Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry

Analytical Chemistry

Volumn 78, Issue 4, 2006, Pages 1005-1014

  Chalmers, Michael J ^a   Busby, Scott A ^a   Pascal, Bruce D ^a   He, Yuanjun ^a   Hendrickson, Christopher L ^b,c   Marshall, Alan G ^b,c   Griffin, Patrick R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

^c FLORIDA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE HYDROGEN/DEUTERIUM EXCHANGE; ION CYCLOTRON; LIGAND INTERACTIONS; PROBING PROTEIN;

CYCLOTRON RESONANCE; DEUTERIUM; FOURIER TRANSFORM INFRARED SPECTROSCOPY; HYDROGEN INORGANIC COMPOUNDS; MASS SPECTROMETRY; PERTURBATION TECHNIQUES; PROTEINS;

MOLECULAR DYNAMICS;

CELL NUCLEUS RECEPTOR; GLITAZONE DERIVATIVE; LIGAND; PARTIAL AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; RETINOIC ACID RECEPTOR ALPHA;

ACCURACY; ANALYTIC METHOD; ARTICLE; AUTOMATION; BINDING SITE; COMPLEX FORMATION; CYCLOTRON; DEUTERIUM HYDROGEN EXCHANGE; HIGH THROUGHPUT SCREENING; INSULIN RESISTANCE; KINETICS; MASS SPECTROMETRY; NON INSULIN DEPENDENT DIABETES MELLITUS; PROCESS OPTIMIZATION; PROTEIN INTERACTION; RECEPTOR UPREGULATION; REPRODUCIBILITY;

AMINO ACID SEQUENCE; AUTOMATION; DEUTERIUM; FOURIER ANALYSIS; HYDROGEN; LIGANDS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR PROBES; MOLECULAR SEQUENCE DATA; PROTEINS;

EID: 33144462544     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac051294f     Document Type: Article

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