P.C.1    Cabral, J.M.S.2    Fernandes, P.3
  • 78
    • 33751231685 scopus 로고    scopus 로고
    • Microscale bioprocess optimization
    • Micheletti M., Lye G.J. Microscale bioprocess optimization. Curr. Opin. Biotech. 2006, 17:611-618.
    • (2006) Curr. Opin. Biotech. , vol.17 , pp. 611-618
    • Micheletti, M.1    Lye, G.J.2
  • 79
    • 73449101512 scopus 로고    scopus 로고
    • Lessons from 60 years of pharmaceutical innovation
    • Munos B. Lessons from 60 years of pharmaceutical innovation. Nat. Rev. Drug Discov. 2009, 8:959-968.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 959-968
    • Munos, B.1
  • 80
    • 84871121406 scopus 로고    scopus 로고
    • Expression of recombinant staphylokinase in the methylotrophic yeast Hansenula polymorpha
    • Moussa M., Ibrahim M., El Ghazaly M., Rohde J., Gnoth S., Anton A., Mueller F. Expression of recombinant staphylokinase in the methylotrophic yeast Hansenula polymorpha. BMC Biotech. 2012, 12(1):96.
    • (2012) BMC Biotech. , vol.12 , Issue.1 , pp. 96
    • Moussa, M.1    Ibrahim, M.2    El Ghazaly, M.3    Rohde, J.4    Gnoth, S.5    Anton, A.6    Mueller, F.7
  • 81
    • 77953202449 scopus 로고    scopus 로고
    • Metabolic flux analysis of wild-type Escherichia coli and mutants deficient in pyruvate-dissimilating enzymes during the fermentative metabolism of glucuronate
    • Murarka A., Clomburg J.M., Gonzalez R. Metabolic flux analysis of wild-type Escherichia coli and mutants deficient in pyruvate-dissimilating enzymes during the fermentative metabolism of glucuronate. Microbiology 2010, 156(6):1860-1872.
    • (2010) Microbiology , vol.156 , Issue.6 , pp. 1860-1872
    • Murarka, A.1    Clomburg, J.M.2    Gonzalez, R.3
  • 82
    • 84885139964 scopus 로고    scopus 로고
    • Microchemostat array with small-volume fraction replenishment for steady-state microbial culture
    • Park J., Wu J.Z., Polymenisb M., Han A. Microchemostat array with small-volume fraction replenishment for steady-state microbial culture. Lab. Chip. 2013, 13:4217.
    • (2013) Lab. Chip. , vol.13 , pp. 4217
    • Park, J.1    Wu, J.Z.2    Polymenisb, M.3    Han, A.4
  • 83
    • 84880362703 scopus 로고    scopus 로고
    • A microfluidic cell culture array with various oxygen tensions
    • Peng C., Liao W., Chen Y., Wu C., Tung Y. A microfluidic cell culture array with various oxygen tensions. Lab. Chip. 2013, 13:3239.
    • (2013) Lab. Chip. , vol.13 , pp. 3239
    • Peng, C.1    Liao, W.2    Chen, Y.3    Wu, C.4    Tung, Y.5
  • 84
    • 84863446028 scopus 로고    scopus 로고
    • A high throughput capillary electrophoresis method to obtain pharmacokinetics and quality attributes of a therapeutic molecule in circulation
    • Piparia R., Ouellette D., Stine W.B., Grinnell C., Tarcsa E., Radziejewski C., Correia I. A high throughput capillary electrophoresis method to obtain pharmacokinetics and quality attributes of a therapeutic molecule in circulation. Landes Biosci. 2012, 4(4):521-531.
    • (2012) Landes Biosci. , vol.4 , Issue.4 , pp. 521-531
    • Piparia, R.1    Ouellette, D.2    Stine, W.B.3    Grinnell, C.4    Tarcsa, E.5    Radziejewski, C.6    Correia, I.7
  • 85
    • 84883290025 scopus 로고    scopus 로고
    • Cell chips as new tools for cell biology - results, perspectives and opportunities
    • Primiceri E., Chiriaco M.S., Rinaldi R., Maruccio G. Cell chips as new tools for cell biology - results, perspectives and opportunities. Lab. Chip. 2013, 13:3789.
    • (2013) Lab. Chip. , vol.13 , pp. 3789
    • Primiceri, E.1    Chiriaco, M.S.2    Rinaldi, R.3    Maruccio, G.4
  • 86
    • 15944379153 scopus 로고    scopus 로고
    • Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD)
    • Puskeiler R., Kaufmann K., Weuster-Botz D. Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD). Biotechnol. Bioeng. 2005, 89(5):512-523.
