-
2
-
-
8844262660
-
Principles for modulation of the nuclear receptor superfamily
-
Gronemeyer H, Gustafsson JA, Laudet V. Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov 2004;3(11):950-964.
-
(2004)
Nat Rev Drug Discov
, vol.3
, Issue.11
, pp. 950-964
-
-
Gronemeyer, H.1
Gustafsson, J.A.2
Laudet, V.3
-
3
-
-
0012473279
-
The nuclear receptor superfamily: The second decade
-
Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, et al. The nuclear receptor superfamily: The second decade. Cell 1995;83(6):835-839.
-
(1995)
Cell
, vol.83
, Issue.6
, pp. 835-839
-
-
Mangelsdorf, D.J.1
Thummel, C.2
Beato, M.3
Herrlich, P.4
Schutz, G.5
Umesono, K.6
-
4
-
-
21344434794
-
The selected pathophysiological aspects of PPARs activation
-
Kiec-Wilk B, Dembinska-Kiec A, Olszanecka A, Bodzioch M, Kawecka-Jaszcz K. The selected pathophysiological aspects of PPARs activation. J Physiol Pharmacol 2005;56(2):149-162.
-
(2005)
J Physiol Pharmacol
, vol.56
, Issue.2
, pp. 149-162
-
-
Kiec-Wilk, B.1
Dembinska-Kiec, A.2
Olszanecka, A.3
Bodzioch, M.4
Kawecka-Jaszcz, K.5
-
5
-
-
0033542873
-
Medical significance of peroxisome proliferator-activated receptors
-
Vamecq J, Latruffe N. Medical significance of peroxisome proliferator-activated receptors. Lancet 1999;354(9173):141-148.
-
(1999)
Lancet
, vol.354
, Issue.9173
, pp. 141-148
-
-
Vamecq, J.1
Latruffe, N.2
-
6
-
-
0034681773
-
Thiazolidinediones: An update
-
Schoonjans K, Auwerx J. Thiazolidinediones: An update. Lancet 2000;355(9208):1008-1010.
-
(2000)
Lancet
, vol.355
, Issue.9208
, pp. 1008-1010
-
-
Schoonjans, K.1
Auwerx, A.J.2
-
7
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990;347(6294):645-650.
-
(1990)
Nature
, vol.347
, Issue.6294
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
8
-
-
0032505096
-
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma
-
Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R, et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 1998;395(6698):137-143.
-
(1998)
Nature
, vol.395
, Issue.6698
, pp. 137-143
-
-
Nolte, R.T.1
Wisely, G.B.2
Westin, S.3
Cobb, J.E.4
Lambert, M.H.5
Kurokawa, R.6
-
9
-
-
0032553542
-
Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma
-
Uppenberg J, Svensson C, Jaki M, Bertilsson G, Jendeberg L, Berkenstam A. Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma. J Biol Chem 1998;273(47): 108-31.
-
(1998)
J Biol Chem
, vol.273
, Issue.47
, pp. 108-131
-
-
Uppenberg, J.1
Svensson, C.2
Jaki, M.3
Bertilsson, G.4
Jendeberg, L.5
Berkenstam, A.6
-
10
-
-
0037435046
-
Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions
-
Jordan VC. Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions. J Med Chem 2003;46(6):883-908.
-
(2003)
J Med Chem
, vol.46
, Issue.6
, pp. 883-908
-
-
Jordan, V.C.1
-
11
-
-
0033306818
-
Raloxifene, a new selective estrogen receptor modulator
-
Goldfrank D, Haytoglu T, Frishman WH, Mohammad Z. Raloxifene, a new selective estrogen receptor modulator. J Clin Pharmacol 1999;39(8):767-774.
-
(1999)
J Clin Pharmacol
, vol.39
, Issue.8
, pp. 767-774
-
-
Goldfrank, D.1
Haytoglu, T.2
Frishman, W.H.3
Mohammad, Z.4
-
12
-
-
12444273748
-
Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator
-
Berger JP, Petro AE, Macnaul KL, Kelly LJ, Zhang BB, Richards K, et al. Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. Mol Endocrinol 2003;17(4):662-676.
