Hydrogen/Deuterium Exchange Reveals Distinct Agonist/Partial Agonist Receptor Dynamics within Vitamin D Receptor/Retinoid X Receptor Heterodimer

Structure

Volumn 18, Issue 10, 2010, Pages 1332-1341

  Zhang, Jun ^a   Chalmers, Michael J ^a   Stayrook, Keith R ^b   Burris, Lorri L ^b   Garcia Ordonez, Ruben D ^a   Pascal, Bruce D ^a   Burris, Thomas P ^a   Dodge, Jeffery A ^b   Griffin, Patrick R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,25 DIHYDROXYERGOCALCIFEROL; 2BETA (3 HYDROXYPROPOXY)CALCITRIOL; ALFACALCIDOL; CELL NUCLEUS RECEPTOR; HETERODIMER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR; VITAMIN D RECEPTOR;

AGONIST; ARTICLE; COMPARATIVE STUDY; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CALCITRIOL; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM; DEUTERIUM EXCHANGE MEASUREMENT; HEK293 CELLS; HUMANS; HYDROGEN; HYDROXYCHOLECALCIFEROLS; KINETICS; LUCIFERASES; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RECEPTORS, CALCITRIOL; RETINOID X RECEPTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 77957770064     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2010.07.007     Document Type: Article

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