Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): A randomised, placebo-controlled, dose-ranging, phase 2 study
for the LAPLACETIMI 57 Investigators In press; PMID:23141813; http://dx.doi.org/10.1016/S0140-6736(12)61770-X
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Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholester-olaemia (MENDEL): A randomised, double-blind, placebo-controlled, phase 2 study
In press; PMID:23141812; http://dx.doi.org/10.1016/S0140-6736(12)
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Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/Kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: The reduction of LDL-C with PCSK9 inhibition in heterozygous familial hypercholesterolemia disorder (RUTHERFORD) randomized trial
Raal F, Scott R, Somaratne R., Bridges I, Li G, Wasserman S.M., et al Low-Density Lipoprotein Cholesterol-Lowering Effects of AMG 145, a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease in Patients With Heterozygous Familial Hypercholesterolemia: The Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) Randomized Trial. Circulation 2012; 126:2408-17; PMID:23129602; http://dx.doi.org/10.1161/CIRCULATIONAHA.112.144055
Effects of AMG 145 on low-density lipoprotein cholesterol levels: Results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins
Dias CS, Shaywitz AJ, Wasserman S.M., Smith B P, Gao B, Stolman D.S., et al Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels: Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers and Hypercholesterolemic Subjects on Statins. J Am Coll Cardiol 2012; 60:1888-98; PMID:23083772; http://dx.doi.org/10.1016/j.jacc. 2012.08.986
Trastuzumab emtansine (T-DM1) vs trastuzumab plus docetaxel (H+T) in previously untreated HER2-positive metastatic breast cancer (MBC): Primary results of a randomized, multicenter, open-label phase II study (TDM4450g/BO21976)
Stockholm, Sweden, September 23-27 abstract 5001
Hurvitz S, Dirix L, Kocsis J., Gianni L, Lu J, Vinholes J., et al Trastuzumab emtansine (T-DM1) vs trastuzumab plus docetaxel (H+T) in previously untreated HER2-positive metastatic breast cancer (MBC): primary results of a randomized, multicenter, open-label phase II study (TDM4450g/BO21976). European Multidisciplinary Cancer Conference, Stockholm, Sweden, September 23-27, 2011; abstract 5001