Multivariate data analysis as a PAT tool for early bioprocess development data

Journal of Biotechnology

Volumn 167, Issue 3, 2013, Pages 262-270

  Mercier, Sarah M ^a   Diepenbroek, Bas ^a   Dalm, Marcella C F ^a,c   Wijffels, Rene H ^b   Streefland, Mathieu ^b  

^a CRUCELL HOLLAND BV   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c SYNTHON BV   (Netherlands)

Author keywords

Bioprocessing; Cell cultivation; Early development; Multivariate data analysis; Process Analytical Technology; Quality by design

Indexed keywords

BIOPROCESSING; CELL CULTIVATION; EARLY DEVELOPMENT; MULTIVARIATE DATA ANALYSIS; PROCESS ANALYTICAL TECHNOLOGY; QUALITY BY DESIGNS;

MULTIVARIANT ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; TOOLS;

QUALITY CONTROL;

ARTICLE; BATCH PROCESS; BIOPROCESS; DATA ANALYSIS; HUMAN; HUMAN CELL; MULTIVARIATE ANALYSIS; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; PRODUCTIVITY; SCALE UP; SENSITIVITY ANALYSIS; UNIVARIATE ANALYSIS; BIOLOGICAL MODEL; BIOLOGY; BIOREACTOR; BIOTECHNOLOGY; CULTURE TECHNIQUE; FACTUAL DATABASE; INFORMATION PROCESSING; PRINCIPAL COMPONENT ANALYSIS; REGRESSION ANALYSIS; TRANSFORMED CELL LINE;

BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CELL LINE, TRANSFORMED; COMPUTATIONAL BIOLOGY; DATA COLLECTION; DATABASES, FACTUAL; HUMANS; LEAST-SQUARES ANALYSIS; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS;

EID: 84881512365     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2013.07.006     Document Type: Article

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