Characterization of elements involved in allosteric light regulation of phosphodiesterase activity by comparison of different functional BlrP1 states

Journal of Molecular Biology

Volumn 426, Issue 4, 2014, Pages 853-868

  Winkler, Andreas ^a   Udvarhelyi, Anikó ^a   Hartmann, Elisabeth ^a   Reinstein, Jochen ^a   Menzel, Andreas ^b   Shoeman, Robert L ^a   Schlichting, Ilme ^a  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^b PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

allostery; BLUF photoreceptor; c di GMP; EAL; HDX

Indexed keywords

BLUE LIGHT REGULATED PHOSPHODIESTERASE 1; CALCIUM; CYCLIC GMP; DIMER; PHOSPHODIESTERASE I; UNCLASSIFIED DRUG; DEUTERIUM; EDETIC ACID; HYDROGEN; MAGNESIUM;

ALLOSTERISM; ARTICLE; BLUE LIGHT; CALCIUM BINDING; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; DIMERIZATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME STRUCTURE; KLEBSIELLA PNEUMONIAE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; X RAY CRYSTALLOGRAPHY; HYDROLYSIS; ILLUMINATION; LIGHT; MASS SPECTROMETRY; OLIGOMERIZATION; PH; POINT MUTATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION; ULTRAVIOLET SPECTROSCOPY;

BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE;

ALLOSTERY; BLRP1; BLUE-LIGHT-REGULATED PHOSPHODIESTERASE 1; BLUF; BLUF-PHOTORECEPTOR; C-DI-GMP; CYCLIC DIMERIC GMP; EAL; EDTA; ETHYLENEDIAMINETETRAACETIC ACID; HDX; HYDROGEN-DEUTERIUM EXCHANGE; LED; LIGHT-EMITTING DIODE; MASS SPECTROMETRY; MS; NMA; NORMAL MODE ANALYSIS; PDE; PHOSPHODIESTERASE; SAXS; SENSOR OF BLUE LIGHT USING FAD; SMALL-ANGLE X-RAY SCATTERING;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CALCIUM; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CYCLIC GMP; DEUTERIUM EXCHANGE MEASUREMENT; KLEBSIELLA PNEUMONIAE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORIC DIESTER HYDROLASES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SCATTERING, SMALL ANGLE; SIGNAL TRANSDUCTION; X-RAY DIFFRACTION;

EID: 84893650116     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.11.018     Document Type: Article

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