-
(2003)
Mol Endocrinol
, vol.17
, Issue.4
, pp. 662-676
-
-
Berger, J.P.1
Petro, A.E.2
Macnaul, K.L.3
Kelly, L.J.4
Zhang, B.B.5
Richards, K.6
-
13
-
-
0032484224
-
A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties
-
Reginato MJ, Bailey ST, Krakow SL, Minami C, Ishii S, Tanaka H, et al. A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties. J Biol Chem 1998;273(49):679-32.
-
(1998)
J Biol Chem
, vol.273
, Issue.49
, pp. 679-732
-
-
Reginato, M.J.1
Bailey, S.T.2
Krakow, S.L.3
Minami, C.4
Ishii, S.5
Tanaka, H.6
-
14
-
-
2642557181
-
A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity
-
Rocchi S, Picard F, Vamecq J, Gelman L, Potier N, Zeyer D, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell 2001;8(4):737-747.
-
(2001)
Mol Cell
, vol.8
, Issue.4
, pp. 737-747
-
-
Rocchi, S.1
Picard, F.2
Vamecq, J.3
Gelman, L.4
Potier, N.5
Zeyer, D.6
-
15
-
-
10644293716
-
Benzoyl 2-methyl indoles as selective PPARgamma modulators
-
Acton JJ, 3rd, Black RM, Jones AB, Moller DE, Colwell L, Doebber TW, et al. Benzoyl 2-methyl indoles as selective PPARgamma modulators. Bioorg Med Chem Lett 2005;15(2):357-362.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, Issue.2
, pp. 357-362
-
-
Acton III, J.J.1
Black, R.M.2
Jones, A.B.3
Moller, D.E.4
Colwell, L.5
Doebber, T.W.6
-
16
-
-
4644313413
-
A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects
-
Ostberg T, Svensson S, Selen G, Uppenberg J, Thor M, Sundbom M, et al. A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects. J Biol Chem 2004;279(39):41124-41130.
-
(2004)
J Biol Chem
, vol.279
, Issue.39
, pp. 41124-41130
-
-
Ostberg, T.1
Svensson, S.2
Selen, G.3
Uppenberg, J.4
Thor, M.5
Sundbom, M.6
-
17
-
-
0027250665
-
Primary structure effects on peptide group hydrogen-exchange
-
Bai YW, Milne JS, Mayne L, Englander SW. Primary structure effects on peptide group hydrogen-exchange. Proteins Struct Funct Gen 1993;17(1):75-86.
-
(1993)
Proteins Struct Funct Gen
, vol.17
, Issue.1
, pp. 75-86
-
-
Bai, Y.W.1
Milne, J.S.2
Mayne, L.3
Englander, S.W.4
-
18
-
-
9744270012
-
Insights into enzyme structure and dynamics elucidated by amide H/D exchange mass spectrometry
-
Busenlehner LS, Armstrong RN. Insights into enzyme structure and dynamics elucidated by amide H/D exchange mass spectrometry. Arch Biochem Biophys 2005;433(1):34-46.
-
(2005)
Arch Biochem Biophys
, vol.433
, Issue.1
, pp. 34-46
-
-
Busenlehner, L.S.1
Armstrong, R.N.2
-
19
-
-
0031571097
-
Touring the landscapes: Partially folded proteins examined by hydrogen exchange
-
Chamberlain AK, Marqusee S. Touring the landscapes: Partially folded proteins examined by hydrogen exchange. Structure 1997;5(7):859-863.
-
(1997)
Structure
, vol.5
, Issue.7
, pp. 859-863
-
-
Chamberlain, A.K.1
Marqusee, S.2
-
20
-
-
0035326304
-
Investigating protein structure and dynamics by hydrogen exchange MS
-
Engen JR, Smith DL. Investigating protein structure and dynamics by hydrogen exchange MS. Anal Chem 2001;73(9):256A-265A.
-
(2001)
Anal Chem
, vol.73
, Issue.9
-
-
Engen, J.R.1
Smith, D.L.2
-
21
-
-
0020855355
-
Hydrogen-exchange and structural dynamics of proteins and nucleic-acids
-
Englander SW, Kallenbach NR. Hydrogen-exchange and structural dynamics of proteins and nucleic-acids. Q Rev Biophys 1983;16(4):521-655.
