Identification of a small molecular insulin receptor agonist with potent antidiabetes activity

Diabetes

Volumn 63, Issue 4, 2014, Pages 1394-1409

  Qiang, Guifen ^a   Xue, Shenghui ^b   Yang, Jenny J ^b   Du, Guanhua ^c   Pang, Xiaobin ^c,d   Li, Xiaoting ^c,d   Goswami, Devrishi ^e   Griffin, Patrick R ^e   Ortlund, Eric A ^a   Chan, Chi Bun ^a   Ye, Keqiang ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c INSTITUTE OF MATERIA MEDICA   (China)

^d HENAN UNIVERSITY   (China)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4548G 05; [9,9' BI 4H NAPHTHOL[2,3 B]PYRAN] 4,4' DIONE,2,2',3,3' TETRAHYDRI 5,5',6,6'8,8' HEXAHYDROXY 2,2',3,3' TETRAMETHYL; ANTIDIABETIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE; INSULIN DERIVATIVE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VERAPAMIL; WARFARIN;

AKT KINASE ASSAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CELL SCREENING; CHO CELL; COMET ASSAY; DEUTERIUM HYDROGEN EXCHANGE; DIABETES MELLITUS; DRUG ACTIVITY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG SCREENING; FLUORESCENCE; GLUCOSE ASSAY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; HIGH THROUGHPUT SCREENING; IC 50; IMMUNOPRECIPITATION; IN VITRO STUDY; INSULIN BINDING; INTRACELLULAR SIGNALING; MALE; MASS SPECTROMETRY; MICRONUCLEUS TEST; MOLECULAR DOCKING; MOUSE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ULTRAVIOLET SPECTROSCOPY; WESTERN BLOTTING; X RAY CRYSTALLOGRAPHY;

ANIMALS; BLOOD GLUCOSE; CHO CELLS; CRICETULUS; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; MALE; MICE; MICE, INBRED C57BL; NAPHTHOQUINONES; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 84897841275     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0334     Document Type: Article

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