Hydrophobic interactions improve selectivity to ERα for benzothiophene SERMs

ACS Medicinal Chemistry Letters

Volumn 3, Issue 3, 2012, Pages 207-210

  Chalmers, Michael J ^a   Wang, Yong ^b   Novick, Scott ^a   Sato, Masahiko ^b   Bryant, Henry U ^b   Montrose Rafizdeh, Chahrzad ^b   Griffin, Patrick R ^a   Dodge, Jeffrey A ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

estrogen receptor ; estrogen receptor ; hydrogen deuterium exchange; SERM

Indexed keywords

BENZOTHIOPHENE DERIVATIVE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; LIGAND; RALOXIFENE; TAMOXIFEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOPHYSICS; BONE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DEUTERIUM HYDROGEN EXCHANGE; DRUG DEVELOPMENT; FEMALE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; UTERUS;

RODENTIA;

EID: 84863257556     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2002532     Document Type: Article

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