-
(1983)
Q Rev Biophys
, vol.16
, Issue.4
, pp. 521-655
-
-
Englander, S.W.1
Kallenbach, N.R.2
-
22
-
-
0030612609
-
Hydrogen exchange: The modern legacy of Linderstrom-Lang
-
Englander SW, Mayne L, Bai Y, Sosnick TR. Hydrogen exchange: The modern legacy of Linderstrom-Lang. Protein Sci 1997;6(5):1101-1109.
-
(1997)
Protein Sci
, vol.6
, Issue.5
, pp. 1101-1109
-
-
Englander, S.W.1
Mayne, L.2
Bai, Y.3
Sosnick, T.R.4
-
23
-
-
2342485044
-
Hydrogen/deuterium exchange mass spectrometry for investigating protein-ligand interactions
-
Garcia RA, Pantazatos D, Villarreal FJ. Hydrogen/deuterium exchange mass spectrometry for investigating protein-ligand interactions. Assay Drug Dev Technol 2004;2(1):81-91.
-
(2004)
Assay Drug Dev Technol
, vol.2
, Issue.1
, pp. 81-91
-
-
Garcia, R.A.1
Pantazatos, D.2
Villarreal, F.J.3
-
24
-
-
84867499821
-
Ligand induced stabilization of nuclear receptors: Use of hydrogen deuterium exchange mass spectrometry to guide design of specific nhr modulators
-
Griffin PR, Hamuro Y, Coales SJ, Southern MR. Ligand induced stabilization of nuclear receptors: Use of hydrogen deuterium exchange mass spectrometry to guide design of specific nhr modulators. Abst Pap Amer Chem Soc 2004;228:U532-U532.
-
(2004)
Abst Pap Amer Chem Soc
, vol.228
-
-
Griffin, P.R.1
Hamuro, Y.2
Coales, S.J.3
Southern, M.R.4
-
25
-
-
0036428762
-
Phosphorylation driven motions in the COOH-terminal Src kinase, Csk, revealed through enhanced hydrogendeuterium exchange and mass spectrometry (DXMS)
-
Hamuro Y, Wong L, Shaffer J, Kim JS, Stranz DD, Jennings PA, et al. Phosphorylation driven motions in the COOH-terminal Src kinase, Csk, revealed through enhanced hydrogendeuterium exchange and mass spectrometry (DXMS). J Mol Biol 2002;323(5):871-881.
-
(2002)
J Mol Biol
, vol.323
, Issue.5
, pp. 871-881
-
-
Hamuro, Y.1
Wong, L.2
Shaffer, J.3
Kim, J.S.4
Stranz, D.D.5
Jennings, P.A.6
-
26
-
-
0344405702
-
Dynamics of cAPK type II beta activation revealed by enhanced amide H/H-2 exchange mass spectrometry (DXMS)
-
Hamuro Y, Zawadzki KM, Kim JS, Stranz DD, Taylor SS, Woods VL. Dynamics of cAPK type II beta activation revealed by enhanced amide H/H-2 exchange mass spectrometry (DXMS). J Mol Biol 2003;327(5):1065-1076.
-
(2003)
J Mol Biol
, vol.327
, Issue.5
, pp. 1065-1076
-
-
Hamuro, Y.1
Zawadzki, K.M.2
Kim, J.S.3
Stranz, D.D.4
Taylor, S.S.5
Woods, V.L.6
-
27
-
-
20444463552
-
Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states
-
Lisal J, Lam TT, Kainov DE, Emmett MR, Marshall AG, Tuma R. Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states. Nat Struct Biol 2005;12(5):460-466.
-
(2005)
Nat Struct Biol
, vol.12
, Issue.5
, pp. 460-466
-
-
Lisal, J.1
Lam, T.T.2
Kainov, D.E.3
Emmett, M.R.4
Marshall, A.G.5
Tuma, R.6
-
28
-
-
17144398382
-
Probing the structure of the infectious amyloid form of the prionforming domain of HET-s using high resolution hydrogen/deuterium exchange monitored by mass spectrometry
-
Nazabal A, Maddelein ML, Bonneu M, Saupe SJ, Schmitter JM. Probing the structure of the infectious amyloid form of the prionforming domain of HET-s using high resolution hydrogen/deuterium exchange monitored by mass spectrometry. J Biol Chem 2005;280(14):220-13.
