Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 26, 2014, Pages 6541-6558

  Huang, Richard Y C ^a   Chen, Guodong ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

HDX MS; Higher order structure; Mass spectrometry; Protein therapeutics

Indexed keywords

CHARACTERIZATION; DRUG PRODUCTS; EPITOPES; HYDROGEN; MASS SPECTROMETRY; SPECTROMETRY;

BIOPHARMACEUTICAL INDUSTRY; CONFORMATIONAL DYNAMICS; HDX-MS; HIGHER-ORDER STRUCTURE; HYDROGEN/DEUTERIUM EXCHANGE; PROTEIN THERAPEUTICS; PROTEIN-PROTEIN INTERACTIONS; THERAPEUTIC DRUGS;

PROTEINS;

PROTEIN;

ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DEUTERIUM HYDROGEN EXCHANGE; EPITOPE MAPPING; HUMAN; MASS SPECTROMETRY; PROCEDURES; PROTEIN CONFORMATION;

ANIMALS; DEUTERIUM EXCHANGE MEASUREMENT; EPITOPE MAPPING; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEINS;

EID: 84928376080     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-7924-3     Document Type: Review

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