    • (2005) Biotechnol. Bioeng. , vol.89 , Issue.5 , pp. 512-523
    • Puskeiler, R.1    Kaufmann, K.2    Weuster-Botz, D.3
  • 88
    • 58149201119 scopus 로고    scopus 로고
    • Development of a simple and low cost micro-bioreactor for high-throughput
    • Rahman P., Pasirayi G., Auger V., Ali Z. Development of a simple and low cost micro-bioreactor for high-throughput. Bioprocess. Biotechnol. Lett. 2009, 31:209-214.
    • (2009) Bioprocess. Biotechnol. Lett. , vol.31 , pp. 209-214
    • Rahman, P.1    Pasirayi, G.2    Auger, V.3    Ali, Z.4
  • 89
    • 84923007754 scopus 로고    scopus 로고
    • High-throughput miniaturized bioreactors for cell culture process development: reproducibility, scalability, and control
    • Rameez S., Mostafa S.S., Miller C., Shukla A.A. High-throughput miniaturized bioreactors for cell culture process development: reproducibility, scalability, and control. Biotechnol. Prog. 2014, 1874. 10.1002/btpr.1874.
    • (2014) Biotechnol. Prog. , pp. 1874
    • Rameez, S.1    Mostafa, S.S.2    Miller, C.3    Shukla, A.A.4
  • 90
    • 80355145782 scopus 로고    scopus 로고
    • Reliable protein production in a Pseudomonas fluorescens expression system
    • Retallack D.M., Jin H., Chew L. Reliable protein production in a Pseudomonas fluorescens expression system. Protein Expr. Purif. 2012, 81(2):157-165.
    • (2012) Protein Expr. Purif. , vol.81 , Issue.2 , pp. 157-165
    • Retallack, D.M.1    Jin, H.2    Chew, L.3
  • 91
    • 84879553677 scopus 로고    scopus 로고
    • Characterization of stirrers for screening studies of enzymatic biomass hydrolyses on a milliliter scale
    • Riedlberger P., Bruning S., Weuster-Botz D. Characterization of stirrers for screening studies of enzymatic biomass hydrolyses on a milliliter scale. Bioprocess Biosyst. Eng. 2013, 36:927-935.
    • (2013) Bioprocess Biosyst. Eng. , vol.36 , pp. 927-935
    • Riedlberger, P.1    Bruning, S.2    Weuster-Botz, D.3
  • 92
    • 84868259526 scopus 로고    scopus 로고
    • An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform
    • Rohe P., Venkanna D., Kleine B., Freudl R., Oldiges M. An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform. Microb. Cell Fact. 2012, 11(1):144.
    • (2012) Microb. Cell Fact. , vol.11 , Issue.1 , pp. 144
    • Rohe, P.1    Venkanna, D.2    Kleine, B.3    Freudl, R.4    Oldiges, M.5
  • 93
    • 84862204695 scopus 로고    scopus 로고
    • Effect of hydrocortisone on the production and glycosylation of an Fc-fusion protein in CHO cell cultures
    • Rouiller Y., Perilleux A., Marsaut M., Stettler M., Vesin M.N., Broly H. Effect of hydrocortisone on the production and glycosylation of an Fc-fusion protein in CHO cell cultures. Biotechnol. Prog. 2012, 28(3):803-813.
    • (2012) Biotechnol. Prog. , vol.28 , Issue.3 , pp. 803-813
    • Rouiller, Y.1    Perilleux, A.2    Marsaut, M.3    Stettler, M.4    Vesin, M.N.5    Broly, H.6
  • 94
    • 84889094657 scopus 로고    scopus 로고
    • Integration of models and experimentation to optimise the production of potential biotherapeutics
    • Royle K.E., Val I.J.D., Kontoravdi C. Integration of models and experimentation to optimise the production of potential biotherapeutics. Drug Discov. Today 2013, 10.1016/j.drudis.2013.07.002.
    • (2013) Drug Discov. Today
    • Royle, K.E.1    Val, I.J.D.2    Kontoravdi, C.3
  • 95
    • 84878836229 scopus 로고    scopus 로고
    • Systems metabolic engineering in an industrial setting
    • Sagt C.M. Systems metabolic engineering in an industrial setting. Appl. Microbiol. Biotechnol. 2013, 97(6):2319-2326.
    • (2013) Appl. Microbiol. Biotechnol. , vol.97 , Issue.6 , pp. 2319-2326
    • Sagt, C.M.1
  • 97
    • 70349617005 scopus 로고    scopus 로고
    • Application of micro-bioreactors in fermentation process development: a review
    • Schapper D., Alam M., Szita N., Lantz A., Gernay K. Application of micro-bioreactors in fermentation process development: a review. Anal. Bioanal. Chem. 2009, 395:679-695.