-
(2005)
J Biol Chem
, vol.280
, Issue.14
, pp. 220-313
-
-
Nazabal, A.1
Maddelein, M.L.2
Bonneu, M.3
Saupe, S.J.4
Schmitter, J.M.5
-
29
-
-
0035075187
-
Kinetics of unfolding and folding from amide hydrogen exchange in native ubiquitin
-
Sivaraman T, Arrington CB, Robertson AD. Kinetics of unfolding and folding from amide hydrogen exchange in native ubiquitin. Nat Struct Biol 2001;8(4):331-333.
-
(2001)
Nat Struct Biol
, vol.8
, Issue.4
, pp. 331-333
-
-
Sivaraman, T.1
Arrington, C.B.2
Robertson, A.D.3
-
30
-
-
14844367046
-
Solvent accessibility of native and hydrolyzed human complement protein 3 analyzed by hydrogen/deuterium exchange and mass spectrometry
-
Winters MS, Spellman DS, Lambris JD. Solvent accessibility of native and hydrolyzed human complement protein 3 analyzed by hydrogen/deuterium exchange and mass spectrometry. J Immunol 2005;174(6):3469-3474.
-
(2005)
J Immunol
, vol.174
, Issue.6
, pp. 3469-3474
-
-
Winters, M.S.1
Spellman, D.S.2
Lambris, J.D.3
-
31
-
-
0942290634
-
Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry
-
Yan XG, Broderick D, Leid ME, Schimerlik MI, Deinzer ML. Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry. Biochemistry 2004;43(4):909-917.
-
(2004)
Biochemistry
, vol.43
, Issue.4
, pp. 909-917
-
-
Yan, X.G.1
Broderick, D.2
Leid, M.E.3
Schimerlik, M.I.4
Deinzer, M.L.5
-
32
-
-
1842868694
-
Mass spectrometric approaches using electrospray ionization charge states and hydrogen-deuterium exchange for determining protein structures and their conformational changes
-
Yan XG, Watson J, Ho PS, Deinzer ML. Mass spectrometric approaches using electrospray ionization charge states and hydrogen-deuterium exchange for determining protein structures and their conformational changes. Mol Cell Proteomics 2004;3(1):10-23.
-
(2004)
Mol Cell Proteomics
, vol.3
, Issue.1
, pp. 10-23
-
-
Yan, X.G.1
Watson, J.2
Ho, P.S.3
Deinzer, M.L.4
-
33
-
-
0027529263
-
Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation
-
Zhang Z, Smith DL. Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation. Protein Sci 1993;2(4):522-531.
-
(1993)
Protein Sci
, vol.2
, Issue.4
, pp. 522-531
-
-
Zhang, Z.1
Smith, D.L.2
-
34
-
-
0033993921
-
Nerve growth factor activation of the extracellular signalregulated kinase pathway is modulated by Ca2+ and calmodulin
-
Egea J, Espinet C, Soler RM, Peiro S, Rocamora N, Comella JX. Nerve growth factor activation of the extracellular signalregulated kinase pathway is modulated by Ca2+ and calmodulin. Mol Cell Biol 2000;20(6):1931-1946.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.6
, pp. 1931-1946
-
-
Egea, J.1
Espinet, C.2
Soler, R.M.3
Peiro, S.4
Rocamora, N.5
Comella, J.X.6
-
35
-
-
1842857772
-
Rapid analysis of protein structure and dynamics by hydrogen/deuterium exchange mass spectrometry
-
Hamuro Y, Coales SJ, Southern MR, Nemeth-Cawley JF, Stranz DD, Griffin PR. Rapid analysis of protein structure and dynamics by hydrogen/deuterium exchange mass spectrometry. J Biomol Tech 2003;14(3):171-182.
-
(2003)
J Biomol Tech
, vol.14
, Issue.3
, pp. 171-182
-
-
Hamuro, Y.1
Coales, S.J.2
Southern, M.R.3
Nemeth-Cawley, J.F.4
Stranz, D.D.5
Griffin, P.R.6
-
36
-
-
33144462544
-
Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry
-
Chalmers MJ, Busby SA, Pascal BD, He Y, Hendrickson CL, Marshall AG, et al. Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry. Anal Chem 2006;78(4):1005-1014.
-
(2006)
Anal Chem
, vol.78
, Issue.4
, pp. 1005-1014
-
-
Chalmers, M.J.1
Busby, S.A.2
Pascal, B.D.3
He, Y.4
Hendrickson, C.L.5
Marshall, A.G.6
-
37
-
-
33746495527
-
Hydrogen/deuterium-exchange (H/D-Ex) of PPARgamma LBD in the presence of various modulators
-
Hamuro Y, Coales SJ, Morrow JA, Molnar KS, Tuske SJ, Southern MR, et al. Hydrogen/deuterium-exchange (H/D-Ex) of PPARgamma LBD in the presence of various modulators. Protein Sci 2006;15(8):1883-1892.
-
(2006)
Protein Sci
, vol.15
, Issue.8
, pp. 1883-1892
-
-
Hamuro, Y.1
Coales, S.J.2
Morrow, J.A.3
Molnar, K.S.4
Tuske, S.J.5
Southern, M.R.6
-
38
-
-
31844439828
-
Ultra performance liquid chromatography (UPLC) further improves hydrogen/deuterium exchange mass spectrometry
-
Wu Y, Engen JR, Hobbins WB. Ultra performance liquid chromatography (UPLC) further improves hydrogen/deuterium exchange mass spectrometry. J Am Soc Mass Spectrometry 2006;17(2):163-167.
-
(2006)
J Am Soc Mass Spectrometry
, vol.17
, Issue.2
, pp. 163-167
-
-
Wu, Y.1
Engen, J.R.2
Hobbins, W.B.3
-
39
-
-
33750617803
-
Improving digestion efficiency under H/D exchange conditions with activated pepsinogen coupled columns
-
Busby SA, Chalmers MJ, Griffin PR. Improving digestion efficiency under H/D exchange conditions with activated pepsinogen coupled columns. Int J Mass Spectrometry 2007;259(1-3):130-139.
-
(2007)
Int J Mass Spectrometry
, vol.259
, Issue.1-3
, pp. 130-139
-
-
Busby, S.A.1
Chalmers, M.J.2
Griffin, P.R.3
-
40
-
-
34249341670
-
The Deuterator: Software for the determination of backbone amide deuterium levels from H/D exchange MS data
-
Pascal BD, Chalmers MJ, Busby SA, Mader CC, Southern MR, Tsinoremas NF, et al. The Deuterator: Software for the determination of backbone amide deuterium levels from H/D exchange MS data. BMC Bioinformatics 2007;8(1):156.
-
(2007)
BMC Bioinformatics
, vol.8
, Issue.1
, pp. 156
-
-
Pascal, B.D.1
Chalmers, M.J.2
Busby, S.A.3
Mader, C.C.4
Southern, M.R.5
Tsinoremas, N.F.6
-
41
-
-
0028972025
-
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
-
Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 1995;83(5):803-812.
-
(1995)
Cell
, vol.83
, Issue.5
, pp. 803-812
-
-
Forman, B.M.1
Tontonoz, P.2
Chen, J.3
Brun, R.P.4
Spiegelman, B.M.5
Evans, R.M.6
-
42
-
-
0028972026
-
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
-
Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 1995;83(5):813-819.
-
(1995)
Cell
, vol.83
, Issue.5
, pp. 813-819
-
-
Kliewer, S.A.1
Lenhard, J.M.2
Willson, T.M.3
Patel, I.4
Morris, D.C.5
Lehmann, J.M.6
-
43
-
-
0032540325
-
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
-
Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 1998;93(2):229-240.
-
(1998)
Cell
, vol.93
, Issue.2
, pp. 229-240
-
-
Nagy, L.1
Tontonoz, P.2
Alvarez, J.G.3
Chen, H.4
Evans, R.M.5
-
44
-
-
0036964284
-
The activity of PPAR gamma in primary human trophoblasts is enhanced by oxidized lipids
-
Schild RL, Schaiff WT, Carlson MG, Cronbach EJ, Nelson DM, Sadovsky Y. The activity of PPAR gamma in primary human trophoblasts is enhanced by oxidized lipids. J Clin Endocrinol Metabolism 2002;87(3):1105-1110.
-
(2002)
J Clin Endocrinol Metabolism
, vol.87
, Issue.3
, pp. 1105-1110
-
-
Schild, R.L.1
Schaiff, W.T.2
Carlson, M.G.3
Cronbach, E.J.4
Nelson, D.M.5
Sadovsky, Y.6
|