Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism

Structure

Volumn 20, Issue 1, 2012, Pages 139-150

  Hughes, Travis S ^a   Chalmers, Michael J ^a   Novick, Scott ^a   Kuruvilla, Dana S ^a   Chang, Mi Ra ^a   Kamenecka, Theodore M ^a   Rance, Mark ^b   Johnson, Bruce A ^c   Burris, Thomas P ^a   Griffin, Patrick R ^a   Kojetin, Douglas J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c One Moon Scientific Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MRL 20; MRL 24; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG MECHANISM; LIGAND BINDING DOMAIN; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN;

DEUTERIUM EXCHANGE MEASUREMENT; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PPAR GAMMA; PROTEIN BINDING; PROTEIN CONFORMATION; THIAZOLIDINEDIONES;

EID: 84855795379     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2011.10.018     Document Type: Article

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