    • (2009) Anal. Bioanal. Chem. , vol.395 , pp. 679-695
    • Schapper, D.1    Alam, M.2    Szita, N.3    Lantz, A.4    Gernay, K.5
  • 98
    • 84876397731 scopus 로고    scopus 로고
    • New options to engineer biofuel microbes: Development and application of a high-throughput screening system
    • Scheel M., Lutke-Eversloh T. New options to engineer biofuel microbes: Development and application of a high-throughput screening system. Metab. Eng. 2013, 17:51-58.
    • (2013) Metab. Eng. , vol.17 , pp. 51-58
    • Scheel, M.1    Lutke-Eversloh, T.2
  • 99
    • 33750844518 scopus 로고    scopus 로고
    • A semi-automated large-scale process for the production of recombinant tagged proteins in the Baculovirus expression system
    • Schlaeppi J.M., Henke M., Mahnke M., Hartmann S., Schmitz R., Pouliquen Y., Kocher H.P. A semi-automated large-scale process for the production of recombinant tagged proteins in the Baculovirus expression system. Protein Expr. Purif. 2006, 50(2):185-195.
    • (2006) Protein Expr. Purif. , vol.50 , Issue.2 , pp. 185-195
    • Schlaeppi, J.M.1    Henke, M.2    Mahnke, M.3    Hartmann, S.4    Schmitz, R.5    Pouliquen, Y.6    Kocher, H.P.7
  • 100
    • 0035387847 scopus 로고    scopus 로고
    • High-throughput proteomics using high-efficiency multiple-capillary liquid chromatography with on-line high-performance ESI FTICR mass spectrometry
    • Shen Y., Tolic N., Zhao R., Pasa-Tolic L., Li L., Berger S.J., Smith R.D. High-throughput proteomics using high-efficiency multiple-capillary liquid chromatography with on-line high-performance ESI FTICR mass spectrometry. Anal. Chem. 2001, 73(13):3011-3021.
    • (2001) Anal. Chem. , vol.73 , Issue.13 , pp. 3011-3021
    • Shen, Y.1    Tolic, N.2    Zhao, R.3    Pasa-Tolic, L.4    Li, L.5    Berger, S.J.6    Smith, R.D.7
  • 101
    • 84855813377 scopus 로고    scopus 로고
    • Robust, small-scale cultivation platform for Streptomyces coelicolor
    • Sohoni S.V., Bapat P.M., Lantz A.E. Robust, small-scale cultivation platform for Streptomyces coelicolor. Microb. Cell Fact. 2012, 11:9.
    • (2012) Microb. Cell Fact. , vol.11 , pp. 9
    • Sohoni, S.V.1    Bapat, P.M.2    Lantz, A.E.3
  • 102
    • 84858074427 scopus 로고    scopus 로고
    • Development of a simple disposable six minibioreactor system for suspension mammalian cell culture
    • Soley A., Fontova A., Galvez J., Sarro E., Lecina M., Bragos R., Godia F. Development of a simple disposable six minibioreactor system for suspension mammalian cell culture. Process Biochem. 2012, 47(4):597-605.
    • (2012) Process Biochem. , vol.47 , Issue.4 , pp. 597-605
    • Soley, A.1    Fontova, A.2    Galvez, J.3    Sarro, E.4    Lecina, M.5    Bragos, R.6    Godia, F.7
  • 103
    • 61349153751 scopus 로고    scopus 로고
    • A new paradigm for bacterial strain engineering
    • Squires C.H., Lucy P. A new paradigm for bacterial strain engineering. Bioprocess Int. 2008, 6:22.
    • (2008) Bioprocess Int. , vol.6 , pp. 22
    • Squires, C.H.1    Lucy, P.2
  • 104
    • 84878801642 scopus 로고    scopus 로고
    • Optimized simultaneous saccharification and co-fermentation of rice straw for ethanol production by Saccharomyces cerevisiae and Scheffersomyces stipitis co-culture using design of experiments
    • Suriyachai N., Laosiripojana N., Champreda V., Unrean P. Optimized simultaneous saccharification and co-fermentation of rice straw for ethanol production by Saccharomyces cerevisiae and Scheffersomyces stipitis co-culture using design of experiments. Bioresour. Technol. 2013, 142:171-178.
    • (2013) Bioresour. Technol. , vol.142 , pp. 171-178
    • Suriyachai, N.1    Laosiripojana, N.2    Champreda, V.3    Unrean, P.4
  • 105
    • 23644437363 scopus 로고    scopus 로고
    • Development of a multiplexed micro-bioreactor system for high-throughput bioprocessing
    • Szita N., Boccazzi P., Zhang Z., Boyle P., Sinskey A.J., Jensen K.F. Development of a multiplexed micro-bioreactor system for high-throughput bioprocessing. Lab. Chip. 2005, 5:819-826.
