A high throughput capillary electrophoresis method to obtain pharmacokinetics and quality attributes of a therapeutic molecule in circulation

mAbs

Volumn 4, Issue 4, 2012, Pages 521-531

  Piparia, Reema ^a   Ouellette, David ^a   Stine, W Blaine ^a   Grinnell, Christine ^a   Tarcsa, Edit ^a   Radziejewski, Czeslaw ^a   Correia, Ivan ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Aggregate; CE SDS; Clearance; Dimer; Fluorophore; Labchip GXII; Pharmacokinetics

Indexed keywords

DIMER; HUMAN MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DIMERIZATION; DRUG BLOOD LEVEL; DRUG ELIMINATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE; FOLLOW UP; FRAGMENTATION REACTION; HIGH THROUGHPUT SCREENING; MALE; MASS SPECTROMETRY; MEDICAL DEVICE; MICROFLUIDIC ANALYSIS; MOLECULAR WEIGHT; NONHUMAN; PLASMA HALF LIFE; RAT; SINGLE DRUG DOSE;

ANIMALS; ANTIBODIES, MONOCLONAL; ELECTROPHORESIS, CAPILLARY; FLUORESCENT DYES; HUMANS; MALE; MICROFLUIDIC ANALYTICAL TECHNIQUES; PROTEIN MULTIMERIZATION; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TIME FACTORS;

EID: 84863446028     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.20099     Document Type: Article

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