Microwell engineering characterization for mammalian cell culture process development

Biotechnology and Bioengineering

Volumn 105, Issue 2, 2010, Pages 260-275

  Barrett, Timothy A ^a   Wu, Andrew ^a   Zhang, Hu ^b   Levy, M Susana ^c   Lye, Gary J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KEELE UNIVERSITY   (United Kingdom)

^c Biogenesis Bago   (Argentina)

Author keywords

Cell culture; High throughput bioprocess development; Hybridoma; Shaken microwell

Indexed keywords

ANTIBODY PRODUCTION; ANTIBODY TITERS; AVERAGE ENERGY DISSIPATION; BIOPROCESS DEVELOPMENT; CELL LINES; CFD SIMULATIONS; EARLY PROCESS DESIGN; FLUID FLOW; GAS-LIQUID MASS TRANSFER; HIGH-THROUGHPUT; HYBRIDOMA CELLS; HYDRODYNAMIC FORCES; LIQUID FILL; LIQUID MIXING; LIQUID-PHASE MIXING; MAMMALIAN CELL CULTURE; MATERIAL REQUIREMENTS; MICRO WELLS; MICROPLATES; MICROTITER PLATES; MICROWELL PLATES; NEGATIVE IMPACTS; OXYGEN TRANSFER RATE; PLATFORM TECHNOLOGY; SHAKE FLASKS; SHAKEN MICROWELL; SHAKING FREQUENCY; SHAKING SPEED; SHEAR RATES; SUSPENSION CELL CULTURE; SUSPENSION CULTURES; WELL PLATES;

ANIMAL CELL CULTURE; ANTIBODIES; BOTTLES; CELL GROWTH; COMPUTATIONAL FLUID DYNAMICS; COST REDUCTION; ELECTRON ENERGY LOSS SPECTROSCOPY; ENERGY DISSIPATION; ENERGY DISSIPATORS; FLOW OF FLUIDS; FLUID DYNAMICS; GROWTH KINETICS; IODINE; LIQUIDS; MAMMALS; MICROCHANNELS; OXYGEN; PROCESS ENGINEERING; SHEAR DEFORMATION;

CELL CULTURE;

OXYGEN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIBODY TITER; ARTICLE; AUTOMATION; CELL GROWTH; CELL LINE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; DECOLORIZATION; ENERGY; FLUID FLOW; GAS; HIGH THROUGHPUT SCREENING; HYBRID CELL; HYBRIDOMA; HYDRODYNAMICS; LIQUID; MAMMAL CELL; NONHUMAN; PREDICTIVE VALIDITY; PROCESS DEVELOPMENT; REPRODUCIBILITY; SHEAR RATE; SIMULATION; SUSPENSION CELL CULTURE;

ANIMALS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; HYBRIDOMAS; IMMUNOGLOBULIN G; OXYGEN;

MAMMALIA; MURINAE;

EID: 74849109030     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22531     Document Type: Article

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