    • (2005) Lab. Chip. , vol.5 , pp. 819-826
    • Szita, N.1    Boccazzi, P.2    Zhang, Z.3    Boyle, P.4    Sinskey, A.J.5    Jensen, K.F.6
  • 106
    • 84914163899 scopus 로고    scopus 로고
    • High-throughput system for screening of Cephalosporin C high-yield strain by 48-deep-well microtiter plates
    • Tan J., Chu J., Hao Y., Guo Y., Zhuang Y., Zhang S. High-throughput system for screening of Cephalosporin C high-yield strain by 48-deep-well microtiter plates. Appl. Biochem. Biotechnol. 2009, 169:1-13.
    • (2009) Appl. Biochem. Biotechnol. , vol.169 , pp. 1-13
    • Tan, J.1    Chu, J.2    Hao, Y.3    Guo, Y.4    Zhuang, Y.5    Zhang, S.6
  • 107
    • 80053631355 scopus 로고    scopus 로고
    • High-throughput protein expression screening and purification in Escherichia coli
    • Vincentelli R., Cimino A., Geerlof A., Kubo A., Satou Y., Cambillau C. High-throughput protein expression screening and purification in Escherichia coli. Methods 2011, 55:65-72.
    • (2011) Methods , vol.55 , pp. 65-72
    • Vincentelli, R.1    Cimino, A.2    Geerlof, A.3    Kubo, A.4    Satou, Y.5    Cambillau, C.6
  • 109
    • 80054017005 scopus 로고    scopus 로고
    • Optimization of flowrate for expansion of human embryonic stem cells in perfusion microbioreactors
    • Titmarsh D., Hidalgo A., Turner J., Wolvetang E., Cooper-White J. Optimization of flowrate for expansion of human embryonic stem cells in perfusion microbioreactors. Biotechnol. Bioeng. 2011, 108:2894-2904.
    • (2011) Biotechnol. Bioeng. , vol.108 , pp. 2894-2904
    • Titmarsh, D.1    Hidalgo, A.2    Turner, J.3    Wolvetang, E.4    Cooper-White, J.5
  • 111
    • 77951104779 scopus 로고    scopus 로고
    • Miniaturized microfluidic formats for cell-based high-throughput screening
    • Upadhaya S., Selvaganapathy P.R. Miniaturized microfluidic formats for cell-based high-throughput screening. Crit. Rev. Biomed. Eng. 2009, 37(3):193-257.
    • (2009) Crit. Rev. Biomed. Eng. , vol.37 , Issue.3 , pp. 193-257
    • Upadhaya, S.1    Selvaganapathy, P.R.2
  • 112
    • 84862802734 scopus 로고    scopus 로고
    • A 24-microwell plate with improved mixing and scalable performance for high throughput cell cultures
    • Wen Y., Zang R., Zhang X., Yang S.T. A 24-microwell plate with improved mixing and scalable performance for high throughput cell cultures. Process Biochem. 2012, 47(4):612-618.
    • (2012) Process Biochem. , vol.47 , Issue.4 , pp. 612-618
    • Wen, Y.1    Zang, R.2    Zhang, X.3    Yang, S.T.4
  • 114
    • 40349113355 scopus 로고    scopus 로고
    • A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture
    • Wu M., Huang S., Cui Z., Cui Z., Lee G. A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture. Biomed. Microdevices 2008, 10:309-319.
    • (2008) Biomed. Microdevices , vol.10 , pp. 309-319
    • Wu, M.1    Huang, S.2    Cui, Z.3    Cui, Z.4    Lee, G.5
  • 115
    • 77950438544 scopus 로고    scopus 로고
    • Microfluidic cell culture systems for drug research
    • Wu M., Huang S., Lee G. Microfluidic cell culture systems for drug research. Lab. Chip. 2010, 10:939-956.
    • (2010) Lab. Chip. , vol.10 , pp. 939-956
    • Wu, M.1    Huang, S.2    Lee, G.3
  • 117
    • 84879883966 scopus 로고    scopus 로고
    • An integrated microfluidic device in marine microalgae culture for toxicity screening application
    • Zheng G., Wang Y., Wang Z., Zhong W., Wang H., Li Y. An integrated microfluidic device in marine microalgae culture for toxicity screening application. Mar. Pollut. Bull. 2013, 72:231-243.
    • (2013) Mar. Pollut. Bull. , vol.72 , pp. 231-243
    • Zheng, G.1    Wang, Y.2    Wang, Z.3    Zhong, W.4    Wang, H.5    Li, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.