Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies

FEBS Letters

Volumn 588, Issue 2, 2014, Pages 308-317

  Zhang, Hao ^a   Cui, Weidong ^a   Gross, Michael L ^a  

^a One Brookings Dr ^*  (United States)

Author keywords

FPOP; Hydrogen deuterium exchange; Ion mobility; Mass spectrometry; Monoclonal antibody; Native ESI; Protein footprinting; Top down and bottom up

Indexed keywords

IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G4; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANTIBODY DETECTION; ANTIGEN BINDING; DRUG APPROVAL; DRUG EFFICACY; DRUG STABILITY; DRUG STORAGE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; ION MOBILITY SPECTROMETRY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN CROSS LINKING; PROTEIN FOOTPRINTING; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEOMICS; REVIEW;

FPOP; HYDROGEN/DEUTERIUM EXCHANGE; ION MOBILITY; MASS SPECTROMETRY; MONOCLONAL ANTIBODY; NATIVE ESI; PROTEIN FOOTPRINTING; TOP-DOWN AND BOTTOM-UP;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOPHYSICAL PROCESSES; HUMANS; MASS SPECTROMETRY;

EID: 84892367060     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.11.027     Document Type: Review

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