Ligand-dependent perturbation of the conformational ensemble for the GPCR β 2 adrenergic receptor revealed by HDX

Structure

Volumn 19, Issue 10, 2011, Pages 1424-1432

  West, Graham M ^a   Chien, Ellen Y T ^b   Katritch, Vsevolod ^c   Gatchalian, Jovylyn ^b   Chalmers, Michael J ^a   Stevens, Raymond C ^b   Griffin, Patrick R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRENOLOL; BETA 2 ADRENERGIC RECEPTOR; CARAZOLOL; CLENBUTEROL; ISOPRENALINE; LIGAND; PROTON; TIMOLOL;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; DRUG EFFECT; ENERGY; LIGAND BINDING; MASS SPECTROMETRY; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; STRUCTURE ANALYSIS;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ADRENERGIC BETA-2 RECEPTOR ANTAGONISTS; ALPRENOLOL; BINDING SITES; CLENBUTEROL; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; HYDROGEN BONDING; LIGANDS; MASS SPECTROMETRY; MEMBRANES; PEPTIDES; PROPANOLAMINES; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ADRENERGIC, BETA-2; TIMOLOL;

EID: 80054081804     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2011.08.001     Document Type: Article

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