Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: Insights into the antagonism of the hypolipidemic agent Z-guggulsterone

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1844, Issue 9, 2014, Pages 1684-1693

  Yang, Liping ^a   Broderick, David ^a   Jiang, Yuan ^a   Hsu, Victor ^a   Maier, Claudia S ^a  

^a OREGON STATE UNIVERSITY   (United States)

Author keywords

Conformational dynamics; Farnesoid X receptor; Guggulsterone; Hydrogen deuterium exchange; Ligand interaction; Mass spectrometry

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; CHENODEOXYCHOLIC ACID; DEUTERIUM; FARNESOID X RECEPTOR; GUGGULSTERONE;

ARTICLE; CHEMICAL REACTION KINETICS; CONFORMATIONAL TRANSITION; DEUTERIUM HYDROGEN EXCHANGE; FLUORESCENCE; IN VITRO STUDY; LIGAND BINDING; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL;

CONFORMATIONAL DYNAMICS; FARNESOID X RECEPTOR; GUGGULSTERONE; HYDROGEN/DEUTERIUM EXCHANGE; LIGAND INTERACTION; MASS SPECTROMETRY;

AMINO ACID SEQUENCE; CHENODEOXYCHOLIC ACID; DEUTERIUM EXCHANGE MEASUREMENT; ESCHERICHIA COLI; HUMANS; HYPOLIPIDEMIC AGENTS; ISOXAZOLES; LIGANDS; MASS SPECTROMETRY; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PREGNENEDIONES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS;

EID: 84904325017     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2014.06.007     Document Type: Article

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