HDX-MS guided drug discovery: Small molecules and biopharmaceuticals

Current Opinion in Structural Biology

Volumn 28, Issue 1, 2014, Pages 105-111

  Marciano, David P ^a   Dharmarajan, Venkatasubramanian ^a   Griffin, Patrick R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCOSYLCERAMIDASE; BIOSIMILAR AGENT; CELL NUCLEUS RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLITAZONE DERIVATIVE; GLUCOSYLCERAMIDASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RECOMBINANT PROTEIN; SR 1664; UNCLASSIFIED DRUG; DEUTERIUM; DRUG; HYDROGEN;

BINDING AFFINITY; CHEMICAL MODIFICATION; COMPUTER PROGRAM; CONFORMATION; DEUTERIUM HYDROGEN EXCHANGE; DRUG RESEARCH; HUMAN; IMAGE PROCESSING; LIGAND BINDING; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STABILITY; PROTEIN TARGETING; REVIEW; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG DEVELOPMENT; PROCEDURES; TRENDS;

DEUTERIUM; DRUG DISCOVERY; HYDROGEN; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS;

EID: 84908667545     PISSN: 0959440X     EISSN: 1879033X     Source Type: Journal    
DOI: 10.1016/j.sbi.2014.08.007     Document Type: Review

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