Measuring dynamics in weakly structured regions of proteins using microfluidics-enabled subsecond H/D exchange mass spectrometry

Analytical Chemistry

Volumn 84, Issue 8, 2012, Pages 3771-3779

  Rob, Tamanna ^a   Liuni, Peter ^a   Gill, Preet Kamal ^a   Zhu, Shaolong ^a   Balachandran, Naresh ^b   Berti, Paul J ^b   Wilson, Derek J ^a  

^a YORK UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CONFORMATIONAL DYNAMICS; CYTOCHROME C; DEVICE PERFORMANCE; DYNAMIC BEHAVIORS; H/D EXCHANGE; HIGH THROUGHPUT; INTEGRATED MICROFLUIDIC DEVICES; MICRO-REACTOR; ON CHIPS; PROSTHETIC GROUPS; PROTEIN DIGESTION; RESIDENCE TIME; SECOND TIME SCALE; SINGLE CHIPS; STATIC MIXERS; SYNTHASES; TETRAMERIC ENZYMES; THREE MODELS; TIME-RESOLVED; UBIQUITIN;

AMIDES; DYNAMICS; ELECTROSPRAY IONIZATION; EXPERIMENTS; MASS SPECTROMETRY; MIXERS (MACHINERY); PORPHYRINS;

PROTEINS;

CYTOCHROME C; PROTEIN; UBIQUITIN;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; INSTRUMENTATION; MICROFLUIDICS; MOLECULAR GENETICS; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; CYTOCHROMES C; MICROFLUIDICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; UBIQUITIN;

EID: 84859904015     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac300365u     Document Type: Article

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