Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures

Biotechnology and Bioengineering

Volumn 106, Issue 1, 2010, Pages 57-67

  Amanullah, Ashraf ^a,c   Otero, Jose Manuel ^a   Mikola, Mark ^a   Hsu, Amy ^a   Zhang, Jinyou ^a,d   Aunins, John ^a   Schreyer, H Brett ^b,e   Hope, James A ^b,f   Russo, A Peter ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Seahorse Bioscience   (United States)

^c GENENTECH INC   (United States)

^d IMMUNOMEDICS INC   (United States)

^e GENOMATICA INC   (United States)

^f JHope Bioprocess Consultants   (United States)

Author keywords

Fed batch CHO cultures; High throughput; Micro bioreactor; Process reproducibility and scalability

Indexed keywords

FED BATCHES; HIGH-THROUGHPUT; MICRO-BIOREACTOR; PROCESS REPRODUCIBILITY AND SCALABILITY; REPRODUCIBILITIES;

BIOCONVERSION; BIOREACTORS; BOTTLES; CELL CULTURE; DISSOLUTION; DISSOLVED OXYGEN; DISSOLVED OXYGEN SENSORS; GROWTH KINETICS; MONOCLONAL ANTIBODIES; SCALABILITY; THROUGHPUT;

BATCH CELL CULTURE;

DISSOLVED OXYGEN; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; BIOREACTOR DESIGN; CELL DENSITY; CHO CELL; CONTROLLED STUDY; FED BATCH CULTURE; GAS PERMEABILITY; HIGH THROUGHPUT SCREENING; METABOLITE; MICROFLUIDIC ANALYSIS; NON INVASIVE MEASUREMENT; NONHUMAN; ONLINE SYSTEM; PH; PROCESS DEVELOPMENT; REACTOR OPTIMIZATION; REPRODUCIBILITY; ROBOTICS; SCALE UP;

ANIMALS; BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; IMMUNOGLOBULIN G; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS;

EID: 77951570798     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.2266     Document Type: Article

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