Understanding the conformational impact of chemical modifications on monoclonal antibodies with diverse sequence variation using hydrogen/deuterium exchange mass spectrometry and structural modeling

Analytical Chemistry

Volumn 86, Issue 7, 2014, Pages 3468-3475

  Zhang, Aming ^a   Hu, Ping ^a,b   Macgregor, Paul ^a   Xue, Yu ^a   Fan, Haihong ^a   Suchecki, Peter ^a   Olszewski, Leonard ^a   Liu, Aston ^a  

^a GLAXOSMITHKLINE   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL MODIFICATION; ESTERIFICATION; GLYCOSYLATION; ISOMERIZATION; ISOMERS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; OXIDATION; REACTION INTERMEDIATES; SURFACE PLASMON RESONANCE; THERMODYNAMIC STABILITY;

AGGREGATION PROPENSITY; CONFORMATIONAL CHANGE; HIGH SPATIAL RESOLUTION; HYDROGEN/DEUTERIUM EXCHANGE; INTERFACE INTERACTION; INTERMEDIATE FORMATION; MONOCLONAL ANTIBODIES (MABS); PROTEIN THERAPEUTICS;

CONFORMATIONS;

AMINO ACID; DEUTERIUM; HYDROGEN; MONOCLONAL ANTIBODY;

CHEMISTRY; GLYCOSYLATION; MASS SPECTROMETRY; OXIDATION REDUCTION REACTION; PROCEDURES; PROTEIN CONFORMATION;

AMINO ACIDS; ANTIBODIES, MONOCLONAL; DEUTERIUM; GLYCOSYLATION; HYDROGEN; MASS SPECTROMETRY; OXIDATION-REDUCTION; PROTEIN CONFORMATION;

EID: 84897562208     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac404130a     Document Type: Article

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