Analysis of the local dynamics of human insulin and a rapid-acting insulin analog by hydrogen/deuterium exchange mass spectrometry

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1834, Issue 6, 2013, Pages 1210-1214

  Nakazawa, Shiori ^a,b   Ahn, Joomi ^c   Hashii, Noritaka ^b   Hirose, Kenji ^d   Kawasaki, Nana ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c WATERS CORPORATION   (United States)

^d Nihon Waters KK   (Japan)

Author keywords

HDX MS; Insulin; Insulin lispro

Indexed keywords

DEUTERIUM; HUMAN INSULIN; INSULIN LISPRO;

ARTICLE; DEUTERIUM HYDROGEN EXCHANGE; DIMERIZATION; DRUG STRUCTURE; DYNAMICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDE MAPPING; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; DEUTERIUM; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; HYDROGEN; INSULIN; INSULIN LISPRO; INSULIN, SHORT-ACTING; MASS SPECTROMETRY; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 84878110309     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2012.11.012     Document Type: Article

References (24)

1. J. Brange, U. Ribel, J.F. Hansen, G. Dodson, M.T. Hansen, S. Havelund, S.G. Melberg, F. Norris, K. Norris, L. Snel, A.R. Sørensen, and H.O. Voigt Monomeric insulins obtained by protein engineering and their medical implications Nature 333 1988 679 682
2. J. Brange, D.R. Owens, S. Kang, and A. Vølund Monomeric insulins and their experimental and clinical implications Diabetes Care 13 1990 923 954
3. E. Mosekilde, K.S. Jensen, C. Binder, S. Pramming, and B. Thorsteinsson Modeling absorption kinetics of subcutaneous injected soluble insulin J. Pharmacokinet. Biopharm. 17 1989 67 87
4. J. Brange, and L. Langkjoer Insulin structure and stability Y.J. Wang, R. Pearlman, Stability and Characterization of Protein and Peptide Drugs: Case Histories vol. 5 1993 Plenum Press New York 315 350
5. D.L. Bakaysa, J. Radziuk, H.A. Havel, M.L. Brader, S. Li, S.W. Dodd, J.M. Beals, A.H. Pekar, and D.N. Brems Physicochemical basis for the rapid time-action of LysB28ProB29-insulin: Dissociation of a protein-ligand complex Protein Sci. 5 1996 2521 2531
6. A. Hvidt, and K. Linderstrøm-Lang Exchange of hydrogen atoms in insulin with deuterium atoms in aqueous solutions Biochim. Biophys. Acta 14 1954 574 575
7. S.W. Englander, L. Mayne, Y. Bai, and T.R. Sosnick Hydrogen exchange: The modern legacy of Linderstrøm-Lang Protein Sci. 6 1997 1101 1109
8. Y. Hamuro, S.J. Coales, M.R. Southern, J.F. Nemeth-Cawley, D.D. Stranz, and P.R. Griffin Rapid analysis of protein structure and dynamics by hydrogen/deuterium exchange mass spectrometry J. Biomol. Tech. 14 2003 171 182
9. J. Borch, T.J.D. Jørgensen, and P. Roepstorff Mass spectrometric analysis of protein interactions Curr. Opin. Chem. Biol. 9 2005 509 516
10. J.R. Engen Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS Anal. Chem. 81 2009 7870 7875
11. J.R. Engen, and D.L. Smith Investigating protein structure and dynamics by hydrogen exchange MS Anal. Chem. 73 2001 256A 265A
12. L.S. Busenlehner, and R.N. Armstrong Insights into enzyme structure and dynamics elucidated by amide H/D exchange mass spectrometry Arch. Biochem. Biophys. 433 2005 34 46
13. X. Yan, J. Watson, P.S. Ho, and M.L. Deinzer Mass spectrometric approaches using electrospray ionization charge states and hydrogen-deuterium exchange for determining protein structures and their conformational changes Mol. Cell Proteomics 3 2004 10 23
14. Z. Zhang, and D.L. Smith Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation Protein Sci. 2 1993 522 531
15. I.A. Kaltashov, C.E. Bobst, and R.R. Abzalimov H/D exchange and mass spectrometry in the studies of protein conformation and dynamics: Is there a need for a top-down approach? Anal. Chem. 81 2009 7892 7899
16. S. Nakazawa, N. Hashii, A. Harazono, and N. Kawasaki Analysis of oligomeric stability of insulin analogs using hydrogen/deuterium exchange mass spectrometry Anal. Biochem. 420 2012 61 67
17. R.K. Chitta, D.L. Rempel, M.A. Grayson, E.E. Remsen, and M.L. Gross Application of SIMSTEX to oligomerization of insulin analogs and mutants J. Am. Soc. Mass Spectrom. 17 2006 1526 1534
18. Y. Bai, J.S. Milne, L. Mayne, and S.W. Englander Primary structure effects on peptide group hydrogen exchange Proteins 17 1993 75 86
19. E. Ciszak, J.M. Beals, B.H. Frank, J.C. Baker, N.D. Carter, and G.D. Smith Role of C-terminal B-chain residues in insulin assembly: The structure of hexameric LysB28ProB29-human insulin Structure 3 1995 615 622
20. Q.X. Hua, W. Jia, and M.A. Weiss Conformational dynamics of insulin Front. Endocrinol. (Lausanne) 2 2011
21. G. Bentley, D. Dodson, G. Dodson, D. Hodgkin, and D. Mercola Structure of insulin in 4-zinc insulin Nature 261 1976 166 168
22. E. Ciszak, and G.D. Smith Crystallographic evidence for dual coordination around zinc in the T3R3 human insulin hexamer Biochemistry 33 1994 1512 1517
23. S. Yamada Insulin glulisine in the management of diabetes Diabetes Metab. Syndr. Obes. 2 2009 111 115
24. M. Norrman, F. Hubálek, and G. Schluckebier Structural characterization of insulin NPH formulations Eur. J. Pharm. Sci. 30 2